Q9SXA1
PR
Gene name |
PI4KA1 |
Protein name |
Phosphatidylinositol 4-kinase alpha 1 |
Names |
PI4-kinase alpha 1ao, PtdIns-4-kinase alpha 1, Phosphatidylinositol 4-OH kinase alpha1, AtPI4Kalpha1, PI-4Kalpha1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G49340 |
EC number |
2.7.1.67: Phosphotransferases with an alcohol group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
1897-1920 (Activation loop from InterPro)
Target domain |
1728-2027 (Catalytic domain of Type III Phosphoinositide 4-kinase alpha) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9SXA1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SXA1-F1 | Predicted | AlphaFoldDB |
104 variants for Q9SXA1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH01327696 | 9 | D>E | No | 1000Genomes | |
| ENSVATH13460908 | 57 | I>T | No | 1000Genomes | |
| tmp_1_18252535_C_T | 61 | P>S | No | 1000Genomes | |
| tmp_1_18252547_G_A | 65 | D>N | No | 1000Genomes | |
| tmp_1_18252554_G_A | 67 | R>H | No | 1000Genomes | |
| ENSVATH13460910 | 69 | K>E | No | 1000Genomes | |
| tmp_1_18252668_T_C | 105 | L>S | No | 1000Genomes | |
| tmp_1_18252700_C_A | 116 | P>T | No | 1000Genomes | |
| ENSVATH13460911 | 121 | E>V | No | 1000Genomes | |
| ENSVATH14268974 | 139 | G>D | No | 1000Genomes | |
| tmp_1_18252828_T_G | 158 | H>Q | No | 1000Genomes | |
| ENSVATH13460912 | 158 | H>R | No | 1000Genomes | |
| ENSVATH00089348 | 210 | I>V | No | 1000Genomes | |
| tmp_1_18252986_G_C | 211 | S>T | No | 1000Genomes | |
| tmp_1_18253064_C_T | 237 | S>F | No | 1000Genomes | |
| ENSVATH04913578 | 238 | S>A | No | 1000Genomes | |
| ENSVATH01327698 | 245 | V>A | No | 1000Genomes | |
| tmp_1_18253163_G_T | 270 | G>V | No | 1000Genomes | |
| ENSVATH04913579 | 271 | A>T | No | 1000Genomes | |
| tmp_1_18253206_C_G | 284 | D>E | No | 1000Genomes | |
| ENSVATH00089351 | 285 | E>D | No | 1000Genomes | |
| ENSVATH13460913 | 300 | I>L | No | 1000Genomes | |
| ENSVATH04913581 | 305 | D>G | No | 1000Genomes | |
| tmp_1_18253300_C_G | 316 | Q>E | No | 1000Genomes | |
| ENSVATH04913582 | 319 | F>L | No | 1000Genomes | |
| tmp_1_18253570_A_G | 348 | T>A | No | 1000Genomes | |
| tmp_1_18253582_G_A | 352 | A>T | No | 1000Genomes | |
| tmp_1_18253763_A_C | 412 | D>A | No | 1000Genomes | |
| ENSVATH13460937 | 456 | S>G | No | 1000Genomes | |
| ENSVATH00089357 | 463 | V>E | No | 1000Genomes | |
| tmp_1_18254087_G_A | 463 | V>M | No | 1000Genomes | |
| tmp_1_18254103_C_T | 468 | A>V | No | 1000Genomes | |
| tmp_1_18254121_C_T | 474 | A>V | No | 1000Genomes | |
| tmp_1_18254178_A_G | 493 | Y>C | No | 1000Genomes | |
| tmp_1_18254347_G_A | 516 | D>N | No | 1000Genomes | |
| ENSVATH04913590 | 521 | V>F | No | 1000Genomes | |
| ENSVATH04913592 | 566 | D>E | No | 1000Genomes | |
| ENSVATH13460942 | 567 | K>E | No | 1000Genomes | |
| tmp_1_18254743_A_T | 594 | T>S | No | 1000Genomes | |
| ENSVATH13460943 | 597 | P>L | No | 1000Genomes | |
| ENSVATH04913595 | 646 | S>I | No | 1000Genomes | |
| tmp_1_18254999_G_A | 648 | G>R | No | 1000Genomes | |
| tmp_1_18255376_A_T | 663 | E>V | No | 1000Genomes | |
| ENSVATH04913605 | 711 | N>S | No | 1000Genomes | |
| tmp_1_18255526_T_C | 713 | V>A | No | 1000Genomes | |
