Q9UQ07
PR
Gene name |
MOK (RAGE, RAGE1) |
Protein name |
MAPK/MAK/MRK overlapping kinase |
Names |
MOK protein kinase, Renal tumor antigen 1, RAGE-1 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:5891 |
EC number |
2.7.11.22: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
144-166 (Activation loop from InterPro)
Target domain |
4-285 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9UQ07
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9UQ07-F1 | Predicted | AlphaFoldDB |
389 variants for Q9UQ07
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
RCV000714770 rs769431982 |
211 | I>missing | Mucopolysaccharidosis, MPS-III-D [ClinVar] | Yes |
ClinVar dbSNP |
|
rs1465670482 CA391012935 |
4 | Y>* | No |
ClinGen TOPMed |
|
|
CA7356378 rs761337400 |
4 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA7356377 rs370364818 |
5 | K>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 6 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7356376 rs762488901 |
7 | I>L | No |
ClinGen ExAC gnomAD |
|
|
rs762488901 CA7356375 |
7 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs374254061 CA7356374 |
8 | G>V | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1193208049 CA391012753 |
9 | K>R | No |
ClinGen gnomAD |
|
|
CA391012705 rs1487604908 |
10 | I>M | No |
ClinGen gnomAD |
|
|
CA267028109 rs988120968 |
12 | E>G | No |
ClinGen TOPMed |
|
|
rs1299813954 CA391012614 |
14 | T>A | No |
ClinGen Ensembl |
|
|
rs746409818 CA7356371 |
14 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA391012501 rs1275748654 |
17 | E>K | No |
ClinGen TOPMed |
|
|
rs1231657667 CA391012406 |
19 | M>I | No |
ClinGen gnomAD |
|
|
rs917372014 CA267028073 |
19 | M>T | No |
ClinGen gnomAD |
|
|
rs776831036 CA7356369 |
20 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA7356368 rs771376564 |
21 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA7356367 rs56283342 |
22 | Q>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1376920292 CA391012124 |
27 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
CA7356363 rs142873895 |
30 | Y>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1272283587 CA391011978 |
31 | A>T | No |
ClinGen TOPMed |
|
|
CA7356362 rs141044352 |
31 | A>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs747544552 CA267028022 |
37 | Q>* | No |
ClinGen gnomAD |
|
|
CA267028017 rs140574092 |
37 | Q>H | No |
ClinGen ESP TOPMed |
|
|
rs1409943456 CA391011772 |
37 | Q>L | No |
ClinGen gnomAD |
|
|
rs369798345 CA7356361 |
38 | R>C | No |
ClinGen ESP ExAC gnomAD |
|
|
CA7356359 rs34114580 VAR_042011 |
38 | R>H | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA7356360 rs34114580 |
38 | R>P | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA267028012 rs369798345 |
38 | R>S | No |
ClinGen ESP ExAC gnomAD |
|
|
rs751319494 CA7356357 |
41 | S>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA391032126 rs1286927711 |
42 | I>N | No |
ClinGen TOPMed |
|
|
CA7356331 rs190817595 |
42 | I>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA391032063 rs1309723623 |
45 | V>F | No |
ClinGen TOPMed gnomAD |
|
|
CA391032049 rs1597441503 |
46 | N>D | No |
ClinGen Ensembl |
|
|
rs1305643956 CA391032035 |
46 | N>I | No |
ClinGen gnomAD |
|
|
rs1305643956 CA391032038 |
46 | N>S | No |
ClinGen gnomAD |
|
|
CA391031969 rs1197725993 |
48 | L>P | No |
ClinGen TOPMed |
|
|
CA7356327 rs141604419 |
49 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA gnomAD |
| TCGA novel | 49 | R>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA391031920 rs1567195696 |
50 | E>D | No |
ClinGen Ensembl |
|
|
CA391031892 rs1273822342 |
51 | I>M | No |
ClinGen TOPMed |
|
|
CA7356324 rs538460156 |
51 | I>T | No |
ClinGen 1000Genomes ExAC |
|
|
CA391031915 rs1387966273 |
51 | I>V | No |
ClinGen gnomAD |
|
|
CA391031890 rs1161193006 |
52 | Q>E | No |
ClinGen gnomAD |
|
|
rs1463473371 CA391031885 |
52 | Q>P | No |
ClinGen gnomAD |
|
|
CA7356321 rs780024030 |
54 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs774789715 CA7356320 |
56 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7356319 rs746962840 |
