AiPD: Autoinhibited Protein Database

Q9ULV8

Gene name	CBLC (CBL3, RNF57)
Protein name	E3 ubiquitin-protein ligase CBL-C
Names	EC 2.3.2.27 , RING finger protein 57 , RING-type E3 ubiquitin transferase CBL-C , SH3-binding protein CBL-3 , SH3-binding protein CBL-C , Signal transduction protein CBL-C
Species	Homo sapiens (Human)
KEGG Pathway	hsa:23624
EC number	2.3.2.27: Aminoacyltransferases
Protein Class

Descriptions

Cbls are adaptor proteins with RING ubiquitin ligase activity, which function as a negative regulator of many signaling pathways. In human CBL, the phosphorylation of Y371 is essential in regulation of the E3 activity of CBL. When Y371 is unmodified, the RING domain is spatially restricted to regions distal from the TKBD substrate-binding site. Phosphorylation facilitates LHR (linker-loop1 (LL1), linker-helix (LH) and linker-loop2 (LL2)) conformational changes that enable the RING domain to approach the N-terminal tyrosine kinase-binding domain (TKBD) substrate-binding site, leading to an increased activity. Specifically, the absence of LH-TKBD contact enables dramatic movement of the RING domain, bringing E2 closer to the TKBD substrate-binding site. Restricting and freeing the RING domain may be a general mechanism for regulating other RING E3s.

Autoinhibitory domains (AIDs)

334-345 (LH region) SS

Target domain	9-323 (TKBD)
Relief mechanism	PTM
Assay

AID

334-345 (LH region)

Target domain

9-323 (TKBD)

Relief mechanism

PTM (Phosphorylation of Tyr371)

Assay

353-404 (RING domain) SS

Target domain	11-321 (TKB domain)
Relief mechanism	PTM
Assay

AID

353-404 (RING domain)

Target domain

11-321 (TKB domain)

Relief mechanism

PTM (Phosphorylation of Y363)

Assay

Accessory elements

No accessory elements

References

Dou H et al. (2012) "Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl", Nature structural & molecular biology, 19, 184-92

Wybenga-Groot LE et al. (2021) "SLAP2 Adaptor Binding Disrupts c-CBL Autoinhibition to Activate Ubiquitin Ligase Function", Journal of molecular biology, 433, 166880

Kobashigawa Y et al. (2011) "Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b", Proceedings of the National Academy of Sciences of the United States of America, 108, 20579-84

Autoinhibited structure

Activated structure

7 structures for Q9ULV8

Entry ID	Method	Resolution	Chain	Position	Source
3OP0	X-ray	252 A	A/B	9-323	PDB
3VRN	X-ray	164 A	A	1-323	PDB
3VRO	X-ray	180 A	A	1-323	PDB
3VRP	X-ray	152 A	A	1-323	PDB
3VRQ	X-ray	239 A	A/B	1-323	PDB
3VRR	X-ray	200 A	A	1-323	PDB
AF-Q9ULV8-F1	Predicted				AlphaFoldDB

