Q9SUA3
Gene name |
D6PKL1 (At4g26610, T15N24.60) |
Protein name |
Serine/threonine-protein kinase D6PKL1 |
Names |
Serine/threonine-protein kinase AGC1-2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G26610 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
265-275 (Activation loop from InterPro)
Target domain |
123-456 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
353-361 (Activation loop from InterPro)
Target domain |
123-456 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9SUA3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SUA3-F1 | Predicted | AlphaFoldDB |
23 variants for Q9SUA3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00539769 | 5 | Y>H | No | 1000Genomes | |
| ENSVATH06780679 | 6 | G>A | No | 1000Genomes | |
| tmp_4_13425606_T_G | 13 | N>K | No | 1000Genomes | |
| tmp_4_13425635_C_T | 23 | P>L | No | 1000Genomes | |
| ENSVATH00539770 | 23 | P>S | No | 1000Genomes | |
| ENSVATH06780680 | 27 | Y>F | No | 1000Genomes | |
| tmp_4_13425685_C_A | 40 | Q>K | No | 1000Genomes | |
| tmp_4_13425751_A_G | 62 | N>D | No | 1000Genomes | |
| ENSVATH14299528 | 102 | D>G | No | 1000Genomes | |
| ENSVATH14299527 | 102 | D>Y | No | 1000Genomes | |
| tmp_4_13425902_G_A | 112 | R>Q | No | 1000Genomes | |
| ENSVATH14299529 | 113 | T>A | No | 1000Genomes | |
| ENSVATH00539771 | 148 | F>Y | No | 1000Genomes | |
| tmp_4_13426018_A_G | 151 | M>V | No | 1000Genomes | |
| ENSVATH02927575 | 296 | C>F | No | 1000Genomes | |
| ENSVATH12245492 | 297 | A>V | No | 1000Genomes | |
| tmp_4_13426598_C_T | 311 | P>S | No | 1000Genomes | |
| ENSVATH00539774 | 319 | Y>F | No | 1000Genomes | |
| ENSVATH02927576 | 327 | D>G | No | 1000Genomes | |
| ENSVATH06780688 | 339 | S>T | No | 1000Genomes | |
| tmp_4_13427001_G_A | 445 | R>H | No | 1000Genomes | |
| ENSVATH06780693 | 497 | Q>P | No | 1000Genomes | |
| ENSVATH00539775 | 498 | S>C | No | 1000Genomes |
No associated diseases with Q9SUA3
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| kinase activity | Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| auxin-activated signaling pathway | The series of molecular signals generated by the binding of the plant hormone auxin to a receptor, and ending with modulation of a downstream cellular process, e.g. transcription. |
| basipetal auxin transport | The unidirectional movement of auxin from the apex to base of an organ, including the shoot, leaf, primary root, or lateral root. |
| phototropism | The movement of an organism, or part of an organism, in response to a light stimulus, usually toward or away from it. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
29 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P83099 | Pkcdelta | Putative protein kinase C delta type homolog | Drosophila melanogaster (Fruit fly) | PR |
| P05130 | Pkc53E | Protein kinase C, brain isozyme | Drosophila melanogaster (Fruit fly) | SS |
| P13677 | inaC | Protein kinase C, eye isozyme | Drosophila melanogaster (Fruit fly) | SS |
| Q8INB9 | Akt | RAC serine/threonine-protein kinase | Drosophila melanogaster (Fruit fly) | SS |
| P05771 | PRKCB | Protein kinase C beta type | Homo sapiens (Human) | SS |
| P17252 | PRKCA | Protein kinase C alpha type | Homo sapiens (Human) | EV |
| P05129 | PRKCG | Protein kinase C gamma type | Homo sapiens (Human) | SS |
| Q02156 | PRKCE | Protein kinase C epsilon type | Homo sapiens (Human) | SS |
| P24723 | PRKCH | Protein kinase C eta type | Homo sapiens (Human) | SS |
| Q04759 | PRKCQ | Protein kinase C theta type | Homo sapiens (Human) | PR |
| Q05655 | PRKCD | Protein kinase C delta type | Homo sapiens (Human) | SS |
| P41743 | PRKCI | Protein kinase C iota type | Homo sapiens (Human) | EV |
| Q05513 | PRKCZ | Protein kinase C zeta type | Homo sapiens (Human) | SS |
| Q9Y243 | AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens (Human) | SS |
| P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens (Human) | EV SS |
| P31749 | AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens (Human) | EV |
| Q9HBY8 | SGK2 | Serine/threonine-protein kinase Sgk2 | Homo sapiens (Human) | SS |
| Q96BR1 | SGK3 | Serine/threonine-protein kinase Sgk3 | Homo sapiens (Human) | SS |
| O00141 | SGK1 | Serine/threonine-protein kinase Sgk1 | Homo sapiens (Human) | PR |
| Q6PGN3 | Dclk2 | Serine/threonine-protein kinase DCLK2 | Mus musculus (Mouse) | PR |
| P70451 | Fer | Tyrosine-protein kinase Fer | Mus musculus (Mouse) | PR |
| Q9JLM8 | Dclk1 | Serine/threonine-protein kinase DCLK1 | Mus musculus (Mouse) | SS |
| Q9ERE3 | Sgk3 | Serine/threonine-protein kinase Sgk3 | Mus musculus (Mouse) | PR |
| P09760 | Fer | Tyrosine-protein kinase Fer | Rattus norvegicus (Rat) | PR |
| Q94E49 | PID2 | Protein kinase PINOID 2 | Oryza sativa subsp japonica (Rice) | PR |
| Q0DCT8 | Os06g0291600 | Protein kinase G11A | Oryza sativa subsp japonica (Rice) | PR |
| O64682 | PID | Protein kinase PINOID | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUL2 | WAG2 | Serine/threonine-protein kinase WAG2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O48963 | PHOT1 | Phototropin-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASKYGSGVL | PENKKEKGDK | ETPETSYSSQ | SVSVNTLADQ | VSSTLSFAPS | SDSKTGGEVK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FNEKSDQSGK | SNTCRPSTSS | DISDESTCSS | FSGNNKPHKA | NDVRWEAIQA | VRTKHGVLGL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NHFRLLKRLG | CGDIGTVHLA | ELHGTRCFFA | MKVMDKGALA | SRKKLLRAQT | EREILQCLDH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PFLPTLYSHF | ETEKFSCLVM | EFCPGGDLHT | LRQRQPGKRF | SEQAAKFYVA | EVLLAMEYLH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MLGIIYRDLK | PENVLVRDDG | HVMLSDFDLS | LRCTVSPTVV | RSTVLASEGQ | KNSGYCAQPA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CIQQPSCISA | PTTCFSPRYF | SSKSKKDKKM | KNETGNQVSP | LPELVAEPTS | ARSMSFVGTH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EYLAPEIIKG | EGHGSAVDWW | TFGIFLYELL | FGKTPFKGSG | NRATLFNVVG | QPLRFPESPV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VSFAARDLIR | SLLVKEPQHR | LAYKRGATEM | KQHPFFEGVN | WALVRCASPP | EIPKPVDYES |
| 490 | 500 | ||||
| APATPAAATS | TSVKSDQSNY | LEFDFF |