56 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA391031750 rs1204434669 |
57 | L>P | No |
ClinGen TOPMed |
|
|
rs1490794706 CA391031722 |
59 | P>L | No |
ClinGen TOPMed |
|
|
CA391031726 rs1490794706 |
59 | P>Q | No |
ClinGen TOPMed |
|
|
rs1476847771 CA391031715 |
60 | H>R | No |
ClinGen TOPMed |
|
|
CA7356317 rs368163826 |
60 | H>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7356315 rs147983922 |
62 | N>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7356316 rs147983922 |
62 | N>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA267044218 rs201578878 |
63 | I>M | No |
ClinGen 1000Genomes |
|
|
rs771538724 CA267044210 |
65 | M>I | No |
ClinGen Ensembl |
|
|
rs753338301 CA7356313 |
65 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs761210348 CA7356311 |
67 | H>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA391031595 rs1305671205 |
67 | H>Q | No |
ClinGen gnomAD |
|
|
CA391031583 rs1323337427 |
68 | E>D | No |
ClinGen TOPMed |
|
|
rs750938879 CA7356310 |
68 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA391031571 rs1329656046 |
69 | V>G | No |
ClinGen TOPMed |
|
|
TCGA novel CA391030692 rs1413399549 |
73 | R>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen gnomAD NCI-TCGA |
|
CA267042965 rs746805358 |
75 | S>C | No |
ClinGen Ensembl |
|
|
CA267042961 rs779785455 |
76 | G>C | No |
ClinGen Ensembl |
|
|
CA7356288 rs764410321 |
78 | L>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 81 | I>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 81 | I>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs541820418 CA267042946 |
81 | I>V | No |
ClinGen Ensembl |
|
|
CA391030549 rs1475726225 |
82 | C>R | No |
ClinGen TOPMed |
|
| TCGA novel | 84 | L>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs34084056 CA7356286 VAR_042012 |
86 | D>N | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
COSM1300404 CA7356284 rs374179019 |
87 | M>I | urinary_tract [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
rs1471900021 CA391030441 |
87 | M>R | No |
ClinGen gnomAD |
|
|
CA7356285 rs765357212 |
87 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA267042919 rs745751072 |
89 | I>V | No |
ClinGen Ensembl |
|
|
rs1188819160 CA391030382 |
90 | Y>* | No |
ClinGen gnomAD |
|
|
rs776862865 CA7356283 |
92 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7356282 rs34931752 |
94 | R>* | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA267042914 rs559580209 |
94 | R>L | No |
ClinGen 1000Genomes ExAC |
|
|
CA7356281 rs559580209 |
94 | R>Q | No |
ClinGen 1000Genomes ExAC |
|
|
rs759859471 CA7356264 |
95 | G>E | No |
ClinGen ExAC gnomAD |
|
|
rs1207147617 CA391030310 |
95 | G>R | No |
ClinGen gnomAD |
|
|
CA391027175 rs1284806277 |
101 | S>P | No |
ClinGen TOPMed |
|
| rs753079987 | 105 | I>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1481923340 CA391027041 |
105 | I>M | No |
ClinGen TOPMed |
|
|
rs145834415 CA7356260 |
105 | I>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed |
|
|
CA7356259 rs145834415 |
105 | I>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed |
|
|
CA7356255 rs140674206 |
106 | M>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs774485388 CA7356256 |
106 | M>L | No |
ClinGen ExAC gnomAD |
|
|
CA7356253 rs775365714 |
107 | H>Q | No |
ClinGen ExAC gnomAD |
|
|
CA391026993 rs1449863124 |
107 | H>R | No |
ClinGen gnomAD |
|
|
rs146870455 CA7356254 |
107 | H>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs769295095 CA7356252 |
109 | M>I | No |
ClinGen ExAC gnomAD |
|
|
rs1214695054 CA391026952 |
109 | M>L | No |
ClinGen gnomAD |
|
|
rs912972442 CA267037329 |
109 | M>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1236065638 CA391026817 |
113 | C>R | No |
ClinGen TOPMed gnomAD |
|
|
rs150272788 CA7356251 |
114 | K>T | No |
ClinGen ESP ExAC gnomAD |
|
|
rs988500240 CA267037324 |
115 | S>F | No |
ClinGen TOPMed gnomAD |
|
|
CA267037317 rs1035713810 |
119 | I>T | No |
ClinGen gnomAD |
|
|
rs1463507341 CA391026654 |
120 | H>R | No |
ClinGen TOPMed |
|
|
CA267037312 rs1003763325 |
120 | H>Y | No |
ClinGen TOPMed |
|
|