580 variants for Q9ULV8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1441915381	3	L>V		No	TOPMed gnomAD
rs772312798	4	A>G		No	ExAC TOPMed gnomAD
rs746098134	4	A>T		No	ExAC TOPMed gnomAD
rs772312798	4	A>V		No	ExAC TOPMed gnomAD
rs780884827	5	V>M		No	ExAC TOPMed gnomAD
rs1032029318	6	A>S		No	TOPMed gnomAD
rs1032029318 COSM4079199	6	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1837663691	6	A>V		No	TOPMed
rs34932144	8	W>*		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2098979082	8	W>*		No	gnomAD
rs34932144	8	W>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1265333098	11	Q>*		No	TOPMed gnomAD
rs1599853389	12	W>C		No	Ensembl
rs773289730	12	W>G		No	ExAC TOPMed gnomAD
rs762946724	13	E>K		No	ExAC TOPMed gnomAD
rs762946724	13	E>Q		No	ExAC TOPMed gnomAD
rs902236013	14	E>D		No	TOPMed gnomAD
rs770372319 COSM4827065	14	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs1967610568	15	A>V		No	gnomAD
rs1399017208	16	R>C		No	TOPMed gnomAD
rs1331119853	16	R>L		No	TOPMed gnomAD
rs773891788	17	A>P		No	ExAC gnomAD
TCGA novel	17	A>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs759152258	17	A>V		No	ExAC gnomAD
rs1369363757	20	R>Q		No	TOPMed gnomAD
rs1967611091	20	R>W		No	gnomAD
rs1000666675	23	R>M		No	TOPMed
rs1225687611	24	M>V		No	TOPMed gnomAD
rs767195128	25	L>P		No	ExAC gnomAD
rs1341836439	26	Q>*		No	TOPMed gnomAD
rs1366818760	26	Q>H		No	TOPMed gnomAD
rs200348346	26	Q>R		No	ESP ExAC TOPMed gnomAD
rs761041888	27	R>H		No	ExAC TOPMed gnomAD
rs761041888	27	R>L		No	ExAC TOPMed gnomAD
rs1418197452	27	R>S		No	gnomAD
rs757709044	30	E>K		No	ExAC TOPMed gnomAD
rs778906584	31	Q>*		No	ExAC gnomAD
rs778906584	31	Q>E		No	ExAC gnomAD
rs778906584	31	Q>K		No	ExAC gnomAD
rs750480822	31	Q>R		No	ExAC TOPMed gnomAD
rs758611319	32	C>R		No	ExAC TOPMed gnomAD
rs758611319	32	C>S		No	ExAC TOPMed gnomAD
rs866606097	34	D>A		No	gnomAD
rs866606097	34	D>G		No	gnomAD
rs780339606	34	D>N		No	ExAC gnomAD
rs1323687243	36	R>Q		No	gnomAD
rs1396002600	37	L>Q		No	TOPMed gnomAD
rs1396002600	37	L>R		No	TOPMed gnomAD
rs1239073449	38	S>F		No	TOPMed gnomAD
rs1967614077	38	S>P		No	TOPMed gnomAD
rs749288188	39	V>L		No	ExAC TOPMed gnomAD
rs749288188	39	V>M		No	ExAC TOPMed gnomAD
rs1967614459	40	S>N		No	TOPMed
rs1397115734	41	P>R		No	TOPMed
rs1445083270	41	P>S		No	TOPMed gnomAD
rs1445083270	41	P>T		No	TOPMed gnomAD
rs983411997	42	P>L		No	TOPMed
rs147885389	42	P>S		No	ESP ExAC TOPMed gnomAD
rs1967615140 COSM3103348	43	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic gnomAD
rs1967615300	44	L>Q		No	TOPMed
rs931299718 COSM3971083	45	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1967615618	46	D>N		No	TOPMed gnomAD
rs775127808	49	P>A		No	ExAC TOPMed gnomAD
rs148948759	49	P>H		No	ESP ExAC TOPMed gnomAD
rs148948759	49	P>L		No	ESP ExAC TOPMed gnomAD
rs775127808	49	P>S		No	ExAC TOPMed gnomAD
rs1446927956	50	R>G		No	gnomAD
rs776955522	50	R>H		No	ExAC TOPMed gnomAD
rs762265193	51	T>I		No	ExAC TOPMed gnomAD
rs1163724186	53	Q>K		No	gnomAD
COSM3535746	56	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs765766542	56	R>P		No	ExAC TOPMed gnomAD
rs765766542	56	R>Q		No	ExAC TOPMed gnomAD
rs1967616911	57	E>A		No	TOPMed gnomAD
rs1455126115	57	E>D		No	gnomAD
rs943884863	57	E>Q		No	TOPMed
rs572115097	58	V>A		No	1000Genomes ExAC gnomAD
rs541721336	59	A>D		No	1000Genomes ExAC TOPMed gnomAD
rs1389009213	59	A>T		No	gnomAD
rs541721336	59	A>V		No	1000Genomes ExAC TOPMed gnomAD
rs1320747390	61	S>P		No	gnomAD
rs1967617790	62	R>P		No	TOPMed
TCGA novel	62	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1967617699	62	R>W		No	Ensembl
rs777753616	63	R>P		No	ExAC TOPMed gnomAD
rs777753616	63	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs115775900	63	R>W		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM4079200	64	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1967618769	66	G>D		No	Ensembl
rs1226709242	66	G>R		No	TOPMed gnomAD
rs1226709242	66	G>S		No	TOPMed gnomAD
rs1159769841	67	G>*		No	Ensembl
rs749090451	67	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1330131412	68	G>A		No	TOPMed gnomAD
rs1967619043	68	G>R		No	Ensembl
rs1207100126	69	G>S		No	gnomAD
