AiPD: Autoinhibited Protein Database

Q9UJV9

Gene name	DDX41 (ABS)
Protein name	Probable ATP-dependent RNA helicase DDX41
Names	DEAD box protein 41, DEAD box protein abstrakt homolog
Species	Homo sapiens (Human)
KEGG Pathway	hsa:51428
EC number	3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-102 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-102 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

6 structures for Q9UJV9

Entry ID	Method	Resolution	Chain	Position	Source
2P6N	X-ray	260 A	A/B	402-569	PDB
5GVR	X-ray	150 A	A	169-402	PDB
5GVS	X-ray	220 A	A/B/C/D	169-399	PDB
5H1Y	X-ray	226 A	A/B	153-410	PDB
8C6J	EM	280 A	CD	1-622	PDB
AF-Q9UJV9-F1	Predicted				AlphaFoldDB

426 variants for Q9UJV9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV001256171 rs141601766 RCV000519179 RCV001256169 RCV000210251	1	M>I	DDX41-related hematologic malignancy predisposition syndrome Myelodysplasia [ClinVar]	Yes	ClinVar dbSNP
rs746278774 RCV000579037 RCV001764696 CA3585373	41	Q>*	DDX41-related hematologic malignancy predisposition syndrome [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV001819963 RCV001256176 rs377745714 CA3585315	48	Q>*	Acute myeloid leukemia [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV003222279 rs766117035 RCV001256167	53	R>missing	Myelodysplasia [ClinVar]	Yes	ClinVar dbSNP
RCV000503753 rs1554111683	78	P>missing	DDX41-related hematologic malignancy predisposition syndrome [ClinVar]	Yes	ClinVar dbSNP
CA3585295 rs773991873 RCV001256174	85	V>F	Aplastic anemia [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs1554111653 RCV000502578	108	K>missing	DDX41-related hematologic malignancy predisposition syndrome [ClinVar]	Yes	ClinVar dbSNP
rs1297703150 RCV001256172	124	R>*	Myelodysplasia [ClinVar]	Yes	ClinVar dbSNP
RCV000210272 RCV000193600 rs762890562 RCV001008139 CA280919	140	D>G	DDX41-related hematologic malignancy predisposition syndrome Acute myeloid leukemia [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV001818508 RCV000210264 CA358665 VAR_076360 rs142143752	164	R>W	DDX41-related hematologic malignancy predisposition syndrome MPLPF; unknown pathological significance; no effect on localization [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt ESP ExAC TOPMed dbSNP gnomAD
RCV001256173 CA3585177 rs746166328 RCV001760302 RCV002222688	173	G>R	DDX41-related hematologic malignancy predisposition syndrome [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA3585049 rs780209663 RCV000465916	237	L>F	Acute myeloid leukemia [ClinVar]	Yes	ClinGen ClinVar ExAC dbSNP gnomAD
rs376093707 CA3585048 RCV000465916	238	P>T	Acute myeloid leukemia [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs1761157695 RCV001256168	240	I>missing	Acute myeloid leukemia [ClinVar]	Yes	ClinVar dbSNP
RCV000504169 CA362374394 rs774698335	339	R>L	DDX41-related hematologic malignancy predisposition syndrome [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV000500690 rs1554111073	382	I>missing	DDX41-related hematologic malignancy predisposition syndrome [ClinVar]	Yes	ClinVar dbSNP
rs747072227 RCV001553497 RCV000210262 VAR_076361 CA358663	396	I>T	DDX41-related hematologic malignancy predisposition syndrome MPLPF; unknown pathological significance [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt ExAC TOPMed dbSNP gnomAD
CA358659 rs869312828 RCV000210250 VAR_076362 RCV002288840	525	R>H	DDX41-related hematologic malignancy predisposition syndrome MPLPF; no effect on localization; changed interaction with spliceosomal complexes [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
RCV001256170 rs866179648 RCV002462887	529	T>missing	Acute myeloid leukemia [ClinVar]	Yes	ClinVar dbSNP
CA132889319 RCV001255164 RCV002570584 rs969403252	556	K>N	DDX41-related hematologic malignancy predisposition syndrome [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP gnomAD
CA3585442 rs138435584	2	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA362378197 rs1399847240	2	E>G		No	ClinGen gnomAD
