Q9SNA3

PR
Gene name
At3g46340 (F18L15.60)
Protein name
Putative receptor-like protein kinase At3g46340
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G46340
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

509-609 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

728-735 (Activation loop from InterPro)

Target domain

591-857 (Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs)

Relief mechanism

Assay

746-753 (Activation loop from InterPro)

Target domain

591-857 (Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9SNA3

Entry ID Method Resolution Chain Position Source
AF-Q9SNA3-F1 Predicted AlphaFoldDB

154 variants for Q9SNA3

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH06245254 8 L>V No 1000Genomes
ENSVATH14380683 15 A>E No 1000Genomes
ENSVATH06245281 68 I>L No 1000Genomes
ENSVATH06245281 68 I>V No 1000Genomes
ENSVATH14380741 69 G>S No 1000Genomes
ENSVATH06245283 79 T>P No 1000Genomes
ENSVATH14380742 97 Y>* No 1000Genomes
ENSVATH00402363 105 K>T No 1000Genomes
tmp_3_17028188_C_A 114 L>I No 1000Genomes
tmp_3_17028189_T_C 114 L>P No 1000Genomes
tmp_3_17028191_T_A 115 Y>N No 1000Genomes
ENSVATH00402364 121 L>H No 1000Genomes
ENSVATH00402364 121 L>R No 1000Genomes
tmp_3_17028252_T_A 135 F>Y No 1000Genomes
tmp_3_17028258_C_T 137 T>I No 1000Genomes
ENSVATH06245285 143 E>G No 1000Genomes
ENSVATH06245284 143 E>K No 1000Genomes
ENSVATH06245286 146 S>T No 1000Genomes
tmp_3_17028297_A_C 150 E>A No 1000Genomes
ENSVATH06245287 158 S>* No 1000Genomes
ENSVATH02448168 168 T>K No 1000Genomes
tmp_3_17028357_C_A 170 T>K No 1000Genomes
tmp_3_17028372_T_C 175 L>S No 1000Genomes
tmp_3_17028393_C_T 182 P>L No 1000Genomes
tmp_3_17028417_C_G 190 T>S No 1000Genomes
ENSVATH06245288 191 G>D No 1000Genomes
ENSVATH14380744 197 T>S No 1000Genomes
ENSVATH06245290 199 R>G No 1000Genomes
tmp_3_17028445_G_C 199 R>S No 1000Genomes
ENSVATH14380746 216 V>F No 1000Genomes
ENSVATH06245295 227 S>T No 1000Genomes
ENSVATH06245297 233 W>C No 1000Genomes
ENSVATH02448174 233 W>S No 1000Genomes
ENSVATH02448175 237 K>R No 1000Genomes
ENSVATH02448176 243 G>R No 1000Genomes
ENSVATH02448176 243 G>S No 1000Genomes
tmp_3_17028662_T_G 245 L>R No 1000Genomes
ENSVATH02448177 245 L>V No 1000Genomes
tmp_3_17028664_G_C 246 V>L No 1000Genomes
ENSVATH06245299 248 K>Q No 1000Genomes
tmp_3_17028671_A_C 248 K>T No 1000Genomes
ENSVATH02448179 249 N>I No 1000Genomes
ENSVATH02448178 249 N>Y No 1000Genomes
tmp_3_17028682_A_T 252 M>L No 1000Genomes
tmp_3_17028720_T_A 264 F>L No 1000Genomes
ENSVATH06245300 265 R>G No 1000Genomes
ENSVATH02448180 271 D>N No 1000Genomes
tmp_3_17028778_T_G 284 S>A No 1000Genomes
ENSVATH12561738 296 E>D No 1000Genomes
tmp_3_17028860_TCC_GCC,T 311 I>S No 1000Genomes
ENSVATH06245302 325 P>L No 1000Genomes
ENSVATH02448184 326 V>F No 1000Genomes
ENSVATH12561740 344 T>S No 1000Genomes
tmp_3_17029000_G_A 358 V>I No 1000Genomes
ENSVATH12561744 361 P>S No 1000Genomes
ENSVATH02448188 375 D>G No 1000Genomes
ENSVATH02448187 375 D>N No 1000Genomes
ENSVATH02448190 379 T>N No 1000Genomes
tmp_3_17029177_C_G 388 Q>E No 1000Genomes
ENSVATH02448192 400 E>D No 1000Genomes
ENSVATH02448193 409 A>T No 1000Genomes
ENSVATH06245307 414 R>K No 1000Genomes
ENSVATH12561761 416 T>I No 1000Genomes
ENSVATH12561763 419 N>S No 1000Genomes
tmp_3_17029364_T_A 421 S>T No 1000Genomes
tmp_3_17029376_T_A 425 L>I No 1000Genomes
ENSVATH02448199 439 L>V No 1000Genomes
ENSVATH02448200 440 D>E No 1000Genomes