rs778923243	71	G>E		No	ExAC TOPMed gnomAD
rs757201148	71	G>R		No	ExAC TOPMed gnomAD
rs778923243	71	G>V		No	ExAC TOPMed gnomAD
rs1967619915	72	G>C		No	gnomAD
rs949078334	72	G>D		No	gnomAD
COSM3892838	72	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1180878122	74	G>R		No	gnomAD
rs1180878122	74	G>S		No	gnomAD
rs1436824407	75	G>C		No	TOPMed
rs1436824407	75	G>R		No	TOPMed
rs1967620589	76	S>F		No	TOPMed
rs1967620512	76	S>P		No	TOPMed
rs530433110	78	D>G		No	1000Genomes ExAC TOPMed gnomAD
rs1426068218	78	D>N		No	TOPMed gnomAD
rs530433110	78	D>V		No	1000Genomes ExAC TOPMed gnomAD
rs1455042710	79	F>V		No	gnomAD
rs1000593338	81	L>F		No	TOPMed gnomAD
rs1000593338	81	L>V		No	TOPMed gnomAD
rs1032038079	83	Y>C		No	TOPMed gnomAD
rs1967621273	83	Y>D		No	TOPMed
rs1032038079	83	Y>S		No	TOPMed gnomAD
rs1260448016	85	A>D		No	TOPMed gnomAD
rs1967621647	86	N>K		No	Ensembl
rs1212319676	86	N>S		No	TOPMed gnomAD
rs746709240	87	L>V		No	ExAC gnomAD
rs1967621877	88	E>G		No	Ensembl
rs1377862471	89	A>D		No	TOPMed gnomAD
rs1277462108	89	A>T		No	TOPMed gnomAD
rs548486447	90	K>E		No	gnomAD
rs768263588	90	K>R		No	ExAC gnomAD
rs1336377385	91	S>N		No	gnomAD
rs1344052233	93	Q>H		No	TOPMed gnomAD
rs1967622995	95	A>G		No	gnomAD
rs1599853907	96	A>T		No	TOPMed
rs1967623248	99	P>A		No	Ensembl
COSM3535748 rs1568554125	100	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl NCI-TCGA
rs967594513	101	R>G		No	TOPMed gnomAD
rs1401164342	101	R>P		No	TOPMed gnomAD
rs1401164342	101	R>Q		No	TOPMed gnomAD
rs967594513	101	R>W		No	TOPMed gnomAD
rs765456312	102	G>C		No	ExAC TOPMed gnomAD
rs1204290245	103	R>*		No	gnomAD
COSM3535749 rs1035887672	104	R>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed
rs1251944026	104	R>S		No	gnomAD
rs1035887672	104	R>T		No	TOPMed
rs1030666838	105	S>G		No	Ensembl
rs1568554186	106	A>T		No	gnomAD
rs1967624562	107	N>D		No	TOPMed
rs563733027	108	D>E		No	1000Genomes TOPMed gnomAD
rs1967624648	108	D>N		No	Ensembl
rs773804002	109	E>D		No	ExAC TOPMed gnomAD
rs1196319108	109	E>K		No	TOPMed gnomAD
rs1196319108	109	E>Q		No	TOPMed gnomAD
rs1967624966	109	E>V		No	Ensembl
rs1421419024	110	L>F		No	TOPMed gnomAD
rs919974224	110	L>P		No	TOPMed gnomAD
COSM3990103	111	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs983465843	111	F>S		No	TOPMed gnomAD
rs1174706035	112	R>P		No	gnomAD
rs1377633149	113	A>E		No	TOPMed gnomAD
rs1967625763	114	G>S		No	Ensembl
rs952747717	115	S>F		No	TOPMed gnomAD
rs1014912119	115	S>P		No	TOPMed gnomAD
rs1014912119	115	S>T		No	TOPMed gnomAD
rs1967626328	117	L>R		No	TOPMed
rs1465638279	117	L>V		No	TOPMed gnomAD
rs1967626391	118	R>T		No	TOPMed
rs372975672	119	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs201563104 COSM998051	119	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs935339144	120	Q>*		No	TOPMed
rs1967706738	120	Q>H		No	gnomAD
rs2965127	121	L>V		No	Ensembl
rs142893738	122	A>S		No	ESP TOPMed gnomAD
rs2122390654	123	K>N		No	Ensembl
rs774630684	123	K>R		No	ExAC TOPMed gnomAD
TCGA novel	123	K>S	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
COSM3535750	126	I>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1170657904	129	S>N		No	gnomAD
rs1599857318	130	H>R		No	Ensembl
rs1967707940	131	M>I		No	TOPMed
rs140833100	132	H>L		No	ESP ExAC TOPMed gnomAD
rs199953740	133	A>S		No	1000Genomes ExAC TOPMed gnomAD
rs199953740	133	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs765128314	134	E>K		No	ExAC gnomAD
rs1967708704	136	H>Y		No	TOPMed
rs1289276617	137	A>P		No	TOPMed gnomAD
rs1289276617	137	A>T		No	TOPMed gnomAD
rs376312238	137	A>V		No	TOPMed gnomAD
rs1394255813	138	L>F		No	TOPMed gnomAD
rs1394255813	138	L>V		No	TOPMed gnomAD
rs981330867	139	F>L		No	gnomAD
rs865916210	140	P>A		No	TOPMed
rs751438592	140	P>L		No	ExAC gnomAD
rs865916210	140	P>S		No	TOPMed
rs1967709870	141	G>E		No	TOPMed
rs377440313	141	G>R		No	ESP ExAC TOPMed gnomAD
TCGA novel	141	G>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs747887583	142	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs747887583	142	G>V		No	ExAC gnomAD
rs144857168	143	K>*		No	ESP ExAC TOPMed gnomAD
rs144857168	143	K>E		No	ESP ExAC TOPMed gnomAD