rs1409915442 CA391026564 |
122 | N>K | No |
ClinGen gnomAD |
|
|
rs1472224633 CA391026555 |
123 | G>E | No |
ClinGen gnomAD |
|
|
rs1182555300 CA391026558 |
123 | G>R | No |
ClinGen gnomAD |
|
|
CA7356223 rs754105740 |
124 | I>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 125 | F>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1189513527 CA391026518 |
126 | H>Y | No |
ClinGen TOPMed gnomAD |
|
|
CA7356222 rs780354764 |
127 | R>G | No |
ClinGen ExAC gnomAD |
|
|
CA7356220 rs567505262 |
129 | V>I | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA7356217 rs752741237 |
132 | E>* | No |
ClinGen ExAC gnomAD |
|
|
rs765015108 CA7356216 |
133 | N>T | No |
ClinGen ExAC gnomAD |
|
|
CA7356214 rs376187124 |
134 | I>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7356215 rs752147803 |
134 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA391026398 rs1380019193 |
135 | L>V | No |
ClinGen gnomAD |
|
|
CA391026388 rs1254906267 |
136 | I>L | No |
ClinGen gnomAD |
|
|
CA391026384 rs1347113074 |
136 | I>T | No |
ClinGen gnomAD |
|
|
rs149850506 RCV000901420 CA7356213 |
137 | K>N | No |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1233760405 CA391025651 |
138 | Q>* | No |
ClinGen gnomAD |
|
|
CA7356177 rs372368259 |
139 | D>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7356176 rs534955495 |
142 | K>R | No |
ClinGen ExAC |
|
|
rs1411598080 CA391025520 |
144 | G>E | No |
ClinGen TOPMed gnomAD |
|
|
CA391025509 rs1388855605 |
145 | D>N | No |
ClinGen TOPMed |
|
|
rs767135878 CA7356174 |
146 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA391025478 rs1306942878 |
146 | F>S | No |
ClinGen TOPMed gnomAD |
|
|
rs546771266 CA7356172 |
150 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs151048366 CA7356173 |
150 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1377439090 CA391025356 |
151 | S>N | No |
ClinGen gnomAD |
|
|
CA391025342 rs1473896907 |
152 | V>I | No |
ClinGen gnomAD |
|
|
rs530261371 CA7356170 |
153 | Y>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs368305066 CA7356171 |
153 | Y>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA391025317 rs530261371 |
153 | Y>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA391025239 rs1280780306 |
157 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
CA391025237 rs1280780306 |
157 | P>R | No |
ClinGen TOPMed gnomAD |
|
|
CA7356168 rs770210905 |
159 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs770210905 CA391025204 |
159 | T>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs895422803 CA391025134 CA267036895 |
161 | Y>* | No |
ClinGen TOPMed gnomAD |
|
|
CA391025123 rs1274984526 |
162 | I>S | No |
ClinGen gnomAD |
|
|
CA7356166 rs776882507 |
162 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1287624455 CA391025103 |
163 | S>F | No |
ClinGen gnomAD |
|
|
CA391025099 rs1597366563 |
164 | T>P | No |
ClinGen Ensembl |
|
|
CA7356164 rs747272869 |
165 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA7356163 rs777807343 |
165 | R>H | No |
ClinGen ExAC gnomAD |
|
|
CA391025040 rs1268794893 |
166 | W>* | No |
ClinGen gnomAD |
|
|
rs1597366480 CA391024997 |
167 | Y>D | No |
ClinGen Ensembl |
|
|
rs181921234 CA7356161 |
168 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs772195338 CA7356162 |
168 | R>W | No |
ClinGen ExAC gnomAD |
|
|
rs1459139626 CA391024915 |
169 | A>V | No |
ClinGen gnomAD |
|
|
CA7356158 rs372487342 |
170 | P>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs144650917 CA7356159 |
170 | P>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs144650917 CA7356160 |
170 | P>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1239296624 CA391024819 |
172 | C>S | No |
ClinGen gnomAD |
|
|
rs751920771 CA267036872 |
172 | C>Y | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 176 | D>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7356155 rs751317725 |
177 | G>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA391024654 rs1597366212 |
178 | F>V | No |
ClinGen Ensembl |
|
| TCGA novel | 179 | Y>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1308652565 CA391024634 |
179 | Y>H | No |
