Q9U280

PR
Gene name
tat-1 (Y49E10.11)
Protein name
Phospholipid-transporting ATPase tat-1
Names
TAT-1
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_Y49E10.11
EC number
7.6.2.1: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9U280

Entry ID Method Resolution Chain Position Source
AF-Q9U280-F1 Predicted AlphaFoldDB

No variants for Q9U280

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9U280

No associated diseases with Q9U280

4 regional properties for Q9U280

Type Name Position InterPro Accession
ptm P-type ATPase, phosphorylation site 388 - 394 IPR018303
domain P-type ATPase, C-terminal 792 - 1042 IPR032630
domain P-type ATPase, N-terminal 17 - 80 IPR032631
domain P-type ATPase, haloacid dehalogenase domain 368 - 814 IPR044492

Functions

Description
EC Number 7.6.2.1 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Early endosome membrane ; Multi-pass membrane protein
  • Recycling endosome membrane ; Multi-pass membrane protein
  • Colocalizes with its chaperone chat-1 at apical and basolateral cell membranes, on early endosomes and on recycling endosomes
  • Also localizes to intracellular tubular and vesicular structures
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

12 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
early endosome A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
early endosome membrane The lipid bilayer surrounding an early endosome.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
late endosome A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
recycling endosome An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
recycling endosome membrane The lipid bilayer surrounding a recycling endosome.
trans-Golgi network The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATPase-coupled intramembrane lipid transporter activity Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases.
magnesium ion binding Binding to a magnesium (Mg) ion.
phosphatidylserine floppase activity Catalysis of the movement of phosphatidylserine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.

6 GO annotations of biological process

Name Definition
endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
lysosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.
negative regulation of phagocytosis, engulfment Any process that stops, prevents, or reduces the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.
phospholipid translocation The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
phospholipid transport The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.
positive regulation of phagocytosis, engulfment Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P39524 DRS2 Phospholipid-transporting ATPase DRS2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) EV
Q9P241 ATP10D Phospholipid-transporting ATPase VD Homo sapiens (Human) PR
Q8TF62 ATP8B4 Probable phospholipid-transporting ATPase IM Homo sapiens (Human) PR
P98198 ATP8B2 Phospholipid-transporting ATPase ID Homo sapiens (Human) PR
O43520 ATP8B1 Phospholipid-transporting ATPase IC Homo sapiens (Human) EV
Q9Y2Q0 ATP8A1 Phospholipid-transporting ATPase IA Homo sapiens (Human) PR
Q148W0 Atp8b1 Phospholipid-transporting ATPase IC Mus musculus (Mouse) SS
P98199 Atp8b2 Phospholipid-transporting ATPase ID Mus musculus (Mouse) PR
P70704 Atp8a1 Phospholipid-transporting ATPase IA Mus musculus (Mouse) PR
D4AA47 Atp8b1 Phospholipid-transporting ATPase IC Rattus norvegicus (Rat) SS
Q5BL50 atp8b1 Phospholipid-transporting ATPase IC Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
10 20 30 40 50 60
MPTEARDNNR HIHLGKVRDP HHQHAQRFCS NRISTCKYNG FSFLPRFLYE QFRRYNNIFF
70 80 90 100 110 120
LAIALLQQIP DVSPTGRYTT AVPFLIILSV SALKEIFEDV KRRRSDNKVN AFSVEILVDG
130 140 150 160 170 180
HWIEKQWKDV SVGDFIRIDN DSLFPADLLL LASSEQQGMA YIETSNLDGE TNLKIKQALD
190 200 210 220 230 240
ITSTMTSPEK LSQFESEITC EPPSRHVNEF NGNIEINGVA RHFGIDQLLL RGARLKNTAW
250 260 270 280 290 300
IFGAVIYTGH DSKLLMNSKR APLKSGTIDV QTNYRIIFLF FVLVALALIS ATGSEIWRGN
310 320 330 340 350 360
NIPQAWYLSF LEHDPKGSFL WGVLTFFILY NNLIPISLQV TLEVVRFFQA IYINNDIEMY
370 380 390 400 410 420
DVNSDSCAIA RTSNLNEELG QVKFIMSDKT GTLTRNVMKF KRLSIGSRNY GNNEDDEFAD
430 440 450 460 470 480
ASLIEDYRQG DEHSTSILEV LKMMAVCHTV VPENKDGQLI YQSSSPDEAA LVRGAASQSV
490 500 510 520 530 540
SFHTRQPQKV ICNVFGEDET IEILDVIDFT SDRKRMSVIV RDGAGGDIKL YTKGADTVIF
550 560 570 580 590 600
ERLEHGKEQE EAVEYCTEHL EDYASFGYRT LCFSMRHLTE QEYSQWAPEY KKAILAIDNR
610 620 630 640 650 660
AKLLADAAEK LERNMILVGA TAIEDKLQEW VPETIQALMA ADIRVWMLTG DKRETAINIA
670 680 690 700 710 720
HSCALCHTNT ELLIVDKTTY EETYQKLEQF VARAIELEKQ EKGFAMVIDG KSLLHALTGE
730 740 750 760 770 780
ARKHFGDLAL RCHAVVCCRM SPMQKAEVVE MVRKLAKHVV LAIGDGANDV AMIQAANVGV
790 800 810 820 830 840
GISGEEGLQA ASASDYAIPR FHFLRRLLLV HGAWNHDRSV KVILYSFYKN ICLYIIELWF
850 860 870 880 890 900
AMFSAWSGQT IFERWTIGMF NVIFTAWPPV VLGLFDHPVP AEQIMKYPAL YASFQNRAFS
910 920 930 940 950 960
IGNFSLWIGL AIVHSLSLFF LTYATMEHQV VWDNGLTGGW LMLGNCAYTF VVATVCFKAL
970 980 990 1000 1010 1020
LECDSWTWPV VVACIGSIGL WIVFVIVYSL VFPHIGGIGA DMAGMAAIMM SSYTFWLALL
1030 1040 1050 1060 1070 1080
FIPLATLLWD LVIKSLFTIA MPTPRELAVM YNKRTTSFNG FERLASYSSN VLENMRLLTS
1090 1100 1110 1120 1130
SLRGSTTGST RSRTASEASL ALAEQTRYGF AFSQDESSAV AQTELIRNVD STREKPTGR