AiPD: Autoinhibited Protein Database

Q9UQ88

Gene name	CDK11A (CDC2L2, CDC2L3, PITSLREB)
Protein name	Cyclin-dependent kinase 11A
Names	Cell division cycle 2-like protein kinase 2, Cell division protein kinase 11A, Galactosyltransferase-associated protein kinase p58/GTA, PITSLRE serine/threonine-protein kinase CDC2L2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:728642
EC number	2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

710-781 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

710-781 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

567-590 (Activation loop from InterPro)

Target domain	426-711 (Protein kinase domain)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9UQ88

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9UQ88-F1	Predicted				AlphaFoldDB

739 variants for Q9UQ88

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV002558699 CA337900554 rs1266756785 RCV001170012	237	R>Q	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP gnomAD
CA337913534 rs1354648264	3	D>G		No	ClinGen gnomAD
CA337913339 rs1330444521	9	K>T		No	ClinGen gnomAD
rs1453588821 CA337913320	10	V>L		No	ClinGen TOPMed
rs941786604 CA16813391	11	K>R		No	ClinGen TOPMed
rs1335016170 CA337913236	12	T>N		No	ClinGen TOPMed
rs1458606649 CA337913204	13	L>F		No	ClinGen TOPMed
CA337913212 rs1170346043	13	L>S		No	ClinGen gnomAD
CA337913187 rs1570446043	14	D>G		No	ClinGen Ensembl
rs1475774736 CA337913192	14	D>N		No	ClinGen TOPMed gnomAD
CA337913176 rs1416585950	15	E>K		No	ClinGen gnomAD
rs775588540 CA530823	16	I>V		No	ClinGen ExAC gnomAD
CA337913127 rs1472497465	17	L>P		No	ClinGen gnomAD
rs1233480421 CA337912971	22	R>Q		No	ClinGen gnomAD
rs571630372 CA530822	23	R>K		No	ClinGen 1000Genomes ExAC TOPMed
CA337912962 rs1206751059	23	R>W		No	ClinGen gnomAD
CA337912917 rs1456558990	25	E>K		No	ClinGen gnomAD
CA16813377 rs908901739	26	Q>R		No	ClinGen TOPMed gnomAD
CA337912880 rs1557804825	27	E>K		No	ClinGen Ensembl
rs1336755741 CA337912784	29	K>I		No	ClinGen gnomAD
CA530817 rs376961550	34	R>C		No	ClinGen ESP ExAC gnomAD
rs1280722947 CA337912666	34	R>H		No	ClinGen gnomAD
rs1280722947 CA337912669	34	R>P		No	ClinGen gnomAD
rs1240882997 CA337912633	35	L>F		No	ClinGen TOPMed
CA337912630 rs1399083735	36	K>E		No	ClinGen gnomAD
rs767014805	37	N>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA337912560 rs1462264338	37	N>I		No	ClinGen gnomAD
CA337912566 rs1462264338	37	N>T		No	ClinGen gnomAD
rs762879797 CA530767	38	S>C		No	ClinGen ExAC TOPMed gnomAD
CA337912072 rs1400220521	40	D>E		No	ClinGen gnomAD
rs1187357536 CA337912088	40	D>H		No	ClinGen gnomAD
CA337912086 rs1187357536	40	D>Y		No	ClinGen gnomAD
CA530765 rs200953503	41	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs776650584 CA530766	41	R>W		No	ClinGen ExAC TOPMed gnomAD
CA337912056 rs1232444133	42	D>H		No	ClinGen TOPMed
CA337912000 rs760857763	44	K>N		No	ClinGen ExAC gnomAD
rs748452843 CA530761	45	R>L		No	ClinGen ExAC TOPMed gnomAD
CA530762 rs748452843	45	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs540105321 CA530763	45	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1418476394 CA337911945	49	E>K		No	ClinGen TOPMed gnomAD
rs1418476394 CA337911941 COSM48277	49	E>Q	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA530757 rs372225055 CA337911899	50	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA530754 rs188565066	51	G>E		No	ClinGen 1000Genomes ExAC TOPMed
CA530755 rs181359165 CA530756	51	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1195904652 CA337911869	52	E>G		No	ClinGen gnomAD
rs1059832 CA530750	57	C>G		No	ClinGen ExAC TOPMed gnomAD
rs1059832 CA530751 VAR_060152	57	C>R		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
CA530749 rs763905836	57	C>S		No	ClinGen ExAC gnomAD
rs1419820840 CA337911775	58	M>V		No	ClinGen TOPMed
rs1570441471 CA337911738	59	E>D		No	ClinGen Ensembl
rs1177013253 CA337911729	60	I>L		No	ClinGen TOPMed
rs1462432910 CA337911698	62	I>L		No	ClinGen TOPMed
rs1570441450 CA337911695	62	I>R		No	ClinGen Ensembl
CA16812465 rs565553918	64	N>K		No	ClinGen ExAC gnomAD
CA530747 rs368753784	66	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs368753784 CA530746	66	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1247569295 CA337911628	66	P>S		No	ClinGen gnomAD
rs201926274 CA16812436	67	Y>*		No	ClinGen TOPMed gnomAD
CA530744 rs773403139	67	Y>C		No	ClinGen ExAC gnomAD
CA337911595 rs1329634414	68	R>K		No	ClinGen gnomAD
TCGA novel	70	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs370759338 CA530743	72	S>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs1164804426 CA337911522	72	S>P		No	ClinGen gnomAD
rs774820411 CA530741	73	M>V		No	ClinGen ExAC TOPMed gnomAD
CA337911461 rs1441078198	75	D>G		No	ClinGen gnomAD
rs770617385 CA16812415	76	R>K		No	ClinGen TOPMed
rs770617385 CA337911432	76	R>T		No	ClinGen TOPMed
rs771649177 CA530689	77	G>R		No	ClinGen ExAC gnomAD
rs747870830 CA530688	77	G>V		No	ClinGen ExAC gnomAD
CA530684 rs749100082	79	E>*		No	ClinGen ExAC TOPMed gnomAD
CA530683 rs201091435	79	E>D		No	ClinGen 1000Genomes ExAC gnomAD
rs749100082 CA337909462	79	E>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	80	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756131673 CA530682	80	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1274366317 CA337909432	80	D>V		No	ClinGen TOPMed
TCGA novel	81	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1354369436 CA337909427	81	D>N		No	ClinGen TOPMed
CA337909340 rs1360434615	84	A>G		No	ClinGen gnomAD
CA530678 rs201674700	85	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1570432368 CA337909318	86	K>E		No	ClinGen Ensembl
rs758644941 CA337909313	86	K>R		No	ClinGen ExAC TOPMed gnomAD
rs758644941 CA530677	86	K>T		No	ClinGen ExAC TOPMed gnomAD
CA337909296 rs1171761951	87	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs752941599 CA530676	87	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1193639926 CA337909252	90	Q>*		No	ClinGen gnomAD
CA337909205 rs1442908347	91	M>I		No	ClinGen TOPMed
CA530672 rs766815750	91	M>T		No	ClinGen ExAC gnomAD
rs1239244294 CA337909222	91	M>V		No	ClinGen TOPMed gnomAD
CA337909180 rs1414398401	92	S>F		No	ClinGen TOPMed gnomAD
VAR_062200 rs7531938	92	S>P		No	UniProt dbSNP
rs1059831 CA337909175	93	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA530670 rs200755605	93	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
VAR_031716 VAR_057775 CA530671 rs1059831	93	R>W		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA337909123 rs1315882882	95	E>D		No	ClinGen gnomAD