rs950718925 CA132896526	2	E>K		No	ClinGen gnomAD
CA362378189 rs994034775	3	E>D		No	ClinGen TOPMed
CA3585441 rs779986873	3	E>K		No	ClinGen ExAC TOPMed gnomAD
CA3585439 rs745639610	4	S>L		No	ClinGen ExAC gnomAD
CA3585440 rs771770596	4	S>T		No	ClinGen ExAC gnomAD
CA362378182 rs779029308	5	E>*		No	ClinGen ExAC TOPMed gnomAD
rs779029308 CA3585438	5	E>K		No	ClinGen ExAC TOPMed gnomAD
rs757444745 CA3585437	6	P>R		No	ClinGen ExAC gnomAD
CA362378171 rs749405703	7	E>*		No	ClinGen ExAC TOPMed gnomAD
CA3585436 rs749405703	7	E>K		No	ClinGen ExAC TOPMed gnomAD
rs749405703 CA132896497	7	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs777823752 CA3585435	8	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1261255726 CA362378161	9	K>E		No	ClinGen TOPMed gnomAD
rs1261255726 CA362378159	9	K>Q		No	ClinGen TOPMed gnomAD
CA362377990 rs1161708828	10	R>G		No	ClinGen TOPMed gnomAD
rs749014474 CA3585400	10	R>Q		No	ClinGen ExAC gnomAD
CA362377989 rs1161708828	10	R>W		No	ClinGen TOPMed gnomAD
rs144762739 CA3585399	11	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA3585398 rs769954237	12	R>C		No	ClinGen ExAC gnomAD
CA3585397 rs61736559	13	T>I		No	ClinGen ExAC TOPMed gnomAD
CA362377976 rs1581811333	13	T>P		No	ClinGen Ensembl
CA362377962 rs1182905371	15	E>Q		No	ClinGen gnomAD
CA3585396 rs781328203	16	V>L		No	ClinGen ExAC gnomAD
rs781328203 CA362377955	16	V>M		No	ClinGen ExAC gnomAD
CA3585394 rs747566780	18	A>T		No	ClinGen ExAC gnomAD
rs545124279 CA3585392	19	G>E		No	ClinGen 1000Genomes ExAC gnomAD
rs780643002 CA3585393 CA132896120	19	G>R		No	ClinGen ExAC TOPMed gnomAD
CA3585391 rs192558384	20	G>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA362377936 rs1374496908	20	G>R		No	ClinGen gnomAD
CA362377918 rs1330322681	22	R>H		No	ClinGen gnomAD
rs755765308 CA3585389	23	S>C		No	ClinGen ExAC gnomAD
rs755765308 CA3585388	23	S>F		No	ClinGen ExAC gnomAD
rs1407262321 CA362377913	24	E>K		No	ClinGen gnomAD
rs752211686 CA3585387	25	A>G		No	ClinGen ExAC gnomAD
CA362377901 rs752211686	25	A>V		No	ClinGen ExAC gnomAD
rs1433636328 CA362377884	28	E>K		No	ClinGen TOPMed
rs138939116 CA362377867	29	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs975031026 CA132896060	29	D>N		No	ClinGen Ensembl
CA3585382 rs377090308	30	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA362377861 rs559527781	30	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs559527781 CA3585383	30	D>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
RCV000482372 CA16618188 rs1064794842	31	E>K		No	ClinGen ClinVar TOPMed dbSNP
rs772969629 CA3585381	32	D>A		No	ClinGen ExAC gnomAD
CA362377833 rs1245318068	32	D>H		No	ClinGen gnomAD
rs1245318068 CA362377835	32	D>N		No	ClinGen gnomAD
rs762082953 CA3585379	33	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs150205465 CA3585380	33	Y>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA362377803 rs1453455783	34	V>G		No	ClinGen Ensembl
CA132896011 rs984823447	35	P>L		No	ClinGen gnomAD
CA362377792 rs984823447	35	P>R		No	ClinGen gnomAD
CA3585377 rs768787901	36	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA3585376 rs11555633	38	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA132895998 rs11555633	38	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA3585375 rs11555633	38	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1406601195 CA362377769	38	P>S		No	ClinGen gnomAD
rs1362518112 CA362377746	40	R>L		No	ClinGen TOPMed gnomAD
rs1398182183 CA362377750	40	R>W		No	ClinGen gnomAD
CA362377738 rs1204442192	41	Q>L		No	ClinGen TOPMed
CA362377733 rs1414400375	42	R>G		No	ClinGen gnomAD
CA362377734 rs1414400375	42	R>S		No	ClinGen gnomAD
CA362377711 rs1174618522	44	Q>*		No	ClinGen TOPMed gnomAD
rs1316833419 CA362377550	47	L>F		No	ClinGen TOPMed gnomAD
rs771688240 CA3585314	51	L>Q		No	ClinGen ExAC TOPMed gnomAD
CA3585313 rs745421135	53	R>G		No	ClinGen ExAC gnomAD
rs1364366603 CA362377471	54	R>S		No	ClinGen TOPMed gnomAD
