Descriptions

G-type lectin S-receptor-like serine/threonine-protein kinase At1g61550 (At1g61550) is annotated based on its experimentally validated activation loop, which is expected to act as accessory element in the autoinhibition of At1g61550.

Autoinhibitory domains (AIDs)

Accessory elements

631-638 (Activation loop from InterPro)

Target domain

489-774 (Protein kinase domain)

Relief mechanism

Assay

649-656 (Activation loop from InterPro)

Target domain

489-774 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9SY95

Entry ID Method Resolution Chain Position Source
AF-Q9SY95-F1 Predicted AlphaFoldDB

149 variants for Q9SY95

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_22707811_A_C 6 C>G No 1000Genomes
ENSVATH14377498 6 C>Y No 1000Genomes
tmp_1_22707778_T_G 17 S>R No 1000Genomes
ENSVATH14377497 25 S>I No 1000Genomes
ENSVATH05024492 27 L>* No 1000Genomes
ENSVATH13684071 34 S>C No 1000Genomes
ENSVATH00110852 39 I>V No 1000Genomes
ENSVATH05024490 50 S>P No 1000Genomes
ENSVATH01424975 51 R>Q No 1000Genomes
tmp_1_22707655_A_T 58 W>R No 1000Genomes
ENSVATH14377484 82 A>V No 1000Genomes
ENSVATH00110849 83 D>N No 1000Genomes
ENSVATH14377483 91 S>N No 1000Genomes
ENSVATH00110848 100 S>G No 1000Genomes
ENSVATH01424973 101 T>I No 1000Genomes
ENSVATH01424972 104 S>Y No 1000Genomes
tmp_1_22707511_C_T 106 G>R No 1000Genomes
ENSVATH01424971 107 E>* No 1000Genomes
ENSVATH05024487 107 E>D No 1000Genomes
ENSVATH13684070 109 F>C No 1000Genomes
ENSVATH14377482 110 A>V No 1000Genomes
ENSVATH05024486 113 G>R No 1000Genomes
ENSVATH05024485 115 S>T No 1000Genomes
ENSVATH05024483 121 S>N No 1000Genomes
ENSVATH05024483 121 S>T No 1000Genomes
tmp_1_22707450_A_G 126 V>A No 1000Genomes
ENSVATH01424969 126 V>L No 1000Genomes
ENSVATH14377481 127 I>R No 1000Genomes
ENSVATH00110847 129 K>R No 1000Genomes
ENSVATH13684068 136 W>R No 1000Genomes
ENSVATH01424966 143 G>S No 1000Genomes
ENSVATH14377480 148 P>L No 1000Genomes
tmp_1_22707378_G_C 150 S>C No 1000Genomes
ENSVATH01424965 153 M>V No 1000Genomes
ENSVATH00110846 159 G>S No 1000Genomes
tmp_1_22707343_G_A 162 R>W No 1000Genomes
ENSVATH14377479 163 V>I No 1000Genomes
ENSVATH05024482 170 Y>H No 1000Genomes
ENSVATH05024481 171 T>I No 1000Genomes
ENSVATH01424964 174 L>S No 1000Genomes
ENSVATH05024480 185 Q>* No 1000Genomes
ENSVATH05024479 197 K>T No 1000Genomes
tmp_1_22707227_C_T 200 W>* No 1000Genomes
ENSVATH01424963 203 G>S No 1000Genomes
tmp_1_22707208_T_G 207 K>Q No 1000Genomes
tmp_1_22707189_A_T 213 V>E No 1000Genomes
tmp_1_22707190_C_T 213 V>I No 1000Genomes
tmp_1_22707187_G_T 214 P>T No 1000Genomes
ENSVATH01424962 247 L>F No 1000Genomes
tmp_1_22707081_A_G 249 V>A No 1000Genomes
tmp_1_22707072_G_A 252 S>L No 1000Genomes
ENSVATH05024477 260 H>R No 1000Genomes
tmp_1_22707045_T_C 261 H>R No 1000Genomes
tmp_1_22706983_C_G 282 V>L No 1000Genomes
tmp_1_22706977_C_T 284 G>R No 1000Genomes
tmp_1_22706963_C_A 288 L>F No 1000Genomes
ENSVATH05024476 292 S>A No 1000Genomes
ENSVATH05024475 292 S>Y No 1000Genomes
tmp_1_22706937_C_T 297 C>Y No 1000Genomes
tmp_1_22706920_A_T 303 F>I No 1000Genomes
ENSVATH05024471 309 E>* No 1000Genomes
ENSVATH05024469 319 G>S No 1000Genomes
tmp_1_22706862_C_T 322 R>K No 1000Genomes
ENSVATH00110843 327 L>H No 1000Genomes
tmp_1_22706832_G_T 332 S>Y No 1000Genomes
ENSVATH00110842 358 G>R No 1000Genomes
