AiPD: Autoinhibited Protein Database

Q9UEW8

Gene name	STK39 (SPAK)
Protein name	STE20/SPS1-related proline-alanine-rich protein kinase
Names	Ste-20-related kinase, DCHT, Serine/threonine-protein kinase 39
Species	Homo sapiens (Human)
KEGG Pathway	hsa:27347
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-88 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-88 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

209-237 (Activation loop from InterPro)

Target domain	63-337 (Protein kinase domain)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q9UEW8

Entry ID	Method	Resolution	Chain	Position	Source
7O86	X-ray	173 A	A/B	441-545	PDB
AF-Q9UEW8-F1	Predicted				AlphaFoldDB

319 variants for Q9UEW8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs774637794 CA1949290	2	A>E		No	ClinGen ExAC gnomAD
rs774637794 CA349253877	2	A>V		No	ClinGen ExAC gnomAD
rs1238134942 CA349253870	3	E>D		No	ClinGen TOPMed gnomAD
CA349253866 rs1376804558	4	P>S		No	ClinGen gnomAD
rs573383297 CA1949284	6	G>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs747014948 CA1949286	6	G>R		No	ClinGen ExAC TOPMed gnomAD
CA1949285 rs747014948	6	G>S		No	ClinGen ExAC TOPMed gnomAD
rs771911950 CA1949283	8	P>L		No	ClinGen ExAC gnomAD
rs1196032004 CA349253838	9	V>L		No	ClinGen TOPMed
CA1949279 rs748780606	12	Q>H		No	ClinGen ExAC gnomAD
CA1949280 rs553432668	12	Q>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1161078101 CA349253780	13	L>V		No	ClinGen TOPMed
CA1949278 rs777494391	14	P>S		No	ClinGen ExAC gnomAD
CA349253752 rs1377908701	15	Q>E		No	ClinGen gnomAD
RCV000332811 rs886043154	19	P>missing		No	ClinVar dbSNP
rs767710354 CA1949274	21	T>I		No	ClinGen ExAC TOPMed gnomAD
rs767710354 CA349253692	21	T>R		No	ClinGen ExAC TOPMed gnomAD
rs1458623915 CA349253686	22	A>G		No	ClinGen gnomAD
rs755401292 CA1949272	23	A>V		No	ClinGen ExAC TOPMed gnomAD
CA1949264 rs751683808	28	P>A		No	ClinGen ExAC gnomAD
rs766564588 CA1949263	29	A>S		No	ClinGen ExAC
rs966503981 CA60478713	31	A>V		No	ClinGen TOPMed
CA349253634 rs1475321276	32	T>A		No	ClinGen TOPMed
CA349253610 rs1341491428	36	A>T		No	ClinGen Ensembl
CA349253604 rs1289326148	37	P>S		No	ClinGen TOPMed
rs893597474 CA60478710	39	A>V		No	ClinGen TOPMed gnomAD
CA349253582 rs1357516694	40	P>L		No	ClinGen TOPMed
rs200509268 CA60478708	41	A>P		No	ClinGen Ensembl
rs1288010117 CA349253572	42	A>G		No	ClinGen TOPMed
rs1241658118 CA349253569	43	P>A		No	ClinGen TOPMed
rs1353134476 CA349253567	43	P>Q		No	ClinGen gnomAD
CA60478707 rs1001841887	46	A>T		No	ClinGen TOPMed
CA60478706 rs906192180	48	A>P		No	ClinGen TOPMed
CA349253540 rs906192180	48	A>S		No	ClinGen TOPMed
CA60478705 rs1046616737	50	A>P		No	ClinGen TOPMed
CA349253509 rs1311218706	53	A>S		No	ClinGen gnomAD
CA349253506 rs1377642110	53	A>V		No	ClinGen TOPMed gnomAD
rs1339842885 CA349253502	54	V>D		No	ClinGen gnomAD
rs1240752153 CA349253503	54	V>F		No	ClinGen gnomAD
CA349253498 rs765358308	55	G>C		No	ClinGen ExAC TOPMed gnomAD
CA1949257 rs765358308	55	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1402310727 CA349253486	56	W>C		No	ClinGen gnomAD
CA349253483 rs1297124211	57	P>S		No	ClinGen gnomAD
rs760545362 CA1949256	59	C>F		No	ClinGen ExAC gnomAD
rs1266405443 CA349253454	61	D>G		No	ClinGen TOPMed
CA60478703 rs908699963	63	Y>F		No	ClinGen TOPMed
rs1160865296 CA349253443	63	Y>H		No	ClinGen gnomAD
rs1368455704 CA349253430	64	E>D		No	ClinGen gnomAD
CA349253437 rs1440842849	64	E>K		No	ClinGen TOPMed gnomAD
CA349253436 rs1440842849	64	E>Q		No	ClinGen TOPMed gnomAD
CA349253420 rs1186069176	66	Q>R		No	ClinGen gnomAD
rs1574593403 CA349253403	68	V>G		No	ClinGen Ensembl
CA349253400 rs1168047946	69	I>F		No	ClinGen TOPMed
rs1193098128 CA349252923	70	G>D		No	ClinGen gnomAD
TCGA novel	70	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA349252921 rs1476964044	71	S>G		No	ClinGen gnomAD
TCGA novel	80	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs202247725 CA349252858	81	L>I		No	ClinGen ExAC TOPMed gnomAD
