Q9SV36
PR
Gene name |
KINUC |
Protein name |
Kinesin-like protein KIN-UC |
Names |
AtKINUc, Protein ARMADILLO REPEAT KINESIN1, Protein ARMADILLO REPEAT-CONTAINING KINESIN 1, Protein CA-ROP2 ENHANCER 1, Protein MORPHOGENESIS OF ROOT HAIR 2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G54870 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SV36
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SV36-F1 | Predicted | AlphaFoldDB |
33 variants for Q9SV36
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_20330834_T_C | 10 | V>A | No | 1000Genomes | |
| ENSVATH00419703 | 32 | A>T | No | 1000Genomes | |
| ENSVATH06316445 | 42 | L>F | No | 1000Genomes | |
| ENSVATH14435549 | 43 | P>S | No | 1000Genomes | |
| ENSVATH06316446 | 68 | S>T | No | 1000Genomes | |
| ENSVATH06316448 | 97 | D>E | No | 1000Genomes | |
| tmp_3_20331870_C_T | 225 | S>F | No | 1000Genomes | |
| tmp_3_20331873_C_A | 226 | S>Y | No | 1000Genomes | |
| tmp_3_20332403_T_A | 329 | S>T | No | 1000Genomes | |
| ENSVATH12764137 | 361 | G>S | No | 1000Genomes | |
| ENSVATH06316490 | 503 | A>V | No | 1000Genomes | |
| ENSVATH00419707 | 512 | K>M | No | 1000Genomes | |
| ENSVATH06316491 | 514 | N>I | No | 1000Genomes | |
| ENSVATH06316493 | 560 | S>L | No | 1000Genomes | |
| ENSVATH14435585 | 568 | D>H | No | 1000Genomes | |
| tmp_3_20333852_C_T | 578 | A>V | No | 1000Genomes | |
| tmp_3_20333867_G_T | 583 | R>L | No | 1000Genomes | |
| ENSVATH02505595 | 605 | L>M | No | 1000Genomes | |
| tmp_3_20334215_G_C | 668 | R>P | No | 1000Genomes | |
| ENSVATH14435586 | 669 | Q>H | No | 1000Genomes | |
| ENSVATH12764179 | 673 | Q>E | No | 1000Genomes | |
| ENSVATH06316500 | 694 | S>L | No | 1000Genomes | |
| ENSVATH08156842 | 701 | T>I | No | 1000Genomes | |
| tmp_3_20334468_C_A | 705 | D>E | No | 1000Genomes | |
| ENSVATH02505598 | 709 | L>M | No | 1000Genomes | |
| tmp_3_20334827_A_G | 761 | M>V | No | 1000Genomes | |
| tmp_3_20334936_G_A | 797 | R>K | No | 1000Genomes | |
| tmp_3_20335090_A_T | 814 | E>D | No | 1000Genomes | |
| tmp_3_20335139_G_T | 831 | A>S | No | 1000Genomes | |
| tmp_3_20335238_C_T | 834 | A>V | No | 1000Genomes | |
| ENSVATH06316516 | 850 | M>T | No | 1000Genomes | |
| tmp_3_20335692_G_A | 899 | D>N | No | 1000Genomes | |
| tmp_3_20336156_T_A | 974 | L>M | No | 1000Genomes |
No associated diseases with Q9SV36
No regional properties for Q9SV36
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9SV36 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| kinesin complex | Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work. |
| microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
| phragmoplast | Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules. |
| spindle | The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| microtubule binding | Binding to a microtubule, a filament composed of tubulin monomers. |
| microtubule motor activity | A motor activity that generates movement along a microtubule, driven by ATP hydrolysis. |
| plus-end-directed microtubule motor activity | A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cytoskeleton-dependent intracellular transport | The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell. |
