Q9SUT8

PR
Gene name
RBOHI (At4g11230, F8L21.20)
Protein name
Probable respiratory burst oxidase homolog protein I
Names
NADPH oxidase RBOHI, AtRBOHI
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G11230
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

824-897 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9SUT8

Entry ID Method Resolution Chain Position Source
AF-Q9SUT8-F1 Predicted AlphaFoldDB

55 variants for Q9SUT8

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_4_6845579_C_T 3 M>I No 1000Genomes
tmp_4_6845578_A_C 4 S>A No 1000Genomes
ENSVATH14133923 6 S>P No 1000Genomes
tmp_4_6845559_T_A 10 H>L No 1000Genomes
tmp_4_6845560_G_T 10 H>N No 1000Genomes
tmp_4_6845558_G_T 10 H>Q No 1000Genomes
ENSVATH11494978 33 A>S No 1000Genomes
ENSVATH06615253 39 P>L No 1000Genomes
ENSVATH06615251 45 S>P No 1000Genomes
ENSVATH02785804 47 E>K No 1000Genomes
ENSVATH06615250 50 L>V No 1000Genomes
ENSVATH06615247 62 I>V No 1000Genomes
ENSVATH06615244 94 L>H No 1000Genomes
ENSVATH06615244 94 L>R No 1000Genomes
tmp_4_6845247_T_G 114 Q>P No 1000Genomes
tmp_4_6845230_G_A 120 R>W No 1000Genomes
ENSVATH00489921 155 P>S No 1000Genomes
ENSVATH00489920 164 G>C No 1000Genomes
tmp_4_6845008_G_A 194 H>Y No 1000Genomes
tmp_4_6845005_G_A 195 L>F No 1000Genomes
tmp_4_6844853_T_A 215 E>V No 1000Genomes
ENSVATH11494928 307 M>I No 1000Genomes
tmp_4_6844024_A_G 316 Y>H No 1000Genomes
ENSVATH06615210 327 I>M No 1000Genomes
tmp_4_6843408_G_A 348 A>V No 1000Genomes
ENSVATH11494914 379 T>I No 1000Genomes
ENSVATH11494913 391 W>C No 1000Genomes
tmp_4_6843243_T_G 403 H>P No 1000Genomes
tmp_4_6843184_T_A 423 M>L No 1000Genomes
tmp_4_6843116_G_C 445 H>Q No 1000Genomes
tmp_4_6842901_C_T 487 D>N No 1000Genomes
tmp_4_6842870_T_A 497 Y>F No 1000Genomes
tmp_4_6842853_G_A 503 P>S No 1000Genomes
tmp_4_6842823_C_G 513 V>L No 1000Genomes
tmp_4_6842669_G_A 564 T>I No 1000Genomes
ENSVATH11494909 580 H>L No 1000Genomes
tmp_4_6842514_C_T 587 V>I No 1000Genomes
ENSVATH00489918 589 M>V No 1000Genomes
ENSVATH06615202 615 E>K No 1000Genomes
tmp_4_6842274_G_A 632 S>F No 1000Genomes
tmp_4_6842266_T_A 635 T>S No 1000Genomes
tmp_4_6842262_G_A 636 S>L No 1000Genomes
tmp_4_6842263_A_T 636 S>T No 1000Genomes
ENSVATH06615199 662 I>V No 1000Genomes
tmp_4_6841990_C_T 684 G>R No 1000Genomes
tmp_4_6841965_A_G 692 V>A No 1000Genomes
ENSVATH11494884 758 N>K No 1000Genomes
tmp_4_6841674_G_C 765 Q>E No 1000Genomes
ENSVATH06615195 766 A>T No 1000Genomes
ENSVATH06615191 791 A>V No 1000Genomes
ENSVATH06615190 794 R>Q No 1000Genomes
tmp_4_6841481_T_A 802 T>S No 1000Genomes
ENSVATH00489915 848 V>I No 1000Genomes
tmp_4_6840831_G_A 929 T>M No 1000Genomes
tmp_4_6840812_A_C 935 D>E No 1000Genomes

No associated diseases with Q9SUT8

5 regional properties for Q9SUT8

Type Name Position InterPro Accession
domain FAD-binding 8 613 - 726 IPR013112
domain Ferric reductase, NAD binding domain 733 - 923 IPR013121
domain Ferric reductase transmembrane component-like domain 414 - 570 IPR013130
domain NADPH oxidase Respiratory burst 159 - 258 IPR013623
domain FAD-binding domain, ferredoxin reductase-type 609 - 729 IPR017927

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ferric-chelate reductase activity Catalysis of the reaction: 2 Fe3+-siderophore + electron donor -> 2 Fe3+-siderophore + electron acceptor.
metal ion binding Binding to a metal ion.
NAD(P)H oxidase H2O2-forming activity Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide.
peroxidase activity Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O.