rs1450758561 CA349252844	83	K>E		No	ClinGen TOPMed gnomAD
CA349252845 rs1450758561	83	K>Q		No	ClinGen TOPMed gnomAD
rs200276483 CA60471233	84	P>L		No	ClinGen gnomAD
rs1287509646 CA349252837	84	P>S		No	ClinGen gnomAD
rs201828648 CA60471232	85	R>G		No	ClinGen Ensembl
rs1216318729 CA349252814	87	E>G		No	ClinGen gnomAD
CA349252817 rs1256864510	87	E>Q		No	ClinGen gnomAD
CA60471231 rs201006515	88	R>C		No	ClinGen gnomAD
COSM377583 COSM377584 rs370455370 CA1949242	88	R>H	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC gnomAD
CA60471229 rs199899584	90	A>V		No	ClinGen Ensembl
rs758605523 CA1949240	91	I>V		No	ClinGen ExAC gnomAD
CA60471227 rs201730893	93	R>Q		No	ClinGen Ensembl
CA60471228 rs769314682	93	R>W		No	ClinGen Ensembl
CA349252767 rs1407541843	95	N>S		No	ClinGen TOPMed gnomAD
TCGA novel	98	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201221907 CA1949239	100	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1464080076 CA349252714	102	S>N		No	ClinGen gnomAD
CA349252710 rs1425882337	103	M>V		No	ClinGen gnomAD
CA60471223 rs954473269	104	D>E		No	ClinGen TOPMed
rs1187292608 CA349252702	104	D>H		No	ClinGen TOPMed gnomAD
rs1187292608 CA349252701	104	D>N		No	ClinGen TOPMed gnomAD
CA349252287 rs1280232976	108	K>E		No	ClinGen gnomAD
CA349252267 rs1219457311	110	I>S		No	ClinGen gnomAD
rs995248971 CA60469592	111	Q>R		No	ClinGen Ensembl
rs1309017650 CA349252251	113	M>V		No	ClinGen gnomAD
rs199693195 CA1949216 COSM1009065 COSM1009064	121	V>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1447312073 CA349252175	123	T>N		No	ClinGen gnomAD
rs1357505871 CA349252163	125	Y>H		No	ClinGen gnomAD
CA349252149 rs1294758361	127	S>T		No	ClinGen gnomAD
rs201746945 CA60469591	135	W>R		No	ClinGen Ensembl
rs1433759725 CA349252068	138	M>I		No	ClinGen gnomAD
rs1286074971 CA349252008	145	S>*		No	ClinGen gnomAD
TCGA novel	145	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA349252006 rs1415590857	146	M>V		No	ClinGen TOPMed gnomAD
CA1949206 rs747479174	149	I>V		No	ClinGen ExAC gnomAD
CA349251917 rs1574517653	152	Y>N		No	ClinGen Ensembl
CA349251898 rs1296099523	153	I>V		No	ClinGen TOPMed gnomAD
rs772371090 CA1949204	156	R>*		No	ClinGen ExAC TOPMed gnomAD
rs376136352 CA349251843	156	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs376136352 COSM1009060 COSM1009061 CA1949203	156	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA60469252 rs202246318	159	H>Q		No	ClinGen TOPMed
TCGA novel	160	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757491102 CA349251765	161	N>I		No	ClinGen ExAC TOPMed gnomAD
CA1949201 rs757491102	161	N>S		No	ClinGen ExAC TOPMed gnomAD
CA349251740 rs1477288860	163	V>F		No	ClinGen gnomAD
CA349251744 rs1477288860	163	V>I		No	ClinGen gnomAD
TCGA novel	164	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA349251688 rs1261697990	167	A>E		No	ClinGen gnomAD
TCGA novel	167	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200991167 CA1949199	167	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
COSM571143 rs756179998 CA1949198	168	I>V	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs751493627 CA1949197	170	A>S		No	ClinGen ExAC gnomAD
rs1405632029 CA349251664	171	T>I		No	ClinGen TOPMed
CA1949196 rs200424635	172	I>V		No	ClinGen ExAC gnomAD
CA60469250 rs375334316	174	K>R		No	ClinGen ESP
TCGA novel	175	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA349251593 rs1477612129	181	D>E		No	ClinGen TOPMed gnomAD
CA60469248 COSM1305822 rs201338418 COSM1305821	182	Y>C	lung NS urinary_tract [Cosmic]	No	ClinGen cosmic curated TOPMed
CA349251561 rs1339950448	186	N>S		No	ClinGen gnomAD
CA349251557 rs201684592	187	G>C		No	ClinGen ExAC gnomAD
COSM1266944 COSM1266945 CA1949194 rs201684592	187	G>S	Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA349251550 rs1311483244	188	Q>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1357790058 CA349251528	190	H>R		No	ClinGen TOPMed
TCGA novel	191	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA349251319 rs1300329889	198	I>F		No	ClinGen TOPMed gnomAD
