Q9STY3

SS
Gene name
PME33 (ARATH33, At3g47400, T21L8.150)
Protein name
Probable pectinesterase/pectinesterase inhibitor 33
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G47400
EC number
3.1.1.11: Carboxylic ester hydrolases
Protein Class

Descriptions

(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.

Autoinhibitory domains (AIDs)

83-237 (PMEI region) SS

Target domain

281-579 (Pectinesterase domain)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9STY3

Entry ID Method Resolution Chain Position Source
AF-Q9STY3-F1 Predicted AlphaFoldDB

72 variants for Q9STY3

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH12610015 16 L>F No 1000Genomes
ENSVATH06258865 18 P>S No 1000Genomes
tmp_3_17465723_C_A 32 T>N No 1000Genomes
ENSVATH06258869 33 D>A No 1000Genomes
tmp_3_17465725_G_C 33 D>H No 1000Genomes
ENSVATH00405478 36 P>L No 1000Genomes
tmp_3_17465741_G_C 38 W>S No 1000Genomes
tmp_3_17465753_T_C 42 V>A No 1000Genomes
ENSVATH12610017 44 P>T No 1000Genomes
ENSVATH06258870 45 P>L No 1000Genomes
ENSVATH06258871 46 P>T No 1000Genomes
ENSVATH06258872 47 E>Q No 1000Genomes
tmp_3_17465768_A_T 47 E>V No 1000Genomes
tmp_3_17465776_C_T 50 P>S No 1000Genomes
ENSVATH12610018 52 P>S No 1000Genomes
ENSVATH12610019 55 T>I No 1000Genomes
ENSVATH02461478 57 S>G No 1000Genomes
ENSVATH06258874 57 S>N No 1000Genomes
ENSVATH06258875 59 S>A No 1000Genomes
ENSVATH06258875 59 S>P No 1000Genomes
tmp_3_17465807_C_T 60 T>I No 1000Genomes
ENSVATH06258877 61 T>A No 1000Genomes
ENSVATH06258878 61 T>N No 1000Genomes
tmp_3_17465816_C_G,T 63 P>L No 1000Genomes
tmp_3_17465816_C_G,T 63 P>R No 1000Genomes
ENSVATH12610021 67 G>E No 1000Genomes
ENSVATH12610023 69 V>G No 1000Genomes
ENSVATH12610049 77 N>S No 1000Genomes
tmp_3_17465863_T_C 79 S>P No 1000Genomes
ENSVATH00405479 82 G>E No 1000Genomes
ENSVATH00405480 94 A>V No 1000Genomes
tmp_3_17465913_G_T 95 E>D No 1000Genomes
ENSVATH06258887 102 R>L No 1000Genomes
ENSVATH12610050 140 V>I No 1000Genomes
tmp_3_17466059_C_T 144 P>L No 1000Genomes
ENSVATH02461480 144 P>S No 1000Genomes
ENSVATH02461481 149 N>S No 1000Genomes
ENSVATH06258894 181 S>* No 1000Genomes
ENSVATH06258893 181 S>T No 1000Genomes
tmp_3_17466172_A_G 182 S>G No 1000Genomes
ENSVATH06258895 182 S>N No 1000Genomes
ENSVATH14392975 183 D>E No 1000Genomes
tmp_3_17466234_C_G 202 I>M No 1000Genomes
ENSVATH12610053 210 E>K No 1000Genomes
tmp_3_17466259_G_A 211 D>N No 1000Genomes
ENSVATH06258900 215 S>W No 1000Genomes
tmp_3_17466274_G_T 216 D>Y No 1000Genomes
ENSVATH14392976 226 N>K No 1000Genomes
tmp_3_17466311_C_T 228 S>L No 1000Genomes
tmp_3_17466316_T_A 230 L>M No 1000Genomes
ENSVATH00405486 236 A>G No 1000Genomes
ENSVATH14392977 237 V>I No 1000Genomes
tmp_3_17466352_A_G 242 M>V No 1000Genomes
ENSVATH00405487 246 D>N No 1000Genomes
ENSVATH14392978 247 H>N No 1000Genomes
ENSVATH06258923 252 N>K No 1000Genomes
ENSVATH06258924 259 S>N No 1000Genomes
tmp_3_17466812_G_C 266 R>T No 1000Genomes
tmp_3_17466856_C_A 281 L>I No 1000Genomes
ENSVATH06258926 284 A>T No 1000Genomes
tmp_3_17466898_C_A 295 Q>K No 1000Genomes
ENSVATH00405492 305 R>S No 1000Genomes
tmp_3_17467015_C_A 334 L>I No 1000Genomes
tmp_3_17467018_G_C 335 V>L No 1000Genomes
ENSVATH12610170 361 T>S No 1000Genomes
tmp_3_17467454_C_G 451 L>V No 1000Genomes
tmp_3_17467457_C_T 452 H>Y No 1000Genomes
tmp_3_17467472_A_G 457 I>V No 1000Genomes
ENSVATH00405499 489 I>L No 1000Genomes
ENSVATH00405500 490 R>Q No 1000Genomes
tmp_3_17467647_A_G 515 N>S No 1000Genomes
tmp_3_17467663_G_C 520 L>F No 1000Genomes