rs1175013945 CA362377465	55	R>C		No	ClinGen TOPMed gnomAD
CA362377461 rs1479333618	55	R>L		No	ClinGen gnomAD
CA362377434 rs1431667147	58	A>G		No	ClinGen TOPMed gnomAD
CA362377432 rs1431667147	58	A>V		No	ClinGen TOPMed gnomAD
rs867483729 CA132895496	59	A>S		No	ClinGen Ensembl
rs1261080038 CA362377399	61	E>D		No	ClinGen gnomAD
CA132895489 rs368429550	62	E>K		No	ClinGen Ensembl
rs749201065 CA3585310	63	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA362377329 rs1231474960	66	S>R		No	ClinGen gnomAD
CA362377324 rs970338234	67	G>R		No	ClinGen TOPMed gnomAD
CA132895475 rs970338234	67	G>S		No	ClinGen TOPMed gnomAD
CA362377315 rs1363890206	68	S>G		No	ClinGen gnomAD
rs1038728566 CA132895457	69	E>D		No	ClinGen Ensembl
CA3585308 rs756008087	70	P>S		No	ClinGen ExAC gnomAD
rs1007652200 CA132895437	71	R>Q		No	ClinGen TOPMed
CA3585307 rs752494819	72	G>R		No	ClinGen ExAC gnomAD
rs781615975 CA3585306	73	D>E		No	ClinGen ExAC TOPMed gnomAD
CA3585305 rs755126084	76	D>E		No	ClinGen ExAC gnomAD
rs1359672157 CA362377214	77	I>V		No	ClinGen gnomAD
CA362377203 rs1164510310	78	P>A		No	ClinGen TOPMed
CA3585304 rs766355942	78	P>L		No	ClinGen ExAC TOPMed gnomAD
CA3585303 rs766355942	78	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs750924167 CA3585301	79	L>V		No	ClinGen ExAC TOPMed gnomAD
CA3585300 rs765682063	81	P>L		No	ClinGen ExAC
CA362377176 rs1178457155	81	P>S		No	ClinGen gnomAD
rs771776006 CA3585297	83	S>F		No	ClinGen ExAC gnomAD
CA3585296 rs759093303	84	N>K		No	ClinGen ExAC gnomAD
rs773991873 CA362377152	85	V>I		No	ClinGen ExAC TOPMed gnomAD
CA3585293 rs199675507	90	Q>*		No	ClinGen 1000Genomes ExAC gnomAD
CA362377074 rs1340906536	93	H>Q		No	ClinGen TOPMed
rs1264141023 CA362377081	93	H>Y		No	ClinGen gnomAD
rs1413731747 CA362377043	96	E>Q		No	ClinGen TOPMed
rs746011638 CA3585261	105	A>G		No	ClinGen ExAC gnomAD
rs1338679836 CA362376860	107	E>G		No	ClinGen gnomAD
rs1327804634 CA362376703	120	V>L		No	ClinGen TOPMed
RCV002249532 CA132895108 RCV000822333 rs200567842	122	E>*		No	ClinGen ClinVar TOPMed dbSNP
rs772916947 CA3585252	122	E>V		No	ClinGen ExAC gnomAD
CA3585251 rs764853110	123	G>S		No	ClinGen ExAC gnomAD
rs771853983 CA3585224	130	K>M		No	ClinGen ExAC TOPMed gnomAD
rs774582005 CA3585222	134	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1007976783 CA132894900	135	G>S		No	ClinGen TOPMed gnomAD
rs1249860463 CA362376495	136	I>V		No	ClinGen gnomAD
CA362376478 rs1407903590	137	T>M		No	ClinGen gnomAD
rs748703307 CA3585217	139	D>E		No	ClinGen ExAC gnomAD
CA3585218 rs770263914	139	D>G		No	ClinGen ExAC TOPMed gnomAD
CA3585219 rs375462407	139	D>H		No	ClinGen ESP ExAC gnomAD
rs1461623455 CA362376313	140	D>E		No	ClinGen gnomAD
rs781486582 CA3585216	141	P>L		No	ClinGen ExAC gnomAD
rs1316889386 CA362376303	142	I>T		No	ClinGen gnomAD
rs915284509 CA132893653	146	W>*		No	ClinGen Ensembl
rs990049233 CA362376247	149	P>A		No	ClinGen gnomAD
rs990049233 CA132893645	149	P>S		No	ClinGen gnomAD
CA362376241 rs1420691936	150	R>C		No	ClinGen TOPMed gnomAD
rs1420691936 CA362376242	150	R>G		No	ClinGen TOPMed gnomAD
CA132893620 rs763624515	150	R>H		No	ClinGen gnomAD
CA3585196 rs747442017	151	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA3585194 rs758775538	152	V>G		No	ClinGen ExAC TOPMed gnomAD
rs151196255 CA3585193	154	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA362376217 rs1421882404	154	S>T		No	ClinGen TOPMed
rs199697328 CA3585190	155	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA3585191 rs755669218	155	M>T		No	ClinGen ExAC gnomAD
rs767486464 CA3585189	158	E>D		No	ClinGen ExAC gnomAD
CA3585188 rs754907965	159	R>*		No	ClinGen ExAC TOPMed gnomAD
CA3585187 rs751416476	159	R>Q		No	ClinGen ExAC gnomAD
rs879654141 CA132893532	160	H>R		No	ClinGen TOPMed
COSM3410168 rs766175686 CA3585186	162	R>C	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA362376166 rs1284585050	162	R>H		No	ClinGen gnomAD
rs1287073745 CA362376159	163	V>A		No	ClinGen gnomAD
CA3585184 rs773515517	163	V>M		No	ClinGen ExAC TOPMed gnomAD
