AiPD: Autoinhibited Protein Database

Q9UJY5

Gene name	GGA1
Protein name	ADP-ribosylation factor-binding protein GGA1
Names	Gamma-adaptin-related protein 1, Golgi-localized, gamma ear-containing, ARF-binding protein 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:26088
EC number
Protein Class	GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN (PTHR45905)

Descriptions

The cytosolic adaptors GGA1-3 mediate sorting of transmembrane proteins. GGA1 contains an autoinhibitory region in hinge region between GAT and GAE domains that is activated by the phosphorylation of a serine positioned three residues upstream of the DXXLL motif. Autoinhibition is achieved by the interaction between DXXLL site and the VHS domain in CGGA1, and the phosphoserine upstream of the DXXLL motif facilitates this interaction.

Autoinhibitory domains (AIDs)

Target domain	8-147 (VHS domain)
Relief mechanism	PTM
Assay	Mutagenesis experiment, Structural analysis

AID

355-362 (Autoinhibitory site in hinge region)

Target domain

8-147 (VHS domain)

Relief mechanism

PTM (Phosphorylation of S355)

Assay

Mutagenesis experiment, Structural analysis

Accessory elements

No accessory elements

References

Cramer JF et al. (2010) "GGA autoinhibition revisited", Traffic (Copenhagen, Denmark), 11, 259-73

Autoinhibited structure

Activated structure

21 structures for Q9UJY5

Entry ID	Method	Resolution	Chain	Position	Source
1J2J	X-ray	160 A	B	166-210	PDB
1JWF	X-ray	210 A	A	1-147	PDB
1JWG	X-ray	200 A	A/B	1-147	PDB
1NA8	X-ray	230 A	A/B	494-639	PDB
1NAF	X-ray	280 A	A	165-314	PDB
1NWM	X-ray	240 A	X	166-302	PDB
1O3X	X-ray	210 A	A	166-305	PDB
1OM9	X-ray	250 A	A/B	494-639	PDB
1OXZ	X-ray	280 A	A	141-326	PDB
1PY1	X-ray	260 A	A/B/C/D	2-157	PDB
1UJJ	X-ray	260 A	A/B	1-147	PDB
1UJK	X-ray	190 A	A/B	1-147	PDB
1X79	X-ray	241 A	A	210-302	PDB
2DWX	X-ray	255 A			PDB
2DWY	X-ray	230 A	A/B/C/D	507-639	PDB
3G2S	X-ray	170 A	A/B	1-147	PDB
3G2T	X-ray	200 A	A/B	1-147	PDB
3G2U	X-ray	230 A	A/B	1-147	PDB
3G2V	X-ray	210 A	A/B	1-147	PDB
3G2W	X-ray	240 A			PDB
AF-Q9UJY5-F1	Predicted				AlphaFoldDB