rs1300329889 CA349251320	198	I>V		No	ClinGen TOPMed gnomAD
rs1330422220 CA349254745	214	S>R		No	ClinGen gnomAD
rs1174705830 CA349254739	215	A>V		No	ClinGen TOPMed gnomAD
rs200906112 CA60466707	221	G>A		No	ClinGen ExAC gnomAD
CA1949156 rs200906112	221	G>D		No	ClinGen ExAC gnomAD
CA1949157 rs200257510	221	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA60466705 rs200027661	225	R>*		No	ClinGen TOPMed gnomAD
CA60466706 rs200027661	225	R>G		No	ClinGen TOPMed gnomAD
rs1486798835 CA349254643	231	T>A		No	ClinGen gnomAD
rs745760424 CA1949154	233	V>I		No	ClinGen ExAC gnomAD
rs1351251071 CA349254622	234	G>D		No	ClinGen gnomAD
CA60466704 rs201333511 COSM1726454 COSM1726455	239	M>I	liver [Cosmic]	No	ClinGen cosmic curated Ensembl
CA349254539 rs1574496975	246	Q>K		No	ClinGen Ensembl
CA1949130 rs749264154	248	R>I		No	ClinGen ExAC gnomAD
rs755937393 CA1949128	250	Y>C		No	ClinGen ExAC gnomAD
rs777480578 CA1949129	250	Y>D		No	ClinGen ExAC gnomAD
TCGA novel	253	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA349254467 rs1193722367	254	A>S		No	ClinGen gnomAD
CA349254421 rs1284277301	260	G>R		No	ClinGen gnomAD
CA349254403 rs1374535691	262	T>I		No	ClinGen gnomAD
CA349254371 rs1265109083	267	A>V		No	ClinGen TOPMed gnomAD
CA1949125 rs754666662	271	A>V		No	ClinGen ExAC TOPMed gnomAD
CA1949123 rs765973701	274	H>Y		No	ClinGen ExAC gnomAD
CA349254321 rs1216378830	275	K>R		No	ClinGen gnomAD
rs763308836 CA1949122	279	M>I		No	ClinGen ExAC TOPMed gnomAD
rs901718939 CA60466684	280	K>T		No	ClinGen TOPMed
CA60466463 rs916396480	283	M>V		No	ClinGen Ensembl
rs1414143514 CA349254203	290	P>A		No	ClinGen gnomAD
CA1949102 rs757876668	296	G>R		No	ClinGen ExAC gnomAD
rs372899334 CA1949099	297	V>L		No	ClinGen ESP ExAC gnomAD
rs369314671 CA1949098	298	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1460414130 CA349254145	299	D>A		No	ClinGen TOPMed
TCGA novel	301	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1949096 rs767450815	302	M>I		No	ClinGen ExAC gnomAD
rs775815629 CA1949097	302	M>T		No	ClinGen ExAC gnomAD
rs558024642 CA1949094	307	G>S		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	308	K>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM134043 rs1285852195 CA349254047	311	R>K	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
TCGA novel	312	K>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1258618607 CA349254028	312	K>I		No	ClinGen TOPMed gnomAD
TCGA novel	320	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1949091 rs776354325	321	D>E		No	ClinGen ExAC TOPMed gnomAD
rs746601162 CA1949089	324	K>R		No	ClinGen ExAC gnomAD
rs771748371 CA1949068	327	T>R		No	ClinGen ExAC gnomAD
CA60465558 rs780056867	330	E>K		No	ClinGen TOPMed gnomAD
rs1559111375 CA349253174	332	L>I		No	ClinGen Ensembl
TCGA novel	334	C>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs911069836 CA349253159	334	C>R		No	ClinGen TOPMed gnomAD
CA349253156 rs1164014837	334	C>S		No	ClinGen gnomAD
rs911069836 CA60465557	334	C>S		No	ClinGen TOPMed gnomAD
rs745570599 CA1949067	335	K>Q		No	ClinGen ExAC gnomAD
rs747145300 CA60465556	335	K>R		No	ClinGen Ensembl
CA349253108 rs1419431156	341	K>E		No	ClinGen gnomAD
rs1559111273 CA349253086	342	N>H		No	ClinGen Ensembl
CA349253060 rs1275285562	345	Y>C		No	ClinGen Ensembl
rs1370925630 CA349253064	345	Y>N		No	ClinGen gnomAD
CA349253047 rs1430623118	347	I>T		No	ClinGen gnomAD
rs1193531417 CA349253009	353	R>K		No	ClinGen gnomAD
rs1802105 CA60465549	354	T>P		No	ClinGen Ensembl
rs1214463284 CA349252998	355	P>A		No	ClinGen gnomAD
CA349252994 rs1480358504	355	P>L		No	ClinGen gnomAD
rs764061473 CA1949054	356	D>A		No	ClinGen ExAC TOPMed gnomAD
CA349252990 rs764061473	356	D>G		No	ClinGen ExAC TOPMed gnomAD
CA1949052 rs775341343	357	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1426461901 CA349252958	361	A>P		No	ClinGen TOPMed
TCGA novel	361	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201077678 CA1949040	365	R>K		No	ClinGen ExAC TOPMed gnomAD