rs201838992 CA530668	96	K>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs72909030 CA530667	97	V>A		No	ClinGen 1000Genomes ExAC gnomAD
CA337909079 rs1187002514	98	H>N		No	ClinGen TOPMed
rs768246706 CA530666	99	H>Y		No	ClinGen ExAC gnomAD
rs542603674 CA530664	100	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	100	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	100	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769812604 CA530662	101	K>R		No	ClinGen ExAC gnomAD
CA16808439 rs1028111893	104	K>*		No	ClinGen TOPMed
CA530661 rs745820114	104	K>R		No	ClinGen ExAC gnomAD
CA337908883 rs1398497577	105	R>G		No	ClinGen TOPMed gnomAD
TCGA novel	105	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA337908867 rs1406393010	106	K>E		No	ClinGen gnomAD
rs752787794 CA530658	106	K>N		No	ClinGen ExAC gnomAD
CA337908864 rs1416608708	106	K>R		No	ClinGen gnomAD
COSM1335926 CA337908851 rs1238991773	107	E>G	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs779182274 CA530657	107	E>K		No	ClinGen ExAC gnomAD
CA16808408 rs201592416	108	K>E		No	ClinGen 1000Genomes
rs746108190 CA530591	109	W>*		No	ClinGen ExAC TOPMed gnomAD
rs1059830 VAR_062199 CA530655	109	W>C		No	ClinGen UniProt 1000Genomes ExAC dbSNP gnomAD
CA337906176 rs1431466897	110	K>*		No	ClinGen gnomAD
CA337906163 rs1557794280	110	K>N		No	ClinGen Ensembl
rs771167585 CA530590	111	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs1203428468 CA337906059	113	R>T		No	ClinGen gnomAD
rs112748730 CA530588	114	V>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA16805144 rs112748730	114	V>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs112748730 CA337906034	114	V>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs778129644 CA530585	117	R>G		No	ClinGen ExAC gnomAD
CA16805111 rs200224067	117	R>K		No	ClinGen Ensembl
rs200224067 CA337905940	117	R>T		No	ClinGen Ensembl
rs752188532 CA530579	118	E>D		No	ClinGen ExAC gnomAD
rs1557794182 CA337905913	118	E>Q		No	ClinGen Ensembl
rs754630865 CA530577	119	H>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA337905860 rs1336369850	120	E>K		No	ClinGen gnomAD
rs1336369850 CA337905858	120	E>Q		No	ClinGen gnomAD
CA530575 rs371899640	121	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs766098874 CA530574	121	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs750242434 CA530572	122	R>Q	Variant assessed as Somatic; 4.824e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs760387372 CA530573	122	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1368996807 CA337905780	123	K>E		No	ClinGen gnomAD
TCGA novel CA530571 rs767371982	123	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ExAC gnomAD
CA337905766 rs1189000654	123	K>R		No	ClinGen gnomAD
rs199510897 CA530570	124	R>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA530568 rs374642406	124	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1274179044 CA337905711	125	H>L		No	ClinGen TOPMed gnomAD
rs1274179044 CA337905713	125	H>R		No	ClinGen TOPMed gnomAD
rs1240371604 CA337905701	126	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs776712506 CA530566	126	R>Q		No	ClinGen ExAC gnomAD
CA337905648 rs1266617537	127	E>*		No	ClinGen gnomAD
CA530564 rs747279722	127	E>G		No	ClinGen ExAC gnomAD
CA337905637 rs747279722	127	E>V		No	ClinGen ExAC gnomAD
CA530563 rs570927461	128	E>*		No	ClinGen 1000Genomes ExAC gnomAD
CA530561 rs772669213	128	E>D		No	ClinGen ExAC gnomAD
CA337905622 rs570927461	128	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs201054761 CA530560	129	Q>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA530559 rs527915790	129	Q>H		No	ClinGen 1000Genomes ExAC gnomAD
rs1328970747 CA337905544	130	D>G		No	ClinGen gnomAD
CA337905551 rs1570415127	130	D>N		No	ClinGen Ensembl
CA530558 rs754510372	131	K>E		No	ClinGen ExAC gnomAD
CA337905493 rs1164971376	132	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA530557 rs753458825	133	R>C		No	ClinGen ExAC TOPMed gnomAD
CA337905482 rs753458825	133	R>G		No	ClinGen ExAC TOPMed gnomAD
rs370418133 CA530555	133	R>H		No	ClinGen ESP ExAC gnomAD
rs370418133 CA530556	133	R>L		No	ClinGen ESP ExAC gnomAD
CA530551 COSM530211 rs751465521	134	R>Q	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA530552 rs200272503	134	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA337905457 rs542594220	135	E>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA530550 rs542594220	135	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs759520770 CA530549	139	Q>E		No	ClinGen ExAC gnomAD
CA337905339 rs1361632246	139	Q>R		No	ClinGen TOPMed
rs1354892963 CA337905305	140	K>N		No	ClinGen gnomAD
rs776785110 CA530548	142	R>G		No	ClinGen ExAC
rs1387090217 CA337905272	142	R>K		No	ClinGen TOPMed
CA530546 rs760989414	142	R>S		No	ClinGen ExAC gnomAD
CA337905247 rs1291051298	143	E>G		No	ClinGen gnomAD
rs748566008 CA530542	144	M>I		No	ClinGen ExAC gnomAD
CA530543 rs772544700	144	M>T		No	ClinGen ExAC
rs769348783 CA337905203	145	A>P		No	ClinGen ExAC gnomAD
rs769348783 CA530540	145	A>S		No	ClinGen ExAC gnomAD
rs769348783 CA530541	145	A>T		No	ClinGen ExAC gnomAD
rs748675685 CA530539	147	E>K		No	ClinGen ExAC gnomAD
CA337905145 rs1331517082	148	H>Y		No	ClinGen TOPMed gnomAD
CA530537 rs779642694	149	S>C		No	ClinGen ExAC gnomAD
rs755670050 CA530536	150	R>W		No	ClinGen ExAC gnomAD
CA530535 COSM424451 rs745508835	151	R>K	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs531731523 CA530534	152	E>*		No	ClinGen 1000Genomes ExAC gnomAD
CA530532 rs751412468	153	R>K		No	ClinGen ExAC
rs757040406 CA337905019	153	R>W		No	ClinGen ExAC gnomAD
CA337902786 rs1341885919	154	D>Y		No	ClinGen gnomAD
rs1269187569 CA337902771	155	R>H		No	ClinGen TOPMed
rs1334325365 CA337902753	156	L>M		No	ClinGen gnomAD
TCGA novel	157	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA337902681 rs1405746010	158	Q>P	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1334364056 CA337902625	160	E>G		No	ClinGen gnomAD
rs1412068441 CA337902608	162	K>E		No	ClinGen TOPMed gnomAD
rs1228954480 CA337902593	163	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA337902570 rs1282580888	165	R>P		No	ClinGen TOPMed
TCGA novel	165	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1230259082 CA337902548	167	R>C		No	ClinGen TOPMed gnomAD
CA337902526 rs1570402181	169	M>R		No	ClinGen Ensembl
rs1570402181 CA337902525	169	M>T		No	ClinGen Ensembl
CA337902511 rs1181927810	171	E>K		No	ClinGen gnomAD
CA337902485 rs1411013842	172	Q>H		No	ClinGen TOPMed