rs1217917009	143	K>M		No	gnomAD
rs1967710418	144	Y>N		No	gnomAD
rs1261713017	144	Y>S		No	gnomAD
rs1487014571	146	G>E		No	gnomAD
rs771366662	147	H>R		No	ExAC TOPMed gnomAD
rs749602901	147	H>Y		No	ExAC gnomAD
rs1409817102	148	M>I		No	TOPMed gnomAD
COSM4079201 rs1190196751	148	M>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs1967711103	148	M>T		No	Ensembl
rs775004600	150	Q>H		No	ExAC TOPMed gnomAD
rs1227040829	150	Q>R		No	TOPMed gnomAD
rs1346752627	152	T>I		No	gnomAD
rs1568555756	152	T>P		No	Ensembl
rs1967711832	153	K>E		No	Ensembl
rs35106910	153	K>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs35106910	153	K>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs775409459	154	A>P		No	ExAC gnomAD
rs1283928118	155	P>T		No	TOPMed
rs764214326	156	A>T		No	ExAC TOPMed gnomAD
rs371124704	158	T>I		No	ESP ExAC TOPMed gnomAD
rs371124704	158	T>N		No	ESP ExAC TOPMed gnomAD
rs762748099	159	F>C		No	ExAC gnomAD
rs1795223132	164	C>F		No	TOPMed gnomAD
rs1967713309	164	C>G		No	TOPMed
rs1384229661	165	G>E		No	TOPMed gnomAD
rs140442555	165	G>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs752145860	167	R>G		No	ExAC TOPMed gnomAD
rs201807125	167	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs752145860	167	R>W		No	ExAC TOPMed gnomAD
rs746229759	168	C>S		No	ExAC TOPMed gnomAD
rs1423933513	169	V>A		No	gnomAD
rs1967720004	169	V>M		No	TOPMed gnomAD
rs1295857633	170	L>M		No	gnomAD
rs1967720388	171	P>S		No	TOPMed
rs2122394590	174	E>*		No	Ensembl
rs114569424	178	L>F		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1383499306	178	L>H		No	TOPMed gnomAD
rs1967720892	180	G>S		No	TOPMed
rs137908794	181	T>I		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1599857841	181	T>P		No	Ensembl
rs200445340	185	V>A		No	1000Genomes ExAC TOPMed gnomAD
rs200445340	185	V>G		No	1000Genomes ExAC TOPMed gnomAD
rs2122394810	185	V>M		No	Ensembl
COSM3535751	186	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1274103082	187	P>R		No	gnomAD
rs770003480	188	G>A		No	ExAC gnomAD
rs1399203802	188	G>R		No	gnomAD
rs759339597	190	T>I		No	ExAC TOPMed gnomAD
rs944222784	190	T>P		No	Ensembl
rs759339597	190	T>R		No	ExAC TOPMed gnomAD
COSM3535752	191	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1188155125	192	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1328874977	192	L>V		No	TOPMed
rs775321656	194	L>*		No	ExAC gnomAD
rs775321656	194	L>S		No	ExAC gnomAD
rs372310813	195	R>C		No	ESP ExAC gnomAD
rs372310813	195	R>G		No	ESP ExAC gnomAD
rs575600792	195	R>H		No	1000Genomes ExAC TOPMed gnomAD
rs149481548	196	T>I		No	ESP TOPMed gnomAD
rs2122395288	197	T>A		No	Ensembl
rs868021585	198	I>T		No	TOPMed gnomAD
rs764965728	199	D>Y		No	ExAC gnomAD
rs1326165886	201	T>P		No	gnomAD
rs750033744	201	T>S		No	ExAC gnomAD
rs1272373909	202	C>Y		No	gnomAD
rs1232819921	203	S>G		No	TOPMed gnomAD
rs780423177	204	G>R		No	ExAC TOPMed gnomAD
rs755482665	205	H>Y		No	ExAC gnomAD
rs781320503	206	V>M		No	ExAC gnomAD
rs769807888	210	E>*		No	ExAC TOPMed gnomAD
rs769807888	210	E>K		No	ExAC TOPMed gnomAD
rs749488002	212	D>H		No	ExAC TOPMed gnomAD
rs749488002	212	D>N		No	ExAC TOPMed gnomAD
rs760567497	213	V>D		No	ExAC gnomAD
rs557856786 COSM4382626	213	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
COSM474903	213	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs768709346	214	F>L		No	ExAC
rs1967725365	215	T>P		No	TOPMed
rs776338309	217	L>F		No	ExAC gnomAD
rs761418172	217	L>P		No	ExAC
rs1967725891	218	F>V		No	Ensembl
TCGA novel	220	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs759899304	221	W>*		No	ExAC gnomAD
rs1967772777	223	T>A		No	Ensembl
rs1483170598	223	T>I		No	TOPMed
rs953975785	224	L>H		No	Ensembl
rs1418805363	227	N>S		No	TOPMed gnomAD
rs767829298	228	W>S		No	ExAC gnomAD
rs753226393	230	L>F		No	ExAC TOPMed gnomAD
rs753226393	230	L>V		No	ExAC TOPMed gnomAD
rs373513195	232	A>V		No	ESP ExAC TOPMed gnomAD
rs1204850508	234	N>H		No	TOPMed
COSM1394498 COSM5135618	236	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs764196556	236	P>T		No	ExAC gnomAD
rs753946761	237	G>D		No	ExAC TOPMed gnomAD
rs1324057395	238	Y>C		No	gnomAD
rs757478241	238	Y>H		No	ExAC TOPMed gnomAD
