Q9SHI4
SS
Gene name |
RLP3 (RFO2, At1g17250, F20D23.5) |
Protein name |
Receptor-like protein 3 |
Names |
AtRLP3 , Protein RESISTANCE TO FUSARIUM OXYSPORUM 2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G17250 |
EC number |
|
Protein Class |
|
Descriptions
Leucine-rich repeat serine/threonine-protein kinase 1 (LRRK1) is a protein involved in the negative regulation of bone mass, acting through the maturation of osteoclasts. In contrast to the mechanism of autoinhibition that occurs in LRRK2, the autoinhibition of LRRK1 is mediated by a steric mechanism involving the ANK domain, which blocks access to the active site of the kinase domain in a dimer-dependent manner. In contrast, the interaction of the N-terminal LRR domain with the N-lobe of the kinase domain contributes to the alleviation of autoinhibition by changing its position relative to the WD40 domain, exposing the exposure of the active site of the kinase domain. The autoinhibited dimer of LRRK1 could be stabilized by a loop (1791-1907) in the WD40 domain. In addition, the kinase activity of LRRK1 is also regulated by the interaction of its COR-B loop with the kinase domain. Phosphorylation of three residues (S1064, T1074, and S1075) in the autoinhibitory COR-B loop significantly increases the kinase activity of LRRK1. Phosphorylation by Rab7a, resulting in the F1065A mutation, also alleviates the autoinhibited state of LRRK1.
Autoinhibitory domains (AIDs)
Target domain |
688-690 (N-lobe of kinase domain) |
Relief mechanism |
Partner binding, Cleavage |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SHI4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SHI4-F1 | Predicted | AlphaFoldDB |
70 variants for Q9SHI4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00028631 | 31 | G>R | No | 1000Genomes | |
| tmp_1_5903328_G_T | 38 | L>I | No | 1000Genomes | |
| tmp_1_5903240_A_G | 67 | V>A | No | 1000Genomes | |
| ENSVATH13911496 | 78 | P>L | No | 1000Genomes | |
| ENSVATH04589757 | 113 | P>S | No | 1000Genomes | |
| ENSVATH01062724 | 118 | R>H | No | 1000Genomes | |
| ENSVATH01062723 | 126 | N>D | No | 1000Genomes | |
| tmp_1_5903061_G_T | 127 | L>I | No | 1000Genomes | |
| ENSVATH11385113 | 129 | H>R | No | 1000Genomes | |
| tmp_1_5903040_C_T | 134 | G>S | No | 1000Genomes | |
| ENSVATH01062722 | 172 | N>D | No | 1000Genomes | |
| ENSVATH04589756 | 174 | C>R | No | 1000Genomes | |
| ENSVATH01062721 | 174 | C>S | No | 1000Genomes | |
| ENSVATH00028626 | 177 | I>V | No | 1000Genomes | |
| ENSVATH04589755 | 190 | E>K | No | 1000Genomes | |
| ENSVATH04589754 | 192 | L>P | No | 1000Genomes | |
| ENSVATH01062720 | 201 | T>S | No | 1000Genomes | |
| ENSVATH04589753 | 211 | K>M | No | 1000Genomes | |
| ENSVATH04589752 | 213 | S>N | No | 1000Genomes | |
| ENSVATH11385112 | 218 | I>M | No | 1000Genomes | |
| ENSVATH00028625 | 221 | F>L | No | 1000Genomes | |
| ENSVATH04589751 | 230 | S>T | No | 1000Genomes | |
| ENSVATH11385111 | 241 | G>S | No | 1000Genomes | |
| ENSVATH11385110 | 264 | S>C | No | 1000Genomes | |
| ENSVATH01062719 | 270 | D>A | No | 1000Genomes | |
| tmp_1_5902623_T_C | 273 | N>D | No | 1000Genomes | |
| ENSVATH11385109 | 289 | G>* | No | 1000Genomes | |
| ENSVATH01062718 | 292 | N>S | No | 1000Genomes | |
| ENSVATH01062717 | 299 | T>K | No | 1000Genomes | |
| tmp_1_5902496_A_T | 315 | I>K | No | 1000Genomes | |
| tmp_1_5902481_C_T | 320 | G>D | No | 1000Genomes | |
| ENSVATH11385107 | 327 | S>R | No | 1000Genomes | |
| ENSVATH04589744 | 364 | S>T | No | 1000Genomes | |
| ENSVATH04589743 | 400 | A>S | No | 1000Genomes | |
| ENSVATH04589742 | 409 | T>R | No | 1000Genomes | |
| ENSVATH00028621 | 424 | I>F | No | 1000Genomes | |
| tmp_1_5902149_T_C | 431 | K>E | No | 1000Genomes | |
| ENSVATH04589740 | 444 | G>D | No | 1000Genomes | |
| ENSVATH01062707 | 461 | T>S | No | 1000Genomes | |
| ENSVATH04589739 | 479 | I>V | No | 1000Genomes | |
| tmp_1_5901936_C_A | 502 | A>S | No | 1000Genomes | |
| ENSVATH00028619 | 503 | V>I | No | 1000Genomes | |
