Q9SCQ7
SS
Gene name |
At3g50690 (T3A5.70) |
Protein name |
Acidic leucine-rich nuclear phosphoprotein 32-related protein |
Names |
ANP32/acidic nuclear phosphoprotein-like protein |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G50690 |
EC number |
|
Protein Class |
|
Descriptions
ANP32A(I1<sup>PP2A</sup>) regulates PP2A activity by functioning as a non-competitive inhibitor of this enzyme. PP2A is a major regulator of the phosphorylation of Tau. The activity of PP2A is compromised in Alzheimer's disease brain. ANP32A has an autoinhibitory domain that negatively affects the interaction of ANP32A with PP2Ac and its ability to modulate the PP2A activity, which lies within amino acid residues 121-163. The inhibitory role of the autoinhibitory region might be regulated through the phosphorylation of Ser-158 or both Ser-158 and Ser-204 by casein kinase II. The autoinhibition is disrupted by C-terminal region.
Autoinhibitory domains (AIDs)
Target domain |
5-169 (Leucine-rich region) |
Relief mechanism |
PTM, Others |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SCQ7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SCQ7-F1 | Predicted | AlphaFoldDB |
86 variants for Q9SCQ7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_18837090_T_C | 3 | E>G | No | 1000Genomes | |
| ENSVATH06289686 | 7 | R>K | No | 1000Genomes | |
| ENSVATH12695890 | 24 | T>M | No | 1000Genomes | |
| ENSVATH06289684 | 30 | A>V | No | 1000Genomes | |
| tmp_3_18836998_C_A | 34 | V>F | No | 1000Genomes | |
| ENSVATH12695889 | 36 | G>R | No | 1000Genomes | |
| ENSVATH06289682 | 40 | P>S | No | 1000Genomes | |
| ENSVATH06289681 | 42 | S>R | No | 1000Genomes | |
| tmp_3_18836929_T_A | 57 | N>Y | No | 1000Genomes | |
| tmp_3_18836923_C_T | 59 | G>S | No | 1000Genomes | |
| ENSVATH12695888 | 71 | N>K | No | 1000Genomes | |
| ENSVATH06289676 | 83 | T>I | No | 1000Genomes | |
| tmp_3_18836824_C_A | 92 | A>S | No | 1000Genomes | |
| ENSVATH06289674 | 97 | F>L | No | 1000Genomes | |
| ENSVATH06289673 | 98 | C>R | No | 1000Genomes | |
| ENSVATH12695887 | 98 | C>Y | No | 1000Genomes | |
| tmp_3_18836749_C_T | 117 | A>T | No | 1000Genomes | |
| ENSVATH06289671 | 134 | L>V | No | 1000Genomes | |
| tmp_3_18836692_C_T | 136 | D>N | No | 1000Genomes | |
| ENSVATH06289670 | 138 | R>Q | No | 1000Genomes | |
| ENSVATH02486767 | 140 | R>M | No | 1000Genomes | |
| tmp_3_18836673_A_G | 142 | F>S | No | 1000Genomes | |
| tmp_3_18836670_C_A | 143 | G>V | No | 1000Genomes | |
| ENSVATH06289668 | 156 | A>V | No | 1000Genomes | |
| ENSVATH06289667 | 175 | D>E | No | 1000Genomes | |
| tmp_3_18836558_C_A,T | 180 | E>D | No | 1000Genomes | |
| ENSVATH06289665 | 185 | E>K | No | 1000Genomes | |
| ENSVATH02486766 | 188 | G>V | No | 1000Genomes | |
| ENSVATH06289663 | 195 | D>G | No | 1000Genomes | |
| ENSVATH06289664 | 195 | D>N | No | 1000Genomes | |
| ENSVATH06289662 | 198 | A>E | No | 1000Genomes | |
