Q9SIQ9
SS
Gene name |
VAMP712 (At2g25340, T22F11.7) |
Protein name |
Vesicle-associated membrane protein 712 |
Names |
AtVAMP712 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G25340 |
EC number |
|
Protein Class |
|
Descriptions
VAMP7 is involved in the targeting and/or fusion of transport vesicles to their target membrane. Longin domain negatively regulates the ability of VAMP7 like other SNARE attachment proteins including Ykt6.
Autoinhibitory domains (AIDs)
Target domain |
126-186 (v-SNARE coiled-coil homology) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
- Wen W et al. (2010) "Lipid-Induced conformational switch controls fusion activity of longin domain SNARE Ykt6", Molecular cell, 37, 383-95
- Martinez-Arca S et al. (2003) "A dual mechanism controlling the localization and function of exocytic v-SNAREs", Proceedings of the National Academy of Sciences of the United States of America, 100, 9011-6
- Gonzalez LC Jr et al. (2001) "A novel snare N-terminal domain revealed by the crystal structure of Sec22b", The Journal of biological chemistry, 276, 24203-11
- Mancias JD et al. (2007) "The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope", Molecular cell, 26, 403-14
Autoinhibited structure
Activated structure
1 structures for Q9SIQ9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SIQ9-F1 | Predicted | AlphaFoldDB |
37 variants for Q9SIQ9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH14550784 | 3 | I>L | No | 1000Genomes | |
| tmp_2_10793823_A_T | 4 | L>I | No | 1000Genomes | |
| tmp_2_10793801_C_T | 11 | G>E | No | 1000Genomes | |
| tmp_2_10793793_C_A | 14 | V>F | No | 1000Genomes | |
| tmp_2_10793783_T_A | 17 | E>V | No | 1000Genomes | |
| tmp_2_10793774_G_C | 20 | T>S | No | 1000Genomes | |
| ENSVATH14550783 | 38 | G>C | No | 1000Genomes | |
| tmp_2_10793720_C_T | 38 | G>D | No | 1000Genomes | |
| ENSVATH13397646 | 52 | V>A | No | 1000Genomes | |
| ENSVATH05588182 | 53 | F>L | No | 1000Genomes | |
| ENSVATH05588181 | 72 | G>E | No | 1000Genomes | |
| tmp_2_10793302_C_T | 73 | R>K | No | 1000Genomes | |
| tmp_2_10793282_G_C | 80 | L>V | No | 1000Genomes | |
| tmp_2_10793266_T_C | 85 | Q>R | No | 1000Genomes | |
| tmp_2_10793254_C_T | 89 | R>Q | No | 1000Genomes | |
| ENSVATH05588164 | 96 | H>Q | No | 1000Genomes | |
| tmp_2_10793228_C_T | 98 | A>T | No | 1000Genomes | |
| ENSVATH05588163 | 103 | M>L | No | 1000Genomes | |
| ENSVATH14550779 | 105 | D>N | No | 1000Genomes | |
| ENSVATH05588162 | 107 | F>L | No | 1000Genomes | |
| tmp_2_10793189_G_C | 111 | L>V | No | 1000Genomes | |
| ENSVATH00246585 | 126 | T>M | No | 1000Genomes | |
| ENSVATH05588161 | 128 | S>N | No | 1000Genomes | |
| ENSVATH13397611 | 132 | G>D | No | 1000Genomes | |
| ENSVATH05588157 | 147 | N>K | No | 1000Genomes | |
| tmp_2_10792983_A_C | 148 | I>S | No | 1000Genomes | |
| ENSVATH05588156 | 155 | L>V | No | 1000Genomes | |
| ENSVATH05588155 | 157 | L>V | No | 1000Genomes | |
| ENSVATH13397606 | 163 | A>T | No | 1000Genomes | |
| tmp_2_10792883_G_C | 181 | N>K | No | 1000Genomes | |
| tmp_2_10792881_G_T,A | 182 | T>K | No | 1000Genomes | |
| tmp_2_10792881_G_T,A | 182 | T>M | No | 1000Genomes | |
| tmp_2_10792863_C_A | 188 | C>F | No | 1000Genomes | |
| ENSVATH05588152 | 189 | K>N | No | 1000Genomes | |
| ENSVATH05588148 | 195 | I>M | No | 1000Genomes | |
| ENSVATH05588147 | 205 | G>V | No | 1000Genomes | |
| ENSVATH05588146 | 209 | A>T | No | 1000Genomes |
No associated diseases with Q9SIQ9
11 regional properties for Q9SIQ9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Ribonuclease III domain | 1283 - 1592 | IPR000999-1 |
| domain | Ribonuclease III domain | 1660 - 1841 | IPR000999-2 |
| domain | Helicase, C-terminal domain-like | 433 - 602 | IPR001650 |
| domain | PAZ domain | 891 - 1066 | IPR003100 |
| domain | Dicer dimerisation domain | 630 - 722 | IPR005034 |
| domain | Helicase/UvrB, N-terminal | 42 - 207 | IPR006935 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 40 - 243 | IPR014001 |
| domain | Double-stranded RNA-binding domain | 1843 - 1908 | IPR014720 |
| domain | Dicer, double-stranded RNA-binding domain | 1824 - 1912 | IPR044441 |
| domain | Dicer, platform domain | 761 - 886 | IPR048512 |
| domain | Dicer, partner-binding domain | 268 - 366 | IPR048513 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| vacuolar membrane | The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q12255 | NYV1 | Vacuolar v-SNARE NYV1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q17QI5 | VAMP7 | Vesicle-associated membrane protein 7 | Bos taurus (Bovine) | SS |
| Q5ZL74 | VAMP7 | Vesicle-associated membrane protein 7 | Gallus gallus (Chicken) | SS |
| P51809 | VAMP7 | Vesicle-associated membrane protein 7 | Homo sapiens (Human) | EV |
| P70280 | Vamp7 | Vesicle-associated membrane protein 7 | Mus musculus (Mouse) | SS |
| Q9JHW5 | Vamp7 | Vesicle-associated membrane protein 7 | Rattus norvegicus (Rat) | SS |
| O49377 | VAMP711 | Vesicle-associated membrane protein 711 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FMR5 | VAMP714 | Vesicle-associated membrane protein 714 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LFP1 | VAMP713 | Vesicle-associated membrane protein 713 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M376 | VAMP727 | Vesicle-associated membrane protein 727 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSILYALVAR | GTVVLAELST | TSTNASTIAK | QILEKIPGNG | DSHVSYSQDR | YVFHVKRTDG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LTVLCMADED | AGRRIPFSFL | EDIHQRFVRT | YGRAIHSAQA | YAMNDEFSRV | LNQQIEYYSN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DPNADTISRI | KGEMNQVRDV | MIENIDNILD | RGERLELLVD | KTANMQGNTF | RFRKQTRRFN |
| 190 | 200 | 210 | |||
| NTVWWRNCKL | TLLLILVLLV | IIYIGVAFAC | HGPTLPSCV |