Q9U2Q9

PR
Gene name
gsk-3
Protein name
Glycogen synthase kinase-3
Names
Species
Caenorhabditis elegans
KEGG Pathway
EC number
2.7.11.26: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

179-201 (Activation loop from InterPro)

Target domain

36-320 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9U2Q9

Entry ID Method Resolution Chain Position Source
AF-Q9U2Q9-F1 Predicted AlphaFoldDB

No variants for Q9U2Q9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9U2Q9

No associated diseases with Q9U2Q9

4 regional properties for Q9U2Q9

Type Name Position InterPro Accession
domain Protein kinase domain 36 - 320 IPR000719
active_site Serine/threonine-protein kinase, active site 157 - 169 IPR008271
binding_site Protein kinase, ATP binding site 42 - 66 IPR017441
domain Glycogen synthase kinase 3, catalytic domain 31 - 323 IPR039192

Functions

Description
EC Number 2.7.11.26 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
tau-protein kinase activity Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein.

11 GO annotations of biological process

Name Definition
engulfment of apoptotic cell The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte.
establishment of mitotic spindle orientation A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
germ cell development The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
left/right axis specification The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes).
negative regulation of canonical Wnt signaling pathway Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
peptidyl-threonine phosphorylation The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
positive regulation of distal tip cell migration Any process that activates or increases the frequency, rate or extent of distal tip cell migration.
positive regulation of engulfment of apoptotic cell Any process that activates or increases the frequency, rate or extent of engulfment of apoptotic cell.
positive regulation of proteasomal ubiquitin-dependent protein catabolic process Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
Wnt signaling pathway, regulating spindle positioning The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with the positioning of the mitotic spindle.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P18431 sgg Protein kinase shaggy Drosophila melanogaster (Fruit fly) SS
P49840 GSK3A Glycogen synthase kinase-3 alpha Homo sapiens (Human) PR
P49841 GSK3B Glycogen synthase kinase-3 beta Homo sapiens (Human) EV
Q80YS9 Stkld1 Serine/threonine kinase-like domain-containing protein STKLD1 Mus musculus (Mouse) PR
Q2NL51 Gsk3a Glycogen synthase kinase-3 alpha Mus musculus (Mouse) SS
Q9WV60 Gsk3b Glycogen synthase kinase-3 beta Mus musculus (Mouse) EV
P18265 Gsk3a Glycogen synthase kinase-3 alpha Rattus norvegicus (Rat) PR
P18266 Gsk3b Glycogen synthase kinase-3 beta Rattus norvegicus (Rat) PR
Q09595 R03D7.5 Putative serine/threonine-protein kinase R03D7.5 Caenorhabditis elegans PR
Q39019 ASK10 Shaggy-related protein kinase kappa Arabidopsis thaliana (Mouse-ear cress) PR
Q9FVS6 ASK4 Shaggy-related protein kinase delta Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MNKQLLSCSL KSGKQVTMVV ASVATDGVDQ QVEISYYDQK VIGNGSFGVV FLAKLSTTNE
70 80 90 100 110 120
MVAIKKVLQD KRFKNRELQI MRKLNHPNIV KLKYFFYSSG EKKDELYLNL ILEYVPETVY
130 140 150 160 170 180
RVARHYSKQR QQIPMIYVKL YMYQLLRSLA YIHSIGICHR DIKPQNLLID PESGVLKLCD
190 200 210 220 230 240
FGSAKYLVRN EPNVSYICSR YYRAPELIFG ATNYTNSIDV WSAGTVMAEL LLGQPIFPGD
250 260 270 280 290 300
SGVDQLVEII KVLGTPTREQ IQSMNPNYKE FKFPQIKAHP WNKVFRVHTP AEAIDLISKI
310 320 330 340 350 360
IEYTPTSRPT PQAACQHAFF DELRNPDARL PSGRPLPTLE MDGPMGTGEV STTSGDVAGP
SA