AiPD: Autoinhibited Protein Database

Q9UHY1

Gene name	NRBP1 (BCON3)
Protein name	Nuclear receptor-binding protein
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:29959
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-83 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-83 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9UHY1

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9UHY1-F1	Predicted				AlphaFoldDB

213 variants for Q9UHY1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA44503250 rs919186043	2	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA346387349 rs919186043	2	S>W		No	ClinGen TOPMed gnomAD
rs1339699398 CA346387409	4	G>E		No	ClinGen gnomAD
rs1313458435 CA346387400	4	G>R		No	ClinGen gnomAD
CA346387425 rs1279468000	5	E>A		No	ClinGen TOPMed gnomAD
TCGA novel	5	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1578547 rs771034587	5	E>Q		No	ClinGen ExAC gnomAD
CA346387448 rs1572687575	6	S>A		No	ClinGen Ensembl
rs1178151171 CA346387475	7	Q>E		No	ClinGen Ensembl
rs774592261 CA1578548	7	Q>H		No	ClinGen ExAC gnomAD
CA1578550 rs771880350	8	T>R		No	ClinGen ExAC gnomAD
rs775353105 CA1578551	9	V>L		No	ClinGen ExAC TOPMed gnomAD
rs1346523771 CA346387572	10	L>R		No	ClinGen TOPMed gnomAD
COSM1019687 CA346387583 rs1212019331	11	S>N	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1285308541 CA346387587	11	S>R		No	ClinGen TOPMed
rs1212019331 CA346387582	11	S>T		No	ClinGen TOPMed gnomAD
rs1285959377 CA346387677	16	P>A		No	ClinGen gnomAD
CA346387709 rs1487573545	17	K>N		No	ClinGen gnomAD
CA346387729 rs1572687650	18	V>G		No	ClinGen Ensembl
CA346387750 rs1195945253	19	E>A		No	ClinGen gnomAD
rs760536735 CA1578552	21	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1432657667 CA346387807	22	S>P		No	ClinGen gnomAD
rs529123835 CA1578553	23	S>L		No	ClinGen 1000Genomes ExAC gnomAD
rs951944318 CA44503307	24	A>S		No	ClinGen TOPMed
rs753276316 CA1578554	24	A>V		No	ClinGen ExAC gnomAD
CA346387874 rs1478898930	26	G>D		No	ClinGen gnomAD
rs1173987845 CA346387895	27	L>P		No	ClinGen gnomAD
CA346387898 rs1417718063	28	T>A		No	ClinGen gnomAD
CA346387909 rs1384132656	28	T>I		No	ClinGen TOPMed gnomAD
rs1299943305 COSM268000 CA346387951	30	V>A	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1385700397 CA346388007	33	P>L		No	ClinGen TOPMed gnomAD
rs755335330 CA1578558	37	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1005987885 CA44503336	37	T>I		No	ClinGen TOPMed
rs1572687798 CA346388116	38	T>I		No	ClinGen Ensembl
rs868607849 CA44503342	39	S>L		No	ClinGen Ensembl
CA1578559 rs781693165	40	A>P		No	ClinGen ExAC TOPMed gnomAD
rs753170710 CA1578560	40	A>V		No	ClinGen ExAC gnomAD
rs1313435812 CA346388152	41	A>P		No	ClinGen gnomAD
CA1578561 rs563642807	42	S>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1219509685 CA346388189	43	P>L		No	ClinGen gnomAD
rs1208085042 CA346388298	47	E>D		No	ClinGen gnomAD
TCGA novel	53	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA346388568 rs1379513593	63	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA1578579 rs756539212	72	N>T		No	ClinGen ExAC TOPMed gnomAD
rs1299031878 CA346388750	74	R>W		No	ClinGen gnomAD
rs764463795 CA1578580	81	S>I		No	ClinGen ExAC
TCGA novel	89	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1335593991 CA346389021	94	V>D		No	ClinGen gnomAD
CA346389018 rs1335593991	94	V>G		No	ClinGen gnomAD
rs199510158 CA44503579	101	F>L		No	ClinGen Ensembl
rs758609544 CA1578585	104	R>H		No	ClinGen ExAC gnomAD
rs369322316 CA1578586	105	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA346389193 rs1320223026	107	Y>C		No	ClinGen gnomAD
CA44503610 rs11539698	109	L>Q		No	ClinGen Ensembl
rs1558334992 CA346389255	111	E>K		No	ClinGen Ensembl
CA346389432 rs1424001450	115	R>H		No	ClinGen gnomAD
CA1578608 rs781036364	138	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1296874066 CA346390068	139	I>V		No	ClinGen gnomAD
rs146226018 CA1578610	144	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs778484098 CA1578631	147	I>V		No	ClinGen ExAC gnomAD
CA346390786 rs1288457589	159	K>Q		No	ClinGen gnomAD
TCGA novel	162	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA44504116 COSM215874 rs1047817538	165	T>I	central_nervous_system [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1480678955 COSM1407454 CA346391099	171	T>M	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs1416126166 CA346391316	177	W>G		No	ClinGen gnomAD
rs111798412 CA44504261	178	K>R		No	ClinGen Ensembl
CA346391632 rs1235759007	194	C>R		No	ClinGen TOPMed gnomAD