rs750591753 CA530506	174	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs1247076120 CA337902442	176	Q>E		No	ClinGen TOPMed
rs1188306273 CA337902437	176	Q>H		No	ClinGen TOPMed
rs1557789975 CA337902431	177	R>L		No	ClinGen Ensembl
CA337902432 rs1557789975	177	R>P		No	ClinGen Ensembl
TCGA novel	177	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	177	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA337902420 rs1461065468	179	Q>*		No	ClinGen gnomAD
CA16802379 rs1055464360	179	Q>H		No	ClinGen TOPMed
rs1230752100 CA337902399	182	R>C		No	ClinGen TOPMed
rs1272281807 CA337902393	183	E>K		No	ClinGen TOPMed gnomAD
CA337902383 rs1228359722	184	R>Q		No	ClinGen gnomAD
CA530502 rs762135149	185	R>Q		No	ClinGen ExAC gnomAD
CA530503 rs767793604	185	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs751920527 CA337902373	186	A>G		No	ClinGen ExAC TOPMed gnomAD
CA530501 rs751920527	186	A>V		No	ClinGen ExAC TOPMed gnomAD
CA16802302 rs925624781	187	E>K		No	ClinGen TOPMed
CA337902355 rs1353236141	189	R>P		No	ClinGen TOPMed gnomAD
rs1353236141 CA337902354	189	R>Q		No	ClinGen TOPMed gnomAD
rs55710038 CA530499	189	R>W		No	ClinGen ExAC TOPMed gnomAD
CA337902353 rs1406484736	190	R>S		No	ClinGen TOPMed gnomAD
CA337902346 rs1488421089	191	K>E		No	ClinGen TOPMed
rs1245529748 CA337902328	192	E>D		No	ClinGen TOPMed
rs1207364443 CA337902321	193	R>Q		No	ClinGen TOPMed
rs1570401705 CA337902301	194	E>D		No	ClinGen Ensembl
rs776054548 CA530497	194	E>Q		No	ClinGen ExAC
CA337902298 rs1274108260	195	A>P		No	ClinGen TOPMed
CA337902291 rs1161756757	196	R>C		No	ClinGen TOPMed gnomAD
rs1161756757 CA337902287	196	R>G		No	ClinGen TOPMed gnomAD
CA337902285 rs1444178149	196	R>H		No	ClinGen gnomAD
CA337901287 rs1311052934	205	T>A		No	ClinGen TOPMed gnomAD
rs1490232127 CA337901282	205	T>M		No	ClinGen TOPMed
CA337901275 rs1206359070	206	M>T		No	ClinGen TOPMed
CA337901215 rs1307918312	208	E>K		No	ClinGen TOPMed
CA337901194 rs1294744304	209	D>N		No	ClinGen TOPMed
CA16801024 rs891480900	212	D>N		No	ClinGen TOPMed gnomAD
rs1437729580 CA337901090	214	V>M		No	ClinGen gnomAD
rs1040708957 CA16801014	221	R>C		No	ClinGen TOPMed
rs1343180348 CA337900917	221	R>H		No	ClinGen TOPMed
rs1463835927 CA337900884	223	P>L		No	ClinGen TOPMed
CA337900886 rs1463835927	223	P>R		No	ClinGen TOPMed
rs1368021068 CA337900858	224	P>L		No	ClinGen TOPMed gnomAD
rs1432103614 CA337900843	225	R>Q		No	ClinGen TOPMed
rs1301361553 CA337900850	225	R>W		No	ClinGen TOPMed gnomAD
CA337900820 rs1424177444	226	P>L		No	ClinGen TOPMed gnomAD
CA337900809 rs1480191273	227	P>L		No	ClinGen TOPMed
CA337900794 rs1250513699	228	R>Q		No	ClinGen TOPMed
CA337900803 rs1161614230	228	R>W		No	ClinGen TOPMed gnomAD
rs1008486738 CA16801009	229	E>K		No	ClinGen TOPMed
rs1263682242 CA337900765	230	R>W		No	ClinGen TOPMed
rs1320871880 CA337900671	232	E>D		No	ClinGen TOPMed
CA337900607 rs1222019469	235	D>N		No	ClinGen TOPMed gnomAD
rs1481343352 CA337900558	237	R>W		No	ClinGen TOPMed gnomAD
rs1488360165 CA337900362	244	P>L		No	ClinGen TOPMed gnomAD
CA337900375 rs1445034413	244	P>S		No	ClinGen TOPMed
CA337900348 rs1213164004	245	A>V		No	ClinGen TOPMed gnomAD
CA337900286 rs1161418073	247	A>T		No	ClinGen TOPMed
CA16800989 rs890008305	247	A>V		No	ClinGen TOPMed gnomAD
rs1315974039 CA337900139	251	A>S		No	ClinGen gnomAD
rs1220237262 CA337900115	252	Q>*		No	ClinGen TOPMed gnomAD
rs1277948827 CA337899886	258	M>V		No	ClinGen TOPMed
CA16800943 rs927269372	261	R>G		No	ClinGen TOPMed
CA337899802 rs1217564238	261	R>K		No	ClinGen TOPMed
CA337899704 rs1478125717	266	D>N		No	ClinGen TOPMed gnomAD
CA337899679 rs1331559311	267	L>V		No	ClinGen TOPMed
rs980406230 CA16800942	269	D>N		No	ClinGen TOPMed
CA337899587 rs1263142000	273	S>N		No	ClinGen TOPMed gnomAD
rs776132018 CA530494	274	E>K		No	ClinGen ExAC TOPMed gnomAD
CA337899526 rs1185837145	279	S>A		No	ClinGen TOPMed
rs1445709410 CA337899523	279	S>L		No	ClinGen TOPMed
CA337899512 rs1216211749	281	E>G		No	ClinGen TOPMed
CA337899516 rs1256296540	281	E>K		No	ClinGen TOPMed gnomAD
CA337899506 rs1351817323	282	S>A		No	ClinGen TOPMed
CA337899499 rs1204682787	283	S>L		No	ClinGen TOPMed gnomAD
rs955735593 CA16800926	285	A>V		No	ClinGen TOPMed gnomAD
rs1349702156 CA337899449	288	G>R		No	ClinGen TOPMed
rs1387516478 CA337899433	290	G>R		No	ClinGen Ensembl
CA337899400 rs1570394254	293	E>*		No	ClinGen Ensembl
rs1203445518 CA337899300	300	E>*		No	ClinGen TOPMed gnomAD
rs1340663875 CA337899288	301	E>K		No	ClinGen gnomAD
rs1283488017 CA337899230	305	G>E		No	ClinGen TOPMed
rs1216243441 CA337899237	305	G>R		No	ClinGen TOPMed
rs1570394080 CA337899212	307	T>P		No	ClinGen Ensembl
CA337899207 rs1365073858	308	S>G		No	ClinGen TOPMed
CA337899205 rs1292086594	308	S>N		No	ClinGen TOPMed
CA337899131 rs1570393993	314	E>A		No	ClinGen Ensembl
CA337899072 rs1237475804	318	E>G		No	ClinGen TOPMed
rs1480871142 CA337899076	318	E>K		No	ClinGen TOPMed
rs1480871142 CA337899075	318	E>Q		No	ClinGen TOPMed
CA337899046 rs1308779493	320	E>D		No	ClinGen TOPMed
rs1225816713 CA337899038	321	E>K		No	ClinGen TOPMed
CA337899005 rs1570393790	323	E>G		No	ClinGen Ensembl
rs1335822527 CA337898972	325	T>I		No	ClinGen TOPMed gnomAD
rs1570393724 CA337898979	325	T>P		No	ClinGen Ensembl
CA337898973 rs1335822527	325	T>S		No	ClinGen TOPMed gnomAD
CA337898967 rs1398501175	326	G>S		No	ClinGen TOPMed gnomAD
CA337898958 rs1199383037	326	G>V		No	ClinGen TOPMed
CA337898933 rs1482021433	328	N>K		No	ClinGen TOPMed
CA337898926 rs1262100342	329	S>F		No	ClinGen TOPMed
CA337898892 rs1296427701	332	A>S		No	ClinGen gnomAD
rs1352557603 CA337898883	333	S>A		No	ClinGen TOPMed
CA337898870 rs1570393619	334	E>A		No	ClinGen Ensembl
CA16800891 rs1007932284	335	Q>H		No	ClinGen TOPMed gnomAD
CA337898852 rs1314140565	336	S>A		No	ClinGen TOPMed
rs1461444530 CA337898843	336	S>F		No	ClinGen gnomAD
CA337898750 rs1487770188	339	E>V		No	ClinGen TOPMed
CA337898732 rs1476273744	341	S>G		No	ClinGen TOPMed gnomAD
CA337898730 rs1346066075	341	S>N		No	ClinGen TOPMed gnomAD
CA337898717 rs1489750510	342	E>*		No	ClinGen TOPMed
rs554157354 CA337898707	342	E>D		No	ClinGen 1000Genomes gnomAD
rs1344270166 CA337898706	343	E>K		No	ClinGen TOPMed gnomAD
rs898705920 CA16800563	346	S>G		No	ClinGen TOPMed
CA530470 rs768661904	346	S>T		No	ClinGen ExAC gnomAD
CA530469 rs749210532	348	D>N		No	ClinGen ExAC TOPMed gnomAD
CA530468 rs780192737	350	E>K		No	ClinGen ExAC gnomAD
CA337898619 rs1453543330	351	R>*		No	ClinGen TOPMed gnomAD