498 variants for Q9UJY5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA411449516 rs1601481715	2	E>A		No	ClinGen Ensembl
CA324125597 rs1000281879	2	E>D		No	ClinGen Ensembl
rs916788941 CA324125583	2	E>K		No	ClinGen TOPMed
rs1031819041 CA324125602	3	P>L		No	ClinGen TOPMed
CA411449532 rs1347433540	4	A>T		No	ClinGen TOPMed
rs1304029909 CA411449541	5	M>V		No	ClinGen TOPMed
CA411449560 rs1424301379	6	E>A		No	ClinGen TOPMed
rs1569192787 CA411449564	6	E>D		No	ClinGen Ensembl
rs948324945 CA324125605	7	P>S		No	ClinGen TOPMed
CA411449578 rs1212633135	8	E>Q		No	ClinGen gnomAD
rs1354633700 CA411449612	11	E>*		No	ClinGen gnomAD
rs777465269 CA10220857	14	I>V		No	ClinGen ExAC TOPMed gnomAD
CA10220881 rs749925397	16	R>I		No	ClinGen ExAC gnomAD
CA411451461 rs1366414064	17	A>D		No	ClinGen gnomAD
CA411451515 rs1455938705	20	P>T		No	ClinGen gnomAD
CA10220885 rs772416767	22	N>K		No	ClinGen ExAC gnomAD
rs748475787 CA10220884	22	N>S		No	ClinGen ExAC gnomAD
rs1332264673 CA411451597	24	E>D		No	ClinGen gnomAD
rs1397915822 CA411451586	24	E>K		No	ClinGen TOPMed gnomAD
rs747186155 CA10220887	26	D>N		No	ClinGen ExAC TOPMed gnomAD
CA411451663 rs1601505839	28	A>P		No	ClinGen Ensembl
rs1290397398 CA411451678	28	A>V		No	ClinGen gnomAD
rs776758741 CA10220889	29	S>N		No	ClinGen ExAC TOPMed gnomAD
CA411451694 rs1344930712	29	S>R		No	ClinGen TOPMed
rs759647000 CA10220890	31	N>D		No	ClinGen ExAC
rs775429217 CA10220892	32	G>S		No	ClinGen ExAC gnomAD
rs762683852 CA10220893	32	G>V		No	ClinGen ExAC gnomAD
CA411451816 rs372038788	34	C>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10220896 rs151193060	35	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA10220897 rs767276418	36	Q>R		No	ClinGen ExAC gnomAD
CA10220898 rs749961784	38	N>S		No	ClinGen ExAC gnomAD
rs779295283 CA10220900	39	E>G		No	ClinGen ExAC TOPMed gnomAD
COSM419562 rs1454217253 CA411451899	39	E>K	urinary_tract [Cosmic]	No	ClinGen cosmic curated gnomAD
CA324130367 rs867858200	40	D>N		No	ClinGen Ensembl
rs532554844 CA10220901	41	F>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs758713338 CA10220902	42	E>K		No	ClinGen ExAC gnomAD
CA411451978 rs1401616478	43	G>E		No	ClinGen gnomAD
CA411452728 rs966799325	45	P>L		No	ClinGen gnomAD
rs966799325 CA324132305	45	P>Q		No	ClinGen gnomAD
CA324132337 rs376388093	47	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA10220927 rs376388093	47	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA411452758 rs1354332547	49	R>Q		No	ClinGen TOPMed
CA10220928 rs756263898	49	R>W		No	ClinGen ExAC gnomAD
rs1351810828 CA411452781	52	A>G		No	ClinGen gnomAD
rs1165799382 CA411452775	52	A>T		No	ClinGen gnomAD
CA411452787 rs1459300884	53	H>Y		No	ClinGen gnomAD
CA411452813 rs1393368489	55	I>F		No	ClinGen gnomAD
rs749327909 CA10220930	56	Q>H		No	ClinGen ExAC gnomAD
rs768774460 CA10220931 COSM1714377	58	P>S	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA411452877 rs1362446088	61	W>L		No	ClinGen gnomAD
rs774375289 CA411452903	63	A>G		No	ClinGen ExAC gnomAD
rs774375289 CA10220932	63	A>V		No	ClinGen ExAC gnomAD
rs1415654124 CA411452926	66	A>V		No	ClinGen TOPMed
rs771955351 CA10220934 COSM1484225	68	T>M	NS breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA411453346 rs1275694861	71	E>A		No	ClinGen gnomAD
CA10220970 rs754074917	72	T>A		No	ClinGen ExAC gnomAD
rs1272331840 CA411453355	72	T>I		No	ClinGen TOPMed gnomAD
rs1272331840 CA411453354	72	T>R		No	ClinGen TOPMed gnomAD
CA10220973 rs752795397	74	M>T		No	ClinGen ExAC TOPMed gnomAD
CA411453365 rs1469393247	74	M>V		No	ClinGen TOPMed gnomAD
CA324133442 rs867456719	76	S>R		No	ClinGen Ensembl
rs758417967 CA10220974	77	C>R		No	ClinGen ExAC gnomAD
rs1601520952 CA411453391	77	C>Y		No	ClinGen Ensembl
rs1431264899 CA411453396	78	G>D		No	ClinGen gnomAD
rs746824920 CA10220976	78	G>S		No	ClinGen ExAC TOPMed gnomAD
CA10220978 rs780840986	80	R>Q		No	ClinGen ExAC TOPMed gnomAD
COSM1034019 CA10220977 rs770591150	80	R>W	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA10220979 rs745564887	81	F>I		No	ClinGen ExAC gnomAD
CA10220980 rs769402630	82	H>Q		No	ClinGen ExAC gnomAD
CA10220981 rs748157403	83	D>N		No	ClinGen ExAC gnomAD
CA10220983 rs772649417	83	D>V		No	ClinGen ExAC gnomAD
CA10220982 rs748157403	83	D>Y		No	ClinGen ExAC gnomAD
rs1203307902 CA411453434	84	E>D		No	ClinGen gnomAD
rs761136453 CA10220985 COSM1416152	84	E>K	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA10220986 rs766603973	85	V>M		No	ClinGen ExAC gnomAD
rs1437059434 CA411453441	86	G>S		No	ClinGen gnomAD
rs754232613 CA10220988	89	R>C		No	ClinGen ExAC gnomAD
rs754232613 CA10220987	89	R>G		No	ClinGen ExAC gnomAD
CA324133497 rs1006534022	92	N>D		No	ClinGen Ensembl
rs765552847 CA10220989	92	N>I		No	ClinGen ExAC gnomAD
CA10220991 rs373156977	93	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA411453491 rs1568978006	93	E>V		No	ClinGen Ensembl
rs1042878999 CA324133522	95	I>V		No	ClinGen TOPMed gnomAD
CA10220993 rs764123688	98	V>L		No	ClinGen ExAC gnomAD
CA10220992 rs764123688	98	V>M		No	ClinGen ExAC gnomAD
rs1406378449 CA411453532	100	P>S		No	ClinGen gnomAD
