AiPD: Autoinhibited Protein Database

Q9UKW6

Gene name	ELF5 (ESE2)
Protein name	ETS-related transcription factor Elf-5
Names	E74-like factor 5, Epithelium-restricted ESE-1-related Ets factor, Epithelium-specific Ets transcription factor 2, ESE-2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:2001
EC number
Protein Class	ETS (PTHR11849)

Descriptions

ELF5 is a Ets transcription factor expressed in differentiated keratinocytes and glandular epithelium. In contrast to ELF3, full-length ELF5 binds poorly to DNA due to the autoinhibition by N-terminal region.

Autoinhibitory domains (AIDs)

Target domain	172-258 (Ets domain)
Relief mechanism	PTM, Partner binding
Assay	Deletion assay, Mutagenesis experiment

AID

1-42 (N-terminal autoinhibitory region)

Target domain

172-258 (Ets domain)

Relief mechanism

PTM (Phosphorylation of S/TP site within Ets domain), Partner binding (Interaction between transcriptional factors and Pointed domain)

Assay

Deletion assay, Mutagenesis experiment

Accessory elements

No accessory elements

References

Oettgen P et al. (1999) "Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes", The Journal of biological chemistry, 274, 29439-52

Autoinhibited structure

Activated structure

2 structures for Q9UKW6

Entry ID	Method	Resolution	Chain	Position	Source
1WWX	NMR	-	A	172-265	PDB
AF-Q9UKW6-F1	Predicted				AlphaFoldDB