CA530467 rs757402171	351	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA530466 rs751757795	353	N>I		No	ClinGen ExAC TOPMed gnomAD
CA337898588 rs1391349555	354	E>K		No	ClinGen TOPMed
CA337898576 rs1268192880	355	N>D		No	ClinGen gnomAD
CA337898564 rs1570390581	356	H>P		No	ClinGen Ensembl
CA16800513 rs1015789392	357	L>P		No	ClinGen TOPMed
rs1448946553 CA337898539	358	L>W		No	ClinGen gnomAD
TCGA novel	360	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754265806 CA530439	361	P>S		No	ClinGen ExAC gnomAD
CA337897808 rs1185237764	362	E>K		No	ClinGen TOPMed
rs766803346 CA530438	363	S>*		No	ClinGen ExAC gnomAD
rs766803346 CA337897775	363	S>L		No	ClinGen ExAC gnomAD
rs756623988 CA530437	364	R>Q		No	ClinGen ExAC gnomAD
rs1233263675 CA337897772	364	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA530435 rs766962720	366	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1361149658 CA337897694	367	R>*		No	ClinGen TOPMed gnomAD
rs1361149658 CA337897703	367	R>G		No	ClinGen TOPMed gnomAD
TCGA novel	367	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA530434 rs773866402	367	R>P		No	ClinGen ExAC gnomAD
rs773866402 CA530433	367	R>Q		No	ClinGen ExAC gnomAD
CA530431 rs762772162	368	D>G		No	ClinGen ExAC gnomAD
rs6658335 CA530428	370	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1353328925 CA337897584	370	G>V		No	ClinGen gnomAD
rs1371649508 CA337897545	372	S>R		No	ClinGen TOPMed
CA530427 rs776669960	373	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1425424023 CA337897516	374	E>A		No	ClinGen gnomAD
rs1367657075 CA337897508	374	E>D		No	ClinGen TOPMed gnomAD
rs772021911 CA530426	378	E>K		No	ClinGen ExAC gnomAD
CA16799995 rs1035159348	382	G>A		No	ClinGen TOPMed gnomAD
rs538694157 CA530423	383	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA530421 rs572960277	384	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1317146130 CA337897324	385	Q>*		No	ClinGen gnomAD
CA530418 rs781753792	385	Q>R		No	ClinGen ExAC gnomAD
rs770654419 CA16799964	386	S>N		No	ClinGen ExAC TOPMed gnomAD
CA530417 rs770654419	386	S>T		No	ClinGen ExAC TOPMed gnomAD
CA337897289 rs751121546	387	S>N		No	ClinGen ExAC TOPMed gnomAD
CA530416 rs751121546	387	S>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	388	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs553132525 CA530414	388	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1161020928 CA337897213	391	E>D		No	ClinGen TOPMed gnomAD
rs765094175 CA530411	391	E>G		No	ClinGen ExAC gnomAD
CA530410 rs759424277	392	G>S		No	ClinGen ExAC gnomAD
CA530408 rs200982240	393	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA530407 rs372466982	394	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs774425238 CA530406	395	V>M		No	ClinGen ExAC TOPMed
rs749540364 CA530404	396	P>A		No	ClinGen ExAC gnomAD
CA337897110 rs746314221	397	D>E		No	ClinGen ExAC TOPMed gnomAD
rs770045003 CA337897118	397	D>N		No	ClinGen ExAC gnomAD
CA337897114 rs1390389600	397	D>V		No	ClinGen TOPMed
rs770045003 CA530402	397	D>Y		No	ClinGen ExAC gnomAD
rs1570387143 CA337897107	398	S>P		No	ClinGen Ensembl
CA530398 rs751066507	399	P>L		No	ClinGen ExAC gnomAD
rs757798116 CA530399	399	P>S		No	ClinGen ExAC TOPMed gnomAD
rs777457352 CA337897067	400	A>G		No	ClinGen ExAC gnomAD
rs777457352 CA530397	400	A>V		No	ClinGen ExAC gnomAD
rs1059828 CA337897039	402	L>*		No	ClinGen ExAC TOPMed gnomAD
rs1059828 CA530394 VAR_031717	402	L>S		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
CA530395 rs1059828	402	L>W		No	ClinGen ExAC TOPMed gnomAD
rs1362889009 CA337897014	403	P>L		No	ClinGen TOPMed gnomAD
rs1362889009 CA337897024	403	P>R		No	ClinGen TOPMed gnomAD
rs367901816 CA337896987	404	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs753671198 CA530392	404	I>V		No	ClinGen ExAC TOPMed gnomAD
CA530389 rs374965804	405	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs760680988 CA530390	405	E>K		No	ClinGen ExAC TOPMed gnomAD
CA337896983 rs760680988	405	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs200726395 CA530388	406	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA337896949 rs1174707279	407	K>R		No	ClinGen gnomAD
CA530387 rs763082026	408	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs775690147 CA530386	411	P>L		No	ClinGen ExAC gnomAD
rs367795282 CA16799769	412	K>M		No	ClinGen ESP TOPMed
CA337896860 rs1570386872	413	Y>S		No	ClinGen Ensembl
CA530385 rs770062280	414	L>V		No	ClinGen ExAC TOPMed gnomAD
COSM1472919 rs1051015506 CA16799753	415	P>L	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA337896811 rs1557784336	416	A>D		No	ClinGen Ensembl
rs371163262 CA337896783	418	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA337895945 rs1311744460	421	R>Q		No	ClinGen gnomAD
rs1380254877 CA337895948	421	R>W		No	ClinGen TOPMed gnomAD
CA16798411 rs776759183	422	S>R		No	ClinGen ExAC TOPMed gnomAD
CA337895919 rs1375514100	423	V>I		No	ClinGen TOPMed gnomAD
CA337895907 rs1435004943	424	E>*		No	ClinGen TOPMed
CA337895912 rs1435004943	424	E>K		No	ClinGen TOPMed
rs1295939309 CA337895881	426	F>L		No	ClinGen gnomAD
rs747435567 CA337895840	428	C>*		No	ClinGen ExAC
CA337895843 rs1363857185	428	C>F		No	ClinGen TOPMed
rs1165038165 CA337895785	433	E>*		No	ClinGen TOPMed gnomAD
rs1294542916 CA337895743	436	T>S		No	ClinGen TOPMed
rs949285719 CA16798345	438	G>E		No	ClinGen TOPMed
rs1430445962 CA337895704	440	V>I		No	ClinGen TOPMed
rs1367017021 CA337895693	441	Y>H		No	ClinGen gnomAD
rs1372586557 CA337895667	442	R>I		No	ClinGen TOPMed
CA337895670 rs1372586557	442	R>K		No	ClinGen TOPMed
CA337895652 rs1168533215	444	K>E		No	ClinGen TOPMed
CA337895639 rs1420194134	445	D>E		No	ClinGen gnomAD
CA337895644 rs773851666	445	D>H		No	ClinGen ExAC gnomAD
CA530362 rs773851666	445	D>Y		No	ClinGen ExAC gnomAD
RCV000480151 rs754605532	447	K>missing		No	ClinVar dbSNP
TCGA novel	449	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA337895615 rs1482740501	449	D>H		No	ClinGen gnomAD
rs759584229 CA530348	451	I>T		No	ClinGen ExAC TOPMed gnomAD
CA16798133 rs55658751	451	I>V		No	ClinGen Ensembl
CA337895568 rs1473847750	454	L>P		No	ClinGen TOPMed
rs376481107 CA530345	456	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA16798121 rs766774315	456	R>W		No	ClinGen ExAC TOPMed gnomAD
CA530342 rs557274278	459	M>T		No	ClinGen ExAC gnomAD
rs1341793242 CA337895529	460	E>Q		No	ClinGen TOPMed gnomAD
CA337895461 rs1383590192	464	E>D		No	ClinGen TOPMed gnomAD
CA530339 rs774758666	464	E>K		No	ClinGen ExAC TOPMed gnomAD
rs768186787 CA530336	466	F>L		No	ClinGen ExAC gnomAD
