Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q9SHJ5

Entry ID Method Resolution Chain Position Source
AF-Q9SHJ5-F1 Predicted AlphaFoldDB

28 variants for Q9SHJ5

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH00008831 21 K>N No 1000Genomes
ENSVATH10701252 60 H>Q No 1000Genomes
tmp_1_1995887_G_T 61 H>N No 1000Genomes
ENSVATH10701251 70 L>F No 1000Genomes
ENSVATH13857848 79 P>L No 1000Genomes
tmp_1_1995719_G_T 117 Q>K No 1000Genomes
tmp_1_1995716_G_C 118 H>D No 1000Genomes
ENSVATH10701250 163 R>K No 1000Genomes
tmp_1_1995539_C_T 177 D>N No 1000Genomes
ENSVATH04530529 196 I>L No 1000Genomes
ENSVATH04530526 200 D>N No 1000Genomes
tmp_1_1995455_T_G 205 T>P No 1000Genomes
ENSVATH01018815 257 G>S No 1000Genomes
ENSVATH04530525 263 K>I No 1000Genomes
ENSVATH00008828 270 F>L No 1000Genomes
ENSVATH00008827 281 G>A No 1000Genomes
ENSVATH04530521 307 M>K No 1000Genomes
ENSVATH01018813 377 R>K No 1000Genomes
ENSVATH04530520 385 L>W No 1000Genomes
tmp_1_1994770_A_T 386 N>K No 1000Genomes
tmp_1_1994760_G_A 390 P>S No 1000Genomes
ENSVATH10701247 393 G>D No 1000Genomes
ENSVATH10701213 459 K>E No 1000Genomes
tmp_1_1994404_G_C 508 S>R No 1000Genomes
ENSVATH04530518 520 M>I No 1000Genomes
ENSVATH04530517 542 G>R No 1000Genomes
ENSVATH00008824 560 V>I No 1000Genomes
ENSVATH10701212 572 D>E No 1000Genomes

No associated diseases with Q9SHJ5

1 regional properties for Q9SHJ5

Type Name Position InterPro Accession
domain Phospholipid/glycerol acyltransferase 382 - 498 IPR002123

Functions

Description
EC Number 2.3.1.15 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
  • Mitochondrion
  • According to PubMed:12897259 it is mitochondrial
  • However, no clear transit peptide is predicted by sequence analysis tools
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

4 GO annotations of molecular function

Name Definition
glycerol-3-phosphate 2-O-acyltransferase activity Catalysis of the reaction: an acyl-CoA + sn-glycerol 3-phosphate = CoA + a 2-acyl-sn-glycerol 3-phosphate.
glycerol-3-phosphate O-acyltransferase activity Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.
phosphatase activity Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity Catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate = coenzyme A + 1-C16:0-alpha,omega-dicarboxyl-2-lysophosphatidate.

3 GO annotations of biological process

Name Definition
CDP-diacylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate.
cutin biosynthetic process The chemical reactions and pathways resulting in the formation of cutin, a waxy substance, which combined with cellulose forms a substance nearly impervious to water and constituting the cuticle in plants.
pollen sperm cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a haploid sperm cell within the plant gametophyte.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9Y679 AUP1 Lipid droplet-regulating VLDL assembly factor AUP1 Homo sapiens (Human) PR
Q6PBN5 aup1 Lipid droplet-regulating VLDL assembly factor AUP1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MVLPELLVIL AEWVLYRLLA KSCYRAARKL RGYGFQLKNL LSLSKTQSLH NNSQHHLHNH
70 80 90 100 110 120
HQQNHPNQTL QDSLDPLFPS LTKYQELLLD KNRACSVSSD HYRDTFFCDI DGVLLRQHSS
130 140 150 160 170 180
KHFHTFFPYF MLVAFEGGSI IRAILLLLSC SFLWTLQQET KLRVLSFITF SGLRVKDMDN
190 200 210 220 230 240
VSRSVLPKFF LENLNIQVYD IWARTEYSKV VFTSLPQVLV ERFLREHLNA DDVIGTKLQE
250 260 270 280 290 300
IKVMGRKFYT GLASGSGFVL KHKSAEDYFF DSKKKPALGI GSSSSPQDHI FISICKEAYF
310 320 330 340 350 360
WNEEESMSKN NALPRERYPK PLIFHDGRLA FLPTPLATLA MFIWLPIGFL LAVFRISVGV
370 380 390 400 410 420
FLPYHVANFL ASMSGVRITF KTHNLNNGRP EKGNSGVLYV CNHRTLLDPV FLTTSLGKPL
430 440 450 460 470 480
TAVTYSLSKF SEFIAPLKTV SLKRDRKKDG EAMQRLLSKG DLVVCPEGTT CREPYLLRFS
490 500 510 520 530 540
PLFAELTEDI VPVAVDARVS MFYGTTASGL KCLDPIFFLM NPRPVYCLEI LKKLPKEMTC
550 560 570 580
AGGKSSFEVA NFIQGELARV LGFECTNLTR RDKYLVLAGN EGIVR