| microtubule-based movement | A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P17210 | Khc | Kinesin heavy chain | Drosophila melanogaster (Fruit fly) | EV |
| P33176 | KIF5B | Kinesin-1 heavy chain | Homo sapiens (Human) | EV |
| O60282 | KIF5C | Kinesin heavy chain isoform 5C | Homo sapiens (Human) | EV |
| Q12840 | KIF5A | Kinesin heavy chain isoform 5A | Homo sapiens (Human) | EV |
| Q61768 | Kif5b | Kinesin-1 heavy chain | Mus musculus (Mouse) | EV |
| P28738 | Kif5c | Kinesin heavy chain isoform 5C | Mus musculus (Mouse) | SS |
| P33175 | Kif5a | Kinesin heavy chain isoform 5A | Mus musculus (Mouse) | SS |
| Q6QLM7 | Kif5a | Kinesin heavy chain isoform 5A | Rattus norvegicus (Rat) | SS |
| Q2PQA9 | Kif5b | Kinesin-1 heavy chain | Rattus norvegicus (Rat) | SS |
| P34540 | unc-116 | Kinesin heavy chain | Caenorhabditis elegans | SS |
| P46864 | KIN14M | Kinesin-like protein KIN-14M | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSSNSSSAV | RSSAKHAAER | IQQHLPPNSN | HAVSLSSSSL | NLPARTSIVA | PGIAHSSRLK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DRPSASSSSS | SSSVSASSPS | TRRSGTPVRR | SQSKDFDDDN | DPGRVRVSVR | VRPRNGEELI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SDADFADLVE | LQPEIKRLKL | RKNNWNSESY | KFDEVFTDTA | SQKRVYEGVA | KPVVEGVLSG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YNGTIMAYGQ | TGTGKTYTVG | KIGKDDAAER | GIMVRALEDI | LLNASSASIS | VEISYLQLYM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ETIQDLLAPE | KNNISINEDA | KTGEVSVPGA | TVVNIQDLDH | FLQVLQVGET | NRHAANTKMN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TESSRSHAIL | TVYVRRAMNE | KTEKAKPESL | GDKAIPRVRK | SKLLIVDLAG | SERINKSGTD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GHMIEEAKFI | NLSLTSLGKC | INALAEGSSH | IPTRDSKLTR | LLRDSFGGSA | RTSLIITIGP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SARYHAETTS | TIMFGQRAMK | IVNMVKLKEE | FDYESLCRKL | ETQVDHLTAE | VERQNKLRNS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EKHELEKRLR | ECENSFAEAE | KNAVTRSKFL | EKENTRLELS | MKELLKDLQL | QKDQCDLMHD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KAIQLEMKLK | NTKQQQLENS | AYEAKLADTS | QVYEKKIAEL | VQRVEDEQAR | STNAEHQLTE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| MKNILSKQQK | SIHEQEKGNY | QYQRELAETT | HTYESKIAEL | QKKLEGENAR | SNAAEDQLRQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| MKRLISDRQV | ISQENEEANE | LKIKLEELSQ | MYESTVDELQ | TVKLDYDDLL | QQKEKLGEEV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| RDMKERLLLE | EKQRKQMESE | LSKLKKNLRE | SENVVEEKRY | MKEDLSKGSA | ESGAQTGSQR |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SQGLKKSLSG | QRATMARLCE | EVGIQKILQL | IKSEDLEVQI | QAVKVVANLA | AEEANQVKIV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| EEGGVEALLM | LVQSSQNSTI | LRVASGAIAN | LAMNEKSQDL | IMNKGGAQLL | AKMVTKTDDP |
| 910 | 920 | 930 | 940 | 950 | 960 |
| QTLRMVAGAL | ANLCGNEKFL | KLLKEEEGIK | GLLTMAQSGN | IDIIAQVARG | MANFAKCETR |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| EIMQGRRKGR | SLLLEEGVLE | WLTSNSHIDS | ASTQRHIELA | LCHLAQNEEN | ANDFKRTGSV |
| 1030 | 1040 | 1050 | |||
| TEIVRISVES | SRDDIRSLAK | KILKTNPYFS | S |