Q9SLI2

PR
Gene name
NEK1 (At1g54510, F20D21.32/F20D21.33)
Protein name
Serine/threonine-protein kinase Nek1
Names
NimA-related protein kinase 1, AtNek1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G54510
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

248-573 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

146-168 (Activation loop from InterPro)

Target domain

4-258 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9SLI2

Entry ID Method Resolution Chain Position Source
AF-Q9SLI2-F1 Predicted AlphaFoldDB

32 variants for Q9SLI2

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_20361794_G_C 42 Q>E No 1000Genomes
tmp_1_20361793_T_A 42 Q>L No 1000Genomes
tmp_1_20361773_G_A 49 H>Y No 1000Genomes
tmp_1_20361212_T_A 120 L>F No 1000Genomes
tmp_1_20361208_A_T 122 S>T No 1000Genomes
ENSVATH13569901 130 V>L No 1000Genomes
ENSVATH00097609 221 S>A No 1000Genomes
ENSVATH14315901 283 S>N No 1000Genomes
tmp_1_20359679_C_G 286 R>T No 1000Genomes
tmp_1_20359619_C_T 306 R>Q No 1000Genomes
tmp_1_20359535_C_T 334 R>H No 1000Genomes
ENSVATH14315900 339 L>* No 1000Genomes
tmp_1_20359510_C_G 342 E>D No 1000Genomes
tmp_1_20359283_G_C 387 H>D No 1000Genomes
tmp_1_20359280_G_T 388 P>T No 1000Genomes
ENSVATH00097605 410 T>M No 1000Genomes
tmp_1_20359159_A_G 428 L>S No 1000Genomes
ENSVATH00097603 430 N>D No 1000Genomes
ENSVATH04961475 445 K>Q No 1000Genomes
ENSVATH00097602 450 P>S No 1000Genomes
ENSVATH04961474 454 Y>F No 1000Genomes
ENSVATH04961471 474 V>I No 1000Genomes
ENSVATH04961470 477 R>H No 1000Genomes
ENSVATH14315898 489 H>R No 1000Genomes
ENSVATH00097600 502 N>S No 1000Genomes
tmp_1_20358935_T_C 503 I>V No 1000Genomes
ENSVATH00097599 529 R>K No 1000Genomes
tmp_1_20358814_G_T 543 A>D No 1000Genomes
tmp_1_20358721_T_A 574 K>M No 1000Genomes
ENSVATH04961467 592 R>* No 1000Genomes
tmp_1_20358663_G_T 593 D>E No 1000Genomes
tmp_1_20358665_C_T 593 D>N No 1000Genomes

No associated diseases with Q9SLI2

3 regional properties for Q9SLI2

Type Name Position InterPro Accession
domain Protein kinase domain 70 - 331 IPR000719
active_site Serine/threonine-protein kinase, active site 189 - 201 IPR008271
binding_site Protein kinase, ATP binding site 76 - 99 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cortical microtubule Arrays of microtubules underlying and connected to the plasma membrane in the cortical cytosol.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
protein phosphorylation The process of introducing a phosphate group on to a protein.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P22209 KIN3 Serine/threonine-protein kinase KIN3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q6P3R8 NEK5 Serine/threonine-protein kinase Nek5 Homo sapiens (Human) PR
Q8NE28 STKLD1 Serine/threonine kinase-like domain-containing protein STKLD1 Homo sapiens (Human) PR
P51957 NEK4 Serine/threonine-protein kinase Nek4 Homo sapiens (Human) PR
P51955 NEK2 Serine/threonine-protein kinase Nek2 Homo sapiens (Human) EV
Q8K1R7 Nek9 Serine/threonine-protein kinase Nek9 Mus musculus (Mouse) SS
Q7TSC3 Nek5 Serine/threonine-protein kinase Nek5 Mus musculus (Mouse) PR
O35942 Nek2 Serine/threonine-protein kinase Nek2 Mus musculus (Mouse) PR
Q10GB1 NEK1 Serine/threonine-protein kinase Nek1 Oryza sativa subsp japonica (Rice) PR
Q6ZEZ5 NEK3 Serine/threonine-protein kinase Nek3 Oryza sativa subsp japonica (Rice) PR
Q8RXT4 NEK4 Serine/threonine-protein kinase Nek4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LT35 NEK6 Serine/threonine-protein kinase Nek6 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEQYEFLEQI GKGSFGSALL VRHKHEKKKY VLKKIRLARQ TQRTRRSAHQ EMELISKMRH
70 80 90 100 110 120
PFIVEYKDSW VEKACYVCIV IGYCEGGDMA QAIKKSNGVH FQEEKLCKWL VQLLMGLEYL
130 140 150 160 170 180
HSNHILHRDV KCSNIFLTKE QDIRLGDFGL AKILTSDDLT SSVVGTPSYM CPELLADIPY
190 200 210 220 230 240
GSKSDIWSLG CCIYEMAYLK PAFKAFDMQA LINKINKTIV SPLPAKYSGP FRGLVKSMLR
250 260 270 280 290 300
KNPEVRPSAS DLLRHPHLQP YVLDVKLRLN NLRRKTLPPE LPSSKRIMKK AHFSEPAVTC
310 320 330 340 350 360
PAFGERQHRS LWNDRALNPE AEEDTASSIK CISRRISDLS IESSSKGTLI CKQVSSSACK
370 380 390 400 410 420
VSKYPLAKSS VTSRRIMETG RRSDHLHPVS GGGTTSKIIP SARRTSLPLT KRATNQEVAA
430 440 450 460 470 480
YNPIVGILQN VKSPEYSINE PQVDKIAIFP LAPYEQDIFF TPMQRKTSSK SSSVSDRSIT
490 500 510 520 530 540
KDKCTVQTHT TWQGIQLNMV DNISDGSSSS DQNATAGASS HTTSSSSRRC RFDPSSYRQR
550 560 570 580 590 600
ADALEGLLEF SARLLQEGRY DELNVLLKPF GPGKVSPRET AIWIAKSLKE NRDKTKMVDL
610
NVSREIPHVG LL