220 variants for Q9UKW6

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs749856752 CA5944989	3	S>Y		No	ClinGen ExAC gnomAD
rs778184333 CA380109886	6	H>N		No	ClinGen ExAC gnomAD
rs778184333 CA5944988	6	H>Y		No	ClinGen ExAC gnomAD
CA380109841 rs1590341876	10	V>G		No	ClinGen Ensembl
CA380109839 rs1394764223	11	M>L		No	ClinGen gnomAD
CA220491747 rs375932861	11	M>T		No	ClinGen ESP TOPMed gnomAD
CA380109819 rs1436877808	13	D>V		No	ClinGen TOPMed gnomAD
CA220491746 rs1027576875	14	S>L		No	ClinGen TOPMed
CA380109809 rs748736492	15	V>E		No	ClinGen ExAC TOPMed gnomAD
CA5944972 rs748736492	15	V>G		No	ClinGen ExAC TOPMed gnomAD
rs865898724 CA220491739	15	V>M		No	ClinGen Ensembl
CA5944970 rs770374808	16	T>I		No	ClinGen ExAC gnomAD
rs1474807372 CA380109799	17	H>R		No	ClinGen gnomAD
CA220491703 rs138296373	18	S>G		No	ClinGen ESP TOPMed
CA5944968 rs781665846	19	T>A		No	ClinGen ExAC TOPMed gnomAD
CA380109787 rs781665846	19	T>P		No	ClinGen ExAC TOPMed gnomAD
rs780368923 CA5944965	21	L>P		No	ClinGen ExAC gnomAD
CA5944962 rs765374106	22	P>L		No	ClinGen ExAC gnomAD
rs765374106 CA5944963	22	P>R		No	ClinGen ExAC gnomAD
rs1359823444 CA380109765	23	N>Y		No	ClinGen TOPMed
rs756122174 CA5944961	24	A>G		No	ClinGen ExAC gnomAD
CA380109748 rs1246385641	25	S>F		No	ClinGen TOPMed gnomAD
CA380109746 rs1224082742	26	F>L		No	ClinGen gnomAD
CA380109739 rs1287219257	27	C>R		No	ClinGen TOPMed
COSM186135 CA380109735 rs1355366001	27	C>Y	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA5944958 rs199968646	28	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA380109730 rs199968646	28	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA5944955 rs201073232	32	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs570283077 CA220491650	33	W>*		No	ClinGen Ensembl
rs769174554 CA5944953	34	T>A		No	ClinGen ExAC gnomAD
CA380109682 rs1161230458	35	D>G		No	ClinGen gnomAD
CA5944952 rs754925066	38	S>G		No	ClinGen ExAC TOPMed gnomAD
CA5944951 rs776939783	38	S>R		No	ClinGen ExAC gnomAD
rs769082005 CA5944950	39	N>D		No	ClinGen ExAC TOPMed gnomAD
CA5944949 rs373891267	41	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA5944948 rs780452653	42	Y>*		No	ClinGen ExAC gnomAD
rs1356325883 CA380109634	42	Y>S		No	ClinGen TOPMed
rs758730793 CA5944947	43	Y>C		No	ClinGen ExAC gnomAD
rs1228039522 CA380109618	44	P>L		No	ClinGen gnomAD
rs148001707 CA5944946	45	A>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5944945 rs146936286	46	F>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA380109604 rs1383259769	47	E>Q		No	ClinGen TOPMed
CA380109595 rs1235625065	48	H>Y		No	ClinGen gnomAD
rs574430500 CA5944943	49	Q>P		No	ClinGen 1000Genomes ExAC gnomAD
CA380109559 rs1396082555	51	A>D		No	ClinGen gnomAD
CA220483609 rs12789251	52	C>S		No	ClinGen TOPMed
CA380109553 rs12789251	52	C>Y		No	ClinGen TOPMed
CA380109533 rs1564979625	55	Y>C		No	ClinGen Ensembl
CA220483608 rs892614098	55	Y>H		No	ClinGen TOPMed gnomAD
CA380109525 rs1564979611	56	W>*		No	ClinGen Ensembl
CA380109527 rs1292866717	56	W>R		No	ClinGen TOPMed
rs1373795290 CA380109514	57	T>I		No	ClinGen TOPMed
CA5944920 rs750107698	61	P>T		No	ClinGen ExAC gnomAD
CA220483600 rs12789224	62	E>Q		No	ClinGen Ensembl
rs1392856104 CA380109470	64	W>*		No	ClinGen TOPMed
CA380109462 rs1479967487	65	T>S		No	ClinGen gnomAD
rs12789595 CA220483593	65	T>S		No	ClinGen Ensembl
rs764751323 CA5944919	66	K>E		No	ClinGen ExAC gnomAD
CA380109457 rs1590331168	66	K>T		No	ClinGen Ensembl
rs147852989 CA5944918	67	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA5944916 rs376593969	67	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA5944917 rs376593969	67	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA380109446 rs1278205905	68	H>R		No	ClinGen gnomAD
CA380109429 rs1348857872	70	W>*		No	ClinGen gnomAD
CA5944915 rs761319439	71	E>A		No	ClinGen ExAC gnomAD
rs772569286 CA5944913	74	Q>P		No	ClinGen ExAC gnomAD
CA380109375 rs142532643	77	C>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5944911 rs774654191	78	D>N		No	ClinGen ExAC TOPMed gnomAD
CA5944910 rs749506182	80	Y>*		No	ClinGen ExAC TOPMed gnomAD
rs1356933418 CA380109355	80	Y>C		No	ClinGen gnomAD
rs12789560 CA220483542	83	D>E		No	ClinGen Ensembl
rs199531792 CA5944908	84	T>I		No	ClinGen 1000Genomes ExAC gnomAD
rs769860948 CA5944907	85	N>D		No	ClinGen ExAC gnomAD
rs1175974545 CA380109319	85	N>K		No	ClinGen gnomAD
