Q9SXB8
Gene name |
At1g11330 (T28P6.2) |
Protein name |
G-type lectin S-receptor-like serine/threonine-protein kinase At1g11330 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G11330 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
666-673 (Activation loop from InterPro)
Target domain |
524-810 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
684-691 (Activation loop from InterPro)
Target domain |
524-810 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9SXB8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SXB8-F1 | Predicted | AlphaFoldDB |
57 variants for Q9SXB8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00017645 | 6 | T>N | No | 1000Genomes | |
| tmp_1_3810390_A_G | 7 | I>V | No | 1000Genomes | |
| ENSVATH01035282 | 12 | V>G | No | 1000Genomes | |
| ENSVATH10973586 | 12 | V>I | No | 1000Genomes | |
| ENSVATH10973586 | 12 | V>L | No | 1000Genomes | |
| ENSVATH04557329 | 16 | L>V | No | 1000Genomes | |
| ENSVATH04557330 | 18 | C>W | No | 1000Genomes | |
| ENSVATH04557331 | 20 | C>F | No | 1000Genomes | |
| ENSVATH01035284 | 24 | R>L | No | 1000Genomes | |
| ENSVATH00017646 | 37 | S>T | No | 1000Genomes | |
| ENSVATH04557334 | 71 | V>A | No | 1000Genomes | |
| ENSVATH01035285 | 77 | K>M | No | 1000Genomes | |
| ENSVATH00017648 | 90 | D>G | No | 1000Genomes | |
| ENSVATH04557335 | 96 | T>S | No | 1000Genomes | |
| tmp_1_3810663_G_A | 98 | G>S | No | 1000Genomes | |
| ENSVATH04557336 | 101 | S>* | No | 1000Genomes | |
| ENSVATH04557336 | 101 | S>L | No | 1000Genomes | |
| ENSVATH00017649 | 115 | N>K | No | 1000Genomes | |
| ENSVATH04557337 | 116 | R>L | No | 1000Genomes | |
| ENSVATH00017650 | 129 | P>S | No | 1000Genomes | |
| ENSVATH13879495 | 136 | L>F | No | 1000Genomes | |
| tmp_1_3810806_A_T | 145 | Q>H | No | 1000Genomes | |
| ENSVATH04557339 | 147 | N>D | No | 1000Genomes | |
| tmp_1_3810862_C_G | 164 | S>C | No | 1000Genomes | |
| ENSVATH10973589 | 205 | T>M | No | 1000Genomes | |
| tmp_1_3810996_C_A | 209 | L>I | No | 1000Genomes | |
| ENSVATH10973591 | 241 | L>F | No | 1000Genomes | |
| ENSVATH04557344 | 268 | N>K | No | 1000Genomes | |
| ENSVATH04557345 | 286 | T>S | No | 1000Genomes | |
| ENSVATH01035288 | 312 | A>D | No | 1000Genomes | |
| ENSVATH04557348 | 316 | P>R | No | 1000Genomes | |
| ENSVATH04557351 | 322 | K>Q | No | 1000Genomes | |
| ENSVATH04557352 | 322 | K>R | No | 1000Genomes | |
| ENSVATH01035290 | 325 | V>F | No | 1000Genomes | |
| ENSVATH00017655 | 342 | M>V | No | 1000Genomes | |
| ENSVATH10973592 | 355 | V>A | No | 1000Genomes | |
| ENSVATH13879496 | 386 | E>Q | No | 1000Genomes | |
| ENSVATH10973593 | 413 | W>* | No | 1000Genomes | |
| ENSVATH04557358 | 430 | L>V | No | 1000Genomes | |
| ENSVATH00017663 | 436 | H>N | No | 1000Genomes | |
| ENSVATH04557370 | 443 | S>I | No | 1000Genomes | |
| tmp_1_3811798_C_A | 445 | L>I | No | 1000Genomes | |
| tmp_1_3811813_G_T | 450 | A>S | No | 1000Genomes | |
| tmp_1_3811822_G_T | 453 | V>L | No | 1000Genomes | |
| ENSVATH01035303 | 457 | M>T | No | 1000Genomes | |
| ENSVATH01035302 | 457 | M>V | No | 1000Genomes | |
| ENSVATH00017668 | 472 | K>R | No | 1000Genomes | |
| ENSVATH00017671 | 476 | A>D | No | 1000Genomes | |
| ENSVATH04557376 | 485 | L>V | No | 1000Genomes | |
| ENSVATH04557377 | 495 | S>N | No | 1000Genomes | |
| tmp_1_3812108_C_T | 519 | T>I | No | 1000Genomes | |
| tmp_1_3812107_A_T | 519 | T>S | No | 1000Genomes | |
| tmp_1_3812116_G_A | 522 | D>N | No | 1000Genomes | |
| ENSVATH10973985 | 616 | K>E | No | 1000Genomes | |
| ENSVATH13879536 | 732 | E>D | No | 1000Genomes | |
| tmp_1_3813199_T_C | 771 | V>A | No | 1000Genomes | |
| ENSVATH10974105 | 837 | T>I | No | 1000Genomes |
No associated diseases with Q9SXB8
6 regional properties for Q9SXB8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 524 - 810 | IPR000719 |
| domain | S-locus glycoprotein domain | 219 - 328 | IPR000858 |
| domain | Bulb-type lectin domain | 32 - 186 | IPR001480 |
| domain | PAN/Apple domain | 349 - 435 | IPR003609 |
| active_site | Serine/threonine-protein kinase, active site | 645 - 657 | IPR008271 |
| domain | S-locus receptor kinase, C-terminal | 797 - 842 | IPR021820 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| carbohydrate binding | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| immune response | Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| recognition of pollen | A cell recognition process in which pollen is recognized and either accepted or rejected by cells in the stigma. |
29 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43481 | KIT | Mast/stem cell growth factor receptor Kit | Bos taurus (Bovine) | SS |
| Q8AXY6 | MUSK | Muscle, skeletal receptor tyrosine protein kinase | Gallus gallus (Chicken) | SS |
