Q9TZC4
PR
Gene name |
pat-4 |
Protein name |
Integrin-linked protein kinase homolog pat-4 |
Names |
ILK homolog, Paralyzed and arrested elongation at two-fold protein 4 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_C29F9.7 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9TZC4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9TZC4-F1 | Predicted | AlphaFoldDB |
No variants for Q9TZC4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9TZC4 | |||||
No associated diseases with Q9TZC4
4 regional properties for Q9TZC4
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| adherens junction | A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules. |
| basal plasma membrane | The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| focal adhesion | A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). |
| integrin complex | A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. |
| M band | The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines. |
| striated muscle dense body | A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| integrin binding | Binding to an integrin. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| protein-macromolecule adaptor activity | The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. |
19 GO annotations of biological process
| Name | Definition |
|---|---|
| cell-matrix adhesion | The binding of a cell to the extracellular matrix via adhesion molecules. |
| embryo development ending in birth or egg hatching | The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. |
| hermaphrodite genitalia morphogenesis | The process in which the anatomical structures of hermaphrodite genitalia are generated and organized. |
| integrin-mediated signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| mitochondrion organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. |
| muscle cell cellular homeostasis | The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state. |
| myofibril assembly | Formation of myofibrils, the repeating units of striated muscle. |
| positive regulation of distal tip cell migration | Any process that activates or increases the frequency, rate or extent of distal tip cell migration. |
| positive regulation of establishment of protein localization | Any process that activates or increases the frequency, rate or extent of establishment of protein localization. |
| positive regulation of locomotion | Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. |
| positive regulation of myosin II filament organization | Any process that activates or increases the frequency, rate or extent of myosin II filament organization. |
| positive regulation of ovulation | Any process that activates or increases the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary. |
| positive regulation of protein localization | Any process that activates or increases the frequency, rate or extent of a protein localization. |
| positive regulation of sarcomere organization | Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. |
| positive regulation of smooth muscle contraction | Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of actin cytoskeleton organization | Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| striated muscle cell development | The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. |
| substrate adhesion-dependent cell spreading | The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q13418 | ILK | Integrin-linked protein kinase | Homo sapiens (Human) | PR |
| O55222 | Ilk | Integrin-linked protein kinase | Mus musculus (Mouse) | PR |
| Q07292 | lin-45 | Raf homolog serine/threonine-protein kinase | Caenorhabditis elegans | PR |
| Q2MHE4 | HT1 | Serine/threonine/tyrosine-protein kinase HT1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O22558 | STY8 | Serine/threonine-protein kinase STY8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWL6 | STY17 | Serine/threonine-protein kinase STY17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4JTP5 | STY46 | Serine/threonine-protein kinase STY46 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q05609 | CTR1 | Serine/threonine-protein kinase CTR1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSLSTHYHAH | KPNVPIIMED | VFGWVREGNA | FQVRVWLDDH | EHDLNVGDDH | AFSLLHWAAK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GGHVAIAEML | LSRGARVNST | NMGDDTSLHL | AAAHGHRQIV | VKLLSRKADV | NATNEHGMTP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LHYACFWGYE | QIAEDLISCG | AAVNVCNKKG | MTPLDVCQPM | CKNTILEIAQ | EHGQSPNDRV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PFKDTTWKGT | KSRTRDATLS | RYTGVDVSSL | NLITKIAESH | SGELWRGKWQ | GNDIVARILN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VQEVTARISR | DFQTEFPALR | IFAHPNICAV | LAAANQPPNL | VIISQYMPFG | SLYNVLHEQS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SVVIDHGQAV | RFALDIARGM | SYLHSLDPML | LRFYLSSKHV | VVDEELTAKL | SMADTKFSFQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EVGKAYSPAW | MSPEALSRAP | EDLNIRAADM | WSFAILLWEL | NTREVPFSDL | PPMECGMKIA |
| 430 | 440 | 450 | 460 | ||
| LEGLRVHIPP | GIARNMNRLM | NICMNEDPGR | RPNFDQIIPI | LERMIL |