CA1949038 rs750511524	369	G>E		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	372	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1949037 rs765291388	373	H>R		No	ClinGen ExAC TOPMed gnomAD
rs752579447 CA349252586	375	H>L		No	ClinGen ExAC gnomAD
CA1949035 rs752579447	375	H>R		No	ClinGen ExAC gnomAD
CA60459513 rs980414959	376	K>E		No	ClinGen gnomAD
rs759384781 CA1949033	378	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1362104547 CA349252554	380	G>R		No	ClinGen gnomAD
rs768321414 CA60459512	381	D>G		No	ClinGen TOPMed
rs1333451147 CA349252547	381	D>N		No	ClinGen TOPMed
rs1419883596 CA349252526	383	E>D		No	ClinGen gnomAD
TCGA novel	383	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA349252512 rs1195351394	385	S>N		No	ClinGen TOPMed gnomAD
CA349252502 rs1186114001	386	D>G		No	ClinGen gnomAD
rs769195080 CA1949028	387	D>G		No	ClinGen ExAC gnomAD
CA1949029 rs772724891	387	D>N		No	ClinGen ExAC TOPMed gnomAD
CA349252493 rs1345491124	388	E>K		No	ClinGen TOPMed
rs1239064986 CA349252482	389	M>T		No	ClinGen gnomAD
rs777023649 CA1949026	389	M>V		No	ClinGen ExAC gnomAD
rs769197906 CA1949025	390	D>N		No	ClinGen ExAC gnomAD
rs747339900 CA1949024	390	D>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs780458695 CA1949023	391	E>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1357740688 CA349252458	392	K>N		No	ClinGen gnomAD
CA1949022 rs201100288	393	S>N		No	ClinGen ExAC TOPMed gnomAD
rs199943116 CA1949020	394	E>K		No	ClinGen ExAC TOPMed gnomAD
rs754000627 CA1949018	398	A>T		No	ClinGen ExAC TOPMed gnomAD
rs767531913 CA1949017	398	A>V		No	ClinGen ExAC gnomAD
rs56031549 CA1949016	399	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1949015 rs751387128	401	S>P		No	ClinGen ExAC TOPMed gnomAD
CA349252390 rs1192275725	403	E>K		No	ClinGen gnomAD
CA349252376 rs56697518	404	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs753329037 CA1948989	406	R>G		No	ClinGen ExAC gnomAD
CA1948988 rs763607390	406	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs947669343 CA60459504	407	R>K		No	ClinGen Ensembl
CA349252349 rs1272326865	407	R>S		No	ClinGen gnomAD
CA349252345 rs1459459172	408	V>A		No	ClinGen TOPMed
rs201915974 CA60459503	408	V>I		No	ClinGen TOPMed gnomAD
CA349252321 rs1301896796	411	E>D		No	ClinGen TOPMed gnomAD
rs992358171 CA60459502	411	E>Q		No	ClinGen Ensembl
CA1948986 rs776007211	413	P>T		No	ClinGen ExAC gnomAD
CA1948985 rs369988565	414	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs376856499 CA1948967	415	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	417	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA349251493 rs1186816829	418	S>G		No	ClinGen gnomAD
rs767907261 CA1948966	420	S>R		No	ClinGen ExAC gnomAD
CA1948962 rs187318954	425	Q>P		No	ClinGen 1000Genomes ExAC gnomAD
rs967406185 CA60458399	426	I>M		No	ClinGen TOPMed
rs1222091118 CA349251429	427	Q>P		No	ClinGen gnomAD
CA60458398 rs371286172	429	L>V		No	ClinGen ESP TOPMed
CA349251410 rs773594176	430	S>C		No	ClinGen ExAC TOPMed gnomAD
CA1948960 rs773594176	430	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA349251406 rs1227540627	431	V>A		No	ClinGen TOPMed
CA1948959 rs770193318	431	V>L		No	ClinGen ExAC gnomAD
rs748206003 CA1948958	432	H>D		No	ClinGen ExAC gnomAD
CA1948956 rs771887076	433	D>A		No	ClinGen ExAC TOPMed gnomAD
CA349251397 rs1314561370	433	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA60458397 rs953426929	434	S>C		No	ClinGen TOPMed
rs745827456 CA1948955	434	S>P		No	ClinGen ExAC TOPMed gnomAD
CA1948937 COSM1400976 COSM1400977 rs776513083	438	P>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA349251212 rs776513083	438	P>L		No	ClinGen ExAC gnomAD
rs905930426 CA60458211	439	N>D		No	ClinGen TOPMed gnomAD
CA60458212 rs905930426	439	N>H		No	ClinGen TOPMed gnomAD
rs183634219 CA1948934	439	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs183634219 CA1948935	439	N>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA349251204 rs1419280954	440	A>S		No	ClinGen gnomAD