| ENSVATH04589738 | 510 | Q>H | No | 1000Genomes | |
| ENSVATH13911495 | 512 | V>E | No | 1000Genomes | |
| ENSVATH04589737 | 514 | S>L | No | 1000Genomes | |
| tmp_1_5901887_C_T | 518 | W>* | No | 1000Genomes | |
| tmp_1_5901873_G_A | 523 | P>S | No | 1000Genomes | |
| ENSVATH11385052 | 563 | L>R | No | 1000Genomes | |
| ENSVATH11385051 | 569 | V>I | No | 1000Genomes | |
| tmp_1_5901705_G_A | 579 | Q>* | No | 1000Genomes | |
| tmp_1_5901689_A_C | 584 | F>C | No | 1000Genomes | |
| ENSVATH11385047 | 602 | P>S | No | 1000Genomes | |
| ENSVATH13911404 | 621 | L>F | No | 1000Genomes | |
| ENSVATH00028618 | 634 | S>N | No | 1000Genomes | |
| tmp_1_5901522_G_T | 640 | L>M | No | 1000Genomes | |
| tmp_1_5901491_G_T | 650 | P>H | No | 1000Genomes | |
| ENSVATH01062695 | 689 | G>E | No | 1000Genomes | |
| ENSVATH01062694 | 692 | L>M | No | 1000Genomes | |
| ENSVATH04589726 | 697 | I>T | No | 1000Genomes | |
| tmp_1_5901347_A_C | 698 | L>R | No | 1000Genomes | |
| ENSVATH00028615 | 705 | S>P | No | 1000Genomes | |
| ENSVATH01062691 | 706 | T>A | No | 1000Genomes | |
| ENSVATH00028614 | 714 | N>S | No | 1000Genomes | |
| ENSVATH11384883 | 725 | K>T | No | 1000Genomes | |
| ENSVATH01062690 | 726 | F>I | No | 1000Genomes | |
| ENSVATH01062689 | 726 | F>L | No | 1000Genomes | |
| ENSVATH01062688 | 727 | I>M | No | 1000Genomes | |
| tmp_1_5901216_A_G | 742 | F>L | No | 1000Genomes | |
| ENSVATH13911403 | 749 | R>* | No | 1000Genomes | |
| ENSVATH00028613 | 753 | F>L | No | 1000Genomes |
No associated diseases with Q9SHI4
7 regional properties for Q9SHI4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | EF-hand domain | 182 - 233 | IPR002048 |
| domain | FAD-binding 8 | 562 - 678 | IPR013112 |
| domain | Ferric reductase, NAD binding domain | 685 - 849 | IPR013121 |
| domain | Ferric reductase transmembrane component-like domain | 363 - 518 | IPR013130 |
| domain | NADPH oxidase Respiratory burst | 103 - 201 | IPR013623 |
| domain | FAD-binding domain, ferredoxin reductase-type | 558 - 681 | IPR017927 |
| binding_site | EF-Hand 1, calcium-binding site | 211 - 223 | IPR018247 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| defense response to fungus | Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| meristem maintenance | Any process involved in maintaining the identity, size and shape of a meristem. |
| response to fungus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. |
40 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3MHH9 | ECM2 | Extracellular matrix protein 2 | Bos taurus (Bovine) | PR |
| P58874 | OPTC | Opticin | Bos taurus (Bovine) | PR |
| Q24K06 | LRRC10 | Leucine-rich repeat-containing protein 10 | Bos taurus (Bovine) | PR |
| Q9V780 | Lap1 | Protein lap1 | Drosophila melanogaster (Fruit fly) | PR |
| Q96NW7 | LRRC7 | Leucine-rich repeat-containing protein 7 | Homo sapiens (Human) | PR |
| Q8IWT6 | LRRC8A | Volume-regulated anion channel subunit LRRC8A | Homo sapiens (Human) | PR |
| Q9HCJ2 | LRRC4C | Leucine-rich repeat-containing protein 4C | Homo sapiens (Human) | PR |
| Q9UFC0 | LRWD1 | Leucine-rich repeat and WD repeat-containing protein 1 | Homo sapiens (Human) | PR |
| Q96L50 | LRR1 | Leucine-rich repeat protein 1 | Homo sapiens (Human) | PR |
| Q86UN2 | RTN4RL1 | Reticulon-4 receptor-like 1 | Homo sapiens (Human) | PR |
| Q8IWK6 | ADGRA3 | Adhesion G protein-coupled receptor A3 | Homo sapiens (Human) | PR |
| Q7L1W4 | LRRC8D | Volume-regulated anion channel subunit LRRC8D | Homo sapiens (Human) | PR |
| Q96FE5 | LINGO1 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 | Homo sapiens (Human) | PR |
| Q8TDW0 | LRRC8C | Volume-regulated anion channel subunit LRRC8C | Homo sapiens (Human) | PR |
| Q38SD2 | LRRK1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Homo sapiens (Human) | EV |
| A6H694 | Lrrc63 | Leucine-rich repeat-containing protein 63 | Mus musculus (Mouse) | PR |
| Q9D9Q0 | Lrrc69 | Leucine-rich repeat-containing protein 69 | Mus musculus (Mouse) | PR |