rs748804386 CA530335	467	P>L		No	ClinGen ExAC TOPMed gnomAD
CA16798057 rs781272091	467	P>T		No	ClinGen Ensembl
CA530333 rs372941585	469	T>M		No	ClinGen ESP ExAC gnomAD
CA337895388 rs1377166491	470	S>F		No	ClinGen gnomAD
rs528622251 CA530328	473	E>D		No	ClinGen 1000Genomes ExAC gnomAD
CA337895355 rs1415351323	473	E>G		No	ClinGen gnomAD
rs547132690 CA530329	473	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs559525010 CA530326	474	I>M		No	ClinGen 1000Genomes ExAC gnomAD
rs1264975096 CA337895308	475	N>K		No	ClinGen gnomAD
CA337895302 rs1322166329	476	T>A		No	ClinGen TOPMed
CA530323 rs750773628	477	I>M		No	ClinGen ExAC
rs760998676 CA530324	477	I>T		No	ClinGen ExAC TOPMed gnomAD
CA337895250 rs1346163253	478	L>F		No	ClinGen TOPMed
rs576602267 CA530322	479	K>E		No	ClinGen ExAC TOPMed gnomAD
rs762130257 CA530321	479	K>T		No	ClinGen ExAC TOPMed gnomAD
rs1295849649 CA337895205	480	A>D		No	ClinGen gnomAD
rs1419856197 CA337895183	481	Q>H		No	ClinGen gnomAD
rs774905323 CA530320	481	Q>R		No	ClinGen ExAC gnomAD
rs769051886 CA530319	482	H>Y		No	ClinGen ExAC gnomAD
rs762470986 CA530318	484	N>H		No	ClinGen ExAC gnomAD
rs769400304 CA530316	485	I>N		No	ClinGen ExAC TOPMed gnomAD
rs769400304 CA337895097	485	I>T		No	ClinGen ExAC TOPMed gnomAD
rs542926483 CA530317	485	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA530313 rs770700733	486	V>A		No	ClinGen ExAC gnomAD
rs758281969 CA530310	488	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1259937678 CA337895024	489	R>K		No	ClinGen TOPMed
CA530248 rs564492756	490	E>D		No	ClinGen 1000Genomes ExAC gnomAD
rs770903653 CA530249	490	E>K		No	ClinGen ExAC TOPMed gnomAD
rs201308032 CA530246	491	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1257806308 CA337894761	493	V>L		No	ClinGen TOPMed
CA337894764 rs1257806308	493	V>M		No	ClinGen TOPMed
rs1254322527 CA337894749	494	G>D		No	ClinGen gnomAD
CA337894756 rs1484531999	494	G>S		No	ClinGen gnomAD
CA337894742 rs1209594409	495	S>N		No	ClinGen gnomAD
rs779278752 CA530243	497	M>I		No	ClinGen ExAC
CA337894645 rs1454756396	497	M>V		No	ClinGen TOPMed
CA530242 rs368047902	499	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA337894520 rs1397699196	500	I>M		No	ClinGen gnomAD
CA530240 rs780664705	500	I>N		No	ClinGen ExAC gnomAD
rs754276993 CA530241	500	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1376969807 CA337894493	501	Y>C		No	ClinGen TOPMed gnomAD
rs749952146 CA530238	503	V>L		No	ClinGen ExAC TOPMed gnomAD
rs749952146 CA530239	503	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA530237 rs767017556	504	M>V		No	ClinGen ExAC gnomAD
rs1059822 CA337894263	506	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA530235 rs751299422	506	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA337894233 rs1166003410	507	V>M		No	ClinGen gnomAD
CA530233 rs762903481	508	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1254738520 CA337894203	508	E>G		No	ClinGen gnomAD
CA337894211 rs1426072836	508	E>Q		No	ClinGen gnomAD
CA337894192 rs1483397577	509	H>Y		No	ClinGen gnomAD
rs1570373309 CA337894161	510	D>A		No	ClinGen Ensembl
COSM898846 CA16797533 rs936549366	510	D>N	endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA530231 rs200942510	512	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1265803136 CA337894061	513	S>N		No	ClinGen gnomAD
rs368648532 CA530230	514	L>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA337894015 rs1570373268	515	M>I		No	ClinGen Ensembl
CA530229 rs773366177	516	E>K		No	ClinGen ExAC gnomAD
CA337893958 rs1311852410	517	T>I		No	ClinGen gnomAD
rs748338152 CA530227	518	M>T		No	ClinGen ExAC gnomAD
CA337893951 rs1351726295	518	M>V		No	ClinGen gnomAD
rs1408821383 CA337893857	520	Q>*		No	ClinGen gnomAD
CA530225 rs768991667	521	P>L		No	ClinGen ExAC gnomAD
rs779154041 CA530226	521	P>S		No	ClinGen ExAC TOPMed gnomAD
rs779154041 CA337893842	521	P>T		No	ClinGen ExAC TOPMed gnomAD
CA337893738 rs1164647783	524	P>S		No	ClinGen gnomAD
CA337893720 rs1473209358	525	G>R		No	ClinGen gnomAD
rs1286422471 CA337893392	526	E>D		No	ClinGen TOPMed gnomAD
rs369296379 CA337893385 CA337893388 COSM1247910	527	V>L	oesophagus [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs369296379 CA530160	527	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA337893350 rs1308732109	528	K>N		No	ClinGen TOPMed gnomAD
TCGA novel	529	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750349983 CA530156	530	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1557779514 CA337893234	533	Q>*		No	ClinGen Ensembl
CA337893216 rs758440722	533	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA337893207 rs1415728933	534	L>V		No	ClinGen gnomAD
rs1474845730 CA337893170	535	L>P		No	ClinGen gnomAD
rs374016782 CA337893154	536	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA530151 rs374016782	536	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1412046998 CA337893163	536	R>W		No	ClinGen gnomAD
rs1250675952 CA337893129	537	G>V		No	ClinGen gnomAD
rs759869925 CA530149	538	V>M		No	ClinGen ExAC gnomAD
TCGA novel	539	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754154891 CA530147	539	K>Q		No	ClinGen ExAC gnomAD
rs766826532 CA530146	539	K>T		No	ClinGen ExAC TOPMed gnomAD
rs773764705 CA530144	540	H>L		No	ClinGen ExAC TOPMed gnomAD
rs773764705 CA337893064	540	H>R		No	ClinGen ExAC TOPMed gnomAD
CA337893071 rs1334834195	540	H>Y		No	ClinGen gnomAD
rs772461086 CA530143	541	L>P		No	ClinGen ExAC gnomAD
CA530141 CA530142 rs377008127	542	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs779742571 CA530138	543	D>E		No	ClinGen ExAC gnomAD
rs372429949 CA530139	543	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA337892999 rs1321409606	544	N>S		No	ClinGen gnomAD
CA530136 rs769575432	549	R>C		No	ClinGen ExAC gnomAD
CA530135 rs369035896	549	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA337892843 rs1406651464	551	L>F		No	ClinGen gnomAD
rs930296152 CA16797177	552	K>E		No	ClinGen TOPMed
rs757164651 CA530133	553	T>M		No	ClinGen ExAC TOPMed gnomAD
CA530132 rs748219267	555	N>S		No	ClinGen ExAC gnomAD
CA530131 rs186584733	560	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA530129 rs375112331	561	A>T		No	ClinGen ExAC TOPMed gnomAD
CA337892624 rs367807408	562	G>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA530126 rs367807408 COSM1247912	562	G>D	oesophagus [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs574355501 CA530127	562	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA530125 rs768015274	563	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs762255154 CA530124	564	L>F		No	ClinGen ExAC gnomAD
