Q9SF37
PR
Gene name |
MCM8 (At3g09660, F11F8.25) |
Protein name |
Probable DNA helicase MCM8 |
Names |
Minichromosome maintenance 8, AtMCM8 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G09660 |
EC number |
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SF37
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SF37-F1 | Predicted | AlphaFoldDB |
52 variants for Q9SF37
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05799402 | 5 | G>C | No | 1000Genomes | |
| tmp_3_2966117_G_T | 17 | T>K | No | 1000Genomes | |
| tmp_3_2966114_C_T | 18 | G>E | No | 1000Genomes | |
| ENSVATH00313781 | 22 | L>I | No | 1000Genomes | |
| ENSVATH00313780 | 24 | I>F | No | 1000Genomes | |
| tmp_3_2966078_A_G | 30 | V>A | No | 1000Genomes | |
| ENSVATH00313779 | 32 | I>L | No | 1000Genomes | |
| tmp_3_2965675_A_G | 76 | S>P | No | 1000Genomes | |
| tmp_3_2965649_G_T | 84 | F>L | No | 1000Genomes | |
| ENSVATH10569515 | 91 | E>K | No | 1000Genomes | |
| tmp_3_2965617_A_C | 95 | I>R | No | 1000Genomes | |
| tmp_3_2965478_A_G | 117 | F>S | No | 1000Genomes | |
| ENSVATH10569433 | 177 | A>D | No | 1000Genomes | |
| tmp_3_2965177_G_A | 189 | R>W | No | 1000Genomes | |
| tmp_3_2965165_C_T | 193 | D>N | No | 1000Genomes | |
| ENSVATH00313769 | 258 | I>T | No | 1000Genomes | |
| tmp_3_2964803_C_T | 282 | G>E | No | 1000Genomes | |
| tmp_3_2964428_G_T | 308 | Q>K | No | 1000Genomes | |
| tmp_3_2964392_T_C | 320 | S>G | No | 1000Genomes | |
| ENSVATH02126140 | 323 | T>I | No | 1000Genomes | |
| ENSVATH02126139 | 328 | D>Y | No | 1000Genomes | |
| ENSVATH10569431 | 338 | E>D | No | 1000Genomes | |
| ENSVATH00313767 | 350 | D>E | No | 1000Genomes | |
| ENSVATH07956949 | 355 | I>M | No | 1000Genomes | |
| tmp_3_2964090_G_A | 388 | R>W | No | 1000Genomes | |
| tmp_3_2963900_G_C | 418 | A>G | No | 1000Genomes | |
| ENSVATH05799376 | 430 | A>V | No | 1000Genomes | |
| tmp_3_2963826_C_T | 443 | D>N | No | 1000Genomes | |
| tmp_3_2963141_C_T | 490 | V>I | No | 1000Genomes | |
| tmp_3_2963060_T_A | 517 | N>Y | No | 1000Genomes | |
| ENSVATH00313749 | 593 | E>K | No | 1000Genomes | |
| ENSVATH05799358 | 602 | R>Q | No | 1000Genomes | |
| ENSVATH05799359 | 602 | R>W | No | 1000Genomes | |
| ENSVATH10569340 | 604 | D>N | No | 1000Genomes | |
| ENSVATH00313748 | 606 | E>K | No | 1000Genomes | |
| ENSVATH13889282 | 624 | S>F | No | 1000Genomes | |
| ENSVATH13889283 | 624 | S>T | No | 1000Genomes | |
| ENSVATH13889281 | 627 | R>W | No | 1000Genomes | |
| ENSVATH00313747 | 628 | N>T | No | 1000Genomes | |
| tmp_3_2962328_T_C | 631 | N>S | No | 1000Genomes | |
| tmp_3_2962233_A_G | 634 | M>T | No | 1000Genomes | |
| tmp_3_2962200_A_T | 645 | F>Y | No | 1000Genomes | |
| ENSVATH00313745 | 679 | V>I | No | 1000Genomes | |
| tmp_3_2962074_A_G | 687 | V>A | No | 1000Genomes | |
| tmp_3_2961817_T_C | 696 | I>M | No | 1000Genomes | |
| ENSVATH05799354 | 705 | L>F | No | 1000Genomes | |
| ENSVATH10569336 | 709 | H>Y | No | 1000Genomes | |
| tmp_3_2961773_A_G | 711 | V>A | No | 1000Genomes | |
| ENSVATH00313739 | 733 | L>V | No | 1000Genomes | |
| ENSVATH02126112 | 746 | S>P | No | 1000Genomes | |
| ENSVATH02126109 | 758 | G>D | No | 1000Genomes | |
| ENSVATH05799352 | 766 | T>S | No | 1000Genomes |
No associated diseases with Q9SF37