CA411453539 rs1255212810	101	K>T		No	ClinGen gnomAD
rs757940217 CA10221040	102	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs781770140 CA10221041	104	G>S		No	ClinGen ExAC gnomAD
CA411453615 rs1181763897	106	R>Q		No	ClinGen TOPMed gnomAD
CA10221042 rs370012020	106	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs551311218 CA10221045	108	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA411453635 rs774568469	109	E>D		No	ClinGen ExAC TOPMed gnomAD
CA324134674 COSM1416153 rs11543985	119	L>F	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA324134673 rs11543985	119	L>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs11543985 CA10221049	119	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA324134675 rs1004259728	120	Y>H		No	ClinGen TOPMed
CA411454191 rs1156474215	121	S>G		No	ClinGen TOPMed
CA324134683 rs1014678619	121	S>N		No	ClinGen TOPMed
rs1306264006 CA411454205	121	S>R		No	ClinGen gnomAD
rs1346455295 CA411454326	127	P>A		No	ClinGen gnomAD
CA10221055 rs759319824	128	E>K		No	ClinGen ExAC TOPMed gnomAD
rs759319824 CA10221054	128	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA411454395 rs1195572812	129	E>D		No	ClinGen gnomAD
rs752344582 CA10221056	129	E>V		No	ClinGen ExAC gnomAD
rs13057290 CA324134781	130	V>L		No	ClinGen Ensembl
rs1459943537 CA411454426	131	K>E		No	ClinGen TOPMed
rs751105266 CA10221059	133	A>T		No	ClinGen ExAC TOPMed gnomAD
CA411454494 rs1486501594	135	A>S		No	ClinGen TOPMed gnomAD
rs1486501594 CA411454488	135	A>T		No	ClinGen TOPMed gnomAD
CA10221062 rs148782175	138	M>I		No	ClinGen 1000Genomes ExAC gnomAD
rs148782175 CA10221061	138	M>I		No	ClinGen 1000Genomes ExAC gnomAD
CA10221063 rs769028814	139	L>V		No	ClinGen ExAC TOPMed gnomAD
rs779029344 CA10221064	140	K>R		No	ClinGen ExAC gnomAD
CA10221065 rs748422092	141	K>N		No	ClinGen ExAC TOPMed gnomAD
rs772252205 CA10221066	142	Q>R		No	ClinGen ExAC gnomAD
CA10221089 rs747098687	144	I>F		No	ClinGen ExAC TOPMed gnomAD
CA10221090 rs770992219	144	I>M		No	ClinGen ExAC gnomAD
CA10221091 rs146936287	145	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10221092 rs199984681	146	K>N		No	ClinGen 1000Genomes ExAC
rs762217256 CA411454862	148	D>H		No	ClinGen ExAC TOPMed gnomAD
rs762217256 CA10221095	148	D>N		No	ClinGen ExAC TOPMed gnomAD
CA411454883 rs1232210107	149	P>R		No	ClinGen gnomAD
rs763839464 CA10221096	149	P>T		No	ClinGen ExAC gnomAD
rs1161141093 CA411454894	150	K>R		No	ClinGen gnomAD
CA411454903 rs1342961020	151	L>I		No	ClinGen gnomAD
rs774104689 CA10221097	152	P>R		No	ClinGen ExAC TOPMed gnomAD
CA324135223 COSM2149465 rs913218146	153	D>G	central_nervous_system [Cosmic]	No	ClinGen cosmic curated Ensembl
rs761255447 CA10221098	155	T>I		No	ClinGen ExAC gnomAD
rs761255447 CA324135233	155	T>N		No	ClinGen ExAC gnomAD
rs1356961974 CA411454991	156	T>A		No	ClinGen gnomAD
CA10221099 rs767107217	156	T>I		No	ClinGen ExAC gnomAD
rs749873760 CA10221100	157	F>L		No	ClinGen ExAC gnomAD
rs755575938 CA10221101	158	P>H		No	ClinGen ExAC gnomAD
CA411455052 rs1226007224	161	P>S		No	ClinGen gnomAD
CA411455064 rs1316463341	162	P>L		No	ClinGen gnomAD
rs765720787 CA10221102	162	P>T		No	ClinGen ExAC TOPMed gnomAD
CA411455067 rs1282812964	163	R>Q		No	ClinGen gnomAD
rs1028786603 CA324135279	163	R>W		No	ClinGen TOPMed gnomAD
rs368458302 CA10221103	164	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA411455103 rs1393089345	167	V>M		No	ClinGen TOPMed
rs1256567023 CA411455181	172	E>K		No	ClinGen gnomAD
CA10221105 rs371106161	172	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1178921251 CA411455226	174	K>R		No	ClinGen gnomAD
CA10221123 rs373435349	177	M>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA411455345 rs1342149501	177	M>T		No	ClinGen TOPMed
CA10221124 rs189717909	180	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA411455496 rs1436968500	186	H>Y		No	ClinGen gnomAD
CA10221125 COSM1034022 rs375317914	187	P>L	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs375317914 CA411455560	187	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs751865774 CA10221126	188	E>K		No	ClinGen ExAC TOPMed gnomAD
CA411455590 rs1601531262	189	D>A		No	ClinGen Ensembl
rs1002304134 CA324135713	191	R>C		No	ClinGen TOPMed gnomAD
CA411455628 rs1242122150	191	R>H		No	ClinGen TOPMed gnomAD
rs1033425098 COSM3842636 CA324135720	192	A>T	breast [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA411455667 rs1419284859	194	N>S		No	ClinGen gnomAD
CA411455731 rs1178633129	198	K>T		No	ClinGen TOPMed
CA411455741 rs1392904716	199	E>K		No	ClinGen gnomAD
rs750517578 CA10221129	201	V>L		No	ClinGen ExAC gnomAD
CA411455777 rs750517578	201	V>M		No	ClinGen ExAC gnomAD
rs1328219696 CA411455795	202	Q>R		No	ClinGen gnomAD
rs747983771 CA10221153	206	K>M		No	ClinGen ExAC gnomAD
rs777506059 CA10221155	207	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs771727569 CA411456557	207	R>W		No	ClinGen ExAC gnomAD
rs1337460267 CA411456630	209	E>D		No	ClinGen gnomAD
CA324138430 rs952446933	212	S>L		No	ClinGen TOPMed gnomAD
rs952446933 CA411456700	212	S>W		No	ClinGen TOPMed gnomAD