No associated diseases with Q9STY3

3 regional properties for Q9STY3

Type Name Position InterPro Accession
domain Pectinesterase, catalytic 281 - 579 IPR000070
domain Pectinesterase inhibitor domain 79 - 241 IPR006501
active_site Pectinesterase, Asp active site 425 - 434 IPR033131

Functions

Description
EC Number 3.1.1.11 Carboxylic ester hydrolases
Subcellular Localization
  • Secreted, cell wall
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

3 GO annotations of molecular function

Name Definition
aspartyl esterase activity Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue.
pectinesterase activity Catalysis of the reaction: pectin + n H2O = n methanol + pectate.
pectinesterase inhibitor activity Binds to and stops, prevents or reduces the activity of pectinesterase.

2 GO annotations of biological process

Name Definition
cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly.
pectin catabolic process The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.

42 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9FHN4 PME60 Probable pectinesterase/pectinesterase inhibitor 60 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FHN5 PME59 Probable pectinesterase/pectinesterase inhibitor 59 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SRX4 PME7 Probable pectinesterase/pectinesterase inhibitor 7 Arabidopsis thaliana (Mouse-ear cress) SS
Q1JPL7 PME18 Pectinesterase/pectinesterase inhibitor 18 Arabidopsis thaliana (Mouse-ear cress) SS
Q84JX1 PME19 Probable pectinesterase/pectinesterase inhibitor 19 Arabidopsis thaliana (Mouse-ear cress) SS
O49298 PME6 Probable pectinesterase/pectinesterase inhibitor 6 Arabidopsis thaliana (Mouse-ear cress) SS
Q42534 PME2 Pectinesterase 2 Arabidopsis thaliana (Mouse-ear cress) SS
Q43867 PME1 Pectinesterase 1 Arabidopsis thaliana (Mouse-ear cress) SS
O48711 PME12 Probable pectinesterase/pectinesterase inhibitor 12 Arabidopsis thaliana (Mouse-ear cress) SS
Q7Y201 PME13 Probable pectinesterase/pectinesterase inhibitor 13 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SKX2 PME16 Probable pectinesterase/pectinesterase inhibitor 16 Arabidopsis thaliana (Mouse-ear cress) SS
O22149 PME17 Probable pectinesterase/pectinesterase inhibitor 17 Arabidopsis thaliana (Mouse-ear cress) SS
O80722 PME4 Pectinesterase 4 Arabidopsis thaliana (Mouse-ear cress) SS
Q5MFV8 PME5 Pectinesterase 5 Arabidopsis thaliana (Mouse-ear cress) SS
O22256 PME20 Probable pectinesterase/pectinesterase inhibitor 20 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GX86 PME21 Probable pectinesterase/pectinesterase inhibitor 21 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M9W7 PME22 Putative pectinesterase/pectinesterase inhibitor 22 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GXA1 PME23 Probable pectinesterase/pectinesterase inhibitor 23 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SG77 PME24 Putative pectinesterase/pectinesterase inhibitor 24 Arabidopsis thaliana (Mouse-ear cress) SS
O49006 PME3 Pectinesterase/pectinesterase inhibitor 3 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LYT5 PME35 Probable pectinesterase/pectinesterase inhibitor 35 Arabidopsis thaliana (Mouse-ear cress) SS