tmp_1_22706748_G_C 360 A>G No 1000Genomes
ENSVATH01424955 369 H>Q No 1000Genomes
tmp_1_22706718_T_C 370 N>S No 1000Genomes
tmp_1_22706685_C_T 381 G>E No 1000Genomes
ENSVATH14377477 392 M>T No 1000Genomes
ENSVATH01424953 399 V>A No 1000Genomes
ENSVATH05024462 417 Q>H No 1000Genomes
ENSVATH13684049 417 Q>R No 1000Genomes
ENSVATH14377475 426 I>V No 1000Genomes
tmp_1_22706418_G_A 434 T>I No 1000Genomes
tmp_1_22706403_G_A 439 A>V No 1000Genomes
tmp_1_22706382_C_A 446 R>I No 1000Genomes
ENSVATH13684048 447 L>W No 1000Genomes
tmp_1_22706373_T_C 449 H>R No 1000Genomes
ENSVATH00110839 458 L>S No 1000Genomes
tmp_1_22706249_T_A 459 Q>L No 1000Genomes
tmp_1_22706217_C_A 470 D>Y No 1000Genomes
tmp_1_22706208_C_T 473 G>S No 1000Genomes
ENSVATH05024457 476 F>V No 1000Genomes
tmp_1_22706196_A_G 477 F>L No 1000Genomes
tmp_1_22706172_C_A 485 A>S No 1000Genomes
ENSVATH05024456 485 A>V No 1000Genomes
ENSVATH00110838 491 L>P No 1000Genomes
ENSVATH05024455 497 Q>H No 1000Genomes
tmp_1_22706114_T_A 504 Y>F No 1000Genomes
tmp_1_22706024_T_G 507 K>T No 1000Genomes
ENSVATH05024453 515 A>V No 1000Genomes
ENSVATH05024452 518 R>W No 1000Genomes
tmp_1_22705980_T_C 522 S>G No 1000Genomes
ENSVATH05024451 524 G>E No 1000Genomes
tmp_1_22705959_C_T 529 E>K No 1000Genomes
ENSVATH14377470 533 E>* No 1000Genomes
ENSVATH05024450 535 L>V No 1000Genomes
ENSVATH13684045 542 H>Y No 1000Genomes
ENSVATH14377469 547 R>W No 1000Genomes
tmp_1_22705886_A_G 553 I>T No 1000Genomes
tmp_1_22705880_C_T 555 G>E No 1000Genomes
ENSVATH01424945 563 E>D No 1000Genomes
tmp_1_22705847_A_C 566 V>G No 1000Genomes
tmp_1_22705848_C_A 566 V>L No 1000Genomes
tmp_1_22705830_T_A 572 T>S No 1000Genomes
tmp_1_22705726_AC_TC,A 581 V>D No 1000Genomes
tmp_1_22705722_C_G 582 E>D No 1000Genomes
tmp_1_22705717_T_C 584 D>G No 1000Genomes
ENSVATH13684042 585 W>* No 1000Genomes
ENSVATH14377467 597 R>C No 1000Genomes
ENSVATH05024441 613 R>P No 1000Genomes
tmp_1_22705592_T_A 626 M>L No 1000Genomes
ENSVATH13684039 630 I>L No 1000Genomes
tmp_1_22705561_G_A 636 A>V No 1000Genomes
ENSVATH05024438 638 M>I No 1000Genomes
ENSVATH05024437 640 E>D No 1000Genomes
tmp_1_22705527_G_C 647 N>K No 1000Genomes
tmp_1_22705396_T_C 662 Y>C No 1000Genomes
tmp_1_22705389_C_T 664 W>* No 1000Genomes
ENSVATH00110832 667 V>L No 1000Genomes
tmp_1_22705378_A_G 668 F>S No 1000Genomes
ENSVATH00110831 670 E>Q No 1000Genomes
ENSVATH01424942 686 S>C No 1000Genomes
tmp_1_22705322_C_T 687 G>R No 1000Genomes
ENSVATH13684037 694 S>R No 1000Genomes
tmp_1_22705279_T_C 701 N>S No 1000Genomes
tmp_1_22705141_C_T 712 E>K No 1000Genomes
tmp_1_22705137_T_G 713 N>T No 1000Genomes
ENSVATH00110830 717 G>D No 1000Genomes
ENSVATH01424940 723 A>V No 1000Genomes
ENSVATH01424939 724 T>A No 1000Genomes
tmp_1_22705080_A_G 732 V>A No 1000Genomes
ENSVATH05024429 745 H>N No 1000Genomes
ENSVATH00110829 748 A>T No 1000Genomes
ENSVATH14377433 749 D>N No 1000Genomes
tmp_1_22705019_G_C 752 N>K No 1000Genomes
tmp_1_22704996_A_G 760 L>P No 1000Genomes
ENSVATH05024428 763 T>I No 1000Genomes
ENSVATH14377432 767 P>A No 1000Genomes
ENSVATH00110828 768 L>V No 1000Genomes
ENSVATH14377431 773 T>K No 1000Genomes
ENSVATH14377430 775 A>V No 1000Genomes
tmp_1_22704927_G_A 783 S>F No 1000Genomes
ENSVATH13684018 783 S>T No 1000Genomes
ENSVATH00110827 792 N>I No 1000Genomes
ENSVATH01424937 795 T>I No 1000Genomes
tmp_1_22704880_C_T 799 V>M No 1000Genomes