CA411456751 rs1347915615	214	R>T		No	ClinGen gnomAD
CA10221158 rs143048877	215	V>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10221159 rs745321038	219	E>K		No	ClinGen ExAC gnomAD
CA10221160 rs186081433	220	E>K		No	ClinGen 1000Genomes ExAC gnomAD
CA411456857 rs1196739534	222	N>K		No	ClinGen gnomAD
CA411456851 rs1231432129	222	N>S		No	ClinGen TOPMed gnomAD
CA324138444 rs922789397	223	N>K		No	ClinGen Ensembl
CA10221161 rs369700552	223	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA10221162 rs762258420	224	N>D		No	ClinGen ExAC gnomAD
rs1380968852 CA411456879	225	V>M		No	ClinGen TOPMed
rs1601536970 CA411456899	226	K>N		No	ClinGen Ensembl
CA10221163 rs374593268	229	T>M		No	ClinGen ESP ExAC
rs761045792 CA10221165	231	M>V		No	ClinGen ExAC gnomAD
CA411456982 rs1172058648	234	S>I		No	ClinGen gnomAD
CA10221167 rs753984641	236	S>N		No	ClinGen ExAC gnomAD
rs1601537055 CA411457019	237	Q>R		No	ClinGen Ensembl
rs1446758786 CA411457032	238	G>D		No	ClinGen TOPMed
rs765255006 CA10221169 COSM33565 VAR_036522	239	G>S	a breast cancer sample; somatic mutation large_intestine breast [UniProt, Cosmic]	No	ClinGen cosmic curated UniProt ExAC TOPMed dbSNP gnomAD
rs758323331 CA10221171	240	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1371147318 CA411457054	241	A>T		No	ClinGen gnomAD
CA10221172 rs777493212	241	A>V		No	ClinGen ExAC gnomAD
rs144361028 CA10221173	242	A>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs756911807 CA10221174	244	S>G		No	ClinGen ExAC gnomAD
CA324138487 rs946739436	244	S>N		No	ClinGen Ensembl
CA411457084 rs756911807	244	S>R		No	ClinGen ExAC gnomAD
rs201248808 CA10221175	245	S>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10221176 rs374211399	245	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM444963 CA10221178 rs368649058	246	E>K	breast [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1195771757 CA411457127	248	L>P		No	ClinGen gnomAD
rs748645220 CA10221179	249	M>I		No	ClinGen ExAC gnomAD
CA411457131 rs1254150004	249	M>L		No	ClinGen gnomAD
CA411457144 rs1265847645	250	K>E		No	ClinGen TOPMed
rs376064851 CA324138589	252	L>Q		No	ClinGen ESP
CA411457203 rs1369568656	254	Q>E		No	ClinGen gnomAD
CA10221210 rs767338938	255	R>C		No	ClinGen ExAC TOPMed gnomAD
rs750216889 CA10221211	255	R>H		No	ClinGen ExAC gnomAD
rs1317647896 CA411457217	256	C>Y		No	ClinGen gnomAD
CA10221213 rs148765384	258	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA10221212 rs755782160	258	R>W		No	ClinGen ExAC gnomAD
CA10221214 rs753292722	259	M>L		No	ClinGen ExAC gnomAD
CA10221215 rs372349388	260	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1211800717 CA411457242	260	R>W		No	ClinGen gnomAD
rs778449961 CA10221216	262	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1419222376 CA411457268	264	F>L		No	ClinGen gnomAD
CA411457271 rs1160664485	265	R>*		No	ClinGen gnomAD
rs201542025 CA10221218	265	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1313067058 CA411457289	268	S>T		No	ClinGen gnomAD
CA324138619 rs976537118	273	N>S		No	ClinGen gnomAD
CA411457326 rs976537118	273	N>T		No	ClinGen gnomAD
rs558600566 CA10221221	276	A>D		No	ClinGen 1000Genomes ExAC gnomAD
rs1314717247 CA411457347	276	A>P		No	ClinGen gnomAD
CA324138623 rs558600566	276	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs865918321 CA324139254	278	A>V		No	ClinGen gnomAD
rs1169024669 CA411458016	282	Q>R		No	ClinGen gnomAD
CA324139266 rs972183114	284	N>H		No	ClinGen gnomAD
CA10221244 COSM1327234 rs756451398	284	N>S	ovary [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1368816395 CA411458095	286	N>D		No	ClinGen gnomAD
CA10221245 rs780259090	286	N>S		No	ClinGen ExAC gnomAD
rs559987076 CA10221247	287	L>F		No	ClinGen 1000Genomes ExAC gnomAD
rs1256155216 CA411458150	289	Q>K		No	ClinGen gnomAD
CA411458206 rs1317231077	292	N>D		No	ClinGen gnomAD
CA411458216 rs1256479696	292	N>S		No	ClinGen TOPMed
rs1214191741 CA411458231	293	L>P		No	ClinGen gnomAD
CA10221249 rs748168677	295	K>E		No	ClinGen ExAC gnomAD
CA411458294 rs1449342581	296	Q>R		No	ClinGen gnomAD
CA324139275 rs955200648	297	L>Q		No	ClinGen gnomAD
CA324139280 rs201952061	298	V>A		No	ClinGen 1000Genomes gnomAD
rs141488222 CA10221251	299	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA10221250 rs772002859	299	R>W		No	ClinGen ExAC TOPMed gnomAD
CA411458344 rs1167680992	300	G>S		No	ClinGen gnomAD
CA411458357 rs1204628061	301	E>K		No	ClinGen TOPMed
rs776262011 CA10221254	305	G>D		No	ClinGen ExAC gnomAD
CA10221253 rs766250520	305	G>S		No	ClinGen ExAC gnomAD
CA411458464 rs1428816510	307	A>T		No	ClinGen gnomAD
rs942354375 CA324139318	310	G>S		No	ClinGen gnomAD
rs752257798 CA10221257	311	S>Y		No	ClinGen ExAC gnomAD
CA411458558 rs1353714232	314	G>R		No	ClinGen gnomAD
CA10221274 rs537234149	315	S>T		No	ClinGen 1000Genomes ExAC gnomAD
CA10221275 rs765008609	316	T>I		No	ClinGen ExAC gnomAD
rs1461976426 CA411458749	317	S>L		No	ClinGen TOPMed
rs1264521408 CA411458754	318	A>S		No	ClinGen gnomAD
CA411458773 rs1329421167	319	L>V		No	ClinGen gnomAD
