Q9T014

PR
Gene name
SPA2 (At4g11110, F2P3.13, F2P3.14, T22B4.90)
Protein name
Protein SPA1-RELATED 2
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G11110
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-73 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9T014

Entry ID Method Resolution Chain Position Source
AF-Q9T014-F1 Predicted AlphaFoldDB

92 variants for Q9T014

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH00489245 5 G>R No 1000Genomes
ENSVATH11487263 8 G>A No 1000Genomes
tmp_4_6772226_C_A 22 Q>K No 1000Genomes
ENSVATH00489246 28 Q>H No 1000Genomes
ENSVATH06613163 29 S>P No 1000Genomes
ENSVATH06613164 32 P>L No 1000Genomes
ENSVATH06613164 32 P>R No 1000Genomes
ENSVATH00489248 89 E>A No 1000Genomes
ENSVATH06613167 92 V>F No 1000Genomes
ENSVATH06613168 116 A>P No 1000Genomes
tmp_4_6772526_C_T 122 R>C No 1000Genomes
ENSVATH14131818 136 P>Q No 1000Genomes
tmp_4_6772587_G_T 142 S>I No 1000Genomes
ENSVATH06613169 146 I>T No 1000Genomes
ENSVATH06613170 156 N>T No 1000Genomes
ENSVATH06613171 159 K>N No 1000Genomes
tmp_4_6772640_A_T 160 M>L No 1000Genomes
tmp_4_6772674_C_A 171 A>D No 1000Genomes
tmp_4_6772692_G_A 177 G>E No 1000Genomes
ENSVATH06613172 180 N>S No 1000Genomes
tmp_4_6772719_T_C 186 V>A No 1000Genomes
ENSVATH11487295 188 R>Q No 1000Genomes
ENSVATH00489249 198 H>Y No 1000Genomes
tmp_4_6772763_A_T 201 I>F No 1000Genomes
ENSVATH00489251 251 A>D No 1000Genomes
ENSVATH11487297 254 I>V No 1000Genomes
tmp_4_6772938_C_T 259 A>V No 1000Genomes
tmp_4_6772950_G_C 263 S>T No 1000Genomes
ENSVATH11487298 268 A>E No 1000Genomes
ENSVATH11487298 268 A>V No 1000Genomes
tmp_4_6772970_T_A 270 Y>N No 1000Genomes
ENSVATH06613174 273 L>F No 1000Genomes
tmp_4_6772983_C_G 274 P>R No 1000Genomes
tmp_4_6773001_C_T 280 T>I No 1000Genomes
ENSVATH06613175 292 T>S No 1000Genomes
tmp_4_6773040_A_G 293 H>R No 1000Genomes
tmp_4_6773091_A_G 310 E>G No 1000Genomes
tmp_4_6773098_G_T 312 Q>H No 1000Genomes
ENSVATH02784243 327 V>M No 1000Genomes
tmp_4_6773156_T_C 332 C>R No 1000Genomes
ENSVATH06613176 334 H>L No 1000Genomes
tmp_4_6773193_G_A 344 R>Q No 1000Genomes
tmp_4_6773198_T_A 346 S>T No 1000Genomes
tmp_4_6773207_A_G 349 K>E No 1000Genomes
ENSVATH06613177 353 E>V No 1000Genomes
ENSVATH14131819 354 N>D No 1000Genomes
tmp_4_6773325_G_T 388 R>L No 1000Genomes
tmp_4_6773351_A_G 397 I>V No 1000Genomes
tmp_4_6773424_T_A 421 V>D No 1000Genomes
ENSVATH06613178 434 E>A No 1000Genomes
tmp_4_6773507_T_C 449 C>R No 1000Genomes
tmp_4_6773975_C_G 493 Q>E No 1000Genomes
ENSVATH11487347 501 E>D No 1000Genomes
ENSVATH02784246 546 Q>H No 1000Genomes
ENSVATH06613194 554 P>S No 1000Genomes
tmp_4_6774541_G_C 556 L>F No 1000Genomes
ENSVATH02784247 566 E>D No 1000Genomes
ENSVATH11487354 579 L>V No 1000Genomes
tmp_4_6774645_G_C 591 G>A No 1000Genomes
ENSVATH02784248 594 M>I No 1000Genomes
ENSVATH02784249 595 E>K No 1000Genomes
ENSVATH02784250 596 E>Q No 1000Genomes
ENSVATH11487365 598 A>E No 1000Genomes
ENSVATH11487365 598 A>V No 1000Genomes
tmp_4_6774686_G_A 605 E>K No 1000Genomes
tmp_4_6774750_C_A 626 S>Y No 1000Genomes
ENSVATH00489261 645 S>C No 1000Genomes
ENSVATH02784251 645 S>R No 1000Genomes
tmp_4_6774810_C_T 646 A>V No 1000Genomes
tmp_4_6774833_G_A 654 A>T No 1000Genomes
tmp_4_6774837_A_G 655 H>R No 1000Genomes
ENSVATH00489262 659 A>T No 1000Genomes
tmp_4_6774871_T_A 666 D>E No 1000Genomes
ENSVATH11487368 670 L>Q No 1000Genomes
ENSVATH06613196 672 N>D No 1000Genomes
tmp_4_6774893_G_A 674 D>N No 1000Genomes
ENSVATH06613197 679 E>K No 1000Genomes
tmp_4_6774980_G_T 703 A>S No 1000Genomes
ENSVATH06613199 717 S>I No 1000Genomes
tmp_4_6775028_T_G 719 L>V No 1000Genomes
ENSVATH06613201 732 D>N No 1000Genomes
ENSVATH11487373 733 R>Q No 1000Genomes
ENSVATH00489265 755 L>V No 1000Genomes
tmp_4_6775180_G_A 769 M>I No 1000Genomes
tmp_4_6775486_G_A 838 C>Y No 1000Genomes
ENSVATH02784253 868 Q>H No 1000Genomes
ENSVATH11487406 912 N>T No 1000Genomes
ENSVATH06613212 965 I>V No 1000Genomes
ENSVATH06613220 975 Y>F No 1000Genomes
tmp_4_6776503_C_G 980 S>C No 1000Genomes
tmp_4_6776610_A_C 1016 K>Q No 1000Genomes
ENSVATH08326223 1022 V>A No 1000Genomes