rs2122409934	239	M>K		No	Ensembl
rs1369996784	239	M>V		No	gnomAD
rs1321205852	240	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1291457488	242	L>R		No	TOPMed
rs779208700	245	D>G		No	ExAC gnomAD
rs779208700	245	D>V		No	ExAC gnomAD
rs1599859761	246	E>K		No	Ensembl
COSM5833772 COSM3823385	247	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs148127553 COSM3103362	247	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
COSM998053	247	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1226540961	248	Q>P		No	gnomAD
rs781082374	249	E>G		No	ExAC
rs141956736	250	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs147316311	250	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs147316311	250	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs141956736	250	R>S		No	ESP ExAC TOPMed gnomAD
rs1392563549	252	Q>P		No	Ensembl
rs1392563549	252	Q>R		No	Ensembl
rs138510701	254	C>F		No	1000Genomes ExAC gnomAD
rs1269891319	255	R>G		No	gnomAD
rs759141229	256	D>E		No	ExAC gnomAD
TCGA novel	256	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	257	K>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1967776739	257	K>E		No	Ensembl
rs1463540514	259	G>D		No	gnomAD
rs767920193	259	G>S		No	ExAC TOPMed gnomAD
rs1162871941	260	S>T		No	gnomAD
rs1967826418	261	Y>F		No	TOPMed
rs1489569438	263	F>L		No	gnomAD
rs761040194	264	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs1568558009	264	R>W		No	TOPMed
rs777222729	265	P>R		No	ExAC gnomAD
rs1486005385	265	P>S		No	TOPMed gnomAD
rs765404486	266	S>N		No	ExAC gnomAD
rs1224709577	266	S>R		No	TOPMed gnomAD
rs558587668	266	S>R		No	1000Genomes ExAC gnomAD
rs1350362593	267	C>R		No	TOPMed gnomAD
rs1350362593	267	C>S		No	TOPMed gnomAD
rs750497513 COSM998055	269	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs201207715	269	R>H		No	1000Genomes ExAC TOPMed gnomAD
rs201207715	269	R>L		No	1000Genomes ExAC TOPMed gnomAD
rs780929631	270	L>Q		No	Ensembl
rs995111410	271	G>E		No	TOPMed gnomAD
rs751768100	271	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs1295944061	272	Q>*		No	gnomAD
rs1967828297	272	Q>R		No	TOPMed
rs1351479922	273	W>*		No	Ensembl
rs1967828447	274	A>P		No	Ensembl
rs753864374	275	I>M		No	ExAC gnomAD
rs777383264	275	I>N		No	ExAC gnomAD
rs755972476	275	I>V		No	ExAC gnomAD
rs778549620	276	G>A		No	ExAC gnomAD
rs143342303	276	G>S		No	ESP ExAC TOPMed gnomAD
rs1280307994	277	Y>C		No	TOPMed gnomAD
rs1967829312	278	V>A		No	Ensembl
rs1399897724	278	V>L		No	TOPMed
rs1405445288	279	S>N		No	TOPMed gnomAD
rs745367240	280	S>P		No	ExAC TOPMed gnomAD
rs1967829584	281	D>H		No	Ensembl
rs1231229315	283	S>N		No	gnomAD
rs1239786858	287	T>A		No	gnomAD
rs1251878645	287	T>I		No	TOPMed gnomAD
rs1452277500	288	I>T		No	gnomAD
rs1967830276	289	P>S		No	Ensembl
rs746620893	290	A>T		No	ExAC TOPMed gnomAD
rs1395689292	291	N>K		No	gnomAD
rs769084079	293	P>H		No	ExAC TOPMed gnomAD
TCGA novel	293	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1416071534	293	P>T		No	gnomAD
rs762419781	297	V>G		No	ExAC TOPMed gnomAD
rs1438693175	298	L>V		No	gnomAD
rs1967831293	301	G>V		No	Ensembl
rs1439241795	302	Q>*		No	gnomAD
rs370388709	304	D>E		No	ESP ExAC TOPMed gnomAD
rs773800624	304	D>Y		No	ExAC TOPMed gnomAD
TCGA novel	305	G>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA
rs61755281	305	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs147455821	308	L>F		No	ESP ExAC TOPMed gnomAD
rs147455821	308	L>V		No	ESP ExAC TOPMed gnomAD
rs780714860	311	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs2122472012	313	K>E		No	Ensembl
rs1284066266	313	K>R		No	gnomAD
rs1968005839	314	T>P		No	Ensembl
rs747797534	315	H>Y		No	ExAC gnomAD
rs756569446	316	N>S		No	ExAC TOPMed gnomAD
rs182254561	318	D>Y		No	1000Genomes
rs1258130935	322	L>F		No	gnomAD
rs760486029	323	G>S		No	ExAC TOPMed gnomAD
rs745945780	325	A>E		No	ExAC TOPMed gnomAD
rs745945780	325	A>G		No	ExAC TOPMed gnomAD
rs774632827	325	A>T		No	ExAC TOPMed gnomAD
rs745945780	325	A>V		No	ExAC TOPMed gnomAD
rs772120427	326	E>D		No	ExAC gnomAD
rs1968007330	327	P>L		No	TOPMed
rs2122472442	327	P>S		No	Ensembl
rs760898443	330	R>C		No	ExAC TOPMed gnomAD