rs1417729809 CA380109313	86	C>Y		No	ClinGen gnomAD
rs779914056 CA5944905	87	I>F		No	ClinGen ExAC gnomAD
rs779914056 CA5944906	87	I>V		No	ClinGen ExAC gnomAD
CA220483520 rs371695751	93	N>S		No	ClinGen ESP
CA5944904 rs758215481	95	S>N		No	ClinGen ExAC gnomAD
CA5944902 rs778735446	96	G>A		No	ClinGen ExAC TOPMed gnomAD
CA5944903 rs778735446	96	G>D		No	ClinGen ExAC TOPMed gnomAD
rs142271255 CA5944899	100	C>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA220483469 rs1056420451	100	C>W		No	ClinGen Ensembl
CA5944898 rs760195057	101	S>G		No	ClinGen ExAC gnomAD
CA5944897 rs753269550	102	M>T		No	ClinGen ExAC gnomAD
rs1213844993 CA380109209	102	M>V		No	ClinGen gnomAD
rs1284610521 CA380109201	103	T>A		No	ClinGen gnomAD
rs768086423 CA5944896	104	Q>R		No	ClinGen ExAC gnomAD
rs1472417702 CA380109189	105	E>K		No	ClinGen TOPMed
rs774629966 CA5944894	107	F>I		No	ClinGen ExAC
rs771315168 CA5944893	108	V>I		No	ClinGen ExAC TOPMed gnomAD
rs773417409 CA5944891	109	E>K		No	ClinGen ExAC gnomAD
CA380109161 rs773417409	109	E>Q		No	ClinGen ExAC gnomAD
CA5944889 rs748180689	110	A>G		No	ClinGen ExAC gnomAD
rs769879511 CA5944890	110	A>S		No	ClinGen ExAC gnomAD
CA5944888 rs775440904	111	A>T		No	ClinGen ExAC TOPMed gnomAD
CA5944887 rs772039935	112	G>C		No	ClinGen ExAC gnomAD
rs1187368108 CA380109138	113	L>F		No	ClinGen gnomAD
CA380109135 rs1475587895	113	L>R		No	ClinGen gnomAD
rs778628535 CA5944884 COSM186133	115	G>S	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs189827054 CA5944883	115	G>V		No	ClinGen 1000Genomes ExAC gnomAD
rs367861770 CA5944881	116	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA380109122 rs367861770	116	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs755707232 CA380109114	117	Y>D		No	ClinGen ExAC TOPMed gnomAD
rs755707232 CA5944880	117	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA5944878 rs752213073	118	L>V		No	ClinGen ExAC gnomAD
CA380109086 rs1362226141	121	I>F		No	ClinGen gnomAD
CA5944877 rs767102738	121	I>T		No	ClinGen ExAC gnomAD
rs201472486 CA5944876	122	L>F		No	ClinGen 1000Genomes ExAC gnomAD
rs1164869420 CA380109075	123	Q>*		No	ClinGen gnomAD
rs766657108 CA5944874	126	R>C		No	ClinGen ExAC gnomAD
CA380109052 rs371514980 COSM186132	126	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs371514980 CA5944873	126	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA5944872 rs773448692	128	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs1227188464 CA380109041	128	Q>R		No	ClinGen TOPMed
CA380108898 rs760699423	129	G>D		No	ClinGen ExAC TOPMed gnomAD
CA380109037 rs1262669443	129	G>S		No	ClinGen gnomAD
CA5944833 rs760699423	129	G>V		No	ClinGen ExAC TOPMed gnomAD
CA5944831 rs767471452	131	S>A		No	ClinGen ExAC TOPMed gnomAD
rs767471452 CA220480268	131	S>T		No	ClinGen ExAC TOPMed gnomAD
CA380108880 rs1259269345	132	F>C		No	ClinGen gnomAD
CA5944829 rs773219474	132	F>L		No	ClinGen ExAC TOPMed gnomAD
rs940775831 CA380108863	134	N>K		No	ClinGen TOPMed
rs1239030433 CA380108865	134	N>S		No	ClinGen TOPMed gnomAD
rs368334489 CA5944827	136	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA380108849 rs1412985726	136	A>V		No	ClinGen gnomAD
CA5944824 rs746621726	138	E>D		No	ClinGen ExAC TOPMed gnomAD
rs199749742 CA5944825	138	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs375363670 CA5944823	139	S>G		No	ClinGen ESP ExAC gnomAD
rs755990303 CA220480220	139	S>R		No	ClinGen Ensembl
CA380108827 rs1454409351	140	K>E		No	ClinGen TOPMed
CA380108821 rs1334419053	140	K>N		No	ClinGen TOPMed
rs1157771524 CA380108825	140	K>T		No	ClinGen gnomAD
CA380108819 rs1564977520	141	A>P		No	ClinGen Ensembl
rs763786160 CA5944808	147	A>T		No	ClinGen ExAC TOPMed gnomAD
rs149927600 CA5944807	147	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs774936568 CA5944806	148	D>H		No	ClinGen ExAC gnomAD
rs1250221106 CA380108743	149	S>F		No	ClinGen gnomAD
rs997497033 CA220474862	150	N>K		No	ClinGen Ensembl
rs771579876 CA5944805	150	N>S		No	ClinGen ExAC gnomAD
CA380108734 rs1203897950	151	C>G		No	ClinGen TOPMed
rs745330084 CA5944804	151	C>Y		No	ClinGen ExAC gnomAD
rs1471657078 CA380108721	153	K>E		No	ClinGen gnomAD
rs1243727572 CA380108708	155	S>R		No	ClinGen TOPMed
rs200367111 CA5944802	156	G>D		No	ClinGen 1000Genomes ExAC gnomAD
CA5944803 rs139323050	156	G>S		No	ClinGen ESP ExAC gnomAD
rs570144194 CA5944801	157	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs368097843 CA5944800	159	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1367110545 CA380108647	161	D>G		No	ClinGen gnomAD
