Q9SCZ4
Gene name |
FER (AAK1, SIR, SRN, At3g51550, F26O13.190) |
Protein name |
Receptor-like protein kinase FERONIA |
Names |
Protein SIRENE |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G51550 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
678-685 (Activation loop from InterPro)
Target domain |
536-810 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
696-703 (Activation loop from InterPro)
Target domain |
536-810 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
7 structures for Q9SCZ4
27 variants for Q9SCZ4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00414742 | 7 | R>Q | No | 1000Genomes | |
| tmp_3_19120539_C_T | 9 | R>H | No | 1000Genomes | |
| tmp_3_19120534_A_G | 11 | S>P | No | 1000Genomes | |
| ENSVATH12710315 | 54 | I>T | No | 1000Genomes | |
| tmp_3_19120371_G_A | 65 | S>L | No | 1000Genomes | |
| ENSVATH12710264 | 76 | A>S | No | 1000Genomes | |
| ENSVATH02490992 | 93 | V>I | No | 1000Genomes | |
| ENSVATH00414738 | 153 | T>S | No | 1000Genomes | |
| ENSVATH02490989 | 179 | A>S | No | 1000Genomes | |
| ENSVATH12710263 | 180 | P>S | No | 1000Genomes | |
| ENSVATH00414734 | 255 | I>L | No | 1000Genomes | |
| ENSVATH14420102 | 280 | T>S | No | 1000Genomes | |
| ENSVATH12710262 | 285 | V>M | No | 1000Genomes | |
| tmp_3_19119591_C_G | 325 | C>S | No | 1000Genomes | |
| ENSVATH00414730 | 426 | Q>E | No | 1000Genomes | |
| ENSVATH06295186 | 432 | S>F | No | 1000Genomes | |
| ENSVATH06295185 | 434 | V>I | No | 1000Genomes | |
| ENSVATH12710257 | 442 | S>L | No | 1000Genomes | |
| ENSVATH12710256 | 446 | T>S | No | 1000Genomes | |
| tmp_3_19119208_C_T | 453 | A>T | No | 1000Genomes | |
| ENSVATH06295182 | 460 | A>G | No | 1000Genomes | |
| ENSVATH14420101 | 469 | G>S | No | 1000Genomes | |
| tmp_3_19118118_C_T | 816 | S>N | No | 1000Genomes | |
| ENSVATH12710224 | 830 | M>V | No | 1000Genomes | |
| tmp_3_19118032_C_T | 845 | D>N | No | 1000Genomes | |
| tmp_3_19118002_C_A | 855 | V>L | No | 1000Genomes | |
| ENSVATH12710223 | 857 | D>G | No | 1000Genomes |
No associated diseases with Q9SCZ4
5 regional properties for Q9SCZ4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 536 - 810 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 539 - 803 | IPR001245 |
| active_site | Serine/threonine-protein kinase, active site | 657 - 669 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 542 - 565 | IPR017441 |
| domain | Malectin-like domain | 38 - 409 | IPR024788 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| filiform apparatus | A complex of cell wall invaginations in a synergid cell, similar to those in transfer cells. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| plasmodesma | A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
14 GO annotations of biological process
| Name | Definition |
|---|---|
| abscisic acid-activated signaling pathway | The series of molecular signals generated by the binding of the plant hormone abscisic acid (ABA) to a receptor, and ending with modulation of a cellular process, e.g. transcription. |
| brassinosteroid mediated signaling pathway | The series of molecular signals mediated by the detection of brassinosteroid. |
| circadian regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours. |
| defense response to fungus | Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. |
| ethylene-activated signaling pathway | The series of molecular signals generated by the reception of ethylene (ethene, C2H4) by a receptor and ending with modulation of a cellular process, e.g. transcription. |
| negative regulation of abscisic acid-activated signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of abscisic acid (ABA) signaling. |
| negative regulation of cell growth | Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. |
| pollen tube reception | Interaction between the pollen tube, part of the male gametophyte, and the ovule, part of the female gametophyte, that results in the arrest of pollen tube growth, rupture of the pollen tube and the release of the sperm cells. |
| post-embryonic development | The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| response to brassinosteroid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus. |
| response to ethylene | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus. |
| root development | The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo. |
| stomatal movement | The process of opening or closing of stomata, which is directly related to the stomatal conductance (measuring rate of passage of either water vapor or carbon dioxide (CO2) through stomata). |
41 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q07407 | htl | Fibroblast growth factor receptor homolog 1 | Drosophila melanogaster (Fruit fly) | PR |
| Q9Y616 | IRAK3 | Interleukin-1 receptor-associated kinase 3 | Homo sapiens (Human) | PR |
| P53667 | LIMK1 | LIM domain kinase 1 | Homo sapiens (Human) | PR |
| P53671 | LIMK2 | LIM domain kinase 2 | Homo sapiens (Human) | PR |
| Q06418 | TYRO3 | Tyrosine-protein kinase receptor TYRO3 | Homo sapiens (Human) | SS |
| P22607 | FGFR3 | Fibroblast growth factor receptor 3 | Homo sapiens (Human) | EV |
| P21802 | FGFR2 | Fibroblast growth factor receptor 2 | Homo sapiens (Human) | EV |
