AiPD: Autoinhibited Protein Database

Q9UFC0

Gene name	LRWD1 (CENP-33)
Protein name	Leucine-rich repeat and WD repeat-containing protein 1
Names	Centromere protein 33, CENP-33, Origin recognition complex-associated protein, ORC-associated protein, ORCA
Species	Homo sapiens (Human)
KEGG Pathway	hsa:222229
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

169-305 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

169-305 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9UFC0

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9UFC0-F1	Predicted				AlphaFoldDB

685 variants for Q9UFC0

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs942139397 CA163444834	2	G>D		No	ClinGen Ensembl
CA368711394 rs1272444045	3	P>L		No	ClinGen TOPMed
rs1322159427 CA368711384	3	P>T		No	ClinGen TOPMed
rs1454372987 CA368711402	4	L>F		No	ClinGen gnomAD
rs1386701376 CA368711435	6	A>V		No	ClinGen gnomAD
CA368711479 rs1218515343	10	M>I		No	ClinGen gnomAD
CA368711476 rs1341821064	10	M>R		No	ClinGen TOPMed
CA368711493 rs1299107006	11	Q>R		No	ClinGen gnomAD
rs1278293518 CA368711507	12	R>H		No	ClinGen TOPMed
rs867907415 CA163444871	13	G>W		No	ClinGen gnomAD
rs1215863037 CA368711526	14	R>C		No	ClinGen gnomAD
CA368711532 rs1199041286	14	R>H		No	ClinGen gnomAD
CA163444888 rs1023209207	16	K>R		No	ClinGen TOPMed gnomAD
CA4413384 rs765973508	17	S>C		No	ClinGen ExAC TOPMed gnomAD
CA368711589 rs1163384777	18	D>E		No	ClinGen TOPMed
rs761307074 CA4413386	18	D>N		No	ClinGen ExAC
rs1488364495 CA368711592	19	R>W		No	ClinGen gnomAD
rs1424337076 CA368711619	21	G>V		No	ClinGen TOPMed
CA368711641 rs1158483641	23	I>N		No	ClinGen gnomAD
CA368711648 rs1192597769	24	R>W		No	ClinGen TOPMed
CA163444932 rs1002390196	25	S>C		No	ClinGen Ensembl
rs757494335	26	L>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1430452923 CA368711675	26	L>V		No	ClinGen TOPMed gnomAD
TCGA novel	27	D>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4413442 rs200711890	32	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA368712352 rs1266459293	34	L>F		No	ClinGen gnomAD
CA368712386 rs1449755963	35	S>C		No	ClinGen gnomAD
CA4413444 rs778703203	36	E>K		No	ClinGen ExAC gnomAD
rs778703203 CA368712398	36	E>Q		No	ClinGen ExAC gnomAD
rs1471979849 CA368712446	38	L>V		No	ClinGen TOPMed gnomAD
rs745574402 CA4413445	40	P>S		No	ClinGen ExAC gnomAD
CA368712598 rs1393586988	45	R>C		No	ClinGen gnomAD
rs773384348 CA368712605	45	R>L		No	ClinGen ExAC gnomAD
CA4413451 rs773384348	45	R>P		No	ClinGen ExAC gnomAD
CA368712691 rs1159129086	51	E>Q		No	ClinGen TOPMed gnomAD
rs990057895 CA163445686	53	D>A		No	ClinGen TOPMed
COSM744377 rs1341261798 CA368712780	55	S>F	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA4413453 rs771346770	57	N>H		No	ClinGen ExAC gnomAD
CA368712824 rs1586736446	57	N>T		No	ClinGen Ensembl
CA368712854 rs1207125477	58	H>P		No	ClinGen gnomAD
CA4413455 rs117376828	60	E>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4413456 rs756456696	61	T>M		No	ClinGen ExAC gnomAD
rs371342787 CA4413459 COSM290324	63	P>L	Variant assessed as Somatic; 0.0 impact. large_intestine central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA4413458 rs371342787	63	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1186419463 CA368712956	63	P>S		No	ClinGen gnomAD
rs979789955 CA163445744	64	D>H		No	ClinGen TOPMed
rs979789955 CA163445750	64	D>Y		No	ClinGen TOPMed
rs1434355842 CA368713001	65	N>S		No	ClinGen TOPMed
CA368713007 rs753783952	66	L>M		No	ClinGen ExAC gnomAD
rs753783952 CA4413460	66	L>V		No	ClinGen ExAC gnomAD
CA368713041 rs1169691082	68	L>V		No	ClinGen gnomAD
rs757104289 CA4413461	69	S>T		No	ClinGen ExAC gnomAD
rs1586736512 CA368713084	70	H>P		No	ClinGen Ensembl
CA368713129 COSM3745437 rs1395607947	72	R>H	liver [Cosmic]	No	ClinGen cosmic curated gnomAD
CA368713134 rs1395607947	72	R>L		No	ClinGen gnomAD
CA368713165 rs1328486327	74	L>F		No	ClinGen gnomAD
CA4413465 rs779659216	75	R>C		No	ClinGen ExAC gnomAD
rs779659216 CA368713186	75	R>G		No	ClinGen ExAC gnomAD
rs1341324971 CA368713194	75	R>H		No	ClinGen gnomAD
CA4413467 rs139115115	77	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs139115115 CA4413468 COSM1083501	77	A>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1364274304 CA368713259	78	N>S		No	ClinGen TOPMed
rs1483294553 CA368713290	79	N>S		No	ClinGen TOPMed gnomAD
CA368713311 rs1199455001	80	Q>*		No	ClinGen gnomAD
CA368713305 rs1199455001	80	Q>K		No	ClinGen gnomAD
rs901406802 CA163445862	82	G>E		No	ClinGen TOPMed gnomAD
rs201713941 CA163445870	84	V>G		No	ClinGen TOPMed gnomAD
CA4413470 rs572352133	84	V>I		No	ClinGen 1000Genomes ExAC gnomAD
rs1389980580 CA368713419	85	T>I		No	ClinGen gnomAD
CA4413471 rs774729386	86	A>T		No	ClinGen ExAC gnomAD
TCGA novel	86	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4413473 rs143977682 CA4413472	87	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA163445911 rs913040809	88	C>Y		No	ClinGen TOPMed
CA4413474 rs775364198	89	Q>L		No	ClinGen ExAC gnomAD
CA368713525 rs1391070066	91	P>S		No	ClinGen gnomAD
CA368713556 rs146433593	92	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4413476 rs764136889	92	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs753792771 CA4413477	92	K>R		No	ClinGen ExAC gnomAD
rs1303313942 CA368713580	94	E>K		No	ClinGen gnomAD
rs750262596 CA4413480	96	L>R		No	ClinGen ExAC gnomAD
rs758064778 CA4413481	97	S>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4413483 rs751231484	100	G>S		No	ClinGen ExAC TOPMed gnomAD
CA368713701 rs1208988500	101	N>K		No	ClinGen gnomAD
CA368713754 rs1463823086	105	T>M		No	ClinGen gnomAD
CA4413503 rs199648871	106	V>L		No	ClinGen ExAC gnomAD
CA4413505 rs757696550	107	N>I		No	ClinGen ExAC TOPMed gnomAD
CA368713821 rs1287210530	107	N>K		No	ClinGen gnomAD
rs757696550 CA4413504	107	N>S		No	ClinGen ExAC TOPMed gnomAD
CA368713827 rs1370683612	108	D>Y		No	ClinGen gnomAD
CA4413506 rs746430950	110	L>V		No	ClinGen ExAC TOPMed gnomAD
CA163446110 rs367718460	112	V>I		No	ClinGen ESP
rs1326543810 CA368713898	113	S>C		No	ClinGen TOPMed
CA163446111 rs980198446	114	F>S		No	ClinGen TOPMed
TCGA novel	115	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1321504989 CA368713927	115	L>P		No	ClinGen gnomAD
rs1321504989 CA368713928	115	L>R		No	ClinGen gnomAD
CA368713938 rs1483697145	116	L>Q		No	ClinGen TOPMed gnomAD
CA368713935 rs747209954	116	L>V		No	ClinGen ExAC gnomAD
CA368713945 rs1249753194	117	P>S		No	ClinGen gnomAD
CA4413511 rs776711578	118	T>A		No	ClinGen ExAC gnomAD
rs200399227 CA4413512	118	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA368713964 rs1470137649	119	L>I		No	ClinGen TOPMed
rs770823521 CA4413515	120	R>C		No	ClinGen ExAC TOPMed gnomAD
rs766162260 CA4413516	120	R>H		No	ClinGen ExAC TOPMed gnomAD
rs766162260 CA4413517	120	R>P		No	ClinGen ExAC TOPMed gnomAD
rs767082952 CA4413519	123	N>S		No	ClinGen ExAC TOPMed gnomAD
CA368714033 rs1339006507	124	G>S		No	ClinGen TOPMed
CA368714056 rs1284143028	125	K>R		No	ClinGen gnomAD
rs1295737558 CA368714069	126	D>G		No	ClinGen TOPMed
CA368714072 rs1295737558	126	D>V		No	ClinGen TOPMed
rs745680542 CA163446246	127	A>T		No	ClinGen Ensembl
