Q9SKD7
PR
Gene name |
CNGC3 (At2g46430, F11C10.12) |
Protein name |
Probable cyclic nucleotide-gated ion channel 3 |
Names |
AtCNGC3, Cyclic nucleotide- and calmodulin-regulated ion channel 3 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G46430 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SKD7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SKD7-F1 | Predicted | AlphaFoldDB |
69 variants for Q9SKD7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00277056 | 24 | T>N | No | 1000Genomes | |
| tmp_2_19058627_C_T | 27 | S>L | No | 1000Genomes | |
| tmp_2_19058629_G_A | 28 | V>I | No | 1000Genomes | |
| ENSVATH13655029 | 36 | R>S | No | 1000Genomes | |
| ENSVATH05728075 | 39 | F>L | No | 1000Genomes | |
| ENSVATH01993613 | 41 | K>M | No | 1000Genomes | |
| ENSVATH01993614 | 48 | T>N | No | 1000Genomes | |
| ENSVATH01993614 | 48 | T>S | No | 1000Genomes | |
| ENSVATH05728076 | 62 | E>K | No | 1000Genomes | |
| ENSVATH01993615 | 65 | K>N | No | 1000Genomes | |
| ENSVATH05728077 | 66 | K>N | No | 1000Genomes | |
| ENSVATH05728078 | 69 | I>M | No | 1000Genomes | |
| tmp_2_19058854_T_TA | 103 | Y>* | No | 1000Genomes | |
| tmp_2_19058890_A_C | 115 | N>H | No | 1000Genomes | |
| tmp_2_19058912_C_G | 122 | T>R | No | 1000Genomes | |
| ENSVATH05728079 | 134 | F>I | No | 1000Genomes | |
| ENSVATH00277058 | 148 | I>S | No | 1000Genomes | |
| ENSVATH00277058 | 148 | I>T | No | 1000Genomes | |
| ENSVATH05728080 | 153 | S>N | No | 1000Genomes | |
| tmp_2_19059029_A_G | 161 | N>S | No | 1000Genomes | |
| ENSVATH05728082 | 187 | P>H | No | 1000Genomes | |
| tmp_2_19059213_A_G | 194 | I>V | No | 1000Genomes | |
| tmp_2_19059223_G_A | 197 | R>K | No | 1000Genomes | |
| ENSVATH05728086 | 202 | A>T | No | 1000Genomes | |
| ENSVATH14620796 | 227 | P>S | No | 1000Genomes | |
| tmp_2_19059340_C_T | 236 | S>F | No | 1000Genomes | |
| ENSVATH13655067 | 260 | V>D | No | 1000Genomes | |
| ENSVATH13655068 | 262 | G>W | No | 1000Genomes | |
| tmp_2_19059561_G_A | 278 | R>H | No | 1000Genomes | |
| ENSVATH01993627 | 286 | N>D | No | 1000Genomes | |
| ENSVATH01993628 | 288 | T>S | No | 1000Genomes | |
| ENSVATH01993629 | 290 | A>E | No | 1000Genomes | |
| ENSVATH05728091 | 291 | Y>* | No | 1000Genomes | |
| ENSVATH01993630 | 291 | Y>N | No | 1000Genomes | |
| ENSVATH00277061 | 299 | E>K | No | 1000Genomes | |
| ENSVATH13655070 | 320 | S>W | No | 1000Genomes | |
| ENSVATH00277063 | 368 | A>S | No | 1000Genomes | |
| ENSVATH14620798 | 415 | A>V | No | 1000Genomes | |
| ENSVATH00277065 | 431 | R>C | No | 1000Genomes | |
| ENSVATH01993644 | 449 | E>D | No | 1000Genomes | |
| ENSVATH01993645 | 452 | L>V | No | 1000Genomes | |
| ENSVATH13655087 | 459 | L>F | No | 1000Genomes | |
| ENSVATH01993648 | 489 | L>V | No | 1000Genomes | |
| ENSVATH01993650 | 510 | P>A | No | 1000Genomes | |
| ENSVATH01993651 | 511 | V>E | No | 1000Genomes | |
| ENSVATH05728096 | 525 | T>S | No | 1000Genomes | |
| ENSVATH14620800 | 528 | Y>S | No | 1000Genomes | |
| ENSVATH01993655 | 531 | R>K | No | 1000Genomes | |
| ENSVATH00277068 | 541 | V>A | No | 1000Genomes | |
| ENSVATH01993668 | 571 | L>S | No | 1000Genomes | |
| ENSVATH01993668 | 571 | L>W | No | 1000Genomes | |
| ENSVATH01993669 | 578 | L>V | No | 1000Genomes | |
| ENSVATH05728097 | 586 | F>C | No | 1000Genomes | |
| ENSVATH01993670 | 586 | F>L | No | 1000Genomes | |
| ENSVATH01993674 | 603 | F>L | No | 1000Genomes | |
| ENSVATH01993690 | 608 | V>G | No | 1000Genomes | |
| ENSVATH01993689 | 608 | V>M | No | 1000Genomes | |
| tmp_2_19061032_G_A | 627 | R>K | No | 1000Genomes | |
| tmp_2_19061056_G_A | 635 | R>H | No | 1000Genomes | |
| ENSVATH05728102 | 636 | E>Q | No | 1000Genomes | |
| ENSVATH01993693 | 643 | N>D | No | 1000Genomes | |
| ENSVATH05728103 | 643 | N>S | No | 1000Genomes | |
| ENSVATH01993696 | 654 | K>Q | No | 1000Genomes | |
| ENSVATH01993701 | 659 | A>V | No | 1000Genomes | |
| ENSVATH01993702 | 662 | Y>N | No | 1000Genomes | |
| ENSVATH01993710 | 688 | M>I | No | 1000Genomes | |
| ENSVATH00277070 | 690 | T>S | No | 1000Genomes | |
| ENSVATH14620825 | 700 | E>K | No | 1000Genomes | |
| ENSVATH05728104 | 706 | T>A | No | 1000Genomes |
No associated diseases with Q9SKD7
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| cAMP binding | Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). |
| cGMP binding | Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). |
| ion channel activity | Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size). |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