| tmp_1_18255553_C_A | 722 | T>N | No | 1000Genomes | |
| ENSVATH00089366 | 760 | E>A | No | 1000Genomes | |
| ENSVATH13460960 | 785 | T>A | No | 1000Genomes | |
| tmp_1_18256245_C_T | 876 | A>V | No | 1000Genomes | |
| tmp_1_18257269_C_G | 938 | S>W | No | 1000Genomes | |
| tmp_1_18257277_C_G | 941 | L>V | No | 1000Genomes | |
| tmp_1_18257344_C_A | 963 | T>N | No | 1000Genomes | |
| ENSVATH14269031 | 965 | A>G | No | 1000Genomes | |
| ENSVATH14269030 | 965 | A>T | No | 1000Genomes | |
| ENSVATH04913629 | 1025 | K>N | No | 1000Genomes | |
| tmp_1_18257967_T_C | 1037 | I>T | No | 1000Genomes | |
| tmp_1_18257972_G_C | 1039 | A>P | No | 1000Genomes | |
| tmp_1_18258150_C_T | 1098 | T>I | No | 1000Genomes | |
| ENSVATH13460998 | 1115 | S>T | No | 1000Genomes | |
| tmp_1_18258285_C_T | 1143 | T>I | No | 1000Genomes | |
| ENSVATH14269034 | 1153 | S>W | No | 1000Genomes | |
| tmp_1_18258319_A_C | 1154 | Q>H | No | 1000Genomes | |
| tmp_1_18258330_C_T | 1158 | T>I | No | 1000Genomes | |
| ENSVATH04913632 | 1166 | L>I | No | 1000Genomes | |
| tmp_1_18258478_G_A | 1171 | G>D | No | 1000Genomes | |
| tmp_1_18258480_G_T | 1172 | G>C | No | 1000Genomes | |
| tmp_1_18258553_C_T | 1196 | S>F | No | 1000Genomes | |
| ENSVATH01327717 | 1224 | A>T | No | 1000Genomes | |
| tmp_1_18258771_A_T | 1269 | S>C | No | 1000Genomes | |
| tmp_1_18259119_C_T | 1297 | A>V | No | 1000Genomes | |
| tmp_1_18259184_C_T | 1319 | R>C | No | 1000Genomes | |
| ENSVATH04913643 | 1323 | A>G | No | 1000Genomes | |
| ENSVATH04913644 | 1331 | M>V | No | 1000Genomes | |
| ENSVATH13461002 | 1366 | G>R | No | 1000Genomes | |
| ENSVATH14269060 | 1372 | P>L | No | 1000Genomes | |
| ENSVATH14269061 | 1376 | D>A | No | 1000Genomes | |
| ENSVATH04913653 | 1381 | N>K | No | 1000Genomes | |
| ENSVATH00089380 | 1385 | S>R | No | 1000Genomes | |
| tmp_1_18259863_C_T | 1407 | S>F | No | 1000Genomes | |
| ENSVATH14269062 | 1414 | R>C | No | 1000Genomes | |
| ENSVATH01327720 | 1419 | L>F | No | 1000Genomes | |
| tmp_1_18259898_T_A | 1419 | L>M | No | 1000Genomes | |
| ENSVATH04913656 | 1437 | T>S | No | 1000Genomes | |
| ENSVATH04913659 | 1500 | V>I | No | 1000Genomes | |
| ENSVATH04913660 | 1510 | V>M | No | 1000Genomes | |
| tmp_1_18260758_T_C | 1522 | I>T | No | 1000Genomes | |
| ENSVATH13461018 | 1530 | E>D | No | 1000Genomes | |
| ENSVATH14269064 | 1540 | N>Y | No | 1000Genomes | |
| ENSVATH04913671 | 1576 | V>L | No | 1000Genomes | |
| ENSVATH14269088 | 1609 | R>S | No | 1000Genomes | |
| tmp_1_18261588_A_G | 1623 | D>G | No | 1000Genomes | |
| tmp_1_18261608_A_G | 1630 | I>V | No | 1000Genomes | |
| tmp_1_18261756_G_A | 1648 | D>N | No | 1000Genomes | |
| ENSVATH14269093 | 1651 | A>V | No | 1000Genomes | |
| tmp_1_18262273_G_A | 1661 | R>Q | No | 1000Genomes | |
| ENSVATH04913688 | 1681 | D>N | No | 1000Genomes | |
| tmp_1_18262380_C_A | 1697 | P>T | No | 1000Genomes | |
| tmp_1_18262497_G_C | 1710 | E>D | No | 1000Genomes | |
| ENSVATH14269094 | 1716 | G>V | No | 1000Genomes | |
| ENSVATH04913692 | 1717 | D>V | No | 1000Genomes | |
| ENSVATH13461070 | 1731 | G>S | No | 1000Genomes | |
| ENSVATH04913693 | 1734 | V>I | No | 1000Genomes | |
| tmp_1_18262662_A_C | 1765 | K>N | No | 1000Genomes | |