Q84R10 PME36 Probable pectinesterase/pectinesterase inhibitor 36 Arabidopsis thaliana (Mouse-ear cress) SS
Q5MFV6 VGDH2 Probable pectinesterase/pectinesterase inhibitor VGDH2 Arabidopsis thaliana (Mouse-ear cress) SS
O81320 PME38 Putative pectinesterase/pectinesterase inhibitor 38 Arabidopsis thaliana (Mouse-ear cress) SS
O81415 PME39 Probable pectinesterase/pectinesterase inhibitor 39 Arabidopsis thaliana (Mouse-ear cress) SS
O81301 PME40 Probable pectinesterase/pectinesterase inhibitor 40 Arabidopsis thaliana (Mouse-ear cress) SS
Q8RXK7 PME41 Probable pectinesterase/pectinesterase inhibitor 41 Arabidopsis thaliana (Mouse-ear cress) SS
Q1PEC0 PME42 Probable pectinesterase/pectinesterase inhibitor 42 Arabidopsis thaliana (Mouse-ear cress) SS
O23447 PME43 Putative pectinesterase/pectinesterase inhibitor 43 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SMY7 PME44 Probable pectinesterase/pectinesterase inhibitor 44 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SMY6 PME45 Putative pectinesterase/pectinesterase inhibitor 45 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FF78 PME46 Probable pectinesterase/pectinesterase inhibitor 46 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FF77 PME47 Probable pectinesterase/pectinesterase inhibitor 47 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LXD9 PME51 Probable pectinesterase/pectinesterase inhibitor 51 Arabidopsis thaliana (Mouse-ear cress) SS
Q3E989 PME54 Probable pectinesterase/pectinesterase inhibitor 54 Arabidopsis thaliana (Mouse-ear cress) SS
Q3E8Z8 PME28 Putative pectinesterase/pectinesterase inhibitor 28 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FJ21 PME58 Probable pectinesterase/pectinesterase inhibitor 58 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FK05 PME61 Probable pectinesterase/pectinesterase inhibitor 61 Arabidopsis thaliana (Mouse-ear cress) SS
Q8L7Q7 PME64 Probable pectinesterase/pectinesterase inhibitor 64 Arabidopsis thaliana (Mouse-ear cress) SS
Q94CB1 PME25 Probable pectinesterase/pectinesterase inhibitor 25 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LXK7 PME32 Probable pectinesterase/pectinesterase inhibitor 32 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M3B0 PME34 Probable pectinesterase/pectinesterase inhibitor 34 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MLRGIFHICL LASFLLLPFS SAVHDSGFTG GTDAPPPWDH NVSPPPETAP SPTPTSSPST
70 80 90 100 110 120
TSPPSPGPVA APSPINNGSV SGDMTWWCNK TPHAETCNYY FRKSSQNNIN LRPPRFRSEF
130 140 150 160 170 180
LRMLVKVALD QAVITHSQTV KFGPSCTNNQ RKAAWSDCVN LFQNTVAQLN RTLKGLNPAA
190 200 210 220 230 240
SSDVKCTDFD AQTWLSTAQT NIETCRSGSE DLNVSDFVMP VISNKNLSDL IGNCLAVNGV
250 260 270 280 290 300
LMKQHDHTTT ANHKEYFPSW VSRHERRLLV SASLAKSSPH LVVAQDRSGH FRSIQAAINF
310 320 330 340 350 360
AARRRFKSRF VIYVKKGVYR ENIDVGNDNH NIMLVGDGER KTIITSGRSV QHGYTTYNSA
370 380 390 400 410 420
TGGFGGQRFV AKDMTFINTA GPLRGQAVAV RSSSDLSVFY RVGIHGFQDT LYIHSQRQFF
430 440 450 460 470 480
RECYISGTID FIFGNAAVVF QNCMILVRRP LHGQANIITA QGRGDPFQNT GITIHSSRII
490 500 510 520 530 540
AASDLKPVIR AYKTYLGRPW QAYSRVTIMK TYIDNSISPL GWSPWLRGSN FALNTVFYGE
550 560 570 580 590
YKNFGPGSST RWRVRWKGFH AITSTAVASR FTVGSLIAGG SWLPATGVPF KSGL