ENSVATH02448201 441 K>R No 1000Genomes
ENSVATH06245311 453 V>L No 1000Genomes
ENSVATH06245312 459 S>G No 1000Genomes
ENSVATH02448206 459 S>N No 1000Genomes
ENSVATH06245319 467 N>K No 1000Genomes
tmp_3_17029672_C_A 471 N>K No 1000Genomes
ENSVATH02448214 479 Q>L No 1000Genomes
ENSVATH02448215 480 A>G No 1000Genomes
ENSVATH14380747 487 D>N No 1000Genomes
ENSVATH02448219 496 Q>E No 1000Genomes
tmp_3_17029853_G_C 502 G>R No 1000Genomes
tmp_3_17029890_T_C 514 M>T No 1000Genomes
ENSVATH06245324 518 L>* No 1000Genomes
ENSVATH02448223 526 I>V No 1000Genomes
ENSVATH12561832 531 V>I No 1000Genomes
ENSVATH12561833 532 L>F No 1000Genomes
ENSVATH02448225 540 K>N No 1000Genomes
ENSVATH06245326 540 K>T No 1000Genomes
ENSVATH06245327 541 P>L No 1000Genomes
ENSVATH02448226 545 E>K No 1000Genomes
ENSVATH06245328 547 L>Q No 1000Genomes
ENSVATH14380748 556 E>D No 1000Genomes
ENSVATH06245329 558 I>V No 1000Genomes
ENSVATH12561853 559 T>A No 1000Genomes
ENSVATH02448233 561 T>I No 1000Genomes
ENSVATH06245330 569 E>K No 1000Genomes
ENSVATH12561854 576 S>T No 1000Genomes
ENSVATH02448237 578 S>L No 1000Genomes
ENSVATH02448239 585 K>N No 1000Genomes
ENSVATH06245331 588 Q>L No 1000Genomes
tmp_3_17030196_C_A 590 P>T No 1000Genomes
ENSVATH14380750 599 V>I No 1000Genomes
ENSVATH06245332 610 Q>E No 1000Genomes
ENSVATH06245333 610 Q>R No 1000Genomes
ENSVATH06245334 613 V>I No 1000Genomes
ENSVATH06245341 649 C>W No 1000Genomes
tmp_3_17030466_C_T 652 R>* No 1000Genomes
tmp_3_17030469_G_C 653 D>H No 1000Genomes
ENSVATH12561882 661 Y>S No 1000Genomes
ENSVATH02448254 671 L>M No 1000Genomes
ENSVATH06245350 675 H>D No 1000Genomes
tmp_3_17030625_T_C 678 S>P No 1000Genomes
ENSVATH12561916 679 V>I No 1000Genomes
ENSVATH06245352 687 Q>E No 1000Genomes
ENSVATH12561917 692 A>S No 1000Genomes
tmp_3_17030668_C_T 692 A>V No 1000Genomes
ENSVATH06245381 722 Q>H No 1000Genomes
ENSVATH06245382 724 T>I No 1000Genomes
ENSVATH02448270 727 M>I No 1000Genomes
ENSVATH06245383 728 A>V No 1000Genomes
ENSVATH06245384 734 R>K No 1000Genomes
tmp_3_17031187_C_T 735 S>F No 1000Genomes
ENSVATH12561959 736 F>S No 1000Genomes
ENSVATH00402378 743 Q>H No 1000Genomes
ENSVATH12561960 747 V>I No 1000Genomes
tmp_3_17031228_G_A 749 A>T No 1000Genomes
tmp_3_17031240_G_A 753 G>R No 1000Genomes
tmp_3_17031454_G_A 761 R>K No 1000Genomes
tmp_3_17031468_G_C 766 A>P No 1000Genomes
tmp_3_17031476_G_A 768 M>I No 1000Genomes
tmp_3_17031475_T_C 768 M>T No 1000Genomes
ENSVATH06245390 782 I>M No 1000Genomes
ENSVATH02448294 790 P>Q No 1000Genomes
ENSVATH00402382 791 A>T No 1000Genomes
tmp_3_17031552_A_T 794 K>* No 1000Genomes
ENSVATH08141402 804 M>I No 1000Genomes
tmp_3_17031618_C_A 816 P>T No 1000Genomes
ENSVATH06245394 817 N>K No 1000Genomes
ENSVATH09433264 819 Q>H No 1000Genomes
ENSVATH14380802 819 Q>K No 1000Genomes
ENSVATH12561964 819 Q>R No 1000Genomes
tmp_3_17031637_A_C 822 Y>S No 1000Genomes
tmp_3_17031652_T_G 827 V>G No 1000Genomes
ENSVATH12562005 828 W>* No 1000Genomes
ENSVATH02448297 835 M>L No 1000Genomes
ENSVATH06245396 841 S>L No 1000Genomes
tmp_3_17031699_G_C 843 E>Q No 1000Genomes
ENSVATH06245397 844 K>N No 1000Genomes
tmp_3_17031712_G_C 847 S>T No 1000Genomes
ENSVATH12562006 859 I>M No 1000Genomes
tmp_3_17031768_C_G 866 Q>E No 1000Genomes
ENSVATH02448303 874 F>L No 1000Genomes
tmp_3_17031797_A_C 875 E>D No 1000Genomes
ENSVATH06245398 877 S>T No 1000Genomes
ENSVATH06245399 881 D>E No 1000Genomes
ENSVATH14380803 884 A>S No 1000Genomes

