Q9SRX4

SS
Gene name
PME7 (ARATH1, At1g02810, F22D16.20)
Protein name
Probable pectinesterase/pectinesterase inhibitor 7
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G02810
EC number
3.1.1.11: Carboxylic ester hydrolases
Protein Class

Descriptions

(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.

Autoinhibitory domains (AIDs)

26-185 (PMEI region) SS

Target domain

265-561 (Pectinesterase domain)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9SRX4

Entry ID Method Resolution Chain Position Source
AF-Q9SRX4-F1 Predicted AlphaFoldDB

43 variants for Q9SRX4

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH04510187 10 T>A No 1000Genomes
tmp_1_618338_C_A 19 L>I No 1000Genomes
ENSVATH04510188 20 A>V No 1000Genomes
tmp_1_618354_C_A 24 T>N No 1000Genomes
ENSVATH00003294 57 C>R No 1000Genomes
ENSVATH04510192 76 R>K No 1000Genomes
ENSVATH10500953 101 G>S No 1000Genomes
ENSVATH04510195 122 S>P No 1000Genomes
tmp_1_618662_T_G 127 S>A No 1000Genomes
tmp_1_618669_C_T 129 P>L No 1000Genomes
tmp_1_618672_A_G 130 K>R No 1000Genomes
tmp_1_618753_C_T 157 S>F No 1000Genomes
tmp_1_618789_C_T 169 A>V No 1000Genomes
tmp_1_618791_T_A 170 L>M No 1000Genomes
tmp_1_618959_T_G 226 L>V No 1000Genomes
tmp_1_618978_C_A 232 T>K No 1000Genomes
tmp_1_618998_C_T 239 L>F No 1000Genomes
ENSVATH01007073 250 N>T No 1000Genomes
ENSVATH04510198 256 G>R No 1000Genomes
ENSVATH01007074 258 M>I No 1000Genomes
tmp_1_619068_G_T 262 S>I No 1000Genomes
tmp_1_619071_A_G 263 D>G No 1000Genomes
tmp_1_619088_C_G 269 Q>E No 1000Genomes
ENSVATH04510204 301 T>A No 1000Genomes
tmp_1_619212_C_T 310 S>L No 1000Genomes
tmp_1_619223_A_G 314 N>D No 1000Genomes
ENSVATH04510208 331 T>N No 1000Genomes
ENSVATH10501031 352 A>V No 1000Genomes
tmp_1_619740_T_G 383 S>A No 1000Genomes
tmp_1_619851_G_A 420 G>R No 1000Genomes
ENSVATH00003298 444 I>V No 1000Genomes
tmp_1_619957_A_T 455 N>I No 1000Genomes
tmp_1_619969_C_T 459 S>L No 1000Genomes
ENSVATH04510235 479 K>E No 1000Genomes
tmp_1_620078_G_T 495 M>I No 1000Genomes
tmp_1_620131_G_A 513 G>D No 1000Genomes
ENSVATH10501033 518 S>N No 1000Genomes
ENSVATH01007079 521 Y>S No 1000Genomes
ENSVATH10501034 545 V>L No 1000Genomes
ENSVATH10501034 545 V>M No 1000Genomes
ENSVATH04510237 563 A>T No 1000Genomes
ENSVATH13850117 564 D>N No 1000Genomes
tmp_1_620329_C_T 579 S>L No 1000Genomes

No associated diseases with Q9SRX4

3 regional properties for Q9SRX4

Type Name Position InterPro Accession
domain Pectinesterase, catalytic 265 - 561 IPR000070
domain Pectinesterase inhibitor domain 23 - 185 IPR006501
active_site Pectinesterase, Asp active site 411 - 420 IPR033131

Functions

Description
EC Number 3.1.1.11 Carboxylic ester hydrolases
Subcellular Localization
  • Secreted, cell wall
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

3 GO annotations of molecular function

Name Definition
aspartyl esterase activity Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue.
pectinesterase activity Catalysis of the reaction: pectin + n H2O = n methanol + pectate.
pectinesterase inhibitor activity Binds to and stops, prevents or reduces the activity of pectinesterase.

2 GO annotations of biological process

Name Definition
cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly.
pectin catabolic process The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.