No associated diseases with Q9T014

12 regional properties for Q9T014

Type Name Position InterPro Accession
domain Protein kinase domain 200 - 550 IPR000719
repeat WD40 repeat 712 - 751 IPR001680-1
repeat WD40 repeat 762 - 886 IPR001680-2
repeat WD40 repeat 890 - 930 IPR001680-3
repeat WD40 repeat 939 - 978 IPR001680-4
repeat WD40 repeat 994 - 1034 IPR001680-5
conserved_site WD40 repeat, conserved site 788 - 802 IPR019775-1
conserved_site WD40 repeat, conserved site 831 - 845 IPR019775-2
conserved_site WD40 repeat, conserved site 915 - 929 IPR019775-3
repeat G-protein beta WD-40 repeat 788 - 802 IPR020472-1
repeat G-protein beta WD-40 repeat 831 - 845 IPR020472-2
repeat G-protein beta WD-40 repeat 915 - 929 IPR020472-3

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
Cul4-RING E3 ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

3 GO annotations of biological process

Name Definition
photomorphogenesis The control of plant growth, development, and differentiation by the duration and nature of light, independent of photosynthesis.
protein phosphorylation The process of introducing a phosphate group on to a protein.
red, far-red light phototransduction The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P19525 EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens (Human) PR
Q9NZJ5 EIF2AK3 Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens (Human) PR
Q8NHY2 COP1 E3 ubiquitin-protein ligase COP1 Homo sapiens (Human) PR
Q9R1A8 Cop1 E3 ubiquitin-protein ligase COP1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MMDEGSVGDV SRIDEADVAH LQFKNSEQSF KPENIEVREV KEVQVQREAG SPDCSYGVIA
70 80 90 100 110 120
DFLDGKNGGD HVELIGNEPC SSRQNTNDEG DVVEELTVKT CEGSSMAIVG RPSSRARLEM
130 140 150 160 170 180
NRSQFLHRFP LDGDLPGSSS MSKKVIDRGT VSILRNAGKM SLPETSNGQL AIIAVNGEAN
190 200 210 220 230 240
EHLTNVERNP VPVEALSHEG IKTKMLSQSG FSQFFVRKTL KGKGVTFRGP PNNRSKARNM
250 260 270 280 290 300
DQQTVASSGS ALVIANTSAK ISSSIPLAAY DGLPCLPSNT SKPSSCANPS DTHRGCGGEG
310 320 330 340 350 360
LSLREWLKSE RQEVNKAECM YIFRQIVDHV DCSHSQGVVL CDLRPSSFKI FKENAVKYVV
370 380 390 400 410 420
SGSQRESFDS NMNKETLSQL ENPLVRRRLG DTSSLSIPAK KQKSSGPSSR QWPMFQRAGG
430 440 450 460 470 480
VNIQTENNDG AIQEFHFRSS QPHCSTVACP FTSVSEQLEE KWYASPEELR GDMRSASSNI
490 500 510 520 530 540
YSLGILLYEL LSQFQCERAR EAAMSDIRHR ILPPKFLSEN PKEAGFCLWL LHPESSCRPS
550 560 570 580 590 600
TRDILQSEVV NGIPDLYAEG LSLSIEQEDT ESELLQHFLF LSQEKRQKHA GNLMEEIASV
610 620 630 640 650 660
EADIEEIVKR RCAIGPPSLE EASSSSPASS VPEMRLIRNI NQLESAYFAA RIDAHLPEAR
670 680 690 700 710 720
YRLRPDRDLL RNSDNTVAEV ENSETWSSDD RVGAFFDGLC KYARYSKFET RGVLRTSELN
730 740 750 760 770 780
NTSNVICSLG FDRDEDYFAT AGVSKKIKIY EFNSLFNESV DIHYPAIEMP NRSKLSGVCW
790 800 810 820 830 840
NNYIRNYLAS SDYDGIVKLW DVTTGQAISH FIEHEKRAWS VDFSEACPTK LASGSDDCSV
850 860 870 880 890 900
KLWNINERNC LGTIRNIANV CCVQFSPQSS HLLAFGSSDF RTYCYDLRNL RTPWCILSGH
910 920 930 940 950 960
NKAVSYAKFL DNETLVTAST DNTLKLWDLK KTTHGGLSTN ACSLTFGGHT NEKNFVGLST
970 980 990 1000 1010 1020
SDGYIACGSE TNEVYAYHRS LPMPITSYKF GSIDPISGKE IEEDNNLFVS SVCWRKRSNM
1030
VVSASSNGSI KVLQLV