CA4413520 rs752415055	127	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA163446272 rs898147005	128	S>F		No	ClinGen Ensembl
rs986641243 CA368714106	129	S>*		No	ClinGen TOPMed gnomAD
CA163446281 rs986641243	129	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA4413522 rs763641989	130	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1330348462 CA830694079	131	Y>*		No	ClinGen TOPMed
rs750898527 CA4413523	131	Y>C		No	ClinGen ExAC gnomAD
rs1275510009 CA368714148	133	Q>*		No	ClinGen gnomAD
rs776457074 CA163446307	134	V>M		No	ClinGen Ensembl
rs911322445 CA163446315	135	E>G		No	ClinGen TOPMed
rs1563653330 CA368714232	139	R>Q		No	ClinGen Ensembl
rs77479583 CA4413525	139	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs751880306 CA4413526 COSM598050	140	E>K	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1181492303 CA368714279	143	S>G		No	ClinGen gnomAD
rs771112724 CA4413554	146	T>K		No	ClinGen ExAC gnomAD
rs1442668983 CA368715694	149	W>G		No	ClinGen TOPMed
rs1249878121 CA368715702	150	E>K		No	ClinGen TOPMed
rs77359539 CA163447539	153	M>R		No	ClinGen TOPMed
CA368715729 rs77359539	153	M>T		No	ClinGen TOPMed
rs914045179 CA163447521	153	M>V		No	ClinGen TOPMed
CA4413555 rs542708497	154	A>V		No	ClinGen ExAC gnomAD
CA4413557 rs202069180	155	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs372583053 CA4413556	155	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA4413558 rs143788158	156	L>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA368715750 rs1330777585	157	G>D		No	ClinGen gnomAD
rs746611053 CA4413559	159	E>K		No	ClinGen ExAC gnomAD
rs1157150803 CA368715772	160	E>D		No	ClinGen gnomAD
rs1393354817 CA368715797	164	K>E		No	ClinGen gnomAD
CA4413560 rs768310536	164	K>R		No	ClinGen ExAC TOPMed gnomAD
CA4413562 rs141905334	166	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs375573347 CA4413564	167	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1411716337 CA368715817	167	A>P		No	ClinGen gnomAD
rs375573347 CA4413563	167	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs753130559 CA4413567	172	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA368715855 COSM1446884 rs1302284212	173	A>T	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA368715877 rs1290924891	176	D>V		No	ClinGen gnomAD
CA368715882 rs1563654506	177	V>I		No	ClinGen Ensembl
CA4413570 rs570334710	178	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4413571 rs757260413	178	R>H		No	ClinGen ExAC TOPMed gnomAD
CA4413572 rs757260413	178	R>L		No	ClinGen ExAC TOPMed gnomAD
CA368715898 rs200102694	179	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA368715892 rs1427349421	179	Y>H		No	ClinGen TOPMed
rs758350510 CA4413574 CA4413575	180	G>R		No	ClinGen ExAC TOPMed gnomAD
rs768504896 CA4413577	182	E>*		No	ClinGen ExAC
CA368715917 rs1586738958	183	S>A		No	ClinGen Ensembl
CA163447679 rs11538920	183	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA4413578 rs11538920	183	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA4413580 rs560973225	185	S>R		No	ClinGen ExAC gnomAD
CA368715926 rs1308666984	185	S>R		No	ClinGen gnomAD
rs772802522 CA4413581	186	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA368715941 rs1315101680	187	F>L		No	ClinGen gnomAD
rs760062101 CA4413583	189	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA368715959 rs1267794288	189	Q>P		No	ClinGen TOPMed
CA4413584 rs768147449	191	R>L		No	ClinGen ExAC TOPMed gnomAD
CA368715972 rs768147449	191	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA368715971 rs1314161074	191	R>W		No	ClinGen TOPMed gnomAD
rs1331185835 CA368715984	192	V>M		No	ClinGen TOPMed gnomAD
rs966938413 CA163448063	193	R>G		No	ClinGen TOPMed gnomAD
rs75691611 CA368715991	193	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs75691611 CA4413613	193	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA368715990 rs966938413	193	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs763006197 CA4413614	195	I>L		No	ClinGen ExAC gnomAD
rs1358630240 CA368716012	196	S>C		No	ClinGen TOPMed
rs1246490265 CA368716009	196	S>P		No	ClinGen TOPMed
CA368716021 rs1485150573	197	E>D		No	ClinGen gnomAD
CA163448086 rs912025356	198	E>*		No	ClinGen TOPMed
CA368716027 rs1265556743	198	E>D		No	ClinGen gnomAD
rs766492912 CA4413615	199	L>R		No	ClinGen ExAC
rs1586739333 CA368716038	200	V>G		No	ClinGen Ensembl
COSM3831479 CA368716042 rs1586739336	201	A>V	breast [Cosmic]	No	ClinGen cosmic curated Ensembl
rs150636663 CA368716046	202	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs150636663 CA4413617 COSM1178977	202	A>T	prostate [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA368716049 rs1197424828	202	A>V		No	ClinGen gnomAD
CA163448120 rs1048034404	203	S>N		No	ClinGen TOPMed
rs1159503607 CA368716059	204	R>K		No	ClinGen TOPMed gnomAD
CA163448148 rs967791669	208	Q>R		No	ClinGen Ensembl
rs1366182970 CA368716092	209	K>E		No	ClinGen gnomAD
rs755933895 CA4413621	210	A>S		No	ClinGen ExAC gnomAD
CA368716120 rs1280853788	213	P>T		No	ClinGen gnomAD
rs1306665029 CA368716138	215	K>M		No	ClinGen TOPMed gnomAD
CA4413623 rs201552506	215	K>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1475749213 CA368716144	216	P>R		No	ClinGen TOPMed
rs770536890 CA4413624	216	P>S		No	ClinGen ExAC gnomAD
CA368716149 rs1266524918	217	P>Q		No	ClinGen gnomAD
rs1490341830 CA368716152	218	E>K		No	ClinGen gnomAD
CA163448209 rs986744469	220	G>R		No	ClinGen TOPMed gnomAD
CA4413626 rs747466458	221	A>T		No	ClinGen ExAC
rs769215241 CA4413627	222	A>G		No	ClinGen ExAC TOPMed gnomAD
rs769215241 CA368716180	222	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1490126942 CA368716185	223	H>P		No	ClinGen TOPMed
CA368716183 rs1368040110	223	H>Y		No	ClinGen gnomAD
rs35310665 CA4413628	224	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA368716198 rs1417070845	225	P>S		No	ClinGen gnomAD
CA163448264 rs529846798	226	R>G		No	ClinGen ExAC TOPMed gnomAD
rs530661786 CA163448269	226	R>S		No	ClinGen 1000Genomes ExAC gnomAD
CA368716234 rs1385839265	229	L>Q		No	ClinGen TOPMed
CA4413644 rs374518114	230	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs147219459 CA368716264	234	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs147219459 CA4413647	234	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs781715136 CA4413646	234	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
CA368716306 rs771146660	237	D>E		No	ClinGen ExAC TOPMed
rs749456596 CA4413650	237	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs149295133 CA4413653	238	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1421915841 CA368716334	239	P>L		No	ClinGen TOPMed gnomAD
CA4413655 rs555553995	239	P>S		No	ClinGen ExAC TOPMed gnomAD
CA4413657 rs368660562	241	S>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1327486373 CA368716376	243	S>P		No	ClinGen gnomAD
CA4413658 rs763929295	244	P>S		No	ClinGen ExAC gnomAD
rs557613738 CA4413660	247	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs753697304 CA4413659	247	R>W	Variant assessed as Somatic; 0.0002108 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs937924960 CA163448557	248	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1321732122 CA368716483	250	A>V		No	ClinGen gnomAD
rs750100070 CA4413662	252	P>L		No	ClinGen ExAC TOPMed gnomAD