No associated diseases with Q9SNA3

10 regional properties for Q9SNA3

Type Name Position InterPro Accession
domain CRIB domain 1436 - 1472 IPR000095
domain Protein kinase domain 71 - 337 IPR000719
domain AGC-kinase, C-terminal 338 - 408 IPR000961
domain Citron homology (CNH) domain 1091 - 1371 IPR001180
domain Pleckstrin homology domain 946 - 1067 IPR001849
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 877 - 926 IPR002219
active_site Serine/threonine-protein kinase, active site 191 - 203 IPR008271
domain Myotonic dystrophy protein kinase, coiled coil 743 - 797 IPR014930
binding_site Protein kinase, ATP binding site 77 - 100 IPR017441
domain Protein kinase, C-terminal 357 - 398 IPR017892

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

36 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q91044 NTRK3 NT-3 growth factor receptor Gallus gallus (Chicken) SS
Q91987 NTRK2 BDNF/NT-3 growth factors receptor Gallus gallus (Chicken) SS
Q91009 NTRK1 High affinity nerve growth factor receptor Gallus gallus (Chicken) SS
P0C0K6 EPHB6 Ephrin type-B receptor 6 Pan troglodytes (Chimpanzee) SS
Q07407 htl Fibroblast growth factor receptor homolog 1 Drosophila melanogaster (Fruit fly) PR
P20594 NPR2 Atrial natriuretic peptide receptor 2 Homo sapiens (Human) PR
Q03145 Epha2 Ephrin type-A receptor 2 Mus musculus (Mouse) PR
Q60750 Epha1 Ephrin type-A receptor 1 Mus musculus (Mouse) SS
P24786 NTRK3 NT-3 growth factor receptor Sus scrofa (Pig) SS
P35739 Ntrk1 High affinity nerve growth factor receptor Rattus norvegicus (Rat) SS
Q03351 Ntrk3 NT-3 growth factor receptor Rattus norvegicus (Rat) SS
Q63604 Ntrk2 BDNF/NT-3 growth factors receptor Rattus norvegicus (Rat) SS
P43293 PBL11 Probable serine/threonine-protein kinase PBL11 Arabidopsis thaliana (Mouse-ear cress) PR
Q3E8W4 ANX2 Receptor-like protein kinase ANXUR2 Arabidopsis thaliana (Mouse-ear cress) PR
Q8LPS5 SERK5 Somatic embryogenesis receptor kinase 5 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGG3 At1g51820 Probable LRR receptor-like serine/threonine-protein kinase At1g51820 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGW2 PAM74 Probable LRR receptor-like serine/threonine-protein kinase PAM74 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FN93 At5g59680 Probable LRR receptor-like serine/threonine-protein kinase At5g59680 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FN94 At5g59670 Receptor-like protein kinase At5g59670 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LIG2 At3g21340 Receptor-like protein kinase At3g21340 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQR3 At2g14510 Leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14510 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LPZ9 SD113 G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 Arabidopsis thaliana (Mouse-ear cress) SS