CA3585183 rs761993024	164	R>Q		No	ClinGen ExAC gnomAD
rs1482033656 CA362376143	166	K>R		No	ClinGen TOPMed
CA564900913 rs1199585468	167	Y>*		No	ClinGen gnomAD
CA362376138 rs1431734476	167	Y>H		No	ClinGen gnomAD
CA132893472 rs985879684	168	H>Y		No	ClinGen gnomAD
CA362376123 rs1260196190	169	I>V		No	ClinGen gnomAD
rs776070170 CA3585179	170	L>V		No	ClinGen ExAC TOPMed gnomAD
CA3585178 rs200005940	171	V>L		No	ClinGen ExAC TOPMed gnomAD
CA362376113 rs200005940	171	V>M		No	ClinGen ExAC TOPMed gnomAD
CA362376084 rs1233284218	175	G>D		No	ClinGen gnomAD
CA132893409 rs377695856	175	G>R		No	ClinGen ESP TOPMed gnomAD
rs377695856 CA362376087	175	G>S		No	ClinGen ESP TOPMed gnomAD
CA3585176 rs551512601	176	I>T		No	ClinGen 1000Genomes ExAC gnomAD
CA3585174 rs747762811	177	P>A		No	ClinGen ExAC gnomAD
rs1365910639 CA362376069	178	P>S		No	ClinGen gnomAD
CA3585172 rs376128262	180	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA3585173 rs376128262	180	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs751504268 CA132893386	181	K>N		No	ClinGen ExAC TOPMed gnomAD
rs766263690 CA3585170	182	S>R		No	ClinGen ExAC TOPMed gnomAD
rs758235844 CA3585169	183	F>Y		No	ClinGen ExAC gnomAD
CA3585168 rs765561953	184	K>R		No	ClinGen ExAC TOPMed gnomAD
CA3585167 rs765561953	184	K>T		No	ClinGen ExAC TOPMed gnomAD
rs1019261450 CA132893356	186	M>I		No	ClinGen TOPMed
CA3585166 rs185950985	187	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1490572026 CA362375974	188	F>I		No	ClinGen TOPMed gnomAD
CA3585165 rs776934246	189	P>L		No	ClinGen ExAC TOPMed gnomAD
CA362375959 rs1450576850	189	P>S		No	ClinGen TOPMed gnomAD
rs764270729 CA3585164	190	A>T		No	ClinGen ExAC gnomAD
rs760795625 CA3585163	190	A>V		No	ClinGen ExAC gnomAD
rs1004241531 CA132892798	193	L>V		No	ClinGen TOPMed gnomAD
rs771510721 CA3585098	195	G>S		No	ClinGen ExAC gnomAD
CA3585097 rs745329544	195	G>V		No	ClinGen ExAC gnomAD
rs149122003 CA362375718	197	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA3585092 rs755920162	200	G>D		No	ClinGen ExAC gnomAD
CA362375666 rs1474350454	202	H>Q		No	ClinGen TOPMed gnomAD
rs905341773 CA132892764	203	H>R		No	ClinGen gnomAD
rs1196477633 CA362375663	203	H>Y		No	ClinGen TOPMed
CA362375639 rs1188918884	205	T>K		No	ClinGen gnomAD
CA3585091 rs373575560	206	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA362375631 rs1480532080	206	P>L		No	ClinGen TOPMed
rs1241092852 CA362375618	208	Q>E		No	ClinGen gnomAD
CA362375604 rs1581807992	209	I>S		No	ClinGen Ensembl
rs755036127 CA3585089	210	Q>H		No	ClinGen ExAC gnomAD
rs1272360706 CA362375584	211	G>D		No	ClinGen gnomAD
rs766913824 CA3585087	213	P>H		No	ClinGen ExAC gnomAD
rs1466709476 CA362375554	214	T>A		No	ClinGen TOPMed
CA362375549 rs1299024433	214	T>I		No	ClinGen gnomAD
rs573545872 CA3585086	215	I>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs369566052 CA3585084	215	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs573545872 CA3585085	215	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs376867329 CA3585064	217	S>P		No	ClinGen ESP ExAC gnomAD
rs765680048 CA3585063	218	G>C		No	ClinGen ExAC gnomAD
CA3585062 rs371460149	218	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA362375483 rs1162015461	219	R>C		No	ClinGen TOPMed
CA3585061 rs754196793	219	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1166599072 CA362375458	221	M>I		No	ClinGen gnomAD
rs773819724 CA3585058	225	A>T		No	ClinGen ExAC gnomAD
CA3585056 rs762515434	230	G>R		No	ClinGen ExAC gnomAD
CA3585054 rs769832683	232	T>I		No	ClinGen ExAC gnomAD
rs747256985 CA3585050	236	T>M		No	ClinGen ExAC TOPMed gnomAD
rs890612475 CA132892330	237	L>W		No	ClinGen TOPMed
rs376093707 CA3585047	238	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA362375300 rs1352012150	239	V>I		No	ClinGen gnomAD
CA3585044 rs139112542	240	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA362375290 rs1433369826	240	I>T		No	ClinGen gnomAD
CA3585045 rs139112542	240	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA3585043 rs778216275	241	M>T		No	ClinGen ExAC TOPMed