CA349251200 rs1185254919	441	N>D		No	ClinGen gnomAD
rs942822043 CA60458210	441	N>I		No	ClinGen TOPMed
CA349251197 rs942822043	441	N>S		No	ClinGen TOPMed
CA1948932 rs553932507	442	E>D		No	ClinGen ExAC TOPMed gnomAD
CA1948931 rs201012106	443	D>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA349251178 rs1213082386	444	Y>D		No	ClinGen TOPMed gnomAD
rs1467197996 CA349251171	445	R>G		No	ClinGen TOPMed gnomAD
rs755705794 CA1948930	445	R>K		No	ClinGen ExAC gnomAD
CA349251160 rs1222614397	446	E>V		No	ClinGen gnomAD
rs200072066 CA1948929	448	S>A		No	ClinGen ExAC gnomAD
rs191390185 CA1948928	448	S>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA349251143 rs1365913790	449	S>F		No	ClinGen gnomAD
CA1948927 rs201894497	449	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA1948925 rs766882116	450	C>S		No	ClinGen ExAC gnomAD
rs371452650 CA1948924	450	C>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs750801957 CA1948923	451	A>V		No	ClinGen ExAC gnomAD
rs762057185 CA1948921	452	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA349251124 rs1443458443	453	N>D		No	ClinGen TOPMed
CA349251117 rs1559079429	454	L>V		No	ClinGen Ensembl
CA1948919 rs764031679	455	V>I		No	ClinGen ExAC gnomAD
CA349254044 rs1197564622	460	N>D		No	ClinGen TOPMed gnomAD
CA1948903 rs754201506	460	N>S		No	ClinGen ExAC gnomAD
TCGA novel	463	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764344658 CA1948902	463	K>R		No	ClinGen ExAC TOPMed gnomAD
CA349253971 rs1256833444	465	L>P		No	ClinGen Ensembl
rs760864948 CA1948901	466	N>S		No	ClinGen ExAC gnomAD
rs753362711 COSM3670298 CA60453039 COSM3670299	469	R>*	central_nervous_system [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1483235189 CA349253946	469	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA1948899 rs200294746	471	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA1948897 rs773159718	474	P>S		No	ClinGen ExAC gnomAD
CA1948896 rs769776880	475	G>R		No	ClinGen ExAC gnomAD
rs761639622 CA1948895	476	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1300472813 CA349253374	478	T>A		No	ClinGen TOPMed
rs1242984484 CA349253352	481	G>D		No	ClinGen gnomAD
CA349253349 rs1342669862	482	V>I		No	ClinGen gnomAD
rs767537417 CA1948877	493	D>G		No	ClinGen ExAC gnomAD
CA349253262 rs1386509212	495	H>Y		No	ClinGen gnomAD
rs1457844606 CA349253255	496	D>N		No	ClinGen gnomAD
rs775463188 CA1948852	501	A>G		No	ClinGen ExAC gnomAD
rs767274202 CA1948851	502	A>G		No	ClinGen ExAC TOPMed gnomAD
CA60447212 rs767274202	502	A>V		No	ClinGen ExAC TOPMed gnomAD
CA349250589 rs1574349451	504	L>F		No	ClinGen Ensembl
rs1259486917 CA349250586	505	Q>*		No	ClinGen TOPMed
CA349250558 rs1195518300	509	D>H		No	ClinGen gnomAD
rs935846655 CA60447211	513	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs199600350 COSM1400973 CA1948850 COSM1400972	513	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA1948834 rs779099780	522	A>S		No	ClinGen ExAC TOPMed gnomAD
CA349251961 rs1260602424	524	G>V		No	ClinGen TOPMed
CA1948832 rs541206860	525	C>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	525	C>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA60446199 rs541206860	525	C>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs541206860 CA1948833	525	C>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs751196398 CA1948831	526	D>N		No	ClinGen ExAC gnomAD
CA1948830 rs762341266	528	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs762341266 CA1948829	528	S>W		No	ClinGen ExAC TOPMed gnomAD
CA349251902 rs1283704632	529	E>D		No	ClinGen gnomAD
rs776910728 CA1948825	535	K>R		No	ClinGen ExAC gnomAD
CA349251815 rs1158204214	537	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA60446198 rs999421278	539	F>S		No	ClinGen gnomAD
CA349251771 rs1285856193	541	Q>*		No	ClinGen gnomAD
rs1344086024 CA349251751	542	L>F		No	ClinGen gnomAD
TCGA novel	542	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA349251753 rs1238519102	542	L>W		No	ClinGen gnomAD
CA349251710 rs1318020616	545	S>R		No	ClinGen gnomAD