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.12 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| MCM complex | A hexameric protein complex required for the initiation and regulation of DNA replication. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| DNA helicase activity | Unwinding of a DNA helix, driven by ATP hydrolysis. |
| metal ion binding | Binding to a metal ion. |
| single-stranded DNA binding | Binding to single-stranded DNA. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| double-strand break repair via homologous recombination | The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. |
| female meiotic nuclear division | A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline. |
| male meiotic nuclear division | A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline. |
| pollen development | The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2KIZ8 | MCM6 | DNA replication licensing factor MCM6 | Bos taurus (Bovine) | PR |
| Q9V461 | Mcm6 | DNA replication licensing factor Mcm6 | Drosophila melanogaster (Fruit fly) | PR |
| Q14566 | MCM6 | DNA replication licensing factor MCM6 | Homo sapiens (Human) | PR |
| P97311 | Mcm6 | DNA replication licensing factor MCM6 | Mus musculus (Mouse) | PR |
| Q62724 | Mcm6 | DNA replication licensing factor MCM6 | Rattus norvegicus (Rat) | PR |
| Q6F353 | Os05g0235800 | DNA replication licensing factor MCM6 | Oryza sativa subsp japonica (Rice) | PR |
| P34647 | mcm-6 | DNA replication licensing factor mcm-6 | Caenorhabditis elegans | PR |
| F4IFF3 | MCM9 | Probable DNA helicase MCM9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q28CM3 | mmcm6 | Maternal DNA replication licensing factor mcm6 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGFYGGGSMA | SGRPESTGID | SLGIGKILAV | YIKDNENLAI | DEDKLQLTAE | LIRVFSASPG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RDIVSQVNED | GGGSFSLSLD | LQQFKKISDI | ENFFINLEDN | PKGVIPCMNA | AVHKVLFDQW |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ETNEFENVMK | INVRLHNYPE | SSISLKNLRA | AYIGKLVTVH | GTVVKVSTVK | PLVTQMAFDC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GKCKTGITRE | FTDGKFSPPL | KCDSHGCKSK | TFTPIRSSAQ | TIDFQKIRVQ | ELQKPEDHEE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GRVPRTVECE | LMEDLVDICI | PGDVVTVTGI | IGVINNYMDI | GGGKSKTKNQ | GFYYLFIEAV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SVKNTKRQSA | FENSEDSSSS | AQTADVGDLY | SFSQRDLEFI | VKFKEEYGSD | TFRRILHSVC |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PSIYGHEIVK | AGITLSLFGG | VRKHSMDRNK | VPVRGDIHVI | IVGDPGLGKS | QLLQAAAAIS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PRGIYVCGNA | TTRAGLTVAV | VKDSMTNDYA | FEAGAMVLAD | GGLCCIDEFD | KMTTEHQALL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EAMEQQCVSV | AKAGLVASLS | ARTSVIAAAN | PVGGHYNRAK | TVNENLKMSA | ALLSRFDLVF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ILLDKPDELL | DKQVSEHIMS | LHSASGETSP | ALKKFKPVNA | ASQNAGYANM | HAEGNSLLSR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LRLDSEKDDD | FSPVPGQLLR | KYISYARNFV | NPKMSKDAGE | IIQKFYLKLR | DHNTSADSTP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ITARQLESLV | RLAQARARVD | LREEITVQDA | MDVVEIMKES | LYDKLIDEHG | VVDFGRSGGM |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SQQKEAKRFL | SALDKQSELQ | QKDCFSVSEM | YSLADRIGLR | VPDIDTFLEN | LNIAGYLLKK |
| 790 | 800 | ||||
| GPKTYQVLSS | SYSRSQSSRS | R |