rs750100070 CA4413663	252	P>R		No	ClinGen ExAC TOPMed gnomAD
rs575719006 CA4413665	253	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA4413667 rs778047531	254	A>S		No	ClinGen ExAC gnomAD
CA4413668 rs749648883	254	A>V		No	ClinGen ExAC TOPMed gnomAD
rs774537250 CA4413670	256	V>A		No	ClinGen ExAC gnomAD
rs1000515753 CA163448636	256	V>M		No	ClinGen Ensembl
CA4413673 rs746121183	258	G>D		No	ClinGen ExAC gnomAD
rs1586739734 CA368716605	260	P>R		No	ClinGen Ensembl
CA163448669 rs902588150	261	V>L		No	ClinGen TOPMed
rs772153478 CA4413674	262	A>V		No	ClinGen ExAC
rs545896317 CA4413675	263	G>R		No	ClinGen 1000Genomes ExAC gnomAD
CA368716650 rs1343820858	264	S>F		No	ClinGen gnomAD
rs112002983 CA4413678	265	D>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4413677 COSM3949666 rs764127576	265	D>N	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA163448730 rs111757318	268	Q>L		No	ClinGen Ensembl
CA163448714 rs111757318	268	Q>P		No	ClinGen Ensembl
rs1245369402 CA368716784	270	A>D		No	ClinGen gnomAD
CA368716778 rs1180055821	270	A>T		No	ClinGen gnomAD
rs1383986891 CA368716822	273	L>V		No	ClinGen gnomAD
rs144573118 CA4413709	274	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA368716831 rs1431719397	274	E>K		No	ClinGen gnomAD
CA368716851 rs750754791	275	P>A		No	ClinGen ExAC TOPMed gnomAD
rs758860057 CA4413712	275	P>H		No	ClinGen ExAC gnomAD
rs750754791 CA368716853	275	P>S		No	ClinGen ExAC TOPMed gnomAD
CA4413711 rs750754791	275	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1384727909 CA368716872	277	H>Y		No	ClinGen gnomAD
CA4413714 rs747282451	278	F>L		No	ClinGen ExAC gnomAD
CA4413716 rs781450486	279	L>P		No	ClinGen ExAC TOPMed gnomAD
CA4413715 rs148425285	279	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1228931373 CA368716912	280	Q>*		No	ClinGen gnomAD
CA368716937 rs1251416337	281	C>F		No	ClinGen gnomAD
rs1193722997 CA368716956	282	H>L		No	ClinGen gnomAD
CA368717067 rs769859590	286	N>K		No	ClinGen ExAC gnomAD
CA4413717 rs748048714	286	N>S		No	ClinGen ExAC gnomAD
rs1440763156 CA368717082	287	S>N		No	ClinGen TOPMed
rs1372587872 CA368717101	288	P>L		No	ClinGen gnomAD
CA163448920 rs372762588	288	P>S		No	ClinGen ESP gnomAD
CA4413719 rs570902848	289	Q>*		No	ClinGen 1000Genomes ExAC
rs1407185666 CA368717198	292	E>D		No	ClinGen TOPMed gnomAD
rs370482367 CA4413721	292	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1421319554 CA368718299	296	W>R		No	ClinGen TOPMed
rs1586740010 CA368718324	297	A>D		No	ClinGen Ensembl
rs1335884705 CA368718351	299	A>T		No	ClinGen gnomAD
rs773848190 CA368718373	300	F>L		No	ClinGen ExAC gnomAD
CA163451089 rs1040788149	301	E>G		No	ClinGen TOPMed
CA368718375 rs1295592224	301	E>K		No	ClinGen gnomAD
COSM744376 rs766967262 CA4413725	302	P>L	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs759222684 CA4413724	302	P>S		No	ClinGen ExAC TOPMed gnomAD
rs765655034 CA4413728	303	A>G		No	ClinGen ExAC gnomAD
rs1203394041 CA368718443	303	A>P		No	ClinGen TOPMed gnomAD
CA368718445 rs1203394041	303	A>S		No	ClinGen TOPMed gnomAD
CA368718447 rs765655034	303	A>V		No	ClinGen ExAC gnomAD
rs1206239968 CA368718460	304	W>C		No	ClinGen gnomAD
rs750992768 CA4413729	304	W>R		No	ClinGen ExAC TOPMed gnomAD
rs1261716822 CA368718467	305	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA4413730 rs758664434	306	E>K		No	ClinGen ExAC gnomAD
rs751985953 CA4413753	307	G>E		No	ClinGen ExAC TOPMed gnomAD
rs766806541 CA4413731 CA368718501	307	G>R		No	ClinGen ExAC gnomAD
CA368718571 rs1297906013	308	A>S		No	ClinGen gnomAD
CA368718568 rs1297906013	308	A>T		No	ClinGen gnomAD
CA368718575 rs1375153004	308	A>V		No	ClinGen TOPMed gnomAD
rs558329285 CA163451444	309	T>I		No	ClinGen 1000Genomes
COSM1214038 rs1226641572 CA368718636	313	V>M	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs756118406 CA4413757	315	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1243643116 CA368718753	317	G>D		No	ClinGen gnomAD
rs979331933 CA163451499	317	G>S		No	ClinGen TOPMed gnomAD
rs1179557588 CA368718757	318	G>R		No	ClinGen TOPMed gnomAD
CA368718763 rs1179557588	318	G>W		No	ClinGen TOPMed gnomAD
rs1586740317 CA368718781	319	E>G		No	ClinGen Ensembl
TCGA novel	319	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368718804 rs1169306137	320	A>V		No	ClinGen TOPMed gnomAD
rs1471142179 CA368718807 CA368718806	321	V>L		No	ClinGen gnomAD
CA163451522 rs572894856	322	C>R		No	ClinGen 1000Genomes ExAC gnomAD
rs572894856 CA4413762	322	C>S		No	ClinGen 1000Genomes ExAC gnomAD
CA368718814 rs1382624077	322	C>Y		No	ClinGen gnomAD
CA163451534 rs866298455	323	V>I		No	ClinGen TOPMed gnomAD
rs866298455 CA368718830	323	V>L		No	ClinGen TOPMed gnomAD
rs746712396 CA368718862	324	I>M		No	ClinGen ExAC TOPMed gnomAD
rs894882359 CA163451541	324	I>T		No	ClinGen TOPMed
CA4413764 rs775099117	324	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1325977545 CA368718905	326	C>Y		No	ClinGen gnomAD
CA368718933 rs1205289989	327	Q>*		No	ClinGen gnomAD
CA4413766 rs539926870	328	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA368718979 rs539926870	328	T>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs749017286 CA163451549	328	T>S		No	ClinGen TOPMed gnomAD
CA163451593 rs967968057	329	G>S		No	ClinGen TOPMed
rs999412968 CA163451602	330	I>F		No	ClinGen TOPMed gnomAD
CA368719033 CA368719037 rs371074849	331	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA4413769 rs371074849	331	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA368719059 rs1563655684	332	L>F		No	ClinGen Ensembl
CA4413770 rs375633907	332	L>R		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	333	H>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4413771 rs759957740	333	H>Q		No	ClinGen ExAC
rs1413182975 CA368719082	333	H>Y		No	ClinGen gnomAD
CA163451699 rs143862915	334	K>E		No	ClinGen ESP TOPMed gnomAD
rs1218934500 CA368719129	335	Y>D		No	ClinGen TOPMed
CA4413772 rs768036912	336	K>R		No	ClinGen ExAC
CA368719190 rs1296459750	337	A>P		No	ClinGen gnomAD
CA368719209 rs1347567402	337	A>V		No	ClinGen gnomAD
rs1283612812 CA368719232	338	P>L		No	ClinGen gnomAD
CA368719223 rs1224372270	338	P>S		No	ClinGen gnomAD
rs573274500 CA4413774	339	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4413776 rs372295492	340	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1215198553 CA368719270	340	E>V		No	ClinGen TOPMed gnomAD
rs751373991 CA4413801	341	E>A		No	ClinGen ExAC gnomAD
rs984806972 CA368719386	341	E>D		No	ClinGen TOPMed
CA368719437 rs1197188798	343	F>S		No	ClinGen gnomAD
CA4413804 rs747796427	346	A>P		No	ClinGen ExAC gnomAD
rs1586740634 CA368719578	348	T>P		No	ClinGen Ensembl
rs777449211 CA4413806	349	A>T		No	ClinGen ExAC TOPMed gnomAD
rs746321891 CA4413807	349	A>V		No	ClinGen ExAC gnomAD
CA163452130 rs1048238984	350	L>V		No	ClinGen TOPMed
CA368719698 rs1316336664	353	V>F		No	ClinGen TOPMed
CA368719695 rs1316336664	353	V>I		No	ClinGen TOPMed
CA4413809 rs201003437	361	R>C		No	ClinGen ExAC gnomAD
rs761091580 CA4413810	361	R>H		No	ClinGen ExAC TOPMed gnomAD
CA368719940 rs1586740671	362	W>C		No	ClinGen Ensembl
CA368719922 rs1563655923	362	W>R		No	ClinGen Ensembl
CA4413812 rs776877482	363	S>C		No	ClinGen ExAC gnomAD