No associated diseases with Q9UEW8

3 regional properties for Q9UEW8

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	63 - 337	IPR000719
binding_site	Protein kinase, ATP binding site	69 - 92	IPR017441
domain	Serine/threonine-protein kinase OSR1/WNK, CCT domain	452 - 509	IPR024678

Functions

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm Nucleus	Nucleus when caspase-cleaved
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

9 GO annotations of cellular component

Name	Definition
apical plasma membrane	The region of the plasma membrane located at the apical end of the cell.
basolateral plasma membrane	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cell body	The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extrinsic component of membrane	The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

5 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
kinase activity	Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

28 GO annotations of biological process

Name	Definition
cellular chloride ion homeostasis	Any process involved in the maintenance of an internal steady state of chloride ions at the level of a cell.
cellular hypotonic response	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell.
cellular response to chemokine	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus.
cellular response to potassium ion	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus.
chemokine (C-X-C motif) ligand 12 signaling pathway	The series of molecular signals initiated by the binding of the chemokine CXCL12 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
inflammatory response	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
macrophage activation	A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
maintenance of lens transparency	A homeostatic process in which the lens is maintained in a highly refractive, transparent state to allow for optimal focusing of light on the retina.
negative regulation of creatine transmembrane transporter activity	Any process that stops, prevents or reduces the frequency, rate or extent of creatine transmembrane transporter activity.
negative regulation of pancreatic juice secretion	Any process that decreases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine.
negative regulation of potassium ion transmembrane transport	Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport.
negative regulation of potassium ion transmembrane transporter activity	Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity.
negative regulation of sodium ion transmembrane transporter activity	Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity.
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
peptidyl-threonine phosphorylation	The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
positive regulation of ion transmembrane transporter activity	Any process that activates or increases the activity of an ion transporter.
positive regulation of p38MAPK cascade	Any process that activates or increases the frequency, rate or extent of p38MAPK cascade.
positive regulation of potassium ion transport	Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of T cell chemotaxis	Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of blood pressure	Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
regulation of inflammatory response	Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
response to aldosterone	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldosterone stimulus.
response to dietary excess	The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
sodium ion transmembrane transport	A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

