Q9SMX5
Gene name |
AGD4 (GCP1, At1g10870, T19D16.20) |
Protein name |
ADP-ribosylation factor GTPase-activating protein AGD4 |
Names |
ARF GAP AGD4, GCN4-complementing protein 1, Protein ARF-GAP DOMAIN 4, AtAGD4 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G10870 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SMX5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SMX5-F1 | Predicted | AlphaFoldDB |
38 variants for Q9SMX5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH04553743 | 42 | M>T | No | 1000Genomes | |
| tmp_1_3623009_C_G | 46 | G>A | No | 1000Genomes | |
| ENSVATH04553734 | 48 | A>T | No | 1000Genomes | |
| ENSVATH10945267 | 54 | A>D | No | 1000Genomes | |
| tmp_1_3622955_C_T | 64 | G>D | No | 1000Genomes | |
| tmp_1_3622431_T_G | 110 | N>T | No | 1000Genomes | |
| ENSVATH04553714 | 128 | K>N | No | 1000Genomes | |
| ENSVATH04553713 | 132 | S>L | No | 1000Genomes | |
| ENSVATH04553699 | 194 | A>T | No | 1000Genomes | |
| ENSVATH04553698 | 194 | A>V | No | 1000Genomes | |
| ENSVATH04553686 | 229 | E>A | No | 1000Genomes | |
| ENSVATH00016772 | 257 | V>L | No | 1000Genomes | |
| ENSVATH00016770 | 262 | S>P | No | 1000Genomes | |
| ENSVATH00016769 | 267 | G>R | No | 1000Genomes | |
| ENSVATH04553685 | 269 | R>C | No | 1000Genomes | |
| ENSVATH10944740 | 269 | R>H | No | 1000Genomes | |
| ENSVATH13877471 | 317 | G>D | No | 1000Genomes | |
| tmp_1_3619314_T_A | 361 | T>S | No | 1000Genomes | |
| ENSVATH10944609 | 403 | A>T | No | 1000Genomes | |
| ENSVATH00016761 | 423 | L>V | No | 1000Genomes | |
| ENSVATH10944608 | 427 | H>Q | No | 1000Genomes | |
| ENSVATH10944607 | 428 | F>I | No | 1000Genomes | |
| ENSVATH00016758 | 437 | L>S | No | 1000Genomes | |
| ENSVATH04553665 | 450 | V>I | No | 1000Genomes | |
| ENSVATH04553664 | 454 | D>N | No | 1000Genomes | |
| tmp_1_3618681_C_A | 467 | D>Y | No | 1000Genomes | |
| ENSVATH04553662 | 499 | V>L | No | 1000Genomes | |
| ENSVATH04553655 | 543 | V>L | No | 1000Genomes | |
| ENSVATH00016753 | 605 | L>P | No | 1000Genomes | |
| ENSVATH10944409 | 608 | A>V | No | 1000Genomes | |
| ENSVATH00016752 | 610 | R>G | No | 1000Genomes | |
| ENSVATH10944408 | 630 | T>P | No | 1000Genomes | |
| ENSVATH13877468 | 646 | I>S | No | 1000Genomes | |
| ENSVATH04553641 | 647 | D>N | No | 1000Genomes | |
| tmp_1_3617478_G_A | 654 | A>V | No | 1000Genomes | |
| ENSVATH04553640 | 674 | S>P | No | 1000Genomes | |
| tmp_1_3617005_G_C | 743 | S>W | No | 1000Genomes | |
| ENSVATH10944298 | 775 | A>T | No | 1000Genomes |
No associated diseases with Q9SMX5
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| metal ion binding | Binding to a metal ion. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A5PK26 | ACAP1 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 | Bos taurus (Bovine) | SS |
| O97902 | ASAP1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Bos taurus (Bovine) | SS |
| A1Z7A6 | Asap | ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein | Drosophila melanogaster (Fruit fly) | SS |
| O43150 | ASAP2 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 | Homo sapiens (Human) | SS |
| Q8TDY4 | ASAP3 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 | Homo sapiens (Human) | SS |
| Q9ULH1 | ASAP1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Homo sapiens (Human) | EV |
| Q15027 | ACAP1 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 | Homo sapiens (Human) | EV |
| Q15057 | ACAP2 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 | Homo sapiens (Human) | PR |
| Q7SIG6 | Asap2 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 | Mus musculus (Mouse) | SS |
| Q9QWY8 | Asap1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Mus musculus (Mouse) | SS |
| Q5U464 | Asap3 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 | Mus musculus (Mouse) | SS |
| Q8K2H4 | Acap1 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 | Mus musculus (Mouse) | SS |
| Q6ZQK5 | Acap2 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 | Mus musculus (Mouse) | PR |
| Q1AAU6 | Asap1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Rattus norvegicus (Rat) | SS |
| Q9C6C3 | AGD2 | ADP-ribosylation factor GTPase-activating protein AGD2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATFINLEDS | PMFQKQVCSL | EGTADELKDR | CQKLYKGVKK | FMGTLGEASK | GESAFAACLE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EFGGGPDDPI | SLSIGGPVIS | KFINALRELA | SYKEFLCSQV | EHVLLERLMN | FISVDLQEAK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ESRHRFDKAA | HSYDQSREKF | VSLKKNTRGE | IVAELEEDLE | NSKSTFEKSR | FNLVNSLMTI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EAKKKYEFLE | SISAIMDAHL | RYFKLGYDLL | NQLEPFIHQI | LTYAQQSKEQ | SKIEQDRLAR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RIQEFRTQSE | LDSQQLVANA | ESSGANGNRV | GGNIPYKNTE | TSLTADKEVI | KQGYLLKRSS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SLRTDWKRKF | FVLDSHGSMY | YYRTNGNKSM | GSHHHYSGSS | DHNTGVFGRF | RARHNRSGSL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TEGSLGYNTI | DLRTSLIKLD | AEDMDLRLCF | RIISPQKTYT | LQAENGADRM | DWVNKITKAI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GTLLNSHFLQ | QSPVRYLDKD | NSSSAPANAV | VSGDQIRHND | SRQNIGDDVS | TILRGLPGNN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ACAECNAPEP | DWASLNLGVL | LCIQCSGVHR | NLGVHISKVR | SLSLDVKVWE | PTILDLFRNL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GNVYCNSLWE | GLLHLDDDCE | DGSALSHASV | SKPCPEDSFS | VKEKYILGKY | LEKALVIKDE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SEANLSAASR | IWEAVQSRNI | REIYRLIVTT | GDVNIINTKF | DDITDIDAYH | HIDAAEKAVK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KRHDPTVCQR | IKESNEPRSC | LQGCSLLHVA | CHIGDSVLLE | LLLQFGADLN | IRDYHGRTPL |
| 730 | 740 | 750 | 760 | 770 | |
| HHCISSGNHK | FAKILLRRGA | RPSIEDDGGL | SVLERAMEMG | AITDEELFLL | LAECA |