CA4413813 rs762049970	363	S>N		No	ClinGen ExAC gnomAD
rs1292882254 CA368719986	364	V>M		No	ClinGen TOPMed
CA368720024 rs1311307667	365	L>V		No	ClinGen gnomAD
CA368720042 rs1229053504	366	A>T		No	ClinGen gnomAD
rs888310940 CA163452191	366	A>V		No	ClinGen gnomAD
rs773290868 CA4413815	368	A>V		No	ClinGen ExAC gnomAD
rs762809716 CA4413816	370	L>P		No	ClinGen ExAC gnomAD
rs751501194 CA163452224	371	R>L		No	ClinGen ExAC TOPMed gnomAD
rs751501194 CA4413818	371	R>P		No	ClinGen ExAC TOPMed gnomAD
rs751501194 CA4413819	371	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs151324218 CA4413817	371	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1434119810 CA368720182	372	G>S		No	ClinGen TOPMed
rs767248735 CA4413820	374	V>L		No	ClinGen ExAC TOPMed gnomAD
CA4413822 rs372063952	375	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA4413821 rs752346910	375	R>W		No	ClinGen ExAC TOPMed gnomAD
rs777353850 CA4413823	376	L>P		No	ClinGen ExAC gnomAD
rs780584773 CA4413826	378	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs756888389 CA4413825	378	H>Y		No	ClinGen ExAC gnomAD
rs769022777 CA4413828	379	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA4413829 rs376560819	380	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA4413830 rs376560819	380	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs763006469 CA368720449	382	G>R		No	ClinGen ExAC TOPMed gnomAD
CA4413833 rs763006469	382	G>S		No	ClinGen ExAC TOPMed gnomAD
CA4413834 rs766409296	383	F>L		No	ClinGen ExAC gnomAD
CA4413836 rs759416316	386	G>R		No	ClinGen ExAC TOPMed gnomAD
CA368720566 rs1233043997	387	V>I		No	ClinGen gnomAD
TCGA novel	387	V>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767286922 CA4413838	389	R>*		No	ClinGen ExAC gnomAD
CA4413837 rs767286922	389	R>G		No	ClinGen ExAC gnomAD
rs756042964 CA4413840	389	R>P		No	ClinGen ExAC TOPMed gnomAD
COSM1446886 rs756042964 CA4413839	389	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs199640101 CA4413841	390	A>S		No	ClinGen 1000Genomes ESP ExAC gnomAD
rs199640101 CA163452345	390	A>T		No	ClinGen 1000Genomes ESP ExAC gnomAD
rs1487394326 CA368720660	392	K>E		No	ClinGen gnomAD
rs1433534747 CA368720700 CA368720698	393	K>N		No	ClinGen gnomAD
CA163452362 rs947785313	393	K>R		No	ClinGen TOPMed gnomAD
rs947785313 CA368720692	393	K>T		No	ClinGen TOPMed gnomAD
rs1175142418 CA368720706	394	A>P		No	ClinGen gnomAD
CA368720708 rs1175142418	394	A>S		No	ClinGen gnomAD
CA368720722 rs1375821269	395	I>F		No	ClinGen gnomAD
CA368720720 rs1375821269	395	I>V		No	ClinGen gnomAD
CA368720737 rs1158653902	396	A>T		No	ClinGen gnomAD
rs1345793699 CA368720846	401	S>N		No	ClinGen gnomAD
CA4413843 rs778313861	402	P>T		No	ClinGen ExAC TOPMed gnomAD
rs747497615 CA368720890	403	A>S		No	ClinGen ExAC TOPMed gnomAD
rs747497615 CA4413844	403	A>T		No	ClinGen ExAC TOPMed gnomAD
rs201885983 CA368720924	404	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs755451370 CA4413845	404	H>R		No	ClinGen ExAC TOPMed gnomAD
rs201914011 CA368720951 CA4413848	405	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs535806746 CA4413847	405	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA368720958 rs1488296900	406	T>A		No	ClinGen gnomAD
rs1179162564 CA368720991	407	H>Q		No	ClinGen gnomAD
CA4413849 rs372243462	407	H>R		No	ClinGen ESP ExAC gnomAD
CA368720975 rs1265004964	407	H>Y		No	ClinGen TOPMed gnomAD
rs749544550 CA4413850	408	L>F		No	ClinGen ExAC gnomAD
rs140653534	410	T>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA4413877 COSM3698013 rs760721958	410	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA4413880 rs761459558	413	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs762347199 CA4413883	416	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs750146673 COSM1214040 CA4413882	416	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1273729005 CA368721431	418	I>V		No	ClinGen TOPMed
rs1563656513 CA368721500	422	I>V		No	ClinGen Ensembl
CA4413887 rs145369828	423	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA368721528 rs1341294266	424	V>L		No	ClinGen gnomAD
CA368721540 rs1276619500	425	P>L		No	ClinGen TOPMed gnomAD
rs201681487 CA368721536	425	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4413889 rs201681487	425	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4413891 rs757701941	427	Q>L		No	ClinGen ExAC gnomAD
rs746146294 CA4413893	428	D>E		No	ClinGen ExAC TOPMed gnomAD
CA4413896 rs142392925	429	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs772001352 CA4413894	429	Y>C		No	ClinGen ExAC gnomAD
CA4413897 rs376949005	430	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs567061763 CA4413898	431	F>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1456641260 CA368721658	432	Q>*		No	ClinGen TOPMed
CA4413899 rs747880474	432	Q>R		No	ClinGen ExAC gnomAD
CA4413928 rs370005669	437	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA368721839 rs765458287	438	T>I		No	ClinGen ExAC TOPMed gnomAD
CA4413929 rs765458287	438	T>R		No	ClinGen ExAC TOPMed gnomAD
CA163453681 rs544990990	440	D>E		No	ClinGen 1000Genomes
rs769341585 CA163453658	440	D>H		No	ClinGen ExAC gnomAD
CA4413931 rs769341585	440	D>N		No	ClinGen ExAC gnomAD
rs202106137 CA4413932	441	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs377312037 CA4413935 COSM1083504	447	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs781364822 CA4413936	447	R>H		No	ClinGen ExAC gnomAD
COSM1214041 rs749067680 CA4413940	452	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1445956311 CA368722052	452	A>V		No	ClinGen gnomAD
rs1341724854 CA368722056	453	S>P		No	ClinGen TOPMed gnomAD
CA368722072 rs1244950835	454	C>R		No	ClinGen gnomAD
rs778503361 CA4413943	455	P>L		No	ClinGen ExAC TOPMed gnomAD
rs778503361 CA4413942	455	P>R		No	ClinGen ExAC TOPMed gnomAD
CA4413946 rs762163297	457	A>T		No	ClinGen ExAC TOPMed gnomAD
rs770332230 CA4413947	458	R>C		No	ClinGen ExAC TOPMed gnomAD
CA4413948 rs542888497	458	R>H		No	ClinGen 1000Genomes ExAC gnomAD
CA368722147 rs542888497	458	R>L		No	ClinGen 1000Genomes ExAC gnomAD
rs372834127 CA163453846	459	L>P		No	ClinGen ESP TOPMed
rs763389210 CA4413949	460	L>P		No	ClinGen ExAC gnomAD
CA368722159 rs1366887176	461	A>T		No	ClinGen gnomAD
CA368722176 rs1464957283	462	G>D		No	ClinGen gnomAD
CA4413953 rs759851428	462	G>S		No	ClinGen ExAC gnomAD
CA368722188 rs1484621352	463	C>S		No	ClinGen TOPMed
CA163453892 rs957285968	463	C>W		No	ClinGen TOPMed gnomAD
rs1404320320 CA368722191	463	C>Y		No	ClinGen gnomAD
rs1332961523 CA368722199	464	E>K		No	ClinGen TOPMed gnomAD
rs374902207 CA4413954	465	G>D		No	ClinGen ESP ExAC gnomAD
rs1554580139 CA4413958	466	G>S		No	ClinGen Ensembl
CA4413960 rs756204371	468	C>Y		No	ClinGen ExAC gnomAD
rs1291804742 CA368722295	470	W>*		No	ClinGen TOPMed
rs1220853858 CA368722306	471	D>Y		No	ClinGen TOPMed
CA163453932 CA368722320 rs757003383	472	V>L		No	ClinGen ExAC TOPMed gnomAD
CA4413964 rs757003383	472	V>M		No	ClinGen ExAC TOPMed gnomAD
CA368722335 rs201589745	473	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4413966 rs201589745	473	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4413965 rs778697756	473	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1262799064 CA368722351	474	L>P		No	ClinGen gnomAD