No associated diseases with Q9SY95

1 regional properties for Q9SY95

Type Name Position InterPro Accession
conserved_site TATA-box binding protein, conserved site 283 - 332 IPR030491

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
carbohydrate binding Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
protein serine kinase activity Catalysis of the reactions
protein serine/threonine kinase activity Catalysis of the reactions
ubiquitin protein ligase binding Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

2 GO annotations of biological process

Name Definition
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
recognition of pollen A cell recognition process in which pollen is recognized and either accepted or rejected by cells in the stigma.

46 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q06805 TIE1 Tyrosine-protein kinase receptor Tie-1 Bos taurus (Bovine) PR
Q06807 TEK Angiopoietin-1 receptor Bos taurus (Bovine) SS
P43481 KIT Mast/stem cell growth factor receptor Kit Bos taurus (Bovine) SS
Q8AXY6 MUSK Muscle, skeletal receptor tyrosine protein kinase Gallus gallus (Chicken) SS
P09208 InR Insulin-like receptor Drosophila melanogaster (Fruit fly) SS
Q02763 TEK Angiopoietin-1 receptor Homo sapiens (Human) SS
P14616 INSRR Insulin receptor-related protein Homo sapiens (Human) SS
P35590 TIE1 Tyrosine-protein kinase receptor Tie-1 Homo sapiens (Human) PR
P08069 IGF1R Insulin-like growth factor 1 receptor Homo sapiens (Human) EV
P06213 INSR Insulin receptor Homo sapiens (Human) EV
Q01973 ROR1 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Homo sapiens (Human) PR
Q01974 ROR2 Tyrosine-protein kinase transmembrane receptor ROR2 Homo sapiens (Human) EV
P30530 AXL Tyrosine-protein kinase receptor UFO Homo sapiens (Human) PR
Q06806 Tie1 Tyrosine-protein kinase receptor Tie-1 Mus musculus (Mouse) SS
P15208 Insr Insulin receptor Mus musculus (Mouse) SS
Q9WTL4 Insrr Insulin receptor-related protein Mus musculus (Mouse) SS
Q60751 Igf1r Insulin-like growth factor 1 receptor Mus musculus (Mouse) SS
Q02858 Tek Angiopoietin-1 receptor Mus musculus (Mouse) SS
Q9Z139 Ror1 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Mus musculus (Mouse) PR
Q9Z138 Ror2 Tyrosine-protein kinase transmembrane receptor ROR2 Mus musculus (Mouse) SS
P15209 Ntrk2 BDNF/NT-3 growth factors receptor Mus musculus (Mouse) SS
Q6VNS1 Ntrk3 NT-3 growth factor receptor Mus musculus (Mouse) SS
P24062 Igf1r Insulin-like growth factor 1 receptor Rattus norvegicus (Rat) SS
Q64716 Insrr Insulin receptor-related protein Rattus norvegicus (Rat) SS
Q62838 Musk Muscle, skeletal receptor tyrosine protein kinase Rattus norvegicus (Rat) SS
P57097 Mertk Tyrosine-protein kinase Mer Rattus norvegicus (Rat) SS
P15127 Insr Insulin receptor Rattus norvegicus (Rat) SS
O64783 At1g61370 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61370 Arabidopsis thaliana (Mouse-ear cress) SS
O64780 At1g61400 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61400 Arabidopsis thaliana (Mouse-ear cress) SS