rs200183396 CA5944799	161	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA5944798 rs748417320	163	H>D		No	ClinGen ExAC TOPMed gnomAD
CA220474826 rs1007949298	163	H>Q		No	ClinGen TOPMed gnomAD
rs781222563 CA5944797	165	H>R		No	ClinGen ExAC gnomAD
rs1325005691 CA380108544	168	T>I		No	ClinGen gnomAD
rs1325005691 CA380108548	168	T>K		No	ClinGen gnomAD
rs749872567 CA5944777	169	S>N		No	ClinGen ExAC gnomAD
rs151267373 CA220474002	170	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs151267373 CA5944776	170	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA380108384 rs1172219509	171	Q>L		No	ClinGen gnomAD
rs1434513018 CA380108379	172	S>G		No	ClinGen gnomAD
rs1426262838 CA380108340	175	L>Q		No	ClinGen gnomAD
rs1193438284 CA380108334	176	W>R		No	ClinGen gnomAD
CA5944774 rs748422640	179	V>G		No	ClinGen ExAC gnomAD
rs770217443 CA5944775	179	V>L		No	ClinGen ExAC
rs201810763 CA5944773	180	R>*		No	ClinGen ExAC TOPMed gnomAD
CA5944771 rs747223156	180	R>L		No	ClinGen ExAC TOPMed gnomAD
rs747223156 CA5944772	180	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5944770 rs143609015	181	D>H		No	ClinGen ESP ExAC gnomAD
CA220473983 rs202014280	181	D>V		No	ClinGen Ensembl
rs140444692 CA5944768	184	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1372525179 CA380108209	186	P>T		No	ClinGen gnomAD
rs755966101 CA5944766	191	G>D		No	ClinGen ExAC gnomAD
CA5944765 rs752473340	194	E>K		No	ClinGen ExAC TOPMed gnomAD
CA380108109 rs752473340	194	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA5944764 rs767275877	197	D>N		No	ClinGen ExAC TOPMed gnomAD
CA220473972 rs886064267	199	E>K		No	ClinGen TOPMed
rs886064267 CA220473967	199	E>Q		No	ClinGen TOPMed
CA380107994 rs1414947242	201	G>R		No	ClinGen gnomAD
rs189568125 CA5944762	204	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5944763 rs759245139	204	R>W		No	ClinGen ExAC gnomAD
COSM109291 rs138616093 CA220473955	205	V>G	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
CA380107939 rs1407863891	205	V>L		No	ClinGen gnomAD
rs762322416 CA5944760	206	V>A		No	ClinGen ExAC
rs1473630179 CA380107931	206	V>I		No	ClinGen gnomAD
CA5944759 rs773801852	208	S>L		No	ClinGen ExAC gnomAD
rs906046172 CA220473926	208	S>T		No	ClinGen Ensembl
CA380107879 rs1483696050	210	A>T		No	ClinGen gnomAD
CA5944756 rs777195973	212	A>T		No	ClinGen ExAC gnomAD
rs1590317779 CA380107849	213	K>T		No	ClinGen Ensembl
rs1316321610 CA380107814	215	W>*		No	ClinGen gnomAD
rs747243326 CA5944754	222	D>A		No	ClinGen ExAC TOPMed
rs747243326 CA220473895	222	D>G		No	ClinGen ExAC TOPMed
rs1437528965 CA380107706	223	R>I		No	ClinGen gnomAD
rs780362758 CA5944753	225	T>I		No	ClinGen ExAC gnomAD
CA380107692 rs1332040902	225	T>S		No	ClinGen gnomAD
CA380107666 rs1304407714	228	K>N		No	ClinGen TOPMed
rs745892681 CA5944751	232	A>V		No	ClinGen ExAC gnomAD
rs752615230 CA5944748	234	R>K		No	ClinGen ExAC gnomAD
rs202163383 CA5944729	235	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
rs778916613 CA5944730	235	Y>H		No	ClinGen ExAC gnomAD
CA380107606 rs1390630267	236	Y>H		No	ClinGen gnomAD
rs1161040026 CA380107588	238	K>E		No	ClinGen TOPMed
rs748082330 CA5944728	242	L>F		No	ClinGen ExAC gnomAD
rs143099997 CA5944726	244	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs759492774 CA5944727	244	R>W		No	ClinGen ExAC TOPMed gnomAD
CA380107545 rs1249048891	245	V>I		No	ClinGen TOPMed gnomAD
rs1203444837 CA380107538	246	D>Y		No	ClinGen TOPMed gnomAD
rs758047118 CA5944723	247	R>*		No	ClinGen ExAC gnomAD
COSM926634 CA5944722 rs750089040	247	R>Q	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs764662088 CA5944721	248	R>K		No	ClinGen ExAC gnomAD
rs866208823 CA220473559	254	G>E		No	ClinGen gnomAD
CA5944720 rs756773499	255	K>T		No	ClinGen ExAC gnomAD
CA5944719 rs754414523 COSM1289549	257	A>V	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs373515223 CA380107455	258	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs548657921 CA5944717 COSM3728039	259	G>R	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs776043452 CA5944716	260	W>R		No	ClinGen ExAC gnomAD
CA220473539 rs954582578	262	E>Q		No	ClinGen TOPMed gnomAD
rs767909038 CA5944715	263	D>N		No	ClinGen ExAC gnomAD
CA380107418 rs1590317051	264	K>E		No	ClinGen Ensembl
CA5944713 rs774566142	265	L>P		No	ClinGen ExAC gnomAD