rs1455583853 CA337892560	565	K>N		No	ClinGen gnomAD
CA337892568 rs1322417142	565	K>R		No	ClinGen gnomAD
rs1306829870 CA337892338	567	G>C		No	ClinGen gnomAD
rs751969001 CA530085	569	F>Y		No	ClinGen ExAC gnomAD
CA530083 rs758938952	570	G>E		No	ClinGen ExAC gnomAD
CA337892219 rs1457075047	570	G>W		No	ClinGen gnomAD
CA530081 rs562414511	572	A>E		No	ClinGen ExAC gnomAD
rs753246844 CA530082	572	A>P		No	ClinGen ExAC TOPMed gnomAD
rs753246844 CA337892183	572	A>T		No	ClinGen ExAC TOPMed gnomAD
CA530080 rs562414511	572	A>V		No	ClinGen ExAC gnomAD
CA530077 rs372661453	573	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA530078 rs372661453	573	R>Q	Variant assessed as Somatic; 4.737e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA337892164 rs756189308	573	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA530075 rs369978825	575	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	575	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774477354 CA337892082	576	G>*		No	ClinGen ExAC TOPMed gnomAD
rs774477354 CA530073	576	G>R		No	ClinGen ExAC TOPMed gnomAD
CA530071 rs745966193	577	S>Y		No	ClinGen ExAC TOPMed gnomAD
rs1480166327 CA337892010	578	P>R		No	ClinGen gnomAD
CA337892016 rs183405236	578	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA530070 rs183405236	578	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1557778806 CA337891920	581	A>D		No	ClinGen Ensembl
rs1265820956 CA337891937	581	A>T		No	ClinGen TOPMed gnomAD
rs771208691 CA530068	582	Y>C		No	ClinGen ExAC
rs1292096698 CA337891884	583	T>A		No	ClinGen gnomAD
rs778084332 CA337891877	583	T>I		No	ClinGen ExAC TOPMed gnomAD
CA530065 rs778084332	583	T>S		No	ClinGen ExAC TOPMed gnomAD
rs754377026 CA530061	584	P>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	584	P>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779466075 CA530062	584	P>S		No	ClinGen ExAC TOPMed gnomAD
rs779466075 CA337891867	584	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1462887623 CA337891858	585	V>F		No	ClinGen TOPMed
rs574343699 CA530058	586	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA530057 rs574343699	586	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA337891831 rs1164279573	587	V>M		No	ClinGen gnomAD
CA337891800 rs1414326465	588	T>I		No	ClinGen gnomAD
rs56410233 CA530054	589	Q>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1239813871 CA337891762	590	W>L		No	ClinGen TOPMed
TCGA novel	590	W>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA530052 rs201693816	592	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs759486089 CA530051	592	R>H		No	ClinGen ExAC TOPMed gnomAD
rs558730635 CA337891689	593	A>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA530049 rs558730635	593	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA530046 rs773483575	594	P>A		No	ClinGen ExAC TOPMed gnomAD
CA337891606 rs1386983147	597	L>P		No	ClinGen TOPMed
CA337891573 rs1258448976	599	G>A		No	ClinGen TOPMed gnomAD
rs772423667 CA530045	599	G>C		No	ClinGen ExAC gnomAD
rs1237862469 CA337891568	600	A>T		No	ClinGen gnomAD
rs1331397300 CA337891557	600	A>V		No	ClinGen gnomAD
CA337891515 rs1443636902	601	K>N		No	ClinGen gnomAD
CA337891537 rs1418489938	601	K>R		No	ClinGen TOPMed
CA529999 rs532125752	602	E>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA337891390 rs1369684445	602	E>Q		No	ClinGen gnomAD
rs777360629 CA337929759	603	Y>*		No	ClinGen ExAC TOPMed gnomAD
CA529997 rs200649303	605	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA529996 rs200649303	605	T>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1271340033 CA337929731	606	A>D		No	ClinGen gnomAD
rs1439852483 CA337929736	606	A>T		No	ClinGen gnomAD
CA529993 rs753808941	607	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs370353171 CA529991	609	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA529992 rs767559638	609	M>V		No	ClinGen ExAC TOPMed gnomAD
CA337929636 rs1239043522	610	W>C		No	ClinGen TOPMed
rs1289180773 CA337929628	611	S>*		No	ClinGen gnomAD
rs1289180773 CA337929627	611	S>L		No	ClinGen gnomAD
rs1197738461 CA337929621	612	V>A		No	ClinGen TOPMed
rs1444649069 CA337929601	613	G>A		No	ClinGen gnomAD
CA337929610 rs1315843305	613	G>S		No	ClinGen TOPMed
CA337929586 rs1219804561	614	C>R		No	ClinGen TOPMed
rs1328006914 CA337929577	614	C>S		No	ClinGen TOPMed gnomAD
rs374606369 CA529987	617	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs879157131 CA337929526 CA337929524	617	G>R		No	ClinGen TOPMed gnomAD
rs879157131 CA16818120	617	G>W		No	ClinGen TOPMed gnomAD
rs760098796 CA529985	618	E>K		No	ClinGen ExAC TOPMed gnomAD
rs760098796 CA529986	618	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1468331735 CA337929497	618	E>V		No	ClinGen gnomAD
CA337929440 rs1181591267	621	T>I		No	ClinGen TOPMed gnomAD
rs777338977 CA529984	622	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA337929433 rs777338977	622	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA337929409 rs1415608300	623	K>E		No	ClinGen TOPMed
CA529981 rs746509028	624	P>L		No	ClinGen ExAC gnomAD
rs561263753 CA529982	624	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA529979 COSM1247908 rs370914124	626	F>L	oesophagus [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1371540541 CA337929310	627	P>R		No	ClinGen gnomAD
CA529977 rs377624799	628	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA529975 rs55675585	629	N>K		No	ClinGen ExAC TOPMed gnomAD
rs754813819 CA529976	629	N>S		No	ClinGen ExAC gnomAD
CA337929277 rs757293035	630	S>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs757293035 COSM256594 CA529973	630	S>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs757293035 CA529974	630	S>W		No	ClinGen ExAC gnomAD
rs575236489 CA529971	631	E>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1210692642 CA337929246	632	I>T		No	ClinGen TOPMed
CA529968 rs765684442	633	D>A		No	ClinGen ExAC TOPMed gnomAD
COSM3802667 CA529969 rs753016535	633	D>N	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1192245768 CA337929225	634	Q>*		No	ClinGen gnomAD
CA529967 rs777216116	634	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA337929199 rs1218094984	636	N>H		No	ClinGen TOPMed gnomAD
CA16818028 rs201615210	636	N>S		No	ClinGen 1000Genomes
rs558644609 CA529964	637	K>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA337929172 rs1136982	637	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1301052941 CA337929133	640	K>*		No	ClinGen gnomAD