| P11362 | FGFR1 | Fibroblast growth factor receptor 1 | Homo sapiens (Human) | EV |
| P22455 | FGFR4 | Fibroblast growth factor receptor 4 | Homo sapiens (Human) | SS |
| P09619 | PDGFRB | Platelet-derived growth factor receptor beta | Homo sapiens (Human) | EV |
| P10721 | KIT | Mast/stem cell growth factor receptor Kit | Homo sapiens (Human) | EV |
| P16234 | PDGFRA | Platelet-derived growth factor receptor alpha | Homo sapiens (Human) | EV |
| P07333 | CSF1R | Macrophage colony-stimulating factor 1 receptor | Homo sapiens (Human) | SS |
| Q8K4B2 | Irak3 | Interleukin-1 receptor-associated kinase 3 | Mus musculus (Mouse) | PR |
| Q8CFA1 | Irak2 | Interleukin-1 receptor-associated kinase-like 2 | Mus musculus (Mouse) | PR |
| O54785 | Limk2 | LIM domain kinase 2 | Mus musculus (Mouse) | PR |
| Q8VCT9 | Tesk2 | Dual specificity testis-specific protein kinase 2 | Mus musculus (Mouse) | PR |
| Q4QQS0 | Irak2 | Interleukin-1 receptor-associated kinase-like 2 | Rattus norvegicus (Rat) | PR |
| O08680 | Epha3 | Ephrin type-A receptor 3 | Rattus norvegicus (Rat) | SS |
| P54757 | Epha5 | Ephrin type-A receptor 5 | Rattus norvegicus (Rat) | SS |
| P54759 | Epha7 | Ephrin type-A receptor 7 | Rattus norvegicus (Rat) | SS |
| P09759 | Ephb1 | Ephrin type-B receptor 1 | Rattus norvegicus (Rat) | SS |
| P0C0K7 | Ephb6 | Ephrin type-B receptor 6 | Rattus norvegicus (Rat) | SS |
| Q19238 | F09A5.2 | Putative tyrosine-protein kinase F09A5.2 | Caenorhabditis elegans | SS |
| Q8LPS5 | SERK5 | Somatic embryogenesis receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWW0 | ALE2 | Receptor-like serine/threonine-protein kinase ALE2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P93050 | BSH | Probable LRR receptor-like serine/threonine-protein kinase RKF3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRP3 | At3g17420 | Probable receptor-like protein kinase At3g17420 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSV3 | WAKL16 | Putative wall-associated receptor kinase-like 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9STF0 | LECRKS3 | Receptor like protein kinase S.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M342 | WAKL15 | Wall-associated receptor kinase-like 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LYN6 | At3g56050 | Probable inactive receptor-like protein kinase At3g56050 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZJ9 | CRCK2 | Calmodulin-binding receptor-like cytoplasmic kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WNY5 | WAKL18 | Wall-associated receptor kinase-like 18 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43293 | PBL11 | Probable serine/threonine-protein kinase PBL11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94C25 | At5g20050 | Probable receptor-like protein kinase At5g20050 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LTC0 | PBL19 | Probable serine/threonine-protein kinase PBL19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FIL7 | CRCK1 | Calmodulin-binding receptor-like cytoplasmic kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E8W4 | ANX2 | Receptor-like protein kinase ANXUR2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ASQ5 | CRCK3 | Calmodulin-binding receptor-like cytoplasmic kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FLW0 | At5g24010 | Probable receptor-like protein kinase At5g24010 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKITEGRFRL | SLLLLLLLIS | AATLISAADY | SPTEKILLNC | GGGASNLTDT | DNRIWISDVK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SKFLSSSSED | SKTSPALTQD | PSVPEVPYMT | ARVFRSPFTY | TFPVASGRKF | VRLYFYPNSY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DGLNATNSLF | SVSFGPYTLL | KNFSASQTAE | ALTYAFIIKE | FVVNVEGGTL | NMTFTPESAP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SNAYAFVNGI | EVTSMPDMYS | STDGTLTMVG | SSGSVTIDNS | TALENVYRLN | VGGNDISPSA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DTGLYRSWYD | DQPYIFGAGL | GIPETADPNM | TIKYPTGTPT | YVAPVDVYST | ARSMGPTAQI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NLNYNLTWIF | SIDSGFTYLV | RLHFCEVSSN | ITKINQRVFT | IYLNNQTAEP | EADVIAWTSS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NGVPFHKDYV | VNPPEGNGQQ | DLWLALHPNP | VNKPEYYDSL | LNGVEIFKMN | TSDGNLAGTN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PIPGPQVTAD | PSKVLRPTTR | KSKSNTAIIA | GAASGAVVLA | LIIGFCVFGA | YRRRKRGDYQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PASDATSGWL | PLSLYGNSHS | AGSAKTNTTG | SYASSLPSNL | CRHFSFAEIK | AATKNFDESR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VLGVGGFGKV | YRGEIDGGTT | KVAIKRGNPM | SEQGVHEFQT | EIEMLSKLRH | RHLVSLIGYC |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EENCEMILVY | DYMAHGTMRE | HLYKTQNPSL | PWKQRLEICI | GAARGLHYLH | TGAKHTIIHR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DVKTTNILLD | EKWVAKVSDF | GLSKTGPTLD | HTHVSTVVKG | SFGYLDPEYF | RRQQLTEKSD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VYSFGVVLFE | ALCARPALNP | TLAKEQVSLA | EWAPYCYKKG | MLDQIVDPYL | KGKITPECFK |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KFAETAMKCV | LDQGIERPSM | GDVLWNLEFA | LQLQESAEEN | GKGVCGDMDM | DEIKYDDGNC |
| 850 | 860 | 870 | 880 | 890 | |
| KGKNDKSSDV | YEGNVTDSRS | SGIDMSIGGR | SLASEDSDGL | TPSAVFSQIM | NPKGR |