| P30530 | AXL | Tyrosine-protein kinase receptor UFO | Homo sapiens (Human) | PR |
| Q01973 | ROR1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Homo sapiens (Human) | PR |
| Q01974 | ROR2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Homo sapiens (Human) | EV |
| P15209 | Ntrk2 | BDNF/NT-3 growth factors receptor | Mus musculus (Mouse) | SS |
| Q6VNS1 | Ntrk3 | NT-3 growth factor receptor | Mus musculus (Mouse) | SS |
| Q9Z138 | Ror2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Mus musculus (Mouse) | SS |
| Q9Z139 | Ror1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Mus musculus (Mouse) | PR |
| Q62838 | Musk | Muscle, skeletal receptor tyrosine protein kinase | Rattus norvegicus (Rat) | SS |
| P57097 | Mertk | Tyrosine-protein kinase Mer | Rattus norvegicus (Rat) | SS |
| O64770 | At1g61490 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61490 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64783 | At1g61370 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61370 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LPZ9 | SD113 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SXB5 | At1g11303 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11303 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SYA0 | At1g61500 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61500 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64793 | At1g67520 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g67520 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LW83 | CES101 | G-type lectin S-receptor-like serine/threonine-protein kinase CES101 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDQ3 | CRK34 | Cysteine-rich receptor-like protein kinase 34 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81833 | SD11 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64780 | At1g61400 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61400 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64776 | At1g61440 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61440 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SY95 | At1g61550 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61550 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64778 | At1g61420 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61420 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64774 | At1g61460 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61460 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64784 | At1g61360 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61360 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64782 | SD129 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-29 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SXB4 | At1g11300 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O13146 | epha3 | Ephrin type-A receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVVSVTIRRR | FVLLLLACTC | LLSRRLCFGE | DRITFSSPIK | DSESETLLCK | SGIFRFGFFT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PVNSTTRLRY | VGIWYEKIPI | QTVVWVANKD | SPINDTSGVI | SIYQDGNLAV | TDGRNRLVWS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TNVSVPVAPN | ATWVQLMDSG | NLMLQDNRNN | GEILWESFKH | PYDSFMPRMT | LGTDGRTGGN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LKLTSWTSHD | DPSTGNYTAG | IAPFTFPELL | IWKNNVPTWR | SGPWNGQVFI | GLPNMDSLLF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LDGFNLNSDN | QGTISMSYAN | DSFMYHFNLD | PEGIIYQKDW | STSMRTWRIG | VKFPYTDCDA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YGRCGRFGSC | HAGENPPCKC | VKGFVPKNNT | EWNGGNWSNG | CMRKAPLQCE | RQRNVSNGGG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GGKADGFLKL | QKMKVPISAE | RSEASEQVCP | KVCLDNCSCT | AYAYDRGIGC | MLWSGDLVDM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QSFLGSGIDL | FIRVAHSELK | THSNLAVMIA | APVIGVMLIA | AVCVLLACRK | YKKRPAPAKD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RSAELMFKRM | EALTSDNESA | SNQIKLKELP | LFEFQVLATS | TDSFSLRNKL | GQGGFGPVYK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GKLPEGQEIA | VKRLSRKSGQ | GLEELMNEVV | VISKLQHRNL | VKLLGCCIEG | EERMLVYEYM |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PKKSLDAYLF | DPMKQKILDW | KTRFNIMEGI | CRGLLYLHRD | SRLKIIHRDL | KASNILLDEN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LNPKISDFGL | ARIFRANEDE | ANTRRVVGTY | GYMSPEYAME | GFFSEKSDVF | SLGVIFLEII |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SGRRNSSSHK | EENNLNLLAY | AWKLWNDGEA | ASLADPAVFD | KCFEKEIEKC | VHIGLLCVQE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VANDRPNVSN | VIWMLTTENM | SLADPKQPAF | IVRRGASEAE | SSDQSSQKVS | INDVSLTAVT |
| GR |