42 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O22256 PME20 Probable pectinesterase/pectinesterase inhibitor 20 Arabidopsis thaliana (Mouse-ear cress) SS
Q8RXK7 PME41 Probable pectinesterase/pectinesterase inhibitor 41 Arabidopsis thaliana (Mouse-ear cress) SS
Q1JPL7 PME18 Pectinesterase/pectinesterase inhibitor 18 Arabidopsis thaliana (Mouse-ear cress) SS
Q84JX1 PME19 Probable pectinesterase/pectinesterase inhibitor 19 Arabidopsis thaliana (Mouse-ear cress) SS
O49298 PME6 Probable pectinesterase/pectinesterase inhibitor 6 Arabidopsis thaliana (Mouse-ear cress) SS
Q42534 PME2 Pectinesterase 2 Arabidopsis thaliana (Mouse-ear cress) SS
Q43867 PME1 Pectinesterase 1 Arabidopsis thaliana (Mouse-ear cress) SS
O48711 PME12 Probable pectinesterase/pectinesterase inhibitor 12 Arabidopsis thaliana (Mouse-ear cress) SS
Q7Y201 PME13 Probable pectinesterase/pectinesterase inhibitor 13 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SKX2 PME16 Probable pectinesterase/pectinesterase inhibitor 16 Arabidopsis thaliana (Mouse-ear cress) SS
O22149 PME17 Probable pectinesterase/pectinesterase inhibitor 17 Arabidopsis thaliana (Mouse-ear cress) SS
O80722 PME4 Pectinesterase 4 Arabidopsis thaliana (Mouse-ear cress) SS
Q5MFV8 PME5 Pectinesterase 5 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GX86 PME21 Probable pectinesterase/pectinesterase inhibitor 21 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M9W7 PME22 Putative pectinesterase/pectinesterase inhibitor 22 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GXA1 PME23 Probable pectinesterase/pectinesterase inhibitor 23 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SG77 PME24 Putative pectinesterase/pectinesterase inhibitor 24 Arabidopsis thaliana (Mouse-ear cress) SS
O49006 PME3 Pectinesterase/pectinesterase inhibitor 3 Arabidopsis thaliana (Mouse-ear cress) SS
Q9STY3 PME33 Probable pectinesterase/pectinesterase inhibitor 33 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LYT5 PME35 Probable pectinesterase/pectinesterase inhibitor 35 Arabidopsis thaliana (Mouse-ear cress) SS
Q84R10 PME36 Probable pectinesterase/pectinesterase inhibitor 36 Arabidopsis thaliana (Mouse-ear cress) SS
Q5MFV6 VGDH2 Probable pectinesterase/pectinesterase inhibitor VGDH2 Arabidopsis thaliana (Mouse-ear cress) SS
O81320 PME38 Putative pectinesterase/pectinesterase inhibitor 38 Arabidopsis thaliana (Mouse-ear cress) SS
O81415 PME39 Probable pectinesterase/pectinesterase inhibitor 39 Arabidopsis thaliana (Mouse-ear cress) SS
O81301 PME40 Probable pectinesterase/pectinesterase inhibitor 40 Arabidopsis thaliana (Mouse-ear cress) SS
Q1PEC0 PME42 Probable pectinesterase/pectinesterase inhibitor 42 Arabidopsis thaliana (Mouse-ear cress) SS
O23447 PME43 Putative pectinesterase/pectinesterase inhibitor 43 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SMY7 PME44 Probable pectinesterase/pectinesterase inhibitor 44 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SMY6 PME45 Putative pectinesterase/pectinesterase inhibitor 45 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FF78 PME46 Probable pectinesterase/pectinesterase inhibitor 46 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FF77 PME47 Probable pectinesterase/pectinesterase inhibitor 47 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LXD9 PME51 Probable pectinesterase/pectinesterase inhibitor 51 Arabidopsis thaliana (Mouse-ear cress) SS
Q3E989 PME54 Probable pectinesterase/pectinesterase inhibitor 54 Arabidopsis thaliana (Mouse-ear cress) SS
Q3E8Z8 PME28 Putative pectinesterase/pectinesterase inhibitor 28 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FJ21 PME58 Probable pectinesterase/pectinesterase inhibitor 58 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FHN5 PME59 Probable pectinesterase/pectinesterase inhibitor 59 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FHN4 PME60 Probable pectinesterase/pectinesterase inhibitor 60 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FK05 PME61 Probable pectinesterase/pectinesterase inhibitor 61 Arabidopsis thaliana (Mouse-ear cress) SS
Q8L7Q7 PME64 Probable pectinesterase/pectinesterase inhibitor 64 Arabidopsis thaliana (Mouse-ear cress) SS
Q94CB1 PME25 Probable pectinesterase/pectinesterase inhibitor 25 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LXK7 PME32 Probable pectinesterase/pectinesterase inhibitor 32 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M3B0 PME34 Probable pectinesterase/pectinesterase inhibitor 34 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MESPIFILIT LSFFLQSVLA SSQTLSNSST ICKTTPDPKY CKSVFPHSQG NVQQYGCFSI
70 80 90 100 110 120
RKSLSQSRKF IRTVDRYIKR NAHLSQPAVI RALQDCRFLA GLTMDYLLTS FETVNDTSAK
130 140 150 160 170 180
TSFKPLSFPK ADDIQTLLSA ALTNEQTCLE GLTTAASYSA TWTVRTGVAL PLVNDTKLLG
190 200 210 220 230 240
VSLALFTKGW VPKKKKRAGF AWAQPRSGSS THTKPFRLFR NGALPLKMTE KTKAVYESLS
250 260 270 280 290 300
RRKLADGDSN GDGDDGSMVL ISDIVTVSQD GTGNFTNITA AVAAAPNNTD GSAGFFLIYV
310 320 330 340 350 360
TAGIYEEYIS IAKNKRYMMM IGDGINQTVV TGNRSVVDGW TTFNSATFAV TAPNFVAVNI
370 380 390 400 410 420
TFRNTAGPEK HQAVALRSGA DFSIFYSCSF EAYQDTLYTH SLRQFYRECD VYGTVDFIFG
430 440 450 460 470 480
NAAVVFQNCN LYPRKPMPNQ FNAITAQGRS DPNQNTGTSI QNCTIKPADD LVSSNYTVKT
490 500 510 520 530 540
YLGRPWKEYS RTVYMQSYID GFVEPVGWRE WNGDFALSTL YYAEYNNTGP GSNTTNRVTW
550 560 570
PGYHVINSTD AANFTVTGLF IEADWIWKTG VPYTSGLIS