rs771650414 CA529961	640	K>N		No	ClinGen ExAC gnomAD
CA337929128 rs1440075622	640	K>R		No	ClinGen TOPMed gnomAD
CA529944 rs1136980	641	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA529943 rs766919639	642	L>Q		No	ClinGen ExAC TOPMed gnomAD
rs1300311600 CA337929044	643	G>R		No	ClinGen gnomAD
CA337929038 rs1460915158	643	G>V		No	ClinGen gnomAD
rs1463019083 CA337929022	645	P>S		No	ClinGen gnomAD
CA529938 rs1294323462	646	S>G		No	ClinGen TOPMed
rs1457651804 CA337929006	646	S>I		No	ClinGen TOPMed
rs1294323462 CA337929014	646	S>R		No	ClinGen TOPMed
CA337929001 rs1187429690	647	E>Q		No	ClinGen gnomAD
CA337928962 rs749032855	649	I>S		No	ClinGen ExAC TOPMed gnomAD
CA529937 rs749032855	649	I>T		No	ClinGen ExAC TOPMed gnomAD
CA337928955 rs1252363890	650	W>*		No	ClinGen gnomAD
rs775236052 CA529936	650	W>C		No	ClinGen ExAC gnomAD
rs1273667219 CA337928937	651	P>L		No	ClinGen gnomAD
CA16817757 rs865873922	651	P>S		No	ClinGen gnomAD
rs1272048263 CA337928931	652	G>D		No	ClinGen gnomAD
rs1331972710 CA337928935	652	G>S		No	ClinGen TOPMed gnomAD
CA529935 rs769681177	653	Y>C		No	ClinGen ExAC gnomAD
rs867481320 CA337928905	654	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1373060240 CA337928888	657	P>L		No	ClinGen TOPMed gnomAD
CA529933 rs781257946	657	P>S		No	ClinGen ExAC gnomAD
VAR_060153 rs866149312 CA529932	658	V>A		No	ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
rs874516 CA529931	660	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA337928866 rs1164349716	661	K>E		No	ClinGen gnomAD
rs1234281338 CA337928862	661	K>M		No	ClinGen TOPMed
rs1257908811 CA337928847	662	M>I		No	ClinGen TOPMed
rs755286013 CA529929	662	M>R		No	ClinGen ExAC TOPMed gnomAD
rs755286013 CA337928850	662	M>T		No	ClinGen ExAC TOPMed gnomAD
rs1157208015 CA337928831	663	T>I		No	ClinGen gnomAD
CA529928 rs754150661	665	S>N		No	ClinGen ExAC TOPMed gnomAD
rs373894114 CA16817679	665	S>R		No	ClinGen Ensembl
CA529926 rs756555532	666	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1251832293 CA337928778	667	H>P		No	ClinGen TOPMed gnomAD
rs1251832293 CA337928776	667	H>R		No	ClinGen TOPMed gnomAD
CA337928764 rs1352236001	668	P>S		No	ClinGen gnomAD
rs1338410191 CA337928752	669	Y>C		No	ClinGen gnomAD
rs761254847 CA529923	669	Y>H		No	ClinGen ExAC gnomAD
CA337928735 rs1353376633	670	N>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs986085109 CA16817636	670	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA337928731 rs1304687982	671	N>H		No	ClinGen gnomAD
CA337928725 rs1570366405	671	N>T		No	ClinGen Ensembl
rs751089541 CA529922	672	L>F		No	ClinGen ExAC gnomAD
CA529921 rs763695200	673	R>C		No	ClinGen ExAC TOPMed gnomAD
CA529920 rs762574327	673	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1287286533 CA337928672	674	K>N		No	ClinGen gnomAD
CA529919 rs775271664	674	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs769472924 CA529918	675	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA529917 rs372303398	675	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA529913 rs779101783	677	G>A		No	ClinGen ExAC TOPMed gnomAD
rs779101783 CA337928631	677	G>E		No	ClinGen ExAC TOPMed gnomAD
rs748202034 CA529915 CA529914	677	G>R		No	ClinGen ExAC TOPMed gnomAD
CA337928624 rs1448182606	678	A>T		No	ClinGen gnomAD
CA337928617 rs1259081923	678	A>V		No	ClinGen gnomAD
rs1570366265 CA337928609	679	L>M		No	ClinGen Ensembl
rs768901474 CA529912	680	L>F		No	ClinGen ExAC gnomAD
CA337928595 rs768901474	680	L>V		No	ClinGen ExAC gnomAD
CA337928577 rs1411337152	682	D>H		No	ClinGen TOPMed gnomAD
rs1213535366 CA337928552	683	Q>R		No	ClinGen gnomAD
CA529911 rs749505383	684	G>S		No	ClinGen ExAC TOPMed gnomAD
CA529908 rs756365885 CA529909	685	F>L		No	ClinGen ExAC TOPMed gnomAD
rs368698821 CA529907	686	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA529905 rs757792406	689	N>I		No	ClinGen ExAC gnomAD
rs1315025021 CA337928350	689	N>K		No	ClinGen gnomAD
CA337928339 rs1432560438	690	K>Q		No	ClinGen gnomAD
rs1185321616 CA337928182	693	T>I		No	ClinGen gnomAD
rs1183064589 CA337928108	697	G>R		No	ClinGen gnomAD
CA337927994 rs1198604989	701	S>C		No	ClinGen TOPMed gnomAD
rs1477531670 CA337927970	702	A>S		No	ClinGen TOPMed
rs1477531670 CA337927981	702	A>T		No	ClinGen TOPMed
rs1231651131 CA337927900	705	G>D		No	ClinGen gnomAD
rs1275179941 CA337927905	705	G>S		No	ClinGen TOPMed gnomAD
CA337927764 rs1333769060	712	R>C		No	ClinGen TOPMed gnomAD
CA337927757 rs1330541281	712	R>H		No	ClinGen TOPMed gnomAD
CA337927727 rs1330262695	714	T>I		No	ClinGen gnomAD
rs1570365222 CA337927734	714	T>P		No	ClinGen Ensembl
CA337927717 rs1217999716	715	P>R		No	ClinGen TOPMed
CA337927695 rs1570365186	716	L>P		No	ClinGen Ensembl
rs1276159636 CA337927682	717	P>S		No	ClinGen TOPMed
rs1233370539 CA337927654	718	I>V		No	ClinGen TOPMed
rs1570365137 CA337927611	719	D>A		No	ClinGen Ensembl
rs1162256804 CA337927633	719	D>N		No	ClinGen TOPMed gnomAD
rs1570365128 CA337927520	722	M>I		No	ClinGen Ensembl
rs1570365118 CA337927500	723	F>S		No	ClinGen Ensembl
rs1404384493 CA337927457	725	T>M		No	ClinGen TOPMed gnomAD
rs1408192472 CA337927420	726	W>*		No	ClinGen gnomAD
CA337927413 rs1159946395	727	P>S		No	ClinGen TOPMed gnomAD
CA337927336 rs1231551410	730	S>R		No	ClinGen TOPMed gnomAD
CA337927309 rs1178544150	732	Q>*		No	ClinGen TOPMed gnomAD
CA337927289 rs1478413913	733	Q>R		No	ClinGen TOPMed
CA529895 rs773336663	734	R>C		No	ClinGen ExAC TOPMed gnomAD
CA337927263 rs1570365028	734	R>H		No	ClinGen Ensembl
rs1254957874 CA337927219	737	R>W		No	ClinGen TOPMed gnomAD
CA337927147 rs1458916138	741	P>L		No	ClinGen TOPMed
CA337927124 rs1451120055	743	P>S		No	ClinGen TOPMed gnomAD
CA337926960 rs1308317408	751	S>N		No	ClinGen TOPMed gnomAD
rs1241959122 CA337926939	752	Q>R		No	ClinGen TOPMed
CA337926854 rs1570364569	754	G>D		No	ClinGen Ensembl
CA337926803 rs1421625089	756	D>N		No	ClinGen TOPMed
CA337926764 rs1242794425	757	D>N		No	ClinGen gnomAD
rs1398723010 CA337926624	761	T>R		No	ClinGen TOPMed
CA337926532 rs1255352142	766	T>P		No	ClinGen TOPMed
CA337926480 rs1285032024	768	T>M		No	ClinGen TOPMed gnomAD
CA337926453 rs1211267363	769	N>K		No	ClinGen gnomAD
CA337926428 rs1261946594	771	G>R		No	ClinGen TOPMed
CA337926390 rs1570364435	774	A>T		No	ClinGen Ensembl
rs1292518113 CA337926362	775	A>T		No	ClinGen TOPMed
rs1229273013 CA337926352	775	A>V		No	ClinGen TOPMed
rs1288502058 CA337926306	778	G>D		No	ClinGen TOPMed
CA337926314 rs1341267306	778	G>S		No	ClinGen TOPMed
CA337926278 rs1165161394	780	S>N		No	ClinGen TOPMed