O64770 At1g61490 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61490 Arabidopsis thaliana (Mouse-ear cress) SS
O64776 At1g61440 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61440 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SYA0 At1g61500 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61500 Arabidopsis thaliana (Mouse-ear cress) SS
O64778 At1g61420 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61420 Arabidopsis thaliana (Mouse-ear cress) SS
O64774 At1g61460 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61460 Arabidopsis thaliana (Mouse-ear cress) PR
O64782 SD129 G-type lectin S-receptor-like serine/threonine-protein kinase SD1-29 Arabidopsis thaliana (Mouse-ear cress) SS
O81833 SD11 G-type lectin S-receptor-like serine/threonine-protein kinase SD1-1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SXB5 At1g11303 G-type lectin S-receptor-like serine/threonine-protein kinase At1g11303 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SXB4 At1g11300 G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LPZ9 SD113 G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LW83 CES101 G-type lectin S-receptor-like serine/threonine-protein kinase CES101 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LDQ3 CRK34 Cysteine-rich receptor-like protein kinase 34 Arabidopsis thaliana (Mouse-ear cress) PR
O64784 At1g61360 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61360 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SXB8 At1g11330 G-type lectin S-receptor-like serine/threonine-protein kinase At1g11330 Arabidopsis thaliana (Mouse-ear cress) PR
O64793 At1g67520 G-type lectin S-receptor-like serine/threonine-protein kinase At1g67520 Arabidopsis thaliana (Mouse-ear cress) PR
O73791 tek Angiopoietin-1 receptor Danio rerio (Zebrafish) (Brachydanio rerio) SS
O13146 epha3 Ephrin type-A receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MTRFACFLFS TLLLSFSYAA ITPTSPLSIG QTLSSPNGIF ELGFFSPNNS RNLYVGIWFK
70 80 90 100 110 120
GIIPRTVVWV ANRENSVTDA TADLAISSNG SLLLFDGKHS TVWSTGETFA SNGSSAELSD
130 140 150 160 170 180
SGNLLVIDKV SGITLWQSFE HLGDTMLPYS SLMYNPGTGE KRVLSSWKSY TDPLPGEFVG
190 200 210 220 230 240
YITTQVPPQG FIMRGSKPYW RSGPWAKTRF TGVPLTDESY THPFSVQQDA NGSVYFSHLQ
250 260 270 280 290 300
RNFKRSLLVL TSEGSLKVTH HNGTDWVLNI DVPANTCDFY GVCGPFGLCV MSIPPKCKCF
310 320 330 340 350 360
KGFVPQFSEE WKRGNWTGGC VRRTELLCQG NSTGRHVNVF HPVANIKPPD FYEFVSSGSA
370 380 390 400 410 420
EECYQSCLHN CSCLAFAYIN GIGCLIWNQE LMDVMQFSVG GELLSIRLAS SEMGGNQRKK
430 440 450 460 470 480
TIIASIVSIS LFVTLASAAF GFWRYRLKHN AIVSKVSLQG AWRNDLKSED VSGLYFFEMK
490 500 510 520 530 540
TIEIATNNFS LVNKLGQGGF GPVYKGKLQD GKEIAVKRLS SSSGQGKEEF MNEILLISKL
550 560 570 580 590 600
QHINLVRILG CCIEGEERLL VYEFMVNKSL DTFIFDSRKR VEIDWPKRFS IIQGIARGLL
610 620 630 640 650 660
YLHRDSRLRI IHRDVKVSNI LLDDKMNPKI SDFGLARMYE GTKYQDNTRR IVGTLGYMSP
670 680 690 700 710 720
EYAWTGVFSE KSDTYSFGVL LLEVISGEKI SRFSYDKERK NLLAYAWESW CENGGVGFLD
730 740 750 760 770 780
KDATDSCHPS EVGRCVQIGL LCVQHQPADR PNTLELLSML TTTSDLPLPK EPTFAVHTSD
790 800
DGSRTSDLIT VNEVTQSVVL GR