CA4413967 rs771764805	474	L>V		No	ClinGen ExAC gnomAD
rs1457579540 CA368722353	475	D>H		No	ClinGen TOPMed
CA368722371 rs1379250292	476	Q>E		No	ClinGen gnomAD
CA163453968 rs370868394	477	P>S		No	ClinGen gnomAD
rs370868394 CA368722385	477	P>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA4413972 rs763587231	478	Q>P		No	ClinGen ExAC TOPMed gnomAD
CA4414013 CA368723329 rs772429333	481	R>S		No	ClinGen ExAC gnomAD
rs774859657 CA4413974	481	R>W		No	ClinGen ExAC TOPMed gnomAD
CA4414014 rs775728037	482	V>A		No	ClinGen ExAC TOPMed gnomAD
rs1426233871 CA368723346	483	C>R		No	ClinGen TOPMed gnomAD
rs747185253 CA4414015	483	C>Y		No	ClinGen ExAC gnomAD
CA368723363 rs1170566528	484	E>K		No	ClinGen gnomAD
CA368723378 rs1450238014	485	V>M		No	ClinGen gnomAD
CA368723395 rs1303510765	486	E>V		No	ClinGen gnomAD
rs527362228 CA163457104	488	V>I		No	ClinGen ExAC TOPMed gnomAD
CA4414018 rs527362228	488	V>L		No	ClinGen ExAC TOPMed gnomAD
rs1228710770 CA368723457	490	S>C		No	ClinGen TOPMed
CA368723451 rs1272152174	490	S>P		No	ClinGen gnomAD
CA163457149 rs879939583	491	E>G		No	ClinGen TOPMed gnomAD
rs561603036 CA4414020	491	E>K		No	ClinGen 1000Genomes ExAC gnomAD
CA368723463 rs561603036	491	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs376086325 CA368723482	492	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
COSM150362 rs1237555697 CA368723475	492	G>C	stomach [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA4414021 rs376086325	492	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA368723505 rs146629843	494	E>*		No	ClinGen 1000Genomes ExAC gnomAD
rs146629843 CA4414023	494	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs146629843 CA368723504	494	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs113220559 CA4414025	495	A>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4414024 rs113220559 RCV000952539	495	A>S		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA4414026 rs767255596	495	A>V		No	ClinGen ExAC gnomAD
rs1416657114 CA368723533	496	S>F		No	ClinGen gnomAD
CA4414027 rs752435769	497	G>A		No	ClinGen ExAC gnomAD
rs141553698 CA4414029	498	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA163457248 rs147046550	498	R>P		No	ClinGen 1000Genomes ESP TOPMed gnomAD
rs147046550 CA4414030	498	R>Q		No	ClinGen 1000Genomes ESP TOPMed gnomAD
rs141553698 CA4414028	498	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA163457269 rs1056146001	499	R>G		No	ClinGen Ensembl
CA368723573 rs1300241009	499	R>K		No	ClinGen gnomAD
rs1341394819 CA368723598	500	V>L		No	ClinGen gnomAD
CA4414032 rs750880780	501	D>G		No	ClinGen ExAC gnomAD
CA368723725 rs1269393410	504	A>V		No	ClinGen gnomAD
rs758830295 CA4414033	505	F>L		No	ClinGen ExAC gnomAD
rs1220869006 CA368723785	506	V>G		No	ClinGen gnomAD
CA163457316 rs1005236323	507	N>S		No	ClinGen TOPMed gnomAD
rs1279316690 CA368723794	507	N>Y		No	ClinGen gnomAD
CA368723856 rs1198117332	509	D>N		No	ClinGen TOPMed
rs780681056 CA4414034	510	I>V		No	ClinGen ExAC gnomAD
CA368723921 rs1240710930	511	V>A		No	ClinGen gnomAD
CA368723911 COSM1214039 rs1193308240	511	V>M	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA368725327 rs1272954186	513	S>F		No	ClinGen TOPMed gnomAD
rs775794017 CA163459045	514	K>R		No	ClinGen Ensembl
rs1201059781 CA368725343	515	G>E		No	ClinGen gnomAD
rs993526415 CA163459071 COSM1446889	516	S>R	large_intestine [Cosmic]	No	ClinGen cosmic curated Ensembl
CA163459101 rs947710319	517	G>S		No	ClinGen TOPMed gnomAD
CA368725403 rs1314946718	519	G>A		No	ClinGen TOPMed
rs367887639 CA4414055	520	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs367887639 CA368725406	520	T>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs1209573737 CA368725428	521	I>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
TCGA novel	522	C>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1390263579 CA368725459	523	L>P		No	ClinGen gnomAD
CA368725465 rs1341822566	524	W>*		No	ClinGen TOPMed gnomAD
CA368725523 rs1292360770	527	R>G		No	ClinGen gnomAD
rs1333123359 CA368725533	527	R>K		No	ClinGen gnomAD
rs1220891433 CA368725544	528	Q>*		No	ClinGen gnomAD
rs1220891433 CA368725547	528	Q>E		No	ClinGen gnomAD
CA4414058 rs368086160	529	T>M		No	ClinGen ExAC TOPMed gnomAD
rs774114154 CA368725584	530	W>*		No	ClinGen ExAC TOPMed gnomAD
CA368725588 rs200423098	530	W>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA4414064 CA163459164 rs200423098	530	W>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs539175596 CA4414061	530	W>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs774114154 CA4414063	530	W>L		No	ClinGen ExAC TOPMed gnomAD
CA368725574 rs539175596	530	W>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs774114154 CA4414062	530	W>S		No	ClinGen ExAC TOPMed gnomAD
CA368725606 rs1443133003	531	G>E		No	ClinGen gnomAD
rs775426091 CA4414065 CA4414066	531	G>R		No	ClinGen ExAC TOPMed gnomAD
rs775426091 CA368725599	531	G>W		No	ClinGen ExAC TOPMed gnomAD
CA368725616 rs776399003	532	G>C		No	ClinGen ExAC TOPMed gnomAD
rs1474080229 CA368725619	532	G>D		No	ClinGen gnomAD
CA368725614 rs776399003	532	G>R		No	ClinGen ExAC TOPMed gnomAD
CA4414068 rs776399003	532	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1474080229 CA368725623	532	G>V		No	ClinGen gnomAD
CA4414071 rs557391679	533	R>L		No	ClinGen 1000Genomes ExAC gnomAD
rs557391679 CA4414070	533	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs761200453 CA4414069	533	R>W		No	ClinGen ExAC TOPMed gnomAD
rs767803214 CA4414073	534	G>A		No	ClinGen ExAC gnomAD
rs767803214 CA368725650	534	G>D		No	ClinGen ExAC gnomAD
rs755491507 CA4414072	534	G>S		No	ClinGen ExAC gnomAD
rs753056744 CA4414074	535	S>N		No	ClinGen ExAC TOPMed gnomAD
CA4414076 rs756549538	535	S>R		No	ClinGen ExAC gnomAD
CA4414078 rs757234013	536	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA4414077 rs749553364	536	Q>K		No	ClinGen ExAC
CA368725703 rs1279251513	537	S>C		No	ClinGen TOPMed gnomAD
CA368725705 rs1279251513	537	S>F		No	ClinGen TOPMed gnomAD
CA4414080 rs145790713	538	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs775622533 CA4414082	541	V>G		No	ClinGen ExAC gnomAD
TCGA novel	542	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1210292387 CA368725764	542	V>M		No	ClinGen gnomAD
rs1563658939 CA368725781	543	V>I		No	ClinGen Ensembl
CA4414084 rs372186219	545	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA4414085 rs372186219	545	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA4414088 rs202055278	546	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA4414087 rs764596350	546	R>W		No	ClinGen ExAC TOPMed gnomAD
CA368725853 rs1431259829	548	Q>*		No	ClinGen TOPMed
rs1391164231 CA368725857	548	Q>R		No	ClinGen TOPMed
rs1172504434 CA368725864	549	W>*		No	ClinGen gnomAD
CA163459372 rs375511324	549	W>C		No	ClinGen ESP
CA4414090 rs554936253	550	S>L	Variant assessed as Somatic; 5.328e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA368725873 rs554936253	550	S>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4414093 rs764540681	552	T>A		No	ClinGen ExAC gnomAD
rs757503363 CA4414095	553	E>K		No	ClinGen ExAC gnomAD
CA368725899 rs1356027610	555	A>P		No	ClinGen gnomAD
CA368725901 rs1356027610	555	A>T		No	ClinGen gnomAD