ClinGen gnomAD |
|
|
rs763695568 CA7356154 |
180 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs765727739 CA7356152 CA7356151 |
181 | Y>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7356150 rs759992875 |
182 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7356149 rs777024727 |
184 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA391024350 rs1254566330 |
186 | W>* | No |
ClinGen TOPMed |
|
|
rs760872343 CA7356147 |
186 | W>* | No |
ClinGen ExAC gnomAD |
|
|
rs1389872445 CA391024271 |
187 | S>R | No |
ClinGen gnomAD |
|
|
CA267036827 rs912683364 |
188 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs1484236277 CA391024207 |
188 | A>V | No |
ClinGen TOPMed |
|
|
CA7356145 rs772285281 |
189 | G>D | No |
ClinGen ExAC gnomAD |
|
|
CA391024199 rs1416580204 |
189 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
rs748164414 CA7356144 |
190 | C>S | No |
ClinGen ExAC gnomAD |
|
|
CA391024125 rs1471693573 |
190 | C>S | No |
ClinGen TOPMed |
|
|
rs1378222793 CA391024107 |
191 | V>M | No |
ClinGen TOPMed |
|
|
CA7356142 rs370137423 |
194 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7356141 rs370137423 |
194 | E>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA267036810 rs757188060 |
196 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7356139 rs757188060 |
196 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7356138 rs746809964 |
196 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA7356137 rs777514411 |
197 | S>T | No |
ClinGen ExAC gnomAD |
|
|
rs750741508 CA7356111 |
198 | L>R | No |
ClinGen ExAC gnomAD |
|
|
rs756636074 CA7356112 |
198 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs569153443 CA7356110 |
199 | Q>* | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1352795722 CA391018520 |
200 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1253865643 CA391018514 |
201 | L>F | No |
ClinGen gnomAD |
|
|
CA391018512 rs1182325344 |
201 | L>P | No |
ClinGen TOPMed gnomAD |
|
|
rs1209418456 CA391018415 |
206 | N>D | No |
ClinGen TOPMed |
|
|
CA391018399 rs1253306454 |
206 | N>K | No |
ClinGen TOPMed |
|
|
CA7356107 rs764383623 |
206 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA391018351 rs775664516 |
209 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7356104 rs140509664 |
210 | Q>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs138025237 CA7356102 |
210 | Q>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1322099610 CA391018288 |
212 | S>* | No |
ClinGen gnomAD |
|
|
CA391018229 rs1174013425 |
216 | D>N | No |
ClinGen TOPMed |
|
|
VAR_070930 rs148360666 CA7356056 |
217 | V>I | No |
ClinGen UniProt ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs74082261 CA7356098 |
218 | I>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7356096 rs768368623 |
219 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs748696455 CA7356095 |
220 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA7356094 rs779568139 |
221 | P>R | No |
ClinGen ExAC gnomAD |
|
|
CA391018148 rs1359963985 |
221 | P>T | No |
ClinGen gnomAD |
|
|
CA7356092 rs374797176 |
222 | A>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7356091 rs374797176 |
222 | A>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs757500685 CA7356090 |
225 | I>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA267024719 rs1025489365 |
225 | I>M | No |
ClinGen TOPMed gnomAD |
|
|
rs1405179150 CA391018041 |
227 | T>A | No |
ClinGen gnomAD |
|
|
rs763765191 CA7356089 |
227 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs763765191 CA7356088 |
227 | T>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA391018013 rs1236514000 |
228 | K>R | No |
ClinGen gnomAD |
|
|
CA7356087 VAR_042013 rs34965156 |
230 | K>R | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA7356086 rs752689694 |
231 | Q>P | No |
ClinGen ExAC gnomAD |
|
|
CA7356064 rs372219539 |
232 | S>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 232 | S>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs761841708 CA7356062 |
234 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA267024370 rs765458019 |