| ENSVATH04913707 | 1961 | S>N | No | 1000Genomes |
No associated diseases with Q9SXA1
4 regional properties for Q9SXA1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phosphatidylinositol 3-/4-kinase, catalytic domain | 1734 - 2025 | IPR000403 |
| domain | Phosphoinositide 3-kinase, accessory (PIK) domain | 1483 - 1677 | IPR001263 |
| conserved_site | Phosphatidylinositol 3/4-kinase, conserved site | 1771 - 1785 | IPR018936 |
| domain | PI4-kinase, N-terminal | 297 - 1469 | IPR045495 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.1.67 | Phosphotransferases with an alcohol group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| extrinsic component of cytoplasmic side of plasma membrane | The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| membrane microdomain | A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| plasma membrane protein complex | Any protein complex that is part of the plasma membrane. |
| plasmodesma | A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-phosphatidylinositol 4-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+). |
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| lipid kinase activity | Catalysis of the phosphorylation of a simple or complex lipid. |
| phosphatidic acid binding | Binding to phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. |
| phosphatidylinositol kinase activity | Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate. |
| phosphatidylinositol-4,5-bisphosphate binding | Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. |
| phosphatidylinositol-4-phosphate binding | Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphatidylinositol phosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. |
| phosphatidylinositol-mediated signaling | The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
| pollen development | The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of shoot system development | Any process that modulates the frequency, rate or extent of shoot development. |
| root development | The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEALTELCDI | IAKNPKQFSE | KLAWICGRCP | QTEWLLAESP | RVSRSHLNAV | LAVARIISKN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PESIDNRAKS | VVNEFLSAIP | ASFRRSFWPH | SFPSQLISSF | YCDFLSYLSC | AADLSPEFGT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EVARFTGEVV | IAAIAPSSGD | SDGDPAISKA | FLVALSQHFP | SILQSDGDKL | ITMLLDQFVL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NRAPASPKEQ | RQQNSANSET | DTSSSQGSPI | STNRYPSGKT | EMASPGDEVA | SHGSNLSSKS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SSSVVMNGGS | IVWKSGVDQL | SFGFSEGSGG | ANPVFRQQVA | SFEDESIESL | EKQEIAFRLI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| THILDKVKID | SKLQDQVRFI | AKRQLQSMSA | FLKSRKRDWN | EQGQVLKTRV | NAKLSVYQAA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AKMKIKSLVS | LETDGKTSKR | LVLETLALLL | DAADACLTSV | WRKMKACEEL | FDSLLSGIAK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IAVARGGQPL | RVLLIRLKPL | VLAVCALPDQ | GAMLESIFKT | SCVIIESAWA | KDRAPVDNFI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| MGLASSIRER | NDYEEQVDRE | KQVPAVQLNV | IRLLADLNVA | VKKPEVADMI | LPLFIESLEE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GDASTPSFLR | LQLLDAVSRI | ATLGFDKSYR | ETVVLMTRSY | LSKLSSVGSV | ESKTSAPEAT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TERVETLPAG | FLTIASGLMD | TKLRSDYRHR | LLSLCSDVGL | AAESKSGGSG | VDFLGPLLPA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VAEICSDFDP | TMDVEPSLLK | LFRNLWFYIA | LFGLAPPIVK | TPTPPLKSTS | NSVNSVGSMS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ATALQAVGGP | YMWDNQWALA | VQRIAQGTPP | LVVSSVKWLE | DELELNALHN | PGSRRGNGNE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KVASTQRLAL | STALGGRVDV | AAMNTISGVK | ATYLLAVAFL | EIIRFISNGG | ILNGESSVSA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| SRSAFSCVFE | YLKTPNLTPA | VSQCLTAIVH | RAFETAVSWL | EDRISLTGKD | ARNRELTTYA |
| 910 | 920 | 930 | 940 | 950 | 960 |
| HACFLIKSMS | QRDEHVRDIS | VNLLTQLRDK | FPQVLWHSSC | LDSLLFSVHD | NTPSTVVNDP |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| AWTAAVRSLY | QKVVREWIII | SLSYAPCTSQ | GLLQDKLCKA | NTWQRAQTTT | DVVSLLSEIK |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| IGTGKNELWS | GIRTANIPAV | MAAAAAASGA | NLKVSEAFNL | EVLGTGVVSA | TVKCNHAGEI |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| AGMRRLYNSI | GGFQSGSTPS | GFGGGLQRLI | SGAFSQAPQP | EDDSFNEMLI | ARFVRLLQQF |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| VNTAEKGGEV | EKSQFRETCS | QATALLLSNL | GGESKTNVEG | FSQLLRLLCW | CPAYISTPDA |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| METGIFIWTW | LVSAAPQLVS | LVLAELVDAW | IWTIDTKRGL | FASDVRYSGP | AAKLRPHLSP |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| GEPEDPPESD | PVDQIVAHRL | WLGFLIDRFE | VVRHNSAEQL | LLLGRMLQRS | TDLEWCFTRH |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| PAAAGTFFSL | MLLGLKFCSC | QTQGNMQKFR | SGLQLLEDRI | YRTSLGWFAH | QPEWYDVNIP |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| NFCHSEALSV | SVFVHFLSNE | LSESSQSDSK | GKPRESGNLI | DVTDQYHPVW | GEMDNYTLGK |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| EKRKQLLLML | CQHEADRLDV | WAQPISSKDS | PYSRLKISSE | KWTEYAKTAF | SVDPRIALSV |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| ASRFPANASV | KSEVTQLVQT | NIVDLRTIPE | ALPYFVTPKN | VEENSVLLQQ | LPHWAACSIT |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| QALEFLTPAY | KGHPRVMAYV | LRVLESYPPE | RVTFFMPQLV | QSLRYDDGRL | VEGYLLRATQ |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| RSDIFAHILI | WHLQGEDVQE | TPKDGSIDKN | AAFQEILPQV | RQHIIDGFSP | NALDMFTREF |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| DFFDKVTSIS | GVLFPLPKEE | RRAGIRRELE | KIEMQGDDLY | LPTAPNKLVR | GIRVDSGIPL |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| QSAAKVPIMI | TFNVIDRDGD | HSDVKPQACI | FKVGDDCRQD | VLALQVISLL | RDIFQAAGLN |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| LYLFPYGVLP | TGAERGIIEV | VPNTRSRSQM | GETTDGGLYE | IFQQDYGPVG | STTFETAREN |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| FLISSAGYAV | ASLLLQPKDR | HNGNLLFDDV | GRLVHIDFGF | ILETSPGGNM | RFESAHFKLS |
| 1930 | 1940 | 1950 | 1960 | 1970 | 1980 |
| HEMTQLLDPS | GVMKSKTWHQ | FVSLCVKGYL | AARRQMDGII | STVQMMLESG | LPCFSRGDPI |
| 1990 | 2000 | 2010 | 2020 | ||
| GNLRKRFHPE | MSEREAAHFM | IHVCTDAYNK | WTTAGYDLIQ | YLQQGIEK |