rs751026115 CA10221279	321	D>G		No	ClinGen ExAC
rs761301935 CA10221280	323	S>L		No	ClinGen ExAC gnomAD
rs112813775 CA324139690	328	P>L		No	ClinGen TOPMed gnomAD
CA411458953 rs112813775	328	P>R		No	ClinGen TOPMed gnomAD
CA411458999 rs375037202	330	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA10221285 rs375037202	330	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA411459005 rs1393429324	331	G>S		No	ClinGen gnomAD
rs747048976 CA10221288	331	G>V		No	ClinGen ExAC gnomAD
rs770902415 CA10221289	332	T>A		No	ClinGen ExAC gnomAD
CA10221291 rs745676668	333	T>N		No	ClinGen ExAC gnomAD
CA10221292 rs769757048	334	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs775393467 CA10221293	336	A>P		No	ClinGen ExAC TOPMed gnomAD
CA10221295 rs768179026	340	R>C		No	ClinGen ExAC gnomAD
rs145352304 CA10221296 COSM1416154	340	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA411459155 rs1272403775	341	P>L		No	ClinGen TOPMed
COSM1308147 rs766943371 CA10221298	343	E>K	urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed
CA324139736 rs760015742	347	P>A		No	ClinGen ExAC gnomAD
CA10221300 rs760015742	347	P>S		No	ClinGen ExAC gnomAD
rs765634709 CA10221301	348	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1378028568 CA411459290	350	P>S		No	ClinGen gnomAD
CA411459338 rs1452825985	354	V>I		No	ClinGen gnomAD
CA324139745 rs140652419	355	S>Y		No	ClinGen ESP gnomAD
rs751689204 CA10221305	357	L>F		No	ClinGen ExAC gnomAD
rs1469854936 CA411459404	358	D>H		No	ClinGen gnomAD
rs781305884 CA10221308	359	D>N		No	ClinGen ExAC gnomAD
rs1032619048 CA324139753	360	E>K		No	ClinGen gnomAD
rs1032619048 CA411459438	360	E>Q		No	ClinGen gnomAD
rs1425433489 COSM70887 CA411459492	362	M>I	ovary [Cosmic]	No	ClinGen cosmic curated gnomAD
CA10221310 rs769849256	363	S>F		No	ClinGen ExAC gnomAD
CA411459533 rs1394638336	365	G>S		No	ClinGen gnomAD
rs780068368 CA10221330	369	P>S		No	ClinGen ExAC gnomAD
CA411460707 rs1320381243	370	T>K		No	ClinGen TOPMed
rs1275725601 CA411460720	371	P>L		No	ClinGen TOPMed
rs1601556553 CA411460713	371	P>S		No	ClinGen Ensembl
CA10221332 rs200692910	372	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA10221333 rs200692910	372	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA10221334 rs200692910	372	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA10221335 rs372506535	374	G>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs527795762 CA10221339	379	G>A		No	ClinGen 1000Genomes ExAC gnomAD
CA10221340 rs527795762	379	G>D		No	ClinGen 1000Genomes ExAC gnomAD
CA10221338 rs770312873	379	G>S		No	ClinGen ExAC gnomAD
rs377214761 CA10221341	381	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs774772612 CA10221342	385	F>L		No	ClinGen ExAC gnomAD
rs766608702 CA10221368	387	S>L		No	ClinGen ExAC TOPMed gnomAD
rs759453188 CA10221370	388	S>L		No	ClinGen ExAC TOPMed gnomAD
CA10221372 rs752444230	389	D>N		No	ClinGen ExAC TOPMed gnomAD
CA10221373 rs758152515	390	A>T		No	ClinGen ExAC gnomAD
rs1276714175 CA411461309	391	T>P		No	ClinGen gnomAD
rs1369569174 CA411461336	392	E>Q		No	ClinGen gnomAD
rs1217411210 CA411461363	393	P>S		No	ClinGen gnomAD
rs751250760 CA10221375	394	P>A		No	ClinGen ExAC gnomAD
rs1318319644 CA411461395	394	P>L		No	ClinGen TOPMed gnomAD
rs780623235 CA10221377	395	A>D		No	ClinGen ExAC gnomAD
rs756895397 CA10221376	395	A>S		No	ClinGen ExAC gnomAD
CA10221378 rs148880676	396	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs769047869 CA10221379	396	P>L		No	ClinGen ExAC TOPMed gnomAD
rs748483973 CA10221381	398	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1568993044 CA411461480	400	Q>E		No	ClinGen Ensembl
rs1478990840 CA411461503	401	A>D		No	ClinGen gnomAD
rs1462177449 CA411461520	402	P>R		No	ClinGen gnomAD
CA411461516 rs1399773725	402	P>S		No	ClinGen gnomAD
CA411461528 rs1325532784	403	S>G		No	ClinGen gnomAD
CA10221385 rs140112498	405	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA324141649 rs933908433	406	S>G		No	ClinGen TOPMed gnomAD
CA411461591 rs933908433	406	S>R		No	ClinGen TOPMed gnomAD
rs776589823 CA10221386	407	R>Q		No	ClinGen ExAC gnomAD
rs759598129 CA10221388	408	P>A		No	ClinGen ExAC gnomAD
CA10221387 rs759598129	408	P>T		No	ClinGen ExAC gnomAD
rs752726816 CA10221389	410	A>S		No	ClinGen ExAC gnomAD
CA10221390 rs201565288	410	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200331822 CA10221392	411	Q>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10221393 rs200648957	413	S>Y		No	ClinGen ExAC gnomAD
CA324141670 rs769521468	414	L>V		No	ClinGen TOPMed
rs917121879 CA324141671	416	A>G		No	ClinGen Ensembl
rs1415612165 CA411461749	417	S>R		No	ClinGen gnomAD
CA10221396 rs755600091	418	S>G		No	ClinGen ExAC gnomAD
rs55830659 CA324141674	418	S>I		No	ClinGen Ensembl
rs150957887 CA10221397	419	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs748705152 CA10221398	420	L>R		No	ClinGen ExAC gnomAD
rs778341426 CA411461811	422	D>H		No	ClinGen ExAC TOPMed gnomAD
CA10221400 rs778341426	422	D>N		No	ClinGen ExAC TOPMed gnomAD
rs771065392 CA10221402	425	L>F		No	ClinGen ExAC gnomAD