rs139273613	330	R>H		No	ESP ExAC TOPMed gnomAD
rs139273613	330	R>L		No	ESP ExAC TOPMed gnomAD
rs772959528	331	I>N		No	ExAC gnomAD
rs766142122	332	H>Q		No	ExAC TOPMed gnomAD
rs536360053	332	H>R		No	1000Genomes ExAC gnomAD
rs1968008177	333	V>A		No	TOPMed gnomAD
rs751449455	333	V>M		No	ExAC TOPMed gnomAD
rs1968008270	335	E>K		No	TOPMed
rs1166415820	336	E>D		No	TOPMed gnomAD
rs1279432747	336	E>G		No	gnomAD
rs897758747	336	E>K		No	gnomAD
rs758907585	338	L>V		No	ExAC
rs1458790653	339	Q>*		No	gnomAD
rs1968075858	339	Q>R		No	TOPMed
rs1316693211	340	L>F		No	TOPMed gnomAD
rs961495774	341	Y>C		No	TOPMed gnomAD
rs961495774	341	Y>F		No	TOPMed gnomAD
rs2122488341	342	W>C		No	Ensembl
rs747076535	343	A>V		No	ExAC gnomAD
rs149074838	344	M>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2122488403	345	D>N		No	Ensembl
rs1240356013	346	S>F		No	TOPMed
rs748321868	347	T>A		No	ExAC TOPMed gnomAD
rs548133945	347	T>I		No	1000Genomes ExAC TOPMed gnomAD
rs748321868	347	T>P		No	ExAC TOPMed gnomAD
TCGA novel	349	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1236477787	350	L>F		No	TOPMed
rs759463367	350	L>H		No	ExAC gnomAD
rs759463367	350	L>P		No	ExAC gnomAD
rs1236477787	350	L>V		No	TOPMed
rs775236973	351	C>R		No	ExAC gnomAD
rs760268560	352	K>E		No	ExAC TOPMed gnomAD
rs2122488661 TCGA novel	352	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs1303390345	354	C>*		No	gnomAD
rs142187731	354	C>S		No	1000Genomes TOPMed
rs142187731	354	C>Y		No	1000Genomes TOPMed
rs952137350	355	A>D		No	TOPMed gnomAD
rs952137350	355	A>G		No	TOPMed gnomAD
rs952137350	355	A>V		No	TOPMed gnomAD
rs1968078232	356	E>A		No	Ensembl
COSM4834391 rs763654909	356	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs763654909	356	E>Q		No	ExAC gnomAD
rs761530274	357	S>C		No	ExAC gnomAD
rs148655912	357	S>N		No	ESP ExAC TOPMed gnomAD
rs1023454829	357	S>R		No	TOPMed gnomAD
rs750794901	358	N>K		No	ExAC TOPMed gnomAD
rs1445991874	358	N>S		No	TOPMed
rs1968078892	359	K>M		No	TOPMed
rs758885229	360	D>N		No	ExAC gnomAD
rs1968079066	360	D>V		No	gnomAD
COSM3535756	361	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs766921120	363	I>N		No	ExAC gnomAD
rs766921120	363	I>T		No	ExAC gnomAD
rs971614881	365	P>L		No	TOPMed gnomAD
rs923737137	365	P>S		No	TOPMed gnomAD
rs923737137	365	P>T		No	TOPMed gnomAD
rs374379148	366	C>F		No	ESP ExAC TOPMed gnomAD
rs374379148	366	C>Y		No	ESP ExAC TOPMed gnomAD
COSM4989668 rs377703099	367	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1295034727	368	H>Y		No	gnomAD
rs1381529020	370	L>F		No	gnomAD
TCGA novel	370	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1968080800	375	L>P		No	TOPMed
rs1968080800	375	L>Q		No	TOPMed
rs1321944719	376	A>T		No	gnomAD
rs768327321	377	A>P		No	ExAC TOPMed gnomAD
rs768327321	377	A>S		No	ExAC TOPMed gnomAD
COSM4829164	378	W>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1349195973	379	Q>*		No	gnomAD
rs1348916531	380	H>R		No	TOPMed gnomAD
rs753138447	381	S>L		No	ExAC gnomAD
rs1302998194	381	S>P		No	TOPMed gnomAD
COSM4079203	385	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1310418136	385	T>N		No	TOPMed gnomAD
rs1232691082	387	P>L		No	TOPMed gnomAD
rs146735092	387	P>T		No	ESP ExAC TOPMed gnomAD
rs757386289	388	F>L		No	ExAC
rs1599871855	388	F>S		No	Ensembl
rs374326666	389	C>Y		No	ESP ExAC TOPMed gnomAD
rs751385301	390	R>C		No	ExAC TOPMed gnomAD
rs754761911 COSM3103385	390	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs751385301	390	R>S		No	ExAC TOPMed gnomAD
rs1968106082	391	C>F		No	TOPMed
rs35457630	392	E>*		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1968106402	392	E>G		No	TOPMed
rs35457630	392	E>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1053116620	394	K>E		No	TOPMed
rs769396781	394	K>N		No	ExAC gnomAD
rs1968106658	396	W>*		No	Ensembl
rs1239721663	396	W>*		No	gnomAD
TCGA novel	396	W>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1192911372	397	E>K		No	TOPMed gnomAD
TCGA novel	397	E>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs777117772	398	A>D		No	ExAC TOPMed gnomAD
rs777117772	398	A>V		No	ExAC TOPMed gnomAD
rs749036591	399	V>M		No	ExAC TOPMed gnomAD