TCGA novel	195	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779546002 CA1578670	196	P>R		No	ClinGen ExAC gnomAD
rs757867684 CA1578669	196	P>T		No	ClinGen ExAC TOPMed gnomAD
rs983579251 CA44504569	197	P>H		No	ClinGen TOPMed gnomAD
rs1451189311 CA346391685	197	P>S		No	ClinGen gnomAD
rs763892200	198	I>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1455394018 CA346391695	198	I>V		No	ClinGen gnomAD
CA44504594 rs1003252519	200	H>R		No	ClinGen TOPMed
TCGA novel	207	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA346391919 rs1284160214	220	S>F		No	ClinGen gnomAD
rs1008624595 CA44507445	225	T>I		No	ClinGen TOPMed gnomAD
TCGA novel	231	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1159316447 CA346393709	233	C>S		No	ClinGen TOPMed
CA1578701 rs768882955	234	R>*		No	ClinGen ExAC gnomAD
rs776856765 CA1578702	234	R>Q		No	ClinGen ExAC gnomAD
rs761946471 CA1578703	235	E>K		No	ClinGen ExAC
CA346393909 rs1439238916	241	H>Y		No	ClinGen TOPMed
CA346393942 rs1171482496	242	F>L		No	ClinGen gnomAD
TCGA novel	248	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1578726 rs774202584	250	V>I		No	ClinGen ExAC gnomAD
CA44507577 rs201083911	261	S>C		No	ClinGen Ensembl
rs201083911 CA44507582	261	S>F		No	ClinGen Ensembl
TCGA novel	271	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA44507741 rs767730395	282	Y>C		No	ClinGen Ensembl
rs1409910374 CA346394736	284	P>S		No	ClinGen gnomAD
CA346394816 rs1292072778	287	A>P		No	ClinGen gnomAD
CA346394893 rs1353010281	290	S>N		No	ClinGen gnomAD
rs1572691822 CA346394944	292	I>T		No	ClinGen Ensembl
rs147955632 CA1578757 CA1578756	293	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA346395107 rs1275723999	299	L>S		No	ClinGen gnomAD
TCGA novel	302	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs71441076 CA44509253	310	S>F		No	ClinGen Ensembl
CA1578781 rs773019385	311	E>D		No	ClinGen ExAC
rs201132320 CA44509268	313	A>V		No	ClinGen 1000Genomes
CA1578783 rs536923313	314	R>C		No	ClinGen 1000Genomes ExAC gnomAD
CA1578782 rs536923313	314	R>G		No	ClinGen 1000Genomes ExAC gnomAD
CA1578784 rs371237665	314	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA346396390 rs371237665	314	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1243702829 CA346396435	316	P>S		No	ClinGen gnomAD
CA1578786 rs764631733	320	E>G		No	ClinGen ExAC gnomAD
TCGA novel	324	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1357154706 CA346396641	325	P>L		No	ClinGen TOPMed
CA1578790 rs750674505	333	L>V		No	ClinGen ExAC gnomAD
CA1578791 rs758065640	337	A>V		No	ClinGen ExAC TOPMed gnomAD
CA1578794 rs145354088	341	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs371384227 CA1578796	344	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA1578798 rs772672860	346	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs758633337 CA1578809	347	M>V		No	ClinGen ExAC gnomAD
TCGA novel	350	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1229817734 CA346397586	352	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	353	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel rs754853866 CA1578812	355	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ExAC gnomAD
rs368054308 CA346397705	356	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1433522225 CA346397806	360	M>V		No	ClinGen TOPMed
CA346397866 rs1474704385	361	D>N		No	ClinGen gnomAD
CA44509717 rs769914699	362	T>A		No	ClinGen ExAC TOPMed gnomAD
CA1578815 rs769914699	362	T>P		No	ClinGen ExAC TOPMed gnomAD
RCV000967947 rs56004639 VAR_041359 CA1578818	365	V>I		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1393243890 CA346398194	370	P>R		No	ClinGen gnomAD
rs1411755765 CA346398199	371	A>T		No	ClinGen TOPMed
rs773905346 CA1578819	375	R>G		No	ClinGen ExAC gnomAD
TCGA novel	376	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777057653 CA1578822	378	V>F		No	ClinGen ExAC gnomAD
rs1482491959 CA346398647	381	L>W		No	ClinGen gnomAD
CA346399412 rs1477664839	383	S>Y		No	ClinGen TOPMed
TCGA novel	393	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1578858 rs369958327	399	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs779726099 CA1578859	400	G>E		No	ClinGen ExAC gnomAD
rs748475059 CA1578860	402	Y>C		No	ClinGen ExAC gnomAD
CA346399931 rs1193397805	402	Y>H		No	ClinGen gnomAD
CA1578861 rs770079968	406	A>V		No	ClinGen ExAC gnomAD
rs1157212067 CA346400008	407	F>S		No	ClinGen gnomAD
CA346400034 rs1391019223	409	L>P		No	ClinGen gnomAD
CA346400046 rs1458643486	410	P>L		No	ClinGen gnomAD