No associated diseases with Q9UKW6

4 regional properties for Q9UKW6

Type	Name	Position	InterPro Accession
domain	CRIB domain	10 - 62	IPR000095
domain	Protein kinase domain	449 - 700	IPR000719
binding_site	Protein kinase, ATP binding site	455 - 479	IPR017441
domain	Serine/threonine-protein kinase PAK5, catalytic domain	426 - 717	IPR028754

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family	PTHR11849	ETS
PANTHER Subfamily	PTHR11849:SF15	ETS-RELATED TRANSCRIPTION FACTOR ELF-5
PANTHER Protein Class	DNA-binding transcription factor helix-turn-helix transcription factor winged helix/forkhead transcription factor
PANTHER Pathway Category	PDGF signaling pathway Ets

2 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name	Definition
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
sequence-specific double-stranded DNA binding	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

2 GO annotations of biological process

Name	Definition
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

25 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q0VC65	ETV6	Transcription factor ETV6	Bos taurus (Bovine)	SS
Q58DT0	ELF5	ETS-related transcription factor Elf-5	Bos taurus (Bovine)	SS
Q9Y603	ETV7	Transcription factor ETV7	Homo sapiens (Human)	SS
P41212	ETV6	Transcription factor ETV6	Homo sapiens (Human)	SS
P78545	ELF3	ETS-related transcription factor Elf-3	Homo sapiens (Human)	SS
P32519	ELF1	ETS-related transcription factor Elf-1	Homo sapiens (Human)	PR
Q99607	ELF4	ETS-related transcription factor Elf-4	Homo sapiens (Human)	PR
Q06546	GABPA	GA-binding protein alpha chain	Homo sapiens (Human)	SS
O95238	SPDEF	SAM pointed domain-containing Ets transcription factor	Homo sapiens (Human)	PR
P50548	ERF	ETS domain-containing transcription factor ERF	Homo sapiens (Human)	PR
P41162	ETV3	ETS translocation variant 3	Homo sapiens (Human)	PR
P11308	ERG	Transcriptional regulator ERG	Homo sapiens (Human)	EV
P43268	ETV4	ETS translocation variant 4	Homo sapiens (Human)	EV
P41161	ETV5	ETS translocation variant 5	Homo sapiens (Human)	SS
P50549	ETV1	ETS translocation variant 1	Homo sapiens (Human)	EV
P41970	ELK3	ETS domain-containing protein Elk-3	Homo sapiens (Human)	SS
P28324	ELK4	ETS domain-containing protein Elk-4	Homo sapiens (Human)	EV
P19419	ELK1	ETS domain-containing protein Elk-1	Homo sapiens (Human)	EV
P15036	ETS2	Protein C-ets-2	Homo sapiens (Human)	EV
P14921	ETS1	Protein C-ets-1	Homo sapiens (Human)	EV
Q60775	Elf1	ETS-related transcription factor Elf-1	Mus musculus (Mouse)	PR
P97360	Etv6	Transcription factor ETV6	Mus musculus (Mouse)	EV
Q9JHC9	Elf2	ETS-related transcription factor Elf-2	Mus musculus (Mouse)	PR
Q9Z2U4	Elf4	ETS-related transcription factor Elf-4	Mus musculus (Mouse)	PR
Q8VDK3	Elf5	ETS-related transcription factor Elf-5	Mus musculus (Mouse)	SS

10	20	30	40	50	60
MPSLPHSHRV	MLDSVTHSTF	LPNASFCDPL	MSWTDLFSNE	EYYPAFEHQT	ACDSYWTSVH
70	80	90	100	110	120
PEYWTKRHVW	EWLQFCCDQY	KLDTNCISFC	NFNISGLQLC	SMTQEEFVEA	AGLCGEYLYF
130	140	150	160	170	180
ILQNIRTQGY	SFFNDAEESK	ATIKDYADSN	CLKTSGIKSQ	DCHSHSRTSL	QSSHLWEFVR
190	200	210	220	230	240
DLLLSPEENC	GILEWEDREQ	GIFRVVKSEA	LAKMWGQRKK	NDRMTYEKLS	RALRYYYKTG
250	260
ILERVDRRLV	YKFGKNAHGW	QEDKL