rs1968107345	400	S>N		No	Ensembl
COSM69047	400	S>V	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1425280513	401	I>V		No	gnomAD
rs1167660429	402	Y>*		No	TOPMed gnomAD
rs1968107653	402	Y>C		No	TOPMed
rs1434461356	402	Y>H		No	gnomAD
rs1399153594	403	Q>P		No	gnomAD
rs3208856	405	H>D		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2122494882	405	H>P		No	Ensembl
rs3208856 VAR_018298	405	H>Y		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs368494441	406	G>C		No	ESP ExAC TOPMed gnomAD
rs2054488140	406	G>D		No	Ensembl
rs368494441	406	G>R		No	ESP ExAC TOPMed gnomAD
rs368494441	406	G>S		No	ESP ExAC TOPMed gnomAD
rs1968108316	407	Q>E		No	TOPMed
rs772388756	408	A>P		No	ExAC gnomAD
rs772388756	408	A>S		No	ExAC gnomAD
rs1568563845	413	S>*		No	TOPMed
rs1568563845	413	S>L		No	TOPMed
rs17852620	413	S>P		No	Ensembl
rs1968108896	414	G>R		No	Ensembl
rs1293493860	416	S>R		No	TOPMed gnomAD
rs764271266	416	S>T		No	ExAC gnomAD
rs762183942	418	D>N		No	ExAC gnomAD
rs765569181	419	Q>E		No	ExAC TOPMed gnomAD
rs750604085	419	Q>H		No	ExAC gnomAD
rs1289790618	419	Q>R		No	TOPMed
rs754849774	420	E>V		No	ExAC gnomAD
rs781113299	421	G>S		No	ExAC gnomAD
rs994347051	423	E>K		No	TOPMed gnomAD
rs1331839617	425	E>K		No	Ensembl
rs1172300265	425	E>V		No	TOPMed gnomAD
rs1025942028	426	L>V		No	TOPMed gnomAD
rs1404017582	427	G>R		No	gnomAD
rs1187731803	429	V>L		No	TOPMed gnomAD
rs1187731803	429	V>M		No	TOPMed gnomAD
COSM3892840	430	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1474012971	430	P>R		No	TOPMed gnomAD
rs745556828	432	S>*		No	ExAC TOPMed gnomAD
rs1838178777	432	S>A		No	Ensembl
COSM5141243 COSM1394500 rs745556828	432	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs557733635	433	A>S		No	1000Genomes ExAC TOPMed gnomAD
COSM3535757	434	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs116023028	435	P>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs777033769	436	L>F		No	ExAC TOPMed gnomAD
rs1265994312	437	P>R		No	gnomAD
rs1599872911	438	P>S		No	Ensembl
rs770035168	439	R>Q		No	ExAC TOPMed gnomAD
rs374048625	439	R>W		No	ESP ExAC TOPMed gnomAD
rs1242181381	441	D>Y		No	gnomAD
rs1272578610	442	L>P		No	TOPMed gnomAD
rs1447035976	443	P>S		No	TOPMed
rs1280385353	444	P>A		No	gnomAD
rs773422704	444	P>H		No	ExAC TOPMed gnomAD
rs773422704	444	P>R		No	ExAC TOPMed gnomAD
rs1968132604	445	R>K		No	Ensembl
rs766555920	445	R>Q	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1183446053	446	K>N		No	TOPMed
rs1386405463	446	K>R		No	TOPMed gnomAD
rs763325522	447	P>L		No	ExAC TOPMed gnomAD
rs138476890	450	A>G		No	1000Genomes ESP ExAC TOPMed gnomAD
rs138476890	450	A>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs997076042	451	Q>R		No	TOPMed
rs1968133016	452	P>S		No	TOPMed
rs1599872994	453	K>E		No	Ensembl
rs61750956	455	R>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1968269207	455	R>S		No	gnomAD
rs61750956	455	R>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs762400110	456	L>P		No	ExAC gnomAD
rs1050232407	458	K>R		No	TOPMed gnomAD
rs1470815090	461	S>P		No	TOPMed
rs753128512	462	P>L		No	ExAC gnomAD
COSM3535759	462	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1968269757	462	P>T		No	Ensembl
COSM5211983 COSM439764	463	P>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM6085374 COSM6085373	464	A>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs756481545	464	A>P		No	ExAC gnomAD
rs756481545	464	A>T		No	ExAC gnomAD
rs904426529	465	A>V		No	Ensembl
COSM998060	467	G>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1185174270	467	G>E		No	gnomAD
rs1968270219	469	Q>*		No	Ensembl
rs1968270267	469	Q>P		No	gnomAD
rs1968270267	469	Q>R		No	gnomAD
TCGA novel	470	D>missing	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1269858060	470	D>G		No	TOPMed
rs770969313	470	D>H		No	ExAC TOPMed gnomAD
rs746139762	472	A>T		No	ExAC TOPMed gnomAD
TCGA novel	473	P>missing	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1418606115	473	P>A		No	TOPMed gnomAD
rs1298249941	473	P>L		No	gnomAD
rs1298249941	473	P>R		No	gnomAD
rs1288290895	475	A>C		No	TOPMed
COSM998062	475	A>L	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic

No associated diseases with Q9ULV8

6 regional properties for Q9ULV8

Type	Name	Position	InterPro Accession
domain	Zinc finger, RING-type	351 - 390	IPR001841
domain	Adaptor protein Cbl, N-terminal helical	14 - 145	IPR003153
domain	Adaptor protein Cbl, EF hand-like	149 - 232	IPR014741
domain	Adaptor protein Cbl, SH2-like domain	226 - 322	IPR014742
conserved_site	Zinc finger, RING-type, conserved site	366 - 375	IPR017907
domain	Adaptor protein Cbl, PTB domain	7 - 321	IPR024159

Functions

		Description
EC Number	2.3.2.27	Aminoacyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
membrane raft	Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

7 GO annotations of molecular function

Name	Definition
calcium ion binding	Binding to a calcium ion (Ca2+).
epidermal growth factor receptor binding	Binding to an epidermal growth factor receptor.
phosphotyrosine residue binding	Binding to a phosphorylated tyrosine residue within a protein.
receptor tyrosine kinase binding	Binding to a receptor that possesses protein tyrosine kinase activity.
SH3 domain binding	Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
ubiquitin protein ligase activity	Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond
zinc ion binding	Binding to a zinc ion (Zn).

10 GO annotations of biological process

Name	Definition
cell surface receptor signaling pathway	The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
negative regulation of epidermal growth factor receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
negative regulation of epidermal growth factor-activated receptor activity	Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity.
negative regulation of MAP kinase activity	Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
negative regulation of neuron apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
protein stabilization	Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
protein ubiquitination	The process in which one or more ubiquitin groups are added to a protein.
response to glial cell derived neurotrophic factor	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

7 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	Homo sapiens (Human)	EV
P22681	CBL	E3 ubiquitin-protein ligase CBL	Homo sapiens (Human)	EV
P22682	Cbl	E3 ubiquitin-protein ligase CBL	Mus musculus (Mouse)	SS
Q3TTA7	Cblb	E3 ubiquitin-protein ligase CBL-B	Mus musculus (Mouse)	SS
Q80XL1	Cblc	E3 ubiquitin-protein ligase CBL-C	Mus musculus (Mouse)	SS
Q8K4S7	Cblb	E3 ubiquitin-protein ligase CBL-B	Rattus norvegicus (Rat)	SS
G3V8H4	Cblc	E3 ubiquitin-protein ligase CBL-C	Rattus norvegicus (Rat)	SS

10	20	30	40	50	60
MALAVAPWGR	QWEEARALGR	AVRMLQRLEE	QCVDPRLSVS	PPSLRDLLPR	TAQLLREVAH
70	80	90	100	110	120
SRRAAGGGGP	GGPGGSGDFL	LIYLANLEAK	SRQVAALLPP	RGRRSANDEL	FRAGSRLRRQ
130	140	150	160	170	180
LAKLAIIFSH	MHAELHALFP	GGKYCGHMYQ	LTKAPAHTFW	RESCGARCVL	PWAEFESLLG
190	200	210	220	230	240
TCHPVEPGCT	ALALRTTIDL	TCSGHVSIFE	FDVFTRLFQP	WPTLLKNWQL	LAVNHPGYMA
250	260	270	280	290	300
FLTYDEVQER	LQACRDKPGS	YIFRPSCTRL	GQWAIGYVSS	DGSILQTIPA	NKPLSQVLLE
310	320	330	340	350	360
GQKDGFYLYP	DGKTHNPDLT	ELGQAEPQQR	IHVSEEQLQL	YWAMDSTFEL	CKICAESNKD
370	380	390	400	410	420
VKIEPCGHLL	CSCCLAAWQH	SDSQTCPFCR	CEIKGWEAVS	IYQFHGQATA	EDSGNSSDQE
430	440	450	460	470
GRELELGQVP	LSAPPLPPRP	DLPPRKPRNA	QPKVRLLKGN	SPPAALGPQD	PAPA