235 | M>I | No |
ClinGen Ensembl |
|
|
CA267024372 rs954216890 |
235 | M>T | No |
ClinGen TOPMed |
|
|
CA391017503 rs1431326156 |
236 | N>I | No |
ClinGen gnomAD |
|
|
rs138565201 CA7356061 |
238 | D>G | No |
ClinGen ESP ExAC gnomAD |
|
|
CA391017462 rs1330963623 |
239 | F>Y | No |
ClinGen TOPMed |
|
|
rs554700010 CA7356059 |
241 | F>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA7356057 rs148360666 |
247 | I>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7356055 VAR_042014 rs34299975 |
248 | P>S | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1197554803 CA391017302 |
251 | T>S | No |
ClinGen TOPMed |
|
|
CA7356052 rs777988109 |
253 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs779216517 CA7356049 |
256 | P>R | No |
ClinGen ExAC gnomAD |
|
|
CA391017209 rs149225385 |
256 | P>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7356050 rs149225385 |
256 | P>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1303065123 CA391017174 |
258 | C>R | No |
ClinGen gnomAD |
|
|
rs1387286871 CA391017149 |
259 | L>F | No |
ClinGen gnomAD |
|
| TCGA novel | 260 | S>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs753928824 CA7356047 |
260 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA391017114 rs1597252044 |
261 | L>F | No |
ClinGen Ensembl |
|
|
rs766520450 CA7356046 |
263 | H>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7356044 rs145179674 |
264 | A>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7356043 rs145179674 |
264 | A>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7356042 rs762680831 |
265 | M>V | No |
ClinGen ExAC gnomAD |
|
|
rs544129107 CA7356040 |
266 | V>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs544129107 CA7356041 |
266 | V>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs759231064 CA7356039 |
267 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA267024327 rs903717441 |
268 | Y>C | No |
ClinGen TOPMed gnomAD |
|
|
CA7356037 rs770532539 |
270 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA7356038 rs770532539 |
270 | P>T | No |
ClinGen ExAC gnomAD |
|
|
rs1484095438 CA391016903 |
271 | D>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1484095438 CA391016900 |
271 | D>G | No |
ClinGen TOPMed gnomAD |
|
|
rs1197414796 CA391016906 COSM284454 |
271 | D>N | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
COSM640 CA391016876 VAR_042015 rs1567133856 |
272 | E>D | breast a breast pleomorphic lobular carcinoma sample; somatic mutation [Cosmic, UniProt] | No |
ClinGen cosmic curated UniProt Ensembl dbSNP |
| TCGA novel | 272 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA391016854 rs1250698064 |
274 | I>T | No |
ClinGen gnomAD |
|
|
CA391016842 rs754455482 |
275 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754455482 CA7356033 |
275 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA391016833 rs1567133769 |
275 | A>V | No |
ClinGen Ensembl |
|
|
CA7356031 rs370359047 |
276 | A>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs368133453 CA267024309 |
277 | H>R | No |
ClinGen Ensembl |
|
|
rs567223050 CA7356030 |
278 | Q>* | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA7356029 rs779981179 |
281 | Q>R | No |
ClinGen ExAC |
|
|
CA267024303 rs970806529 |
282 | H>L | No |
ClinGen TOPMed |
|
|
rs1411537268 CA391016719 |
282 | H>Q | No |
ClinGen gnomAD |
|
|
rs550324505 CA7356027 |
284 | Y>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA7356026 rs764047005 |
286 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
rs1403898066 CA391016652 |
286 | Q>R | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 287 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 288 | Q>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs758366870 CA7356025 |
289 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA391016471 rs1437702579 |
291 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
CA391016422 rs1186223605 |
293 | K>R | No |
ClinGen gnomAD |
|
|
rs747099142 CA7355987 |
294 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA7355988 rs201589543 |
294 | R>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA7355986 rs778767225 |