rs776877315 CA10221403	426	L>M		No	ClinGen ExAC gnomAD
CA324141720 rs909521837	426	L>P		No	ClinGen Ensembl
CA411461877 rs1478175876	427	G>R		No	ClinGen TOPMed
rs376214395 CA10221404	428	K>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA411461902 rs1351443827	429	T>N		No	ClinGen gnomAD
CA411461898 rs1601559328	429	T>P		No	ClinGen Ensembl
rs1196159416 CA411461908	430	L>V		No	ClinGen TOPMed
rs1285563034 CA411462003	436	P>L		No	ClinGen gnomAD
rs1198004568 CA411461998	436	P>S		No	ClinGen TOPMed
rs1036723091 CA324141725	437	P>L		No	ClinGen TOPMed gnomAD
rs1036723091 CA411462012	437	P>Q		No	ClinGen TOPMed gnomAD
rs762932796 CA10221407	438	E>K		No	ClinGen ExAC gnomAD
rs1356389128 CA411462039	439	S>P		No	ClinGen gnomAD
rs1215082330 CA411462067	441	Q>*		No	ClinGen gnomAD
CA10221408 rs371105985	441	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA10221409 rs774134872	442	V>L		No	ClinGen ExAC TOPMed gnomAD
CA10221410 rs761555283	443	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1273098456 CA411462097	443	R>W		No	ClinGen TOPMed
rs1377832515 CA411462106	444	W>R		No	ClinGen TOPMed
rs1358766831 CA411462702	445	E>K		No	ClinGen TOPMed
rs768609545 CA10221430	450	T>I		No	ClinGen ExAC gnomAD
CA10221431 rs768609545	450	T>N		No	ClinGen ExAC gnomAD
rs1601562212 CA411462796	450	T>P		No	ClinGen Ensembl
rs374503060 CA10221433	452	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1273648347 CA411462825	452	R>W		No	ClinGen TOPMed gnomAD
rs1260197321 CA411462835	453	L>V		No	ClinGen gnomAD
CA411462873 rs1275665518	454	T>R		No	ClinGen gnomAD
rs144625677 CA10221435	456	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA10221437 rs138525343	456	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA10221436 rs144625677	456	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA411462952 rs1200899148	459	Q>K		No	ClinGen TOPMed gnomAD
CA10221439 rs764724465	460	N>S		No	ClinGen ExAC gnomAD
rs143093104 CA324142068	461	K>Q		No	ClinGen ESP
CA10221440 rs201140527	463	S>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA411463028 rs1401962525	463	S>N		No	ClinGen gnomAD
CA411463073 rs1488781384	465	C>R		No	ClinGen TOPMed
rs886653852 CA324142073	465	C>Y		No	ClinGen TOPMed gnomAD
CA411463100 rs1231231169	466	S>I		No	ClinGen TOPMed
rs781661736 CA10221442	467	S>A		No	ClinGen ExAC gnomAD
CA411463118 rs1388066376	467	S>F		No	ClinGen gnomAD
CA10221443 rs746158093	468	P>L		No	ClinGen ExAC gnomAD
CA10221445 rs780207604	469	S>N		No	ClinGen ExAC gnomAD
rs749391451 CA10221446	470	S>F		No	ClinGen ExAC gnomAD
rs199622924 CA10221448	472	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1218305859 CA411463258	475	L>R		No	ClinGen TOPMed
rs1418215687 CA411463271	476	L>P		No	ClinGen TOPMed gnomAD
rs771891326 CA10221450	478	T>A		No	ClinGen ExAC TOPMed gnomAD
rs190695286 CA10221452	479	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs918164171 CA324142116	480	S>F		No	ClinGen TOPMed gnomAD
CA10221456 rs369421250	483	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA10221455 rs369421250	483	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA10221457 rs764902383	485	R>G		No	ClinGen ExAC TOPMed gnomAD
COSM1034024 rs942059565 CA324142143	487	P>L	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1365443969 CA411463475	488	Q>H		No	ClinGen gnomAD
rs1160978387 CA411463467	488	Q>R		No	ClinGen gnomAD
CA411463509 rs1266583591	490	P>T		No	ClinGen TOPMed
rs754056164 CA10221459	491	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1382062528 COSM3150559 CA411463578	494	E>K	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA10221461 rs144761956	495	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs1323763324 CA411463599	495	L>P		No	ClinGen gnomAD
rs1217238302 CA411463750	503	P>S		No	ClinGen TOPMed gnomAD
rs1217238302 CA411463744	503	P>T		No	ClinGen TOPMed gnomAD
CA411463813 rs1185751323	506	S>F		No	ClinGen gnomAD
CA411463853 rs1230737174	508	K>R		No	ClinGen gnomAD
CA10221480 rs761140024	511	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1336293022 CA411464166	515	V>L		No	ClinGen TOPMed gnomAD
rs1336293022 CA411464163	515	V>L		No	ClinGen TOPMed gnomAD
CA411464159 rs1336293022	515	V>M		No	ClinGen TOPMed gnomAD
rs1371012600 CA411464221	517	V>A		No	ClinGen gnomAD
rs1307198078 CA411464213	517	V>M		No	ClinGen gnomAD
rs777889440 CA10221487	518	Y>S		No	ClinGen ExAC gnomAD
CA411464292 rs1251898426	520	Q>E		No	ClinGen TOPMed
rs1601565947 CA411464295	520	Q>R		No	ClinGen Ensembl
CA10221490 rs375756142	522	G>S		No	ClinGen ESP ExAC gnomAD
rs745588956 CA10221491	524	R>C		No	ClinGen ExAC TOPMed gnomAD
rs143909159 CA10221492	524	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs143909159 CA411464381	524	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs71317060 CA324142605	526	L>F		No	ClinGen Ensembl
CA411464555 rs1387896390	530	A>G		No	ClinGen TOPMed
CA411464574 rs140697419	531	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs140697419 CA10221496	531	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA324142618 rs946830995	531	R>W		No	ClinGen TOPMed gnomAD