20 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9C0K7	STRADB	STE20-related kinase adapter protein beta	Homo sapiens (Human)	PR
Q7RTN6	STRADA	STE20-related kinase adapter protein alpha	Homo sapiens (Human)	PR
Q9H2G2	SLK	STE20-like serine/threonine-protein kinase	Homo sapiens (Human)	PR
O94804	STK10	Serine/threonine-protein kinase 10	Homo sapiens (Human)	PR
O95747	OXSR1	Serine/threonine-protein kinase OSR1	Homo sapiens (Human)	PR
Q9Y4K4	MAP4K5	Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (Human)	PR
Q92918	MAP4K1	Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (Human)	EV
Q12851	MAP4K2	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (Human)	EV
Q8IVH8	MAP4K3	Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (Human)	SS
Q9P289	STK26	Serine/threonine-protein kinase 26	Homo sapiens (Human)	PR
Q9Y6E0	STK24	Serine/threonine-protein kinase 24	Homo sapiens (Human)	PR
O00506	STK25	Serine/threonine-protein kinase 25	Homo sapiens (Human)	PR
Q8K4T3	Stradb	STE20-related kinase adapter protein beta	Mus musculus (Mouse)	PR
Q3UUJ4	Strada	STE20-related kinase adapter protein alpha	Mus musculus (Mouse)	PR
Q6P9R2	Oxsr1	Serine/threonine-protein kinase OSR1	Mus musculus (Mouse)	PR
Q9Z1W9	Stk39	STE20/SPS1-related proline-alanine-rich protein kinase	Mus musculus (Mouse)	PR
Q863I2	OXSR1	Serine/threonine-protein kinase OSR1	Sus scrofa (Pig)	PR
Q7TNZ6	Strada	STE20-related kinase adapter protein alpha	Rattus norvegicus (Rat)	PR
O88506	Stk39	STE20/SPS1-related proline-alanine-rich protein kinase	Rattus norvegicus (Rat)	PR
O23304	BLUS1	Serine/threonine-protein kinase BLUS1	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MAEPSGSPVH	VQLPQQAAPV	TAAAAAAPAA	ATAAPAPAAP	AAPAPAPAPA	AQAVGWPICR
70	80	90	100	110	120
DAYELQEVIG	SGATAVVQAA	LCKPRQERVA	IKRINLEKCQ	TSMDELLKEI	QAMSQCSHPN
130	140	150	160	170	180
VVTYYTSFVV	KDELWLVMKL	LSGGSMLDII	KYIVNRGEHK	NGVLEEAIIA	TILKEVLEGL
190	200	210	220	230	240
DYLHRNGQIH	RDLKAGNILL	GEDGSVQIAD	FGVSAFLATG	GDVTRNKVRK	TFVGTPCWMA
250	260	270	280	290	300
PEVMEQVRGY	DFKADMWSFG	ITAIELATGA	APYHKYPPMK	VLMLTLQNDP	PTLETGVEDK
310	320	330	340	350	360
EMMKKYGKSF	RKLLSLCLQK	DPSKRPTAAE	LLKCKFFQKA	KNREYLIEKL	LTRTPDIAQR
370	380	390	400	410	420
AKKVRRVPGS	SGHLHKTEDG	DWEWSDDEMD	EKSEEGKAAF	SQEKSRRVKE	ENPEIAVSAS
430	440	450	460	470	480
TIPEQIQSLS	VHDSQGPPNA	NEDYREASSC	AVNLVLRLRN	SRKELNDIRF	EFTPGRDTAD
490	500	510	520	530	540
GVSQELFSAG	LVDGHDVVIV	AANLQKIVDD	PKALKTLTFK	LASGCDGSEI	PDEVKLIGFA

QLSVS