295 | A>S | No |
ClinGen ExAC gnomAD |
|
|
rs1465688640 CA391016356 |
296 | L>P | No |
ClinGen TOPMed |
|
|
rs1465688640 CA391016354 |
296 | L>R | No |
ClinGen TOPMed |
|
|
CA391016331 rs754933467 |
297 | G>A | No |
ClinGen ExAC gnomAD |
|
|
CA391016348 rs1301330553 |
297 | G>R | No |
ClinGen TOPMed |
|
|
CA7355985 rs754933467 |
297 | G>V | No |
ClinGen ExAC gnomAD |
|
|
CA267024035 rs538410949 |
303 | G>S | No |
ClinGen Ensembl |
|
|
rs202050742 CA7355983 |
305 | P>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1190953262 CA391016109 |
306 | E>G | No |
ClinGen gnomAD |
|
|
CA7355981 rs750096165 |
308 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7355980 rs767131016 |
308 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750096165 CA391016074 |
308 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM1165709 CA7355978 rs376559474 |
311 | P>L | large_intestine [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
rs369246500 CA7355979 |
311 | P>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs142160037 CA7355977 |
312 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA267024013 rs569285770 |
315 | S>T | No |
ClinGen gnomAD |
|
|
rs763411219 CA7355976 |
316 | N>D | No |
ClinGen ExAC TOPMed |
|
|
rs749472975 CA7355971 |
318 | C>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs775903228 CA7355974 |
318 | C>W | No |
ClinGen ExAC gnomAD |
|
|
CA267024006 rs918133288 |
318 | C>Y | No |
ClinGen Ensembl |
|
|
CA391015826 rs1429240050 |
319 | Q>* | No |
ClinGen TOPMed gnomAD |
|
|
rs765578765 CA7355973 |
319 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs747117393 CA391015793 |
321 | S>C | No |
ClinGen gnomAD |
|
|
CA267023999 rs747117393 |
321 | S>F | No |
ClinGen gnomAD |
|
|
CA267023295 rs1051008426 |
329 | Q>H | No |
ClinGen TOPMed |
|
|
rs772097630 CA391014042 |
330 | S>A | No |
ClinGen ExAC gnomAD |
|
|
rs772097630 CA7355948 |
330 | S>P | No |
ClinGen ExAC gnomAD |
|
|
rs1422305127 CA391013937 |
333 | Q>* | No |
ClinGen TOPMed |
|
|
rs775224634 CA7355946 |
334 | E>G | No |
ClinGen ExAC gnomAD |
|
|
rs1160829157 CA391013806 |
336 | D>E | No |
ClinGen TOPMed |
|
|
CA7355945 rs781739262 |
337 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs745607485 CA7355944 |
337 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs1416644350 CA391013743 |
338 | P>S | No |
ClinGen gnomAD |
|
|
CA391013642 rs1406566883 |
340 | R>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs756949555 CA7355942 |
340 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA391013611 rs1468225627 |
341 | R>Q | No |
ClinGen gnomAD |
|
|
COSM3952925 rs1390722946 CA391013586 |
342 | G>* | haematopoietic_and_lymphoid_tissue [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs746718113 CA7355941 |
343 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs757783627 CA7355939 |
344 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA7355937 rs779242360 |
345 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA7355938 rs200992317 |
345 | Y>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 348 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7355936 rs755543077 |
349 | L>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs374806877 CA7355934 |
351 | K>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs374806877 CA7355935 |
351 | K>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA267023268 rs909385616 |
352 | L>P | No |
ClinGen TOPMed |
|
|
rs760870257 CA7355933 |
353 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA267023264 rs985330375 |
354 | L>F | No |
ClinGen TOPMed |
|
|
CA7355932 rs750706626 |
355 | S>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1215486792 CA391013178 |
356 | G>A | No |
ClinGen TOPMed |
|
|
CA267023258 rs950904649 |
358 | V>G | No |
ClinGen TOPMed |
|
|
rs761740131 CA7355930 |
359 | R>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA267023251 rs572960058 |
361 | S>L | No |
ClinGen TOPMed |
|
|
rs572960058 CA391012946 |
361 | S>W | No |
ClinGen TOPMed |
|
|
CA267023246 rs776555918 |