CA132892277 rs551630412	245	E>K		No	ClinGen Ensembl
CA362375238 rs1365346524	245	E>V		No	ClinGen gnomAD
CA3585041 rs751293126	246	Q>E		No	ClinGen ExAC gnomAD
rs146175373 CA3585040	247	E>G		No	ClinGen ESP ExAC gnomAD
rs749923024 CA3585038	249	R>K		No	ClinGen ExAC TOPMed gnomAD
CA3585036 rs200707924	250	L>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1479512527 CA362375180	251	P>L		No	ClinGen gnomAD
rs747842313 CA132892244	251	P>S		No	ClinGen TOPMed gnomAD
CA3585034 rs768526031	254	K>R		No	ClinGen ExAC gnomAD
CA3585033 rs760338178	255	R>C		No	ClinGen ExAC gnomAD
rs775735135 CA3585032	255	R>H		No	ClinGen ExAC gnomAD
rs746011550 CA3585030	256	E>K		No	ClinGen ExAC TOPMed gnomAD
CA362375111 rs1289634533	258	P>L		No	ClinGen TOPMed
CA3585029 rs778947112	258	P>T		No	ClinGen ExAC
CA3585027 rs139780256	259	Y>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA362375088 rs1302857325	261	L>F		No	ClinGen gnomAD
CA3585023 rs181004515	262	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA362375057 rs1318216671	264	C>S		No	ClinGen gnomAD
rs758121960 CA3585022	266	S>L		No	ClinGen ExAC gnomAD
rs1000039111 CA132892067	267	R>Q		No	ClinGen TOPMed gnomAD
rs748590587 CA3585007	267	R>W		No	ClinGen ExAC TOPMed gnomAD
CA132892060 rs901158764	268	E>*		No	ClinGen gnomAD
CA362375003 rs901158764	268	E>Q		No	ClinGen gnomAD
CA3585003 rs745544108	270	A>V		No	ClinGen ExAC TOPMed gnomAD
CA3585002 rs778379292	271	R>W		No	ClinGen ExAC gnomAD
rs1581807260 CA362374957	273	T>P		No	ClinGen Ensembl
CA362374942 rs200122668	274	H>P		No	ClinGen TOPMed gnomAD
CA132892016 rs200122668	274	H>R		No	ClinGen TOPMed gnomAD
rs1271915654 CA362374933	275	G>D		No	ClinGen gnomAD
CA3585001 rs756840368	275	G>S		No	ClinGen ExAC gnomAD
CA132892012 rs568464531	277	L>V		No	ClinGen 1000Genomes TOPMed
CA3585000 rs753251952	281	C>Y		No	ClinGen ExAC gnomAD
COSM1066414 CA3584999 rs764156386	282	R>C	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs756029240 CA3584998	282	R>H		No	ClinGen ExAC TOPMed gnomAD
CA362374856 rs1313680693	283	L>P		No	ClinGen gnomAD
rs1581807179 CA362374849	284	L>P		No	ClinGen Ensembl
rs1263166065 CA362374831	286	E>Q		No	ClinGen TOPMed
rs767306529 CA3584996	287	D>V		No	ClinGen ExAC gnomAD
CA3584995 rs759290290	288	S>G		No	ClinGen ExAC gnomAD
rs763133277 CA3584992	293	R>C		No	ClinGen ExAC TOPMed gnomAD
CA3584991 rs773162771	293	R>H		No	ClinGen ExAC TOPMed gnomAD
CA362374752 rs1187779694	294	C>F		No	ClinGen gnomAD
rs748680511 CA3584989	295	A>T		No	ClinGen ExAC TOPMed gnomAD
CA3584988 rs777236551	296	L>F		No	ClinGen ExAC gnomAD
rs778667883 CA3584985	298	I>N		No	ClinGen ExAC TOPMed gnomAD
CA3584986 rs778667883	298	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1561733539 CA362374731	298	I>V		No	ClinGen Ensembl
rs1408427651 CA362374710	301	M>T		No	ClinGen TOPMed gnomAD
rs888992244 CA132891902	302	S>F		No	ClinGen Ensembl
rs141982967 CA3584983	303	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3584982 rs141982967	303	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1238582918 CA362374673	306	Q>H		No	ClinGen gnomAD
CA132891889 rs996454252	307	M>R		No	ClinGen TOPMed gnomAD
rs777158421 CA3584981	308	E>D		No	ClinGen ExAC gnomAD
CA132891862 rs371035635	309	T>I		No	ClinGen ESP TOPMed gnomAD
rs1581807013 CA362374657	309	T>P		No	ClinGen Ensembl
CA132891855 rs899399494	311	R>*		No	ClinGen TOPMed gnomAD
COSM3429318 rs1050311907 CA132891846	311	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs377107791 CA362374611	312	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs755552331 CA3584980	312	H>Y		No	ClinGen ExAC gnomAD
CA3584940 rs768156226	313	G>D		No	ClinGen ExAC TOPMed gnomAD
rs780667117 CA3584942	313	G>R		No	ClinGen ExAC TOPMed gnomAD
CA3584941 rs780667117	313	G>S		No	ClinGen ExAC TOPMed gnomAD
rs780003390 CA3584938	316	M>V		No	ClinGen ExAC
rs758175653 CA362374575	318	V>L		No	ClinGen ExAC TOPMed gnomAD
rs758175653 CA3584937	318	V>M		No	ClinGen ExAC TOPMed gnomAD