1 GO annotations of biological process

Name Definition
response to osmotic stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96PH1 NOX5 NADPH oxidase 5 Homo sapiens (Human) EV
Q948T9 RBOHB Respiratory burst oxidase homolog protein B Solanum tuberosum (Potato) PR
Q948U0 RBOHA Respiratory burst oxidase homolog protein A Solanum tuberosum (Potato) PR
Q5ZAJ0 RBOHB Respiratory burst oxidase homolog protein B Oryza sativa subsp japonica (Rice) PR
O48538 RBOHF Respiratory burst oxidase homolog protein F Arabidopsis thaliana (Mouse-ear cress) PR
P92949 CDC5 Ferric reduction oxidase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q8W110 FRO4 Ferric reduction oxidase 4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FIJ0 RBOHD Respiratory burst oxidase homolog protein D Arabidopsis thaliana (Mouse-ear cress) PR
Q9FJD6 RBOHH Putative respiratory burst oxidase homolog protein H Arabidopsis thaliana (Mouse-ear cress) PR
F4I4K7 FRO3 Ferric reduction oxidase 3, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
O81211 RBOHE Respiratory burst oxidase homolog protein E Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSMSFSGGTH NDRWGSDLAS AGEFTQSFPS LPATYSPSPS SSSSSGEELL EVTIEFPSGV
70 80 90 100 110 120
IINIDSVTGT GTDISGTDLE ITSCSDSGSG SRSLSLGWSA SSERLTAGTN SKQQIQKISR
130 140 150 160 170 180
RGYGYSSRSA PEPVVPHRGE ITDSVNLPRA LSQRPTRPNR DGSGTERAIH GLKFISSKEN
190 200 210 220 230 240
GIVDWNDVQN NFAHLSKDGY LFKSDFAHCI GLENENSKEF ADELFDALCR RRRIMVDKIN
250 260 270 280 290 300
LQELYEFWYQ ITDESFDSRL QIFFNMVKNG DGRITENEVK EIIILSASAN NLSRLRERAE
310 320 330 340 350 360
EYAALIMEEL APDGLYSQYI ELKDLEILLL EKDISHSYSL PFSQTSRALS QNLKDRRWRM
370 380 390 400 410 420
SRNLLYSLQD NWKRIWVLTL WFVIMAWLFM WKCYQYKHKD AFHVMGYCLV MAKGAAETLK
430 440 450 460 470 480
FNMALILLPV CRNTITYLRS TALSHSVPFD DCINFHKTIS VAIISAMLLH ATSHLACDFP
490 500 510 520 530 540
RILASTDTDY KRYLVKYFGV TRPTYFGLVN TPVGITGIIM VAFMLIAFTL ASRRCRRNLT
550 560 570 580 590 600
KLPKPFDKLT GYNAFWYSHH LLLTVYVLLV IHGVSLYLEH KWYRKTVWMY LAVPVLLYVG
610 620 630 640 650 660
ERIFRFFRSR LYTVEICKVV IYPGNVVVLR MSKPTSFDYK SGQYVFVQCP SVSKFEWHPF
670 680 690 700 710 720
SITSSPGDDY LSIHIRQRGD WTEGIKKAFS VVCHAPEAGK SGLLRADVPN QRSFPELLID
730 740 750 760 770 780
GPYGAPAQDH WKYDVVLLVG LGIGATPFVS ILRDLLNNII KQQEQAECIS GSCSNSNISS
790 800 810 820 830 840
DHSFSCLNSE AASRIPQTQR KTLNTKNAYF YWVTREQGSF DWFKEIMNEI ADSDRKGVIE
850 860 870 880 890 900
MHNYLTSVYE EGDTRSNLLT MIQTLNHAKN GVDIFSGTKV RTHFGRPKWK KVLSKISTKH
910 920 930 940
RNARIGVFYC GVPSLGKELS TLCHEFNQTG ITRFDFHKEQ F