31 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q03041 | CNGA2 | Cyclic nucleotide-gated olfactory channel | Bos taurus (Bovine) | PR |
| Q00194 | CNGA1 | cGMP-gated cation channel alpha-1 | Bos taurus (Bovine) | PR |
| Q29441 | CNGA3 | Cyclic nucleotide-gated cation channel alpha-3 | Bos taurus (Bovine) | PR |
| Q90980 | Cyclic nucleotide-gated channel rod photoreceptor subunit alpha | Gallus gallus (Chicken) | PR | |
| Q28279 | CNGA1 | cGMP-gated cation channel alpha-1 | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| Q9UL51 | HCN2 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | Homo sapiens (Human) | SS |
| Q9Y3Q4 | HCN4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Homo sapiens (Human) | EV |
| O60741 | HCN1 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Homo sapiens (Human) | SS |
| Q9P1Z3 | HCN3 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | Homo sapiens (Human) | SS |
| Q16281 | CNGA3 | Cyclic nucleotide-gated cation channel alpha-3 | Homo sapiens (Human) | PR |
| P29973 | CNGA1 | cGMP-gated cation channel alpha-1 | Homo sapiens (Human) | PR |
| Q16280 | CNGA2 | Cyclic nucleotide-gated olfactory channel | Homo sapiens (Human) | PR |
| O88704 | Hcn1 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Mus musculus (Mouse) | SS |
| O88705 | Hcn3 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | Mus musculus (Mouse) | SS |
| O70507 | Hcn4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Mus musculus (Mouse) | SS |
| O88703 | Hcn2 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | Mus musculus (Mouse) | EV |
| Q9JJZ8 | Cnga3 | Cyclic nucleotide-gated cation channel alpha-3 | Mus musculus (Mouse) | PR |
| P29974 | Cnga1 | cGMP-gated cation channel alpha-1 | Mus musculus (Mouse) | PR |
| Q62398 | Cnga2 | Cyclic nucleotide-gated olfactory channel | Mus musculus (Mouse) | PR |
| Q9JKA9 | Hcn2 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | Rattus norvegicus (Rat) | SS |
| Q9JKA7 | Hcn4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Rattus norvegicus (Rat) | SS |
| Q9JKB0 | Hcn1 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Rattus norvegicus (Rat) | SS |
| Q9JKA8 | Hcn3 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | Rattus norvegicus (Rat) | SS |
| Q62927 | Cnga1 | cGMP-gated cation channel alpha-1 | Rattus norvegicus (Rat) | PR |
| Q00195 | Cnga2 | Cyclic nucleotide-gated olfactory channel | Rattus norvegicus (Rat) | PR |
| A2ZX97 | Os01g0718700 | Potassium channel KAT6 | Oryza sativa subsp japonica (Rice) | PR |
| Q6K3T2 | Os02g0245800 | Potassium channel KAT1 | Oryza sativa subsp japonica (Rice) | PR |
| P92960 | ATHB-4 | Potassium channel KAT3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q39128 | KAT1 | Potassium channel KAT1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDR2 | CNGC19 | Putative cyclic nucleotide-gated ion channel 19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SU64 | CNGC16 | Probable cyclic nucleotide-gated ion channel 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMNPQRNKFV | RFNGNDDEFS | TKTTRPSVSS | VMKTVRRSFE | KGSEKIRTFK | RPLSVHSNKN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KENNKKKKIL | RVMNPNDSYL | QSWNKIFLLL | SVVALAFDPL | FFYIPYVKPE | RFCLNLDKKL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QTIACVFRTF | IDAFYVVHML | FQFHTGFITP | SSSGFGRGEL | NEKHKDIALR | YLGSYFLIDL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LSILPIPQVV | VLAIVPRMRR | PASLVAKELL | KWVIFCQYVP | RIARIYPLFK | EVTRTSGLVT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ETAWAGAALN | LFLYMLASHV | FGSFWYLISI | ERKDRCWREA | CAKIQNCTHA | YLYCSPTGED |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NRLFLNGSCP | LIDPEEITNS | TVFNFGIFAD | ALQSGVVESR | DFPKKFFYCF | WWGLRNLSAL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GQNLKTSAFE | GEIIFAIVIC | ISGLVLFALL | IGNMQKYLQS | TTVRVEEMRV | KRRDAEQWMS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HRMLPDDLRK | RIRKYEQYKW | QETKGVEEEA | LLSSLPKDLR | KDIKRHLCLK | LLKKVPWFQA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| MDDRLLDALC | ARLKTVLYTE | KSYIVREGEP | VEDMLFIMRG | NLISTTTYGG | RTGFFNSVDL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VAGDFCGDLL | TWALDPLSSQ | FPISSRTVQA | LTEVEGFLLS | ADDLKFVATQ | YRRLHSKQLR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| HMFRFYSVQW | QTWAACFIQA | AWKRHCRRKL | SKALREEEGK | LHNTLQNDDS | GGNKLNLGAA |
| 670 | 680 | 690 | 700 | ||
| IYASRFASHA | LRNLRANAAA | RNSRFPHMLT | LLPQKPADPE | FPMDET |