364 | S>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM76159 CA267023244 rs971063841 |
364 | S>C | ovary Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
CA7355926 rs776555918 |
364 | S>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746805923 CA7355924 |
365 | S>G | No |
ClinGen ExAC gnomAD |
|
|
CA391012814 rs1567125396 |
365 | S>I | No |
ClinGen Ensembl |
|
|
CA391012808 CA391012805 rs1450154085 |
365 | S>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1289402749 CA391012785 |
366 | P>R | No |
ClinGen gnomAD |
|
|
rs1367315929 CA391012792 |
366 | P>S | No |
ClinGen gnomAD |
|
|
rs1367315929 CA391012798 |
366 | P>T | No |
ClinGen gnomAD |
|
|
rs777238096 CA7355923 |
367 | T>M | No |
ClinGen ExAC gnomAD |
|
|
rs777238096 CA391012746 |
367 | T>R | No |
ClinGen ExAC gnomAD |
|
|
CA7355921 rs771783119 |
369 | Q>E | No |
ClinGen ExAC |
|
|
CA7355920 rs747574257 |
372 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs370862359 CA7355919 |
373 | G>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7355918 rs755452949 |
373 | G>V | No |
ClinGen ExAC gnomAD |
|
|
rs376500482 CA267023222 |
374 | S>C | No |
ClinGen ESP TOPMed |
|
|
rs754398378 CA7355917 |
375 | G>V | No |
ClinGen ExAC gnomAD |
|
|
rs375311855 CA267023218 |
377 | N>S | No |
ClinGen gnomAD |
|
|
CA7355916 rs780389117 |
378 | G>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA391012460 rs1286770698 |
378 | G>R | No |
ClinGen TOPMed |
|
|
CA391012437 rs780389117 |
378 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs756400941 CA7355915 |
379 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1291280241 CA391012387 |
380 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
CA267023209 rs200154662 |
381 | P>A | No |
ClinGen Ensembl |
|
|
rs1309063618 CA391012341 |
381 | P>L | No |
ClinGen gnomAD |
|
|
rs750813353 CA7355913 |
382 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA267023203 rs999135815 |
384 | R>T | No |
ClinGen TOPMed |
|
|
rs767585856 CA7355911 |
385 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA7355907 rs759544127 |
386 | L>S | No |
ClinGen ExAC gnomAD |
|
|
CA7355906 rs776643895 |
387 | K>T | No |
ClinGen ExAC gnomAD |
|
|
CA267023185 rs571028436 |
389 | I>M | No |
ClinGen 1000Genomes |
|
| TCGA novel | 390 | P>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7355904 rs760501303 |
391 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA7355902 rs771594873 |
393 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1201737498 CA391011952 |
394 | K>N | No |
ClinGen gnomAD |
|
|
rs970114266 CA267023120 |
395 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
CA7355872 rs188685734 |
397 | P>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs758728974 CA7355870 |
398 | Q>K | No |
ClinGen ExAC gnomAD |
|
|
CA7355869 rs2236493 VAR_024576 |
398 | Q>R | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1567123795 CA391011466 |
399 | K>E | No |
ClinGen Ensembl |
|
|
CA391011452 rs991599667 |
399 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
CA391011444 rs1597222381 |
400 | D>A | No |
ClinGen Ensembl |
|
|
rs755989264 CA7355867 |
400 | D>E | No |
ClinGen ExAC gnomAD |
|
|
CA391011407 rs1193688499 |
402 | K>N | No |
ClinGen TOPMed |
|
|
rs767356918 CA7355865 |
402 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767356918 CA391011411 |
402 | K>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA391011399 rs1181376629 |
403 | P>S | No |
ClinGen gnomAD |
|
|
CA391011385 rs1417483213 |
404 | A>S | No |
ClinGen gnomAD |
|
|
rs1244812583 CA391011379 |
404 | A>V | No |
ClinGen gnomAD |
|
|
CA7355864 rs375778084 |
405 | P>L | Variant assessed as Somatic; 4.624e-05 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA gnomAD |
|
rs763697006 CA7355862 |
406 | Q>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs879228335 CA267023093 |
407 | Q>R | No |
ClinGen Ensembl |
|
|
rs1350796323 CA391011318 |
409 | R>C | No |
ClinGen gnomAD |
|
|
COSM199872 CA391011315 rs1597221902 |
409 | R>H | large_intestine [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
rs1259573022 CA391011302 |
410 | L>R | No |
ClinGen gnomAD |
|
