Q9TW45
SS
Gene name |
par-1 (H39E23.1) |
Protein name |
Serine/threonine-protein kinase par-1 |
Names |
EC 2.7.11.1 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_H39E23.1 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
MARK1 is a Ser/Thr protein kinase involved in various cellular processes. It is part of the CAMK-like kinase family and has roles in diseases like Alzheimer’s and cancer. The kinase’s autoinhibition is mediated by its C-terminal KA1 domain, which interacts with the kinase domain to prevent substrate binding and activation. The KA1 domain binds to the αD-helix, blocking the peptide substrate binding site and inhibiting the kinase. This autoinhibition is alleviated by the binding of anionic phospholipid membranes to the KA1 domain, which reverses MARK1 autoinhibition and stimulates kinase activity.
Autoinhibitory domains (AIDs)
Target domain |
170-421 (Protein kinase domain) |
Relief mechanism |
Others |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
0 structures for Q9TW45
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| No available structures | |||||
No variants for Q9TW45
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9TW45 | |||||
No associated diseases with Q9TW45
6 regional properties for Q9TW45
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 170 - 421 | IPR000719 |
| domain | Kinase associated domain 1 (KA1) | 1143 - 1192 | IPR001772 |
| active_site | Serine/threonine-protein kinase, active site | 288 - 300 | IPR008271 |
| domain | Ubiquitin-associated domain | 440 - 482 | IPR015940 |
| binding_site | Protein kinase, ATP binding site | 176 - 199 | IPR017441 |
| domain | Serine/threonine-protein kinase MARK 1-4, catalytic domain | 169 - 421 | IPR049508 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| cell periphery | The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| P granule | A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| metal ion binding | Binding to a metal ion. |
| myosin II tail binding | Binding to the tail region of a myosin II heavy chain. |
| protein serine kinase activity | Catalysis of the reactions |
| protein serine/threonine kinase activity | Catalysis of the reactions |
| tau-protein kinase activity | Catalysis of the reaction |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| asymmetric neuroblast division | The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials. |
| asymmetric protein localization involved in cell fate determination | Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types. |
| embryonic pattern specification | The process that results in the patterns of cell differentiation that will arise in an embryo. |
| establishment of cell polarity | The specification and formation of anisotropic intracellular organization or cell growth patterns. |
| establishment or maintenance of cell polarity | Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| microtubule cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| polarity specification of anterior/posterior axis | Any process resulting in the establishment of polarity along the anterior/posterior axis. |
| vulval development | The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P57059 | SIK1 | Serine/threonine-protein kinase SIK1 | Homo sapiens (Human) | PR |
| P27448 | MARK3 | MAP/microtubule affinity-regulating kinase 3 | Homo sapiens (Human) | SS |
| Q96L34 | MARK4 | MAP/microtubule affinity-regulating kinase 4 | Homo sapiens (Human) | SS |
| Q9P0L2 | MARK1 | Serine/threonine-protein kinase MARK1 | Homo sapiens (Human) | EV |
| Q7KZI7 | MARK2 | Serine/threonine-protein kinase MARK2 | Homo sapiens (Human) | SS |
| Q8C0N0 | Gm4922 | Sperm motility kinase Z | Mus musculus (Mouse) | PR |
| Q8C0X8 | Sperm motility kinase X | Mus musculus (Mouse) | PR | |
| A0AUV4 | Gm7168 | Sperm motility kinase Y | Mus musculus (Mouse) | PR |
| Q03141 | Mark3 | MAP/microtubule affinity-regulating kinase 3 | Mus musculus (Mouse) | SS |
| Q8CIP4 | Mark4 | MAP/microtubule affinity-regulating kinase 4 | Mus musculus (Mouse) | SS |
| Q8VHJ5 | Mark1 | Serine/threonine-protein kinase MARK1 | Mus musculus (Mouse) | SS |
| Q05512 | Mark2 | Serine/threonine-protein kinase MARK2 | Mus musculus (Mouse) | SS |
| Q8VHF0 | Mark3 | MAP/microtubule affinity-regulating kinase 3 | Rattus norvegicus (Rat) | SS |
| O08678 | Mark1 | Serine/threonine-protein kinase MARK1 | Rattus norvegicus (Rat) | SS |
| O08679 | Mark2 | Serine/threonine-protein kinase MARK2 | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSASVGKKP | EHVNTPPGDN | QQKSSKENQK | SNKDKQSSNQ | PPGQIPHSTN | SGTRKSSGSG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LKTANLKHPA | RPSTESSTSS | SHHRRPAQEM | NGTSTATATG | GGGTSGATTT | ASSGAPAASS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GGSSARYSSS | GRSHPTSGSS | SSHARSTGQS | GMSSRSAARR | NDQDVHVGKY | KLLKTIGKGN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FAKVKLAKHV | ITGHEVAIKI | IDKTALNPSS | LQKLFREVKI | MKQLDHPNIV | KLYQVMETEQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TLYLVLEYAS | GGEVFDYLVA | HGRMKEKEAR | AKFRQIVSAV | QYLHSKNIIH | RDLKAENLLL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DQDMNIKIAD | FGFSNTFSLG | NKLDTFCGSP | PYAAPELFSG | KKYDGPEVDV | WSLGVILYTL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VSGSLPFDGQ | NLKELRERVL | RGKYRIPFYM | STDCENLLKK | FLVINPQRRS | SLDNIMKDRW |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MNVGYEDDEL | KPFIEPPKDQ | IDEQRIEKLI | QIFQLGFNKA | AILESVEKEK | FEDIHATYLL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LGERKSDMDA | SEITMAQSLL | SHSSINVSSS | LGQHPAGVIT | REHVTSSSAS | GSSASPSRYS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RSSATATGAS | ITAGSALASA | ANAQKHQQSS | AAPSSGSSSS | RRSSQNDAAA | TAAGGTVVMS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GTRHGGVQMR | AQPTSRQATI | SLLQPPSYKP | SSNTTQIAQI | PPLFNRNSTA | TSSAAQPSTG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ITGTRKIADP | KGRIPLNSTA | VQGHRTATGA | VAANNGGIPS | HRDHAQQQQY | MNQLTSSTMM |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SKLINKTPAA | GGTAATSSSS | SSSATSTAPL | QKSGSQISHA | PTEPVIREDD | DENNSENQNG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| NVPLIGGVGP | QTSPAVQVPT | EDATSSSDKE | QQQQKASSET | PKESKPSMIH | QSPSMPPSQM |
| 850 | 860 | 870 | 880 | 890 | 900 |
| MTAMESLKLS | ESGQTGGPTV | ATGGPPQRAT | SQQMSRSATT | NSANMGASSG | GAAAAASATN |
| 910 | 920 | 930 | 940 | 950 | 960 |
| QLSGAPSSTG | ASSQQYHPKA | PSSSSSSSTN | PPHQHQLTHN | ASFSVTPSSY | QIPTSTAVNV |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| TSTGMPTSSS | SSAFPRNTRN | RQTFHGKTEK | DKGGDDSSDE | IGETPGNVSI | GATGPSANNA |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| EATIWSKLSK | LTRRDHNRES | MTQPVSGRAG | TIGASQGQQT | AAALAAIREQ | SGPIAPGAGQ |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| VAPSLPIHEG | DVKPRSLRFT | WSMKTTSSLA | PDDMMREIRK | VLDANGCDYE | QRERYMILCV |
| 1150 | 1160 | 1170 | 1180 | 1190 | |
| HGDPNTDSLV | QWEMEVCKLP | RLSLNGVRFK | RISGTSIGFK | NIASKIAQEL | NL |