CA368725920 rs1260413561	557	F>L		No	ClinGen gnomAD
CA4414099 rs150762600	558	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA4414098 rs758603982	558	S>P		No	ClinGen ExAC TOPMed gnomAD
CA368725924 rs150762600	558	S>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA4414105 rs747690267	561	A>P		No	ClinGen ExAC TOPMed gnomAD
rs747690267 CA4414104	561	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA163459468 rs924972310	562	C>Y		No	ClinGen TOPMed gnomAD
CA4414108 rs770459556	563	P>A		No	ClinGen ExAC TOPMed gnomAD
CA368725951 rs770459556	563	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1428783000 CA368725972	564	D>E		No	ClinGen gnomAD
CA4414148 rs748871732	565	K>E		No	ClinGen ExAC TOPMed gnomAD
rs569362171 CA4414150	566	G>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs142410118 CA4414149	566	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA368725987 rs1413873679	567	I>F		No	ClinGen gnomAD
TCGA novel	567	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4414152 rs771519188	567	I>T		No	ClinGen ExAC TOPMed gnomAD
CA368725999 rs1215075507	569	L>F		No	ClinGen gnomAD
TCGA novel	569	L>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4414154 rs201275039	569	L>R		No	ClinGen 1000Genomes ExAC gnomAD
rs557927414 CA4414156	570	C>F		No	ClinGen 1000Genomes ExAC gnomAD
CA163459770 rs145973282	570	C>R		No	ClinGen ESP TOPMed gnomAD
CA4414158 rs773720792	572	D>N		No	ClinGen ExAC TOPMed gnomAD
CA4414157 rs773720792	572	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA368726020 rs1563659273	573	E>K		No	ClinGen Ensembl
rs1265792257 CA368726028	574	E>K		No	ClinGen gnomAD
CA368726039 rs766694949	575	G>D		No	ClinGen ExAC TOPMed gnomAD
CA4414161 rs766694949	575	G>V		No	ClinGen ExAC TOPMed gnomAD
CA4414162 rs774487177	576	N>D		No	ClinGen ExAC gnomAD
CA368726048 rs143165955 COSM1622141	577	V>L	liver [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs143165955 CA4414163	577	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs752620718 CA4414165	578	W>*		No	ClinGen ExAC gnomAD
CA368726056 rs1375002144	578	W>*		No	ClinGen gnomAD
CA368726063 rs1300343517	579	L>F		No	ClinGen gnomAD
CA4414168 rs144458335	580	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs10249943 CA4414172	581	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4414170 rs757089708	581	D>G		No	ClinGen ExAC gnomAD
CA4414169 rs753613507	581	D>N		No	ClinGen ExAC TOPMed gnomAD
rs767161528 CA4414174	582	V>F		No	ClinGen ExAC gnomAD
CA4414173 rs767161528 COSM1330210	582	V>I	ovary Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA4414175 rs748602816	583	S>R		No	ClinGen ExAC gnomAD
rs770420634 CA4414176	585	I>M		No	ClinGen ExAC gnomAD
rs774107879 CA163459911	585	I>V		No	ClinGen Ensembl
rs1452325826 CA368726105	586	L>Q		No	ClinGen TOPMed
CA4414177 rs773914956	589	P>L		No	ClinGen ExAC gnomAD
CA368726126 rs1489755477	589	P>S		No	ClinGen gnomAD
rs771241277 CA4414179	590	P>R		No	ClinGen ExAC gnomAD
rs749651123 CA4414178	590	P>S		No	ClinGen ExAC gnomAD
CA4414180 rs537769035	592	L>M		No	ClinGen 1000Genomes ExAC gnomAD
rs148981077 CA4414183	593	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4414182 rs201290252	593	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201290252 CA4414181	593	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA368726160 rs1586745957	596	L>P		No	ClinGen Ensembl
rs1369310153 CA368726166	597	Q>R		No	ClinGen TOPMed
CA4414189 rs757003570	598	A>D		No	ClinGen ExAC TOPMed gnomAD
CA368726170 rs1563659434	598	A>T		No	ClinGen Ensembl
CA368726174 rs757003570	598	A>V		No	ClinGen ExAC TOPMed gnomAD
CA4414191 rs750036357	600	T>A		No	ClinGen ExAC gnomAD
CA368726184 rs757995965	600	T>I		No	ClinGen ExAC gnomAD
CA4414192 rs757995965	600	T>K		No	ClinGen ExAC gnomAD
CA368726189 rs1190354754	601	Q>R		No	ClinGen TOPMed
rs144678334 CA368726211	603	L>M		No	ClinGen ESP ExAC gnomAD
rs144678334 CA4414238	603	L>V		No	ClinGen ESP ExAC gnomAD
CA368726224 rs1586746300	605	W>R		No	ClinGen Ensembl
CA4414241 rs147900518	607	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA830703567 rs1253473823	609	W>*		No	ClinGen TOPMed
CA4414243 rs780413395	609	W>C		No	ClinGen ExAC TOPMed gnomAD
CA368726254 rs1586746322	609	W>L		No	ClinGen Ensembl
rs758639657 CA4414242	609	W>R		No	ClinGen ExAC TOPMed gnomAD
CA163460422 rs916318558	610	A>S		No	ClinGen TOPMed gnomAD
rs200710432 CA4414244	610	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs755193043 CA4414245	611	L>F		No	ClinGen ExAC TOPMed gnomAD
CA368726267 rs1247956420	612	G>S		No	ClinGen gnomAD
CA368726275 rs1311955066	613	Q>*		No	ClinGen gnomAD
CA4414246 rs781455530	613	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs369747780 CA4414247	614	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs979096454 CA163460435	617	K>N		No	ClinGen TOPMed
TCGA novel	618	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4414253 rs549030610	619	M>T		No	ClinGen 1000Genomes ExAC TOPMed
rs759460734 CA4414254	620	V>L		No	ClinGen ExAC TOPMed gnomAD
rs767255967 CA4414256	621	N>T		No	ClinGen ExAC gnomAD
CA368726335 rs1415293052	622	T>I		No	ClinGen gnomAD
rs1446362200 CA368726339	623	V>A		No	ClinGen gnomAD
rs775244670 CA4414257	623	V>L		No	ClinGen ExAC gnomAD
CA4414258 rs191022008	624	V>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs763680178 CA4414259	625	A>S		No	ClinGen ExAC gnomAD
rs763680178 CA4414260	625	A>T		No	ClinGen ExAC gnomAD
rs758912423 CA4414262	626	N>I		No	ClinGen ExAC TOPMed gnomAD
CA4414261 rs758912423	626	N>S		No	ClinGen ExAC TOPMed gnomAD
CA4414264 rs755389275	628	S>A		No	ClinGen ExAC TOPMed gnomAD
CA4414265 rs781361448	628	S>Y		No	ClinGen ExAC TOPMed gnomAD
rs748433864 CA4414266	629	F>S		No	ClinGen ExAC TOPMed gnomAD
rs756100065 CA4414267	630	T>I		No	ClinGen ExAC gnomAD
CA368726379 rs1586746447	631	Y>H		No	ClinGen Ensembl
CA368726388 rs1371776557	632	L>F		No	ClinGen gnomAD
rs889192109 CA163460634	634	A>D		No	ClinGen TOPMed
rs150396748 CA4414271 COSM199901	634	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA163460658 rs745627593	635	L>P		No	ClinGen ExAC
CA4414272 rs745627593	635	L>Q		No	ClinGen ExAC
CA368726403 rs1240839730	635	L>V		No	ClinGen gnomAD
rs772019011 CA4414273	636	T>M		No	ClinGen ExAC gnomAD
rs760386246 CA4414275	638	S>A		No	ClinGen ExAC gnomAD
CA4414276 rs763448049	638	S>Y		No	ClinGen ExAC gnomAD
CA368726422 rs1192494910	639	N>H		No	ClinGen gnomAD
rs761375055 CA4414278	639	N>S		No	ClinGen ExAC TOPMed gnomAD
rs767947918 CA4414282	641	V>A		No	ClinGen ExAC gnomAD
CA4414281 rs376230863	641	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	642	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368726450 rs1307885949	643	I>T		No	ClinGen TOPMed
CA368726459 rs1291863826	644	W>*		No	ClinGen gnomAD
rs1586746538 CA368726455	644	W>R		No	ClinGen Ensembl
rs756353133 CA4414286	645	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1392167880 CA368726469	646	R>K		No	ClinGen gnomAD
CA368726470 rs1392167880	646	R>T		No	ClinGen gnomAD
rs1277527121 CA368726480	647	M>I		No	ClinGen TOPMed
rs757453164 CA4414290	648	M>Q		No	ClinGen ExAC TOPMed gnomAD
CA368726489 rs148895778	648	M>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD

No associated diseases with Q9UFC0

7 regional properties for Q9UFC0

Type	Name	Position	InterPro Accession
repeat	Leucine-rich repeat	48 - 69	IPR001611
repeat	WD40 repeat	272 - 325	IPR001680-1
repeat	WD40 repeat	381 - 422	IPR001680-2
repeat	WD40 repeat	540 - 581	IPR001680-3
repeat	Leucine-rich repeat, typical subtype	46 - 69	IPR003591
conserved_site	WD40 repeat, conserved site	408 - 422	IPR019775
repeat	Leucine rich repeat 4	47 - 87	IPR025875

Functions

		Description
EC Number
Subcellular Localization	Nucleus Chromosome, centromere Chromosome, telomere Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Chromosome, centromere, kinetochore	Localizes to heterochromatin during G1 phase Restricted to centromeres or telomeres as cells progress though S phase When cells enter mitosis, relocalizes to centromeres Recruitment to pericentric heterochromatin largely depends on the presence of H3K9me3
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

10 GO annotations of cellular component

Name	Definition
chromosome, telomeric region	The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
kinetochore	A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
microtubule organizing center	An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
nuclear origin of replication recognition complex	A multisubunit complex that is located at the replication origins of a chromosome in the nucleus.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
pericentric heterochromatin	Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3).