CA3584935 rs779344903	322	G>E		No	ClinGen ExAC gnomAD
rs1487823188 CA362374546	323	R>C		No	ClinGen TOPMed gnomAD
rs1248764875 CA362374545	323	R>H		No	ClinGen TOPMed gnomAD
CA362374508 rs1581805799	328	L>R		No	ClinGen Ensembl
rs1335035111 CA362374505	329	Q>*		No	ClinGen gnomAD
CA362374495 rs1267127828	330	K>E		No	ClinGen gnomAD
rs1307172822 CA362374460	332	M>I		No	ClinGen gnomAD
rs1226241789 CA362374471	332	M>V		No	ClinGen gnomAD
RCV001008395 rs1581805747	336	D>missing		No	ClinVar dbSNP
rs764270601 CA3584931	337	I>T		No	ClinGen ExAC gnomAD
CA362374419 rs1218515094	337	I>V		No	ClinGen gnomAD
rs148384288 CA362374404	338	C>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs148384288 CA3584929	338	C>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs148384288 CA3584930	338	C>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs759862062 CA3584927	339	R>C		No	ClinGen ExAC TOPMed gnomAD
RCV000501123 CA3584926 rs774698335 RCV002264947	339	R>H		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs1184919983 CA362374388	340	Y>F		No	ClinGen TOPMed
rs1459080623 CA362374366	342	A>V		No	ClinGen gnomAD
rs370129260 CA3584921	345	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs775327364 CA3584920	349	M>K		No	ClinGen ExAC gnomAD
CA362374299 rs1383184862	350	I>L		No	ClinGen TOPMed
rs1581805617 CA362374292	350	I>T		No	ClinGen Ensembl
CA362374288 rs1246615905	351	D>N		No	ClinGen gnomAD
CA3584917 rs778864620	355	E>K		No	ClinGen ExAC gnomAD
CA132890981 rs778864620	355	E>Q		No	ClinGen ExAC gnomAD
rs1260731752 CA362374234	356	G>S		No	ClinGen gnomAD
CA362374192 rs1284223764	360	T>I		No	ClinGen TOPMed gnomAD
CA132890938 rs267600572	363	S>Y		No	ClinGen Ensembl
CA3584913 rs756198515	366	K>T		No	ClinGen ExAC gnomAD
rs1490086789 CA362374075	368	Q>*		No	ClinGen TOPMed
CA3584879 rs747672157	369	R>*		No	ClinGen ExAC TOPMed gnomAD
RCV000502075 RCV001770380 CA3584878 rs747672157	369	R>G		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs773047033 CA132890623	370	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1264711183 CA362374045	371	T>S		No	ClinGen gnomAD
CA3584876 rs769417886	371	T>S		No	ClinGen ExAC gnomAD
rs200003905 CA132890614	373	L>I		No	ClinGen Ensembl
rs144057590 CA3584874	381	K>*		No	ClinGen ESP ExAC gnomAD
rs1408564822 CA362373909	385	F>S		No	ClinGen TOPMed
rs774143705 CA132890575	392	K>N		No	ClinGen Ensembl
rs1371336249 CA362373834	393	P>A		No	ClinGen TOPMed
CA362373828 rs1455997810	393	P>L		No	ClinGen gnomAD
CA362373793 rs1321675449	398	V>M		No	ClinGen TOPMed gnomAD
rs1561732025 CA362373778	400	R>H		No	ClinGen Ensembl
CA3584867 rs758885853	401	A>T		No	ClinGen ExAC gnomAD
rs1337445434 CA362373767	402	G>E		No	ClinGen TOPMed
rs781544959 CA132890543	404	A>G		No	ClinGen Ensembl
CA362373713 rs1228057039	409	I>T		No	ClinGen gnomAD
CA3584862 rs752416266	409	I>V		No	ClinGen ExAC gnomAD
CA362373699 rs1290351850	410	Q>H		No	ClinGen gnomAD
CA362373702 rs1275110923	410	Q>L		No	ClinGen TOPMed
CA3584832 rs775645581	412	V>A		No	ClinGen ExAC
CA362373641 rs775645581	412	V>G		No	ClinGen ExAC
CA3584833 rs367653265	412	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA3584830 rs772162239	413	E>G		No	ClinGen ExAC TOPMed gnomAD
rs749721635 CA3584826	422	V>M		No	ClinGen ExAC gnomAD
rs1581804278 CA362373540	423	Y>S		No	ClinGen Ensembl
rs1323392935 CA362373522	425	L>H		No	ClinGen TOPMed
RCV000627551 rs1554110980	426	E>missing		No	ClinVar dbSNP
rs376656648 CA132890169	426	E>K		No	ClinGen ESP TOPMed
CA362373497 rs945210248	427	C>F		No	ClinGen gnomAD
CA132890164 rs945210248	427	C>Y		No	ClinGen gnomAD
rs1187303932 CA362373476	430	K>E		No	ClinGen gnomAD
CA3584822 rs757978164	433	P>S		No	ClinGen ExAC gnomAD
CA3584820 rs765273800	434	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1458994357 CA362373406	435	V>I		No	ClinGen TOPMed
CA3584794 rs759692436	437	I>T		No	ClinGen ExAC gnomAD
CA3584793 rs751738235	439	A>V		No	ClinGen ExAC gnomAD
CA3584792 rs766401102	440	E>D		No	ClinGen ExAC gnomAD