| Q8BGI7 | Lrrc39 | Leucine-rich repeat-containing protein 39 | Mus musculus (Mouse) | PR |
| Q7TT36 | Adgra3 | Adhesion G protein-coupled receptor A3 | Mus musculus (Mouse) | PR |
| P59383 | Lrrn4 | Leucine-rich repeat neuronal protein 4 | Mus musculus (Mouse) | PR |
| Q9D1T0 | Lingo1 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 | Mus musculus (Mouse) | PR |
| Q8R502 | Lrrc8c | Volume-regulated anion channel subunit LRRC8C | Mus musculus (Mouse) | PR |
| Q80WG5 | Lrrc8a | Volume-regulated anion channel subunit LRRC8A | Mus musculus (Mouse) | PR |
| Q8K0S5 | Rtn4rl1 | Reticulon-4 receptor-like 1 | Mus musculus (Mouse) | PR |
| Q80TE7 | Lrrc7 | Leucine-rich repeat-containing protein 7 | Mus musculus (Mouse) | PR |
| Q5DU41 | Lrrc8b | Volume-regulated anion channel subunit LRRC8B | Mus musculus (Mouse) | PR |
| Q5RKR3 | Islr2 | Immunoglobulin superfamily containing leucine-rich repeat protein 2 | Mus musculus (Mouse) | PR |
| Q8C031 | Lrrc4c | Leucine-rich repeat-containing protein 4C | Mus musculus (Mouse) | PR |
| P70587 | Lrrc7 | Leucine-rich repeat-containing protein 7 | Rattus norvegicus (Rat) | PR |
| Q4V8G0 | Lrrc63 | Leucine-rich repeat-containing protein 63 | Rattus norvegicus (Rat) | PR |
| Q80WD0 | Rtn4rl1 | Reticulon-4 receptor-like 1 | Rattus norvegicus (Rat) | PR |
| Q9TZM3 | lrk-1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Caenorhabditis elegans | SS |
| Q5G5E0 | PIRL5 | Plant intracellular Ras-group-related LRR protein 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGT6 | EFR | LRR receptor-like serine/threonine-protein kinase EFR | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGE4 | At1g12460 | Probable LRR receptor-like serine/threonine-protein kinase At1g12460 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGJ1 | At1g74360 | Probable LRR receptor-like serine/threonine-protein kinase At1g74360 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6XAT2 | ERL2 | LRR receptor-like serine/threonine-protein kinase ERL2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| B0JZ65 | lrwd1 | Leucine-rich repeat and WD repeat-containing protein 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q68F79 | lrrc8e | Volume-regulated anion channel subunit LRRC8E | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| B0R160 | lrwd1 | Leucine-rich repeat and WD repeat-containing protein 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTNEGRFKAK | GFVRTSSTTR | PIQALSFHMI | GILLQCVLFI | SVLSIAVSEA | LCNSQDRESL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LWFSGNVSSS | VSPLNWNPSI | DCCSWEGITC | DDSPDSHITA | ISLPFRALYG | KLPLSVLRLH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HLSQLNLSHN | RLSGHLPSGF | LSALDQLKVL | DLSYNSLDGE | LPVEQTFRNG | SNRCFPIRIV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DLSSNFLQGE | ILPSSIFMQG | TFDLISFNVS | KNSFTGSIPS | FMCKSSPQLS | KLDFSYNDFT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GNIPQGLGRC | LKLSVLQAGF | NNISGEIPSD | IYNLSELEQL | FLPVNHLSGK | INDDITHLTK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LKSLELYSNH | LGGEIPMDIG | QLSRLQSLQL | HINNITGTVP | PSLANCTNLV | KLNLRLNRLE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GTLSELDFSR | FQSLSILDLG | NNSFSGDFPW | RVHSCKSLSA | MRFASNKLTG | QISPHVLELE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SLSILSLSDN | KLMNITGALG | ILQGCRNLST | LLIGKNFYNE | TFPSDKDLIS | SDGFPNLQIF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ASGGSGLRGE | IPAWLIKLKS | LAVIDLSHNQ | LVGSIPGWLG | TFPHLFYIDL | SENLLSGELP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KDLFQLKALM | SQKAYDATER | NYLKLPVFVS | PNNVTTHQQY | NQLFSLPPGI | YIRRNNLKGS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IPIEVGQLKV | LHVLELSHNY | LSGIIPHELS | KLTSLERLDL | SNNHLSGRIP | WSLTSLHYMS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YFNVVNNSLD | GPIPTGSQFD | TFPQANFKGN | PLLCGGILLT | SCKASTKLPA | TTTNKADTED |
| 730 | 740 | 750 | |||
| EEELKFIFIL | GVATGFFVSY | CFYWCFFARL | DAFISK |