Q9TTY2

PR
Gene name
FER
Protein name
Tyrosine-protein kinase Fer
Names
Proto-oncogene c-Fer, p94-Fer
Species
Canis lupus familiaris (Dog) (Canis familiaris)
KEGG Pathway
cfa:403754
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

12-91 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9TTY2

Entry ID Method Resolution Chain Position Source
AF-Q9TTY2-F1 Predicted AlphaFoldDB

No variants for Q9TTY2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9TTY2

No associated diseases with Q9TTY2

No regional properties for Q9TTY2

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9TTY2

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cytoplasm, cytoskeleton
  • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cell projection
  • Cell junction
  • Membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Nucleus
  • Cytoplasm, cell cortex
  • Associated with the chromatin
  • Detected on microtubules in polarized and motile vascular endothelial cells
  • Colocalizes with F-actin at the cell cortex
  • Colocalizes with PECAM1 and CTNND1 at nascent cell-cell contacts (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cell projection A prolongation or process extending from a cell, e.g. a flagellum or axon.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
epidermal growth factor receptor binding Binding to an epidermal growth factor receptor.
lipid binding Binding to a lipid.
non-membrane spanning protein tyrosine kinase activity Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.

5 GO annotations of biological process

Name Definition
actin cytoskeleton reorganization A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
cell population proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population.
positive regulation of cell migration Any process that activates or increases the frequency, rate or extent of cell migration.
positive regulation of NF-kappaB transcription factor activity Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
regulation of epidermal growth factor receptor signaling pathway Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P16591 FER Tyrosine-protein kinase Fer Homo sapiens (Human) PR
P70451 Fer Tyrosine-protein kinase Fer Mus musculus (Mouse) PR
P09760 Fer Tyrosine-protein kinase Fer Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MGFGSDLKNS HEAVLKLQDW ELRLLETVKK FMALRIKSDK EYASTLQNLC NQVDKESTVQ
70 80 90 100 110 120
MNYVSNVSKS WLLMIQQTEQ LSRIMKTHAE DLNSGPLHRL TMMIKDKQQV KKSFIGVHQQ
130 140 150 160 170 180
IEAEMIKVTK TELEKLKSSY RQLIKEMNSA KEKYKEALAK GKETEKAKER YDKATMKLHV
190 200 210 220 230 240
LHNQYVLALK GAQLHQNQYY DTTLPLLLDS LQKMQEEMIK ALKGIFDEYS QITSLVTEEI
250 260 270 280 290 300
VNVHKEIQMS VEQIDPSTEY NNFIDVHRTT AAKEQEIEFD TSLLEENENL QANEIMWNNL
310 320 330 340 350 360
TAESLQVMLK TLAEELIQTQ QMLVNKEEAV LELEKRIEES SKTCEKKSDI VLLLSQKQTL
370 380 390 400 410 420
EELKQSVQQL RCTEAKFTAQ KELLEQKVQE NEGKEPPPVV NYEEDARSVT SMERKERLSK
430 440 450 460 470 480
FESIRHSIAG IIRSPKSALG SSTFSDTIPI SEKPLAEQDW YHGAIPRIEA QDLLKQQGDF
490 500 510 520 530 540
LVRESHGKPG EYVLSVYSDG QRRHFIIQFV DNLYRFEGTG FSNIPQLIDH HYTTKQVITK
550 560 570 580 590 600
KSGVVLLNPI PKDKKWVLNH EDVTLGELLG KGNFGEVYKG ILKDKTAVAV KTCKEDLPQE
610 620 630 640 650 660
LKIKFLQEAK ILKQYDHPNI VKLIGVCTQR QPIYIIMELV PGGDFLSFLR KKKDEIKLKQ
670 680 690 700 710 720
LVKFSLDAAS GMSYLESKNC IHRDLAARNC LVGENNVLKI SDFGMSRQED GGVYSSSGLK
730 740 750 760 770 780
QIPIKWTAPE ALNYGRYSSE SDVWSFGILL WETFSLGVCP YPGMTNQQAT EQVERGYRIS
790 800 810 820
APQHCPEDIF KIMMKCWDYK PENRPKFSEL QKELTVIKKK VTQ