CA3584791 rs763081149	441	K>E		No	ClinGen ExAC gnomAD
rs1296093002 CA362373316	444	D>V		No	ClinGen TOPMed
rs1234794202 CA362373321	444	D>Y		No	ClinGen gnomAD
rs1287227574 CA362373311	445	V>M		No	ClinGen TOPMed gnomAD
CA362373282 rs1375453537	448	I>V		No	ClinGen TOPMed gnomAD
CA3584784 rs778575920	457	V>I		No	ClinGen ExAC gnomAD
CA362373196 rs778575920	457	V>L		No	ClinGen ExAC gnomAD
rs777752482 CA3584781	460	V>I		No	ClinGen ExAC TOPMed gnomAD
CA362373003 rs1329727523	471	R>W		No	ClinGen TOPMed
RCV001256175 RCV001751523 CA3584739 rs200307685	479	R>Q		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
CA3584740 rs768638631	479	R>W		No	ClinGen ExAC TOPMed gnomAD
rs780011110 CA3584738	481	G>S		No	ClinGen ExAC gnomAD
rs1300267169 CA362372890	482	K>N		No	ClinGen gnomAD
rs1394709760 CA362372894	482	K>R		No	ClinGen gnomAD
CA3584735 rs746112739	487	V>L		No	ClinGen ExAC gnomAD
CA3584733 rs757449267	491	V>I		No	ClinGen ExAC TOPMed gnomAD
CA362372772 rs1172483916	495	G>S		No	ClinGen TOPMed
CA132889675 rs774057488	501	I>N		No	ClinGen Ensembl
CA3584728 rs753078023	504	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1481054471 CA362372672	505	I>V		No	ClinGen gnomAD
rs1231734986 CA362372639	507	Y>*		No	ClinGen gnomAD
CA362372647 rs1265067440	507	Y>N		No	ClinGen gnomAD
rs199756165 CA3584727	510	P>S		No	ClinGen ExAC TOPMed gnomAD
rs772902682 CA3584725	513	I>T		No	ClinGen ExAC gnomAD
CA132889653 rs1014402897	516	Y>C		No	ClinGen TOPMed
rs1191544621 CA362372485	519	R>W		No	ClinGen TOPMed gnomAD
CA3584697 rs774299454	526	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1405173089 CA362372417	527	G>A		No	ClinGen gnomAD
rs1581802660 CA362372400	529	T>A		No	ClinGen Ensembl
rs749555218 CA3584695	529	T>I		No	ClinGen ExAC TOPMed gnomAD
CA362372397 rs749555218	529	T>R		No	ClinGen ExAC TOPMed gnomAD
rs1275046805 CA362372372	532	A>T		No	ClinGen gnomAD
rs1429676926 CA362372355	533	T>I		No	ClinGen gnomAD
CA132889539 rs1031559373	534	T>A		No	ClinGen TOPMed
rs1382668708 CA362372342	535	F>I		No	ClinGen gnomAD
CA3584688 rs755467087	539	A>V		No	ClinGen ExAC gnomAD
rs1581802095 CA362372255	543	S>*		No	ClinGen Ensembl
CA3584654 rs140371153	548	L>F		No	ClinGen ESP ExAC gnomAD
CA132889330 rs113077379	548	L>P		No	ClinGen Ensembl
rs1167201781 CA362372142	561	P>A		No	ClinGen gnomAD
CA132889311 rs998093581	561	P>L		No	ClinGen Ensembl
rs746326361 CA3584649	562	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1176022439 CA362372133	563	L>M		No	ClinGen gnomAD
CA362372127 rs1471357257	564	Q>E		No	ClinGen gnomAD
CA362372121 rs1233873125	564	Q>H		No	ClinGen gnomAD
rs781182074 CA3584648	565	V>L		No	ClinGen ExAC gnomAD
CA3584647 rs781182074	565	V>M		No	ClinGen ExAC gnomAD
rs1467756814 CA362372107	567	H>R		No	ClinGen gnomAD
rs747823734 CA3584646	568	C>R		No	ClinGen ExAC TOPMed gnomAD
rs757180883 CA3584644	569	G>R		No	ClinGen ExAC TOPMed gnomAD
CA362372085 rs1222072296	570	D>E		No	ClinGen gnomAD
rs367918756 CA3584642	575	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1195314927 CA362372007	580	R>C		No	ClinGen gnomAD
rs778787490 CA3584618	580	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1312801443 CA362371995	582	C>Y		No	ClinGen gnomAD
rs1413539474 CA362371983	584	F>L		No	ClinGen gnomAD
CA362371935 rs1395944669	591	R>Q		No	ClinGen TOPMed
rs763815974 CA3584615	594	D>H		No	ClinGen ExAC TOPMed gnomAD
rs1167946851 CA362371898	597	K>*		No	ClinGen gnomAD
rs1167946851 CA362371896	597	K>Q		No	ClinGen gnomAD
rs1187062751 CA362371864	601	M>I		No	ClinGen gnomAD
rs1257961807 CA362371832	605	Q>H		No	ClinGen gnomAD
CA3584611 rs759638837	609	I>V		No	ClinGen ExAC gnomAD
rs763471166 CA3584608	610	G>S		No	ClinGen ExAC TOPMed gnomAD
CA3584607 rs773727212	610	G>V		No	ClinGen ExAC gnomAD
rs770220016 CA3584606	611	R>H		No	ClinGen ExAC TOPMed gnomAD
CA3584605 rs746674889	614	Y>C		No	ClinGen ExAC gnomAD
rs771535420 CA3584603	617	H>R		No	ClinGen ExAC TOPMed gnomAD
rs745374460 CA3584602	620	M>V		No	ClinGen ExAC gnomAD