P43298 TMK1 Receptor protein kinase TMK1 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGI2 At1g67720 Probable LRR receptor-like serine/threonine-protein kinase At1g67720 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWW0 ALE2 Receptor-like serine/threonine-protein kinase ALE2 Arabidopsis thaliana (Mouse-ear cress) PR
P93050 BSH Probable LRR receptor-like serine/threonine-protein kinase RKF3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRP3 At3g17420 Probable receptor-like protein kinase At3g17420 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M2S4 LECRKS4 L-type lectin-domain containing receptor kinase S.4 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWZ5 SD25 G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 Arabidopsis thaliana (Mouse-ear cress) PR
O64556 At2g19230 Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At2g19230 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SXB4 At1g11300 G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 Arabidopsis thaliana (Mouse-ear cress) PR
Q84JQ4 PRK2 Pollen receptor-like kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q93ZS4 NIK3 Protein NSP-INTERACTING KINASE 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q94AG2 SERK1 Somatic embryogenesis receptor kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
O64477 At2g19130 G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 Arabidopsis thaliana (Mouse-ear cress) SS
Q9XIC7 SERK2 Somatic embryogenesis receptor kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEFPHSVLLV VLIIATFAIS NLVQAEEDQE GFISLDCGLP PNEVSPYIEP FTGLRFSSDS
70 80 90 100 110 120
SFIQSGKIGK VDKSFEATTL KSYMTLRYFP DGKRNCYNLI VKQGKTYMIR ATALYGNYDG
130 140 150 160 170 180
LNISPKFDLY IGANFWTTLD AGEYLSGVVE EVNYIPRSNS LDVCLVKTDT STPFLSLLEL
190 200 210 220 230 240
RPLDNDSYLT GSGSLKTFRR YYLSNSESVI AYPEDVKDRI WEPTFDSEWK QIWTTLKPNN
250 260 270 280 290 300
SNGYLVPKNV LMTAAIPAND SAPFRFTEEL DSPTDELYVY LHFSEVQSLQ ANESREFDIL
310 320 330 340 350 360
WSGEVAYEAF IPEYLNITTI QTNTPVTCPG GKCNLELKRT KNSTHPPLIN AIEFYTVVNF
370 380 390 400 410 420
PQLETNETDV VAIKDIKATY ELNRITWQGD PCVPQKFIWE GLDCNSKDAL TLPRITSLNL
430 440 450 460 470 480
SSTGLTGNIA AGIQNLTHLD KLDLSNNNLT GGVPEFLASM KSLSFINLSK NNLNGSIPQA
490 500 510 520 530 540
LLKREKDGLK LSVDEQIRCF PGSCVITKKK FPVMIVALVS SAVVVILVVL VLIFVFKKKK
550 560 570 580 590 600
PSNLEDLPPS SNTPRENITS TSISDTSIET KRKRFSYSEV MEMTKNLQRP LGEGGFGVVY
610 620 630 640 650 660
HGDINGSSQQ VAVKLLSQSS TQGYKEFKAE VELLLRVHHI NLVSLVGYCD ERDHLALIYE
670 680 690 700 710 720
YMSNKDLKHH LSGKHGGSVL KWNTRLQIAV DAALGLEYLH IGCRPSMVHR DVKSTNILLD
730 740 750 760 770 780
DQFTAKMADF GLSRSFQLGD ESQVSTVVAG TPGYLDPEYY RTGRLAEMSD VYSFGIVLLE
790 800 810 820 830 840
IITNQRVIDP AREKSHITEW TAFMLNRGDI TRIMDPNLQG DYNSRSVWRA LELAMMCANP
850 860 870 880
SSEKRPSMSQ VVIELKECIR SENKTQGMDS HSSFEQSMSF DTKAVPSAR