No associated diseases with Q9UQ88

3 regional properties for Q9UQ88

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	426 - 711	IPR000719
active_site	Serine/threonine-protein kinase, active site	546 - 558	IPR008271
domain	Cyclin-dependent kinase 11/PITSLRE, catalytic domain	420 - 711	IPR045267

Functions

		Description
EC Number	2.7.11.22	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cyclin-dependent protein kinase holoenzyme complex	Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity	Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

11 GO annotations of biological process

Name	Definition
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
mitotic cell cycle	Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of apoptotic process	Any process that modulates the occurrence or rate of cell death by apoptotic process.
regulation of cell cycle	Any process that modulates the rate or extent of progression through the cell cycle.
regulation of cell growth	Any process that modulates the frequency, rate, extent or direction of cell growth.
regulation of centrosome cycle	Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation.
regulation of DNA-templated transcription	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of mitotic cell cycle	Any process that modulates the rate or extent of progress through the mitotic cell cycle.
regulation of mRNA processing	Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide.
regulation of RNA splicing	Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

15 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q15131	CDK10	Cyclin-dependent kinase 10	Homo sapiens (Human)	PR
Q00526	CDK3	Cyclin-dependent kinase 3	Homo sapiens (Human)	PR
Q96Q40	CDK15	Cyclin-dependent kinase 15	Homo sapiens (Human)	PR
O94921	CDK14	Cyclin-dependent kinase 14	Homo sapiens (Human)	PR
Q00537	CDK17	Cyclin-dependent kinase 17	Homo sapiens (Human)	PR
P49336	CDK8	Cyclin-dependent kinase 8	Homo sapiens (Human)	PR
Q9BWU1	CDK19	Cyclin-dependent kinase 19	Homo sapiens (Human)	PR
P50750	CDK9	Cyclin-dependent kinase 9	Homo sapiens (Human)	PR
Q5MAI5	CDKL4	Cyclin-dependent kinase-like 4	Homo sapiens (Human)	PR
Q00532	CDKL1	Cyclin-dependent kinase-like 1	Homo sapiens (Human)	PR
Q92772	CDKL2	Cyclin-dependent kinase-like 2	Homo sapiens (Human)	PR
Q8IZL9	CDK20	Cyclin-dependent kinase 20	Homo sapiens (Human)	PR
P21127	CDK11B	Cyclin-dependent kinase 11B	Homo sapiens (Human)	PR
Q09437	cdk-11.1	Cyclin-dependent kinase 11.1	Caenorhabditis elegans	PR
Q9FGW5	CDKG1	Cyclin-dependent kinase G1	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MGDEKDSWKV	KTLDEILQEK	KRRKEQEEKA	EIKRLKNSDD	RDSKRDSLEE	GELRDHCMEI
70	80	90	100	110	120
TIRNSPYRRE	DSMEDRGEED	DSLAIKPPQQ	MSRKEKVHHR	KDEKRKEKWK	HARVKEREHE
130	140	150	160	170	180
RRKRHREEQD	KARREWERQK	RREMAREHSR	RERDRLEQLE	RKRERERKMR	EQQKEQREQK
190	200	210	220	230	240
ERERRAEERR	KEREARREVS	AHHRTMREDY	SDKVKASHWS	RSPPRPPRER	FELGDGRKPG
250	260	270	280	290	300
EARPAPAQKP	AQLKEEKMEE	RDLLSDLQDI	SDSERKTSSA	ESSSAESGSG	SEEEEEEEEE
310	320	330	340	350	360
EEEEGSTSEE	SEEEEEEEEE	EEEETGSNSE	EASEQSAEEV	SEEEMSEDEE	RENENHLLVV
370	380	390	400	410	420
PESRFDRDSG	ESEEAEEEVG	EGTPQSSALT	EGDYVPDSPA	LLPIELKQEL	PKYLPALQGC
430	440	450	460	470	480
RSVEEFQCLN	RIEEGTYGVV	YRAKDKKTDE	IVALKRLKME	KEKEGFPITS	LREINTILKA
490	500	510	520	530	540
QHPNIVTVRE	IVVGSNMDKI	YIVMNYVEHD	LKSLMETMKQ	PFLPGEVKTL	MIQLLRGVKH
550	560	570	580	590	600
LHDNWILHRD	LKTSNLLLSH	AGILKVGDFG	LAREYGSPLK	AYTPVVVTQW	YRAPELLLGA
610	620	630	640	650	660
KEYSTAVDMW	SVGCIFGELL	TQKPLFPGNS	EIDQINKVFK	ELGTPSEKIW	PGYSELPVVK
670	680	690	700	710	720
KMTFSEHPYN	NLRKRFGALL	SDQGFDLMNK	FLTYFPGRRI	SAEDGLKHEY	FRETPLPIDP
730	740	750	760	770	780
SMFPTWPAKS	EQQRVKRGTS	PRPPEGGLGY	SQLGDDDLKE	TGFHLTTTNQ	GASAAGPGFS

LKF