1 associated diseases with Q9UJV9

[MIM: 616871]: Myeloproliferative/lymphoproliferative neoplasms, familial (MPLPF)

A familial cancer predisposition syndrome with incomplete penetrance, characterized by increased susceptibility to myeloid neoplasms and rarely to lymphoid malignancies. MPLPF inheritance is autosomal dominant. {ECO:0000269|PubMed:25920683, ECO:0000269|PubMed:26712909}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.

Without disease ID

A familial cancer predisposition syndrome with incomplete penetrance, characterized by increased susceptibility to myeloid neoplasms and rarely to lymphoid malignancies. MPLPF inheritance is autosomal dominant. {ECO:0000269|PubMed:25920683, ECO:0000269|PubMed:26712909}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.

5 regional properties for Q9UJV9

Type	Name	Position	InterPro Accession
domain	Helicase, C-terminal	407 - 567	IPR001650
domain	DEAD/DEAH box helicase domain	205 - 384	IPR011545
domain	Helicase superfamily 1/2, ATP-binding domain	200 - 411	IPR014001
domain	RNA helicase, DEAD-box type, Q motif	181 - 209	IPR014014
domain	DDX41, DEAD-box helicase domain	192 - 397	IPR044113

Functions

		Description
EC Number	3.6.4.13	Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
catalytic step 2 spliceosome	A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spliceosomal complex	Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.

5 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
metal ion binding	Binding to a metal ion.
RNA binding	Binding to an RNA molecule or a portion thereof.
RNA helicase activity	Unwinding of an RNA helix, driven by ATP hydrolysis.

4 GO annotations of biological process

Name	Definition
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
cell population proliferation	The multiplication or reproduction of cells, resulting in the expansion of a cell population.
mRNA splicing, via spliceosome	The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.

16 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9V3C0	abs	ATP-dependent RNA helicase abstrakt	Drosophila melanogaster (Fruit fly)	PR
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	Homo sapiens (Human)	PR
Q9NQI0	DDX4	Probable ATP-dependent RNA helicase DDX4	Homo sapiens (Human)	SS
O15523	DDX3Y	ATP-dependent RNA helicase DDX3Y	Homo sapiens (Human)	SS
O00571	DDX3X	ATP-dependent RNA helicase DDX3X	Homo sapiens (Human)	EV
Q9UHL0	DDX25	ATP-dependent RNA helicase DDX25	Homo sapiens (Human)	PR
Q9UMR2	DDX19B	ATP-dependent RNA helicase DDX19B	Homo sapiens (Human)	PR
Q9NUU7	DDX19A	ATP-dependent RNA helicase DDX19A	Homo sapiens (Human)	PR
P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	Homo sapiens (Human)	PR
O00148	DDX39A	ATP-dependent RNA helicase DDX39A	Homo sapiens (Human)	PR
Q13838	DDX39B	Spliceosome RNA helicase DDX39B	Homo sapiens (Human)	PR
Q91VN6	Ddx41	Probable ATP-dependent RNA helicase DDX41	Mus musculus (Mouse)	PR
Q5Z6G5	Os06g0697200	DEAD-box ATP-dependent RNA helicase 35B	Oryza sativa subsp japonica (Rice)	PR
Q0E3X4	Os02g0150100	DEAD-box ATP-dependent RNA helicase 35A	Oryza sativa subsp japonica (Rice)	PR
Q9LU46	RH35	DEAD-box ATP-dependent RNA helicase 35	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SZB4	RH43	Putative DEAD-box ATP-dependent RNA helicase 43	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MEESEPERKR	ARTDEVPAGG	SRSEAEDEDD	EDYVPYVPLR	QRRQLLLQKL	LQRRRKGAAE
70	80	90	100	110	120
EEQQDSGSEP	RGDEDDIPLG	PQSNVSLLDQ	HQHLKEKAEA	RKESAKEKQL	KEEEKILESV
130	140	150	160	170	180
AEGRALMSVK	EMAKGITYDD	PIKTSWTPPR	YVLSMSEERH	ERVRKKYHIL	VEGDGIPPPI
190	200	210	220	230	240
KSFKEMKFPA	AILRGLKKKG	IHHPTPIQIQ	GIPTILSGRD	MIGIAFTGSG	KTLVFTLPVI
250	260	270	280	290	300
MFCLEQEKRL	PFSKREGPYG	LIICPSRELA	RQTHGILEYY	CRLLQEDSSP	LLRCALCIGG
310	320	330	340	350	360
MSVKEQMETI	RHGVHMMVAT	PGRLMDLLQK	KMVSLDICRY	LALDEADRMI	DMGFEGDIRT
370	380	390	400	410	420
IFSYFKGQRQ	TLLFSATMPK	KIQNFAKSAL	VKPVTINVGR	AGAASLDVIQ	EVEYVKEEAK
430	440	450	460	470	480
MVYLLECLQK	TPPPVLIFAE	KKADVDAIHE	YLLLKGVEAV	AIHGGKDQEE	RTKAIEAFRE
490	500	510	520	530	540
GKKDVLVATD	VASKGLDFPA	IQHVINYDMP	EEIENYVHRI	GRTGRSGNTG	IATTFINKAC
550	560	570	580	590	600
DESVLMDLKA	LLLEAKQKVP	PVLQVLHCGD	ESMLDIGGER	GCAFCGGLGH	RITDCPKLEA
610	620
MQTKQVSNIG	RKDYLAHSSM	DF