CA1578864 rs372579058	411	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1019689 CA1578863 rs372579058	411	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs199714909 CA1578862	411	R>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	413	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA346400085 COSM1019690 rs774546607	413	Q>H	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA44509943 rs11539699	414	Q>*		No	ClinGen Ensembl
rs1572696364 CA346400214	420	V>A		No	ClinGen Ensembl
CA346400274 rs1465315760	424	V>F		No	ClinGen TOPMed
CA346400272 rs1465315760	424	V>I		No	ClinGen TOPMed
rs767995482 CA1578867	425	V>M		No	ClinGen ExAC gnomAD
TCGA novel	426	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1330713982 CA346400308	426	P>L		No	ClinGen gnomAD
rs760459804 CA346400321	427	P>H		No	ClinGen ExAC gnomAD
CA1578869 rs760459804	427	P>R		No	ClinGen ExAC gnomAD
TCGA novel	428	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763804268 CA1578870	428	S>P		No	ClinGen ExAC gnomAD
rs1410562987 CA346400378	431	T>S		No	ClinGen TOPMed
rs753734841 VAR_041360 COSM20720 CA1578872	432	P>L	ovary an ovarian mucinous carcinoma sample; somatic mutation [Cosmic, UniProt]	No	ClinGen cosmic curated UniProt ExAC dbSNP gnomAD
CA1578873 rs761644081	433	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1180949430 CA346400461	436	P>Q		No	ClinGen TOPMed
CA1578874 rs765209087	442	R>H		No	ClinGen ExAC gnomAD
rs1226923253 CA346400852	448	Q>L		No	ClinGen gnomAD
rs574325125 CA1578896	453	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1578899 rs754561047	455	E>D		No	ClinGen ExAC gnomAD
rs751134996 CA1578898	455	E>Q		No	ClinGen ExAC gnomAD
rs34260196 CA346401263	460	H>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs34260196 VAR_041361 CA1578901	460	H>R		No	ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
rs138754846	461	H>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs199938360 CA1578902	461	H>Y		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	462	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA346401439 rs1186395768	463	T>K		No	ClinGen gnomAD
rs1308187702 CA346401453	464	L>V		No	ClinGen TOPMed
rs1450060996 CA346401470	465	L>M		No	ClinGen gnomAD
rs773070005 CA1578914	471	K>R		No	ClinGen ExAC TOPMed gnomAD
rs546007305 CA346401702	472	L>V		No	ClinGen 1000Genomes gnomAD
rs773699029 CA1578917	474	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs767027817 CA1578919	475	H>N		No	ClinGen ExAC gnomAD
rs765694579 CA1578922	482	P>A		No	ClinGen ExAC gnomAD
rs750877807 CA1578923	483	N>D		No	ClinGen ExAC gnomAD
rs750877807 CA44510327	483	N>H		No	ClinGen ExAC gnomAD
CA44510609 rs977150998	485	N>H		No	ClinGen Ensembl
rs1228525765 CA346402393	487	P>L		No	ClinGen TOPMed
rs781330388 CA1578950	488	E>K		No	ClinGen ExAC TOPMed gnomAD
CA1578951 rs374507004	490	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs754046270 CA44510625	499	I>V		No	ClinGen Ensembl
rs756295007 CA1578952	500	S>G		No	ClinGen ExAC gnomAD
CA1578974 rs757484710	504	Q>H		No	ClinGen ExAC gnomAD
CA44510738 rs141808993	504	Q>R		No	ClinGen ESP
rs1381091916 CA346402884	505	S>I		No	ClinGen gnomAD
CA346402881 rs1381091916	505	S>N		No	ClinGen gnomAD
rs778753969 CA1578976	506	R>G		No	ClinGen ExAC gnomAD
CA346402891 rs141700147	506	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1578977 COSM184422 rs141700147	506	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs778753969 CA1578975	506	R>W		No	ClinGen ExAC gnomAD
CA346402932 rs1362882652	508	T>I		No	ClinGen gnomAD
CA1578978 rs780172704	510	L>V		No	ClinGen ExAC gnomAD
CA1578979 rs746470640	516	N>K		No	ClinGen ExAC TOPMed gnomAD
rs866974645 CA44510784	516	N>S		No	ClinGen Ensembl
rs1483784394 CA346403199	517	K>N		No	ClinGen gnomAD
CA346403209 rs1208451074	518	F>I		No	ClinGen gnomAD
rs768298741 CA1578980	519	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
COSM418753 CA346403323 rs1451925011	521	A>V	urinary_tract [Cosmic]	No	ClinGen cosmic curated gnomAD
CA44510798 rs1003536519	522	R>S		No	ClinGen Ensembl
rs1025675347 CA44510811	523	N>D		No	ClinGen Ensembl
TCGA novel	525	T>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1578981 rs371589798	525	T>I		No	ClinGen ESP ExAC gnomAD
CA346403405 rs1572698259	525	T>P		No	ClinGen Ensembl
rs1427251074 CA346403427	526	L>F		No	ClinGen TOPMed
rs761556440 CA1578982	527	N>K		No	ClinGen ExAC gnomAD
rs887157695 CA44510818	528	S>L		No	ClinGen TOPMed gnomAD
CA1578983 rs769393462	530	A>T		No	ClinGen ExAC gnomAD
rs1437274482 CA346403660	533	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD

No associated diseases with Q9UHY1

2 regional properties for Q9UHY1

Type	Name	Position	InterPro Accession
domain	ABC1 atypical kinase-like domain	129 - 387	IPR004147
domain	ADCK1-like domain	128 - 392	IPR045307

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, cell cortex Endomembrane system Cell projection, lamellipodium	Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
cell cortex	The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endomembrane system	A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
lamellipodium	A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

3 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

2 GO annotations of biological process

Name	Definition
endoplasmic reticulum to Golgi vesicle-mediated transport	The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.

12 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P51957	NEK4	Serine/threonine-protein kinase Nek4	Homo sapiens (Human)	PR
Q9Y3S1	WNK2	Serine/threonine-protein kinase WNK2	Homo sapiens (Human)	SS
Q9H4A3	WNK1	Serine/threonine-protein kinase WNK1	Homo sapiens (Human)	SS
Q9BYP7	WNK3	Serine/threonine-protein kinase WNK3	Homo sapiens (Human)	SS
Q9Y2U5	MAP3K2	Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (Human)	PR
Q99759	MAP3K3	Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (Human)	PR
Q99J45	Nrbp1	Nuclear receptor-binding protein	Mus musculus (Mouse)	PR
Q9STK6	WNK3	Probable serine/threonine-protein kinase WNK3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8RXE5	WNK10	Probable serine/threonine-protein kinase WNK10	Arabidopsis thaliana (Mouse-ear cress)	PR
Q944Q0	WNK8	Serine/threonine-protein kinase WNK8	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LVL5	WNK4	Probable serine/threonine-protein kinase WNK4	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8LST2	WNK7	Probable serine/threonine-protein kinase WNK7	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MSEGESQTVL	SSGSDPKVES	SSSAPGLTSV	SPPVTSTTSA	ASPEEEEESE	DESEILEESP
70	80	90	100	110	120
CGRWQKRREE	VNQRNVPGID	SAYLAMDTEE	GVEVVWNEVQ	FSERKNYKLQ	EEKVRAVFDN
130	140	150	160	170	180
LIQLEHLNIV	KFHKYWADIK	ENKARVIFIT	EYMSSGSLKQ	FLKKTKKNHK	TMNEKAWKRW
190	200	210	220	230	240
CTQILSALSY	LHSCDPPIIH	GNLTCDTIFI	QHNGLIKIGS	VAPDTINNHV	KTCREEQKNL
250	260	270	280	290	300
HFFAPEYGEV	TNVTTAVDIY	SFGMCALEMA	VLEIQGNGES	SYVPQEAISS	AIQLLEDPLQ
310	320	330	340	350	360
REFIQKCLQS	EPARRPTARE	LLFHPALFEV	PSLKLLAAHC	IVGHQHMIPE	NALEEITKNM
370	380	390	400	410	420
DTSAVLAEIP	AGPGREPVQT	LYSQSPALEL	DKFLEDVRNG	IYPLTAFGLP	RPQQPQQEEV
430	440	450	460	470	480
TSPVVPPSVK	TPTPEPAEVE	TRKVVLMQCN	IESVEEGVKH	HLTLLLKLED	KLNRHLSCDL
490	500	510	520	530
MPNENIPELA	AELVQLGFIS	EADQSRLTSL	LEETLNKFNF	ARNSTLNSAA	VTVSS