| TCGA novel | 411 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7355861 rs762631956 |
412 | T>A | No |
ClinGen ExAC |
|
|
rs774958063 CA7355859 |
413 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA391011272 rs1290953916 |
413 | I>V | No |
ClinGen Ensembl |
|
|
CA7355857 rs745376012 |
414 | V>G | No |
ClinGen ExAC gnomAD |
|
|
rs1382444313 CA391011248 |
415 | R>W | No |
ClinGen gnomAD |
|
|
CA7355856 rs777138987 |
416 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs771365640 CA7355855 |
416 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA7355853 rs778326923 |
417 | G>D | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs748441503 CA391011208 |
418 | G>E | No |
ClinGen ExAC gnomAD |
|
|
CA7355852 rs772403983 |
418 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA7355851 rs748441503 |
418 | G>V | No |
ClinGen ExAC gnomAD |
|
|
rs1026112886 CA267023070 |
419 | R>T | No |
ClinGen Ensembl |
|
|
rs779128398 CA391011179 |
420 | R>Y | No |
ClinGen ExAC TOPMed gnomAD |
No associated diseases with Q9UQ07
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.22 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| ciliary base | Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area. |
| cilium | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cyclin-dependent protein serine/threonine kinase activity | Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| metal ion binding | Binding to a metal ion. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
20 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P20794 | MAK | Serine/threonine-protein kinase MAK | Homo sapiens (Human) | PR |
| Q8TD08 | MAPK15 | Mitogen-activated protein kinase 15 | Homo sapiens (Human) | SS |
| P45984 | MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens (Human) | SS |
| P45983 | MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens (Human) | EV |
| P53779 | MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens (Human) | EV |
| Q9UBE8 | NLK | Serine/threonine-protein kinase NLK | Homo sapiens (Human) | SS |
| P27361 | MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens (Human) | SS |
| P28482 | MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens (Human) | EV |
| P31152 | MAPK4 | Mitogen-activated protein kinase 4 | Homo sapiens (Human) | SS |
| Q16659 | MAPK6 | Mitogen-activated protein kinase 6 | Homo sapiens (Human) | SS |
| Q13164 | MAPK7 | Mitogen-activated protein kinase 7 | Homo sapiens (Human) | SS |
| P53778 | MAPK12 | Mitogen-activated protein kinase 12 | Homo sapiens (Human) | SS |
| O15264 | MAPK13 | Mitogen-activated protein kinase 13 | Homo sapiens (Human) | SS |
| Q15759 | MAPK11 | Mitogen-activated protein kinase 11 | Homo sapiens (Human) | SS |
| Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Homo sapiens (Human) | SS |
| Q04859 | Mak | Serine/threonine-protein kinase MAK | Mus musculus (Mouse) | PR |
| Q9JKV2 | Cilk1 | Serine/threonine-protein kinase ICK | Mus musculus (Mouse) | PR |
| Q9WVS4 | Mok | MAPK/MAK/MRK overlapping kinase | Mus musculus (Mouse) | PR |
| P20793 | Mak | Serine/threonine-protein kinase MAK | Rattus norvegicus (Rat) | PR |
| P43294 | MHK | Serine/threonine-protein kinase MHK | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKNYKAIGKI | GEGTFSEVMK | MQSLRDGNYY | ACKQMKQRFE | SIEQVNNLRE | IQALRRLNPH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PNILMLHEVV | FDRKSGSLAL | ICELMDMNIY | ELIRGRRYPL | SEKKIMHYMY | QLCKSLDHIH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RNGIFHRDVK | PENILIKQDV | LKLGDFGSCR | SVYSKQPYTE | YISTRWYRAP | ECLLTDGFYT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YKMDLWSAGC | VFYEIASLQP | LFPGVNELDQ | ISKIHDVIGT | PAQKILTKFK | QSRAMNFDFP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FKKGSGIPLL | TTNLSPQCLS | LLHAMVAYDP | DERIAAHQAL | QHPYFQEQRK | TEKRALGSHR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KAGFPEHPVA | PEPLSNSCQI | SKEGRKQKQS | LKQEEDRPKR | RGPAYVMELP | KLKLSGVVRL |
| 370 | 380 | 390 | 400 | 410 | |
| SSYSSPTLQS | VLGSGTNGRV | PVLRPLKCIP | ASKKTDPQKD | LKPAPQQCRL | PTIVRKGGR |