3 GO annotations of molecular function

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
methyl-CpG binding	Binding to a methylated cytosine/guanine dinucleotide.
methylated histone binding	Binding to a histone in which a residue has been modified by methylation.

3 GO annotations of biological process

Name	Definition
chromatin organization	The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
DNA replication initiation	The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
establishment of protein localization to chromatin	The directed movement of a protein to a part of a chromosome that is organized into chromatin.

36 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3MHH9	ECM2	Extracellular matrix protein 2	Bos taurus (Bovine)	PR
P58874	OPTC	Opticin	Bos taurus (Bovine)	PR
Q24K06	LRRC10	Leucine-rich repeat-containing protein 10	Bos taurus (Bovine)	PR
Q9V780	Lap1	Protein lap1	Drosophila melanogaster (Fruit fly)	PR
Q96NW7	LRRC7	Leucine-rich repeat-containing protein 7	Homo sapiens (Human)	PR
Q8IWT6	LRRC8A	Volume-regulated anion channel subunit LRRC8A	Homo sapiens (Human)	PR
Q9HCJ2	LRRC4C	Leucine-rich repeat-containing protein 4C	Homo sapiens (Human)	PR
Q96L50	LRR1	Leucine-rich repeat protein 1	Homo sapiens (Human)	PR
Q86UN2	RTN4RL1	Reticulon-4 receptor-like 1	Homo sapiens (Human)	PR
Q8IWK6	ADGRA3	Adhesion G protein-coupled receptor A3	Homo sapiens (Human)	PR
Q7L1W4	LRRC8D	Volume-regulated anion channel subunit LRRC8D	Homo sapiens (Human)	PR
Q96FE5	LINGO1	Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1	Homo sapiens (Human)	PR
Q8TDW0	LRRC8C	Volume-regulated anion channel subunit LRRC8C	Homo sapiens (Human)	PR
Q38SD2	LRRK1	Leucine-rich repeat serine/threonine-protein kinase 1	Homo sapiens (Human)	EV
A6H694	Lrrc63	Leucine-rich repeat-containing protein 63	Mus musculus (Mouse)	PR
Q9D9Q0	Lrrc69	Leucine-rich repeat-containing protein 69	Mus musculus (Mouse)	PR
Q8BGI7	Lrrc39	Leucine-rich repeat-containing protein 39	Mus musculus (Mouse)	PR
Q7TT36	Adgra3	Adhesion G protein-coupled receptor A3	Mus musculus (Mouse)	PR
P59383	Lrrn4	Leucine-rich repeat neuronal protein 4	Mus musculus (Mouse)	PR
Q9D1T0	Lingo1	Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1	Mus musculus (Mouse)	PR
Q8R502	Lrrc8c	Volume-regulated anion channel subunit LRRC8C	Mus musculus (Mouse)	PR
Q80WG5	Lrrc8a	Volume-regulated anion channel subunit LRRC8A	Mus musculus (Mouse)	PR
Q8K0S5	Rtn4rl1	Reticulon-4 receptor-like 1	Mus musculus (Mouse)	PR
Q80TE7	Lrrc7	Leucine-rich repeat-containing protein 7	Mus musculus (Mouse)	PR
Q5DU41	Lrrc8b	Volume-regulated anion channel subunit LRRC8B	Mus musculus (Mouse)	PR
Q5RKR3	Islr2	Immunoglobulin superfamily containing leucine-rich repeat protein 2	Mus musculus (Mouse)	PR
Q8C031	Lrrc4c	Leucine-rich repeat-containing protein 4C	Mus musculus (Mouse)	PR
P70587	Lrrc7	Leucine-rich repeat-containing protein 7	Rattus norvegicus (Rat)	PR
Q4V8G0	Lrrc63	Leucine-rich repeat-containing protein 63	Rattus norvegicus (Rat)	PR
Q80WD0	Rtn4rl1	Reticulon-4 receptor-like 1	Rattus norvegicus (Rat)	PR
Q9TZM3	lrk-1	Leucine-rich repeat serine/threonine-protein kinase 1	Caenorhabditis elegans	SS
Q9SHI4	RLP3	Receptor-like protein 3	Arabidopsis thaliana (Mouse-ear cress)	SS
Q5G5E0	PIRL5	Plant intracellular Ras-group-related LRR protein 5	Arabidopsis thaliana (Mouse-ear cress)	PR
Q68F79	lrrc8e	Volume-regulated anion channel subunit LRRC8E	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
B0JZ65	lrwd1	Leucine-rich repeat and WD repeat-containing protein 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
B0R160	lrwd1	Leucine-rich repeat and WD repeat-containing protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MGPLSARLLM	QRGRPKSDRL	GKIRSLDLSG	LELLSEHLDP	KLLCRLTQLQ	ELDLSNNHLE
70	80	90	100	110	120
TLPDNLGLSH	LRVLRCANNQ	LGDVTALCQF	PKLEELSLEG	NPFLTVNDNL	KVSFLLPTLR
130	140	150	160	170	180
KVNGKDASST	YSQVENLNRE	LTSRVTAHWE	KFMATLGPEE	EAEKAQADFV	KSAVRDVRYG
190	200	210	220	230	240
PESLSEFTQW	RVRMISEELV	AASRTQVQKA	NSPEKPPEAG	AAHKPRARLA	ALKRPDDVPL
250	260	270	280	290	300
SLSPSKRACA	SPSAQVEGSP	VAGSDGSQPA	VKLEPLHFLQ	CHSKNNSPQD	LETQLWACAF
310	320	330	340	350	360
EPAWEEGATS	QTVATCGGEA	VCVIDCQTGI	VLHKYKAPGE	EFFSVAWTAL	MVVTQAGHKK
370	380	390	400	410	420
RWSVLAAAGL	RGLVRLLHVR	AGFCCGVIRA	HKKAIATLCF	SPAHETHLFT	ASYDKRIILW
430	440	450	460	470	480
DIGVPNQDYE	FQASQLLTLD	TTSIPLRLCP	VASCPDARLL	AGCEGGCCCW	DVRLDQPQKR
490	500	510	520	530	540
RVCEVEFVFS	EGSEASGRRV	DGLAFVNEDI	VASKGSGLGT	ICLWSWRQTW	GGRGSQSTVA
550	560	570	580	590	600
VVVLARLQWS	STELAYFSLS	ACPDKGIVLC	GDEEGNVWLY	DVSNILKQPP	LLPAALQAPT
610	620	630	640
QILKWPQPWA	LGQVVTKTMV	NTVVANASFT	YLTALTDSNI	VAIWGRM