CA10221498 rs766815610	534	L>P		No	ClinGen ExAC gnomAD
rs759856474 CA10221500	536	G>R		No	ClinGen ExAC gnomAD
rs765521088 CA10221501	537	R>C		No	ClinGen ExAC TOPMed gnomAD
CA411464680 rs1294008682	537	R>H		No	ClinGen TOPMed gnomAD
CA411464704 rs1221411442	538	S>F		No	ClinGen gnomAD
rs150803628 CA324142633	539	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs150803628 CA10221503	539	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA411464742 rs764151001	540	V>L		No	ClinGen ExAC TOPMed gnomAD
CA411464738 rs764151001	540	V>L		No	ClinGen ExAC TOPMed gnomAD
CA10221504 rs764151001	540	V>M		No	ClinGen ExAC TOPMed gnomAD
CA411464846 rs1601566411	544	V>G		No	ClinGen Ensembl
rs1601566438 CA411464867	545	V>G		No	ClinGen Ensembl
CA411464854 rs1248918976	545	V>I		No	ClinGen gnomAD
rs756020591 CA10221509	547	M>V		No	ClinGen ExAC TOPMed gnomAD
CA411465005 rs1264348872	551	A>D		No	ClinGen gnomAD
CA411464995 rs1301619360	551	A>T		No	ClinGen TOPMed
CA411465003 rs1264348872	551	A>V		No	ClinGen gnomAD
rs1568996904 CA411465012	552	P>A		No	ClinGen Ensembl
rs1479042892 CA411465024	553	Q>*		No	ClinGen TOPMed gnomAD
CA411465022 rs1479042892	553	Q>E		No	ClinGen TOPMed gnomAD
CA411465066 rs1329084163	554	P>L		No	ClinGen TOPMed
rs748959990 CA10221511	554	P>S		No	ClinGen ExAC TOPMed gnomAD
rs768342061 CA10221512	556	R>C		No	ClinGen ExAC TOPMed gnomAD
CA10221513 rs754026793	556	R>H		No	ClinGen ExAC TOPMed gnomAD
CA10221516 rs771461283	559	V>L		No	ClinGen ExAC TOPMed gnomAD
CA10221515 rs771461283	559	V>M		No	ClinGen ExAC TOPMed gnomAD
rs377276769 CA324142743	561	Q>R		No	ClinGen ESP gnomAD
CA411465282 rs1340881021	562	S>T		No	ClinGen gnomAD
CA324142745 rs997698138	564	V>A		No	ClinGen Ensembl
rs765564370 CA10221518	564	V>I		No	ClinGen ExAC gnomAD
CA10221519 rs775923665	565	P>A		No	ClinGen ExAC gnomAD
rs770325825 CA10221536	567	V>I		No	ClinGen ExAC gnomAD
rs1179368201 CA411465505	568	M>L		No	ClinGen gnomAD
rs775718087 CA10221537	568	M>T		No	ClinGen ExAC gnomAD
CA411465590 rs1601567781	570	V>G		No	ClinGen Ensembl
CA10221540 rs774761293	574	P>A		No	ClinGen ExAC gnomAD
CA411465690 rs1568997375	574	P>L		No	ClinGen Ensembl
CA10221541 rs762094245	576	S>L		No	ClinGen ExAC gnomAD
rs149933005 CA10221543	578	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1379677852 CA411465913	581	P>S		No	ClinGen gnomAD
CA411465937 rs1279543857	582	A>V		No	ClinGen gnomAD
CA324142934 rs28378510	583	F>L		No	ClinGen Ensembl
CA411466011 rs1346122946	585	P>A		No	ClinGen gnomAD
rs753595978 CA10221546	586	I>V		No	ClinGen ExAC TOPMed gnomAD
CA324142969 rs1009030319	587	V>A		No	ClinGen TOPMed gnomAD
rs369595461 CA10221548	587	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA411466133 rs1240101021	588	H>P		No	ClinGen gnomAD
rs1240101021 CA411466136	588	H>R		No	ClinGen gnomAD
CA10221549 rs372987949	589	P>L		No	ClinGen ESP ExAC gnomAD
CA411466194 rs1179550231	590	S>A		No	ClinGen gnomAD
CA10221550 rs146676662	590	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1478210520 CA411466213	591	A>V		No	ClinGen gnomAD
rs777327586 CA10221551	592	I>V		No	ClinGen ExAC gnomAD
rs752480500 CA10221568	607	R>C		No	ClinGen ExAC gnomAD
CA10221569 rs200530152	607	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA324143067 rs992630857	608	L>F		No	ClinGen TOPMed
CA10221571 rs751065837	609	R>C		No	ClinGen ExAC TOPMed gnomAD
CA10221572 rs756834619	609	R>H		No	ClinGen ExAC gnomAD
CA10221573 rs146516799	616	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1224610032 CA411466802	618	D>Y		No	ClinGen gnomAD
CA10221574 rs749866448	622	N>D		No	ClinGen ExAC TOPMed gnomAD
rs113612442 CA411466862	622	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs779425656 CA10221576	623	E>K		No	ClinGen ExAC TOPMed gnomAD
rs748465828 CA10221577	624	M>I		No	ClinGen ExAC gnomAD
rs748465828 CA10221578	624	M>I		No	ClinGen ExAC gnomAD
CA411466873 rs1300088803	624	M>L		No	ClinGen TOPMed
CA411466881 rs1426379576	625	G>E		No	ClinGen gnomAD
CA10221580 rs528995138	626	D>E		No	ClinGen 1000Genomes ExAC gnomAD
rs773526813 CA10221579	626	D>H		No	ClinGen ExAC gnomAD
CA324143100 rs920248151	629	Q>H		No	ClinGen TOPMed gnomAD
rs1162192810 CA411466918	630	F>L		No	ClinGen gnomAD
rs1601568989 CA411466916	630	F>S		No	ClinGen Ensembl
rs1365546959 CA411466925	631	P>L		No	ClinGen gnomAD
CA411466928 rs781127608	632	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA10221582 rs781127608	632	P>R		No	ClinGen ExAC TOPMed gnomAD
rs540636311 CA10221581	632	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA10221583 rs559322947	634	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs765088639 CA10221584	635	T>A		No	ClinGen ExAC TOPMed gnomAD
rs765088639 CA411466943	635	T>P		No	ClinGen ExAC TOPMed gnomAD
rs762701050 CA10221586	636	W>G		No	ClinGen ExAC gnomAD
rs762701050 CA411466949	636	W>R		No	ClinGen ExAC gnomAD
CA411466959 rs200183314	637	G>D		No	ClinGen ExAC gnomAD
CA10221587 rs200183314	637	G>V		No	ClinGen ExAC gnomAD
rs1173622694 CA411466964	638	S>N		No	ClinGen TOPMed
CA10221589 rs756849609	639	L>P		No	ClinGen ExAC gnomAD

No associated diseases with Q9UJY5

5 regional properties for Q9UJY5

Type	Name	Position	InterPro Accession
domain	VHS domain	8 - 147	IPR002014
domain	GAT domain	171 - 300	IPR004152
domain	Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain	507 - 631	IPR008152
domain	Gamma-adaptin ear (GAE) domain	510 - 631	IPR008153
domain	N-terminal extension of GAT domain	169 - 207	IPR041198

Functions

		Description
EC Number
Subcellular Localization	Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein Endosome membrane ; Peripheral membrane protein Early endosome membrane ; Peripheral membrane protein
PANTHER Family	PTHR45905	GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN
PANTHER Subfamily	PTHR45905:SF4	ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

9 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
early endosome	A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
early endosome membrane	The lipid bilayer surrounding an early endosome.
endosome membrane	The lipid bilayer surrounding an endosome.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

3 GO annotations of molecular function

Name	Definition
phosphatidylinositol binding	Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
small GTPase binding	Binding to a small monomeric GTPase.
ubiquitin binding	Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

8 GO annotations of biological process

Name	Definition
Golgi to plasma membrane protein transport	The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.
intracellular protein transport	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
positive regulation of protein catabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
protein localization	Any process in which a protein is transported to, or maintained in, a specific location.
protein localization to cell surface	A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane.
protein localization to ciliary membrane	A process in which a protein is transported to, or maintained in, a location within a ciliary membrane.
retrograde transport, endosome to Golgi	The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.
toxin transport	The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

5 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9NZ52	GGA3	ADP-ribosylation factor-binding protein GGA3	Homo sapiens (Human)	EV
Q9UJY4	GGA2	ADP-ribosylation factor-binding protein GGA2	Homo sapiens (Human)	SS
Q6P5E6	Gga2	ADP-ribosylation factor-binding protein GGA2	Mus musculus (Mouse)	SS
Q8R0H9	Gga1	ADP-ribosylation factor-binding protein GGA1	Mus musculus (Mouse)	SS
Q8BMI3	Gga3	ADP-ribosylation factor-binding protein GGA3	Mus musculus (Mouse)	SS

10	20	30	40	50	60
MEPAMEPETL	EARINRATNP	LNKELDWASI	NGFCEQLNED	FEGPPLATRL	LAHKIQSPQE
70	80	90	100	110	120
WEAIQALTVL	ETCMKSCGKR	FHDEVGKFRF	LNELIKVVSP	KYLGSRTSEK	VKNKILELLY
130	140	150	160	170	180
SWTVGLPEEV	KIAEAYQMLK	KQGIVKSDPK	LPDDTTFPLP	PPRPKNVIFE	DEEKSKMLAR
190	200	210	220	230	240
LLKSSHPEDL	RAANKLIKEM	VQEDQKRMEK	ISKRVNAIEE	VNNNVKLLTE	MVMSHSQGGA
250	260	270	280	290	300
AAGSSEDLMK	ELYQRCERMR	PTLFRLASDT	EDNDEALAEI	LQANDNLTQV	INLYKQLVRG
310	320	330	340	350	360
EEVNGDATAG	SIPGSTSALL	DLSGLDLPPA	GTTYPAMPTR	PGEQASPEQP	SASVSLLDDE
370	380	390	400	410	420
LMSLGLSDPT	PPSGPSLDGT	GWNSFQSSDA	TEPPAPALAQ	APSMESRPPA	QTSLPASSGL
430	440	450	460	470	480
DDLDLLGKTL	LQQSLPPESQ	QVRWEKQQPT	PRLTLRDLQN	KSSSCSSPSS	SATSLLHTVS
490	500	510	520	530	540
PEPPRPPQQP	VPTELSLASI	TVPLESIKPS	NILPVTVYDQ	HGFRILFHFA	RDPLPGRSDV
550	560	570	580	590	600
LVVVVSMLST	APQPIRNIVF	QSAVPKVMKV	KLQPPSGTEL	PAFNPIVHPS	AITQVLLLAN
610	620	630
PQKEKVRLRY	KLTFTMGDQT	YNEMGDVDQF	PPPETWGSL