| ENSVATH06289661 | 200 | A>S | No | 1000Genomes | |
| tmp_3_18836499_G_A | 200 | A>V | No | 1000Genomes | |
| ENSVATH00413442 | 201 | P>L | No | 1000Genomes | |
| ENSVATH06289659 | 202 | R>P | No | 1000Genomes | |
| ENSVATH06289660 | 202 | R>W | No | 1000Genomes | |
| ENSVATH06289658 | 203 | M>I | No | 1000Genomes | |
| tmp_3_18836458_C_T | 214 | V>I | No | 1000Genomes | |
| ENSVATH06289656 | 225 | A>V | No | 1000Genomes | |
| tmp_3_18836407_C_T | 231 | E>K | No | 1000Genomes | |
| ENSVATH00413441 | 233 | A>T | No | 1000Genomes | |
| tmp_3_18836374_G_C,A | 242 | R>G | No | 1000Genomes | |
| tmp_3_18836373_C_T | 242 | R>Q | No | 1000Genomes | |
| tmp_3_18836374_G_C,A | 242 | R>W | No | 1000Genomes | |
| ENSVATH02486765 | 243 | A>V | No | 1000Genomes | |
| tmp_3_18836355_A_C | 248 | L>R | No | 1000Genomes | |
| ENSVATH12695886 | 252 | N>D | No | 1000Genomes | |
| tmp_3_18836341_C_G | 253 | G>R | No | 1000Genomes | |
| ENSVATH06289653 | 257 | R>G | No | 1000Genomes | |
| ENSVATH02486763 | 287 | E>D | No | 1000Genomes | |
| tmp_3_18836235_T_A | 288 | N>I | No | 1000Genomes | |
| ENSVATH06289651 | 303 | E>K | No | 1000Genomes | |
| ENSVATH06289649 | 304 | E>D | No | 1000Genomes | |
| ENSVATH06289650 | 304 | E>K | No | 1000Genomes | |
| ENSVATH06289650 | 304 | E>Q | No | 1000Genomes | |
| ENSVATH06289647 | 310 | N>K | No | 1000Genomes | |
| ENSVATH14416600 | 313 | R>C | No | 1000Genomes | |
| tmp_3_18836143_C_T | 319 | G>R | No | 1000Genomes | |
| tmp_3_18836136_G_T | 321 | T>K | No | 1000Genomes | |
| ENSVATH06289646 | 322 | S>G | No | 1000Genomes | |
| tmp_3_18836126_C_G | 324 | L>F | No | 1000Genomes | |
| tmp_3_18836100_T_A | 333 | H>L | No | 1000Genomes | |
| ENSVATH06289645 | 338 | D>G | No | 1000Genomes | |
| ENSVATH06289644 | 341 | D>G | No | 1000Genomes | |
| ENSVATH06289643 | 347 | G>R | No | 1000Genomes | |
| tmp_3_18836043_C_T | 352 | G>E | No | 1000Genomes | |
| ENSVATH06289628 | 371 | E>G | No | 1000Genomes | |
| ENSVATH00413438 | 374 | G>V | No | 1000Genomes | |
| ENSVATH06289627 | 377 | Y>C | No | 1000Genomes | |
| ENSVATH06289626 | 382 | V>A | No | 1000Genomes | |
| tmp_3_18835464_T_A | 384 | Q>L | No | 1000Genomes | |
| tmp_3_18835446_G_A | 390 | A>V | No | 1000Genomes | |
| tmp_3_18835440_C_A | 392 | G>V | No | 1000Genomes | |
| ENSVATH06289625 | 393 | N>S | No | 1000Genomes | |
| ENSVATH14416596 | 396 | E>K | No | 1000Genomes | |
| ENSVATH06289624 | 397 | P>L | No | 1000Genomes | |
| ENSVATH02486757 | 400 | E>D | No | 1000Genomes | |
| tmp_3_18835391_T_G | 408 | E>D | No | 1000Genomes | |
| ENSVATH00413436 | 413 | D>N | No | 1000Genomes | |
| tmp_3_18835315_C_T | 434 | D>N | No | 1000Genomes | |
| ENSVATH06289620 | 437 | G>D | No | 1000Genomes | |
| ENSVATH06289621 | 437 | G>S | No | 1000Genomes | |
| ENSVATH06289620 | 437 | G>V | No | 1000Genomes | |
| ENSVATH12695825 | 440 | D>N | No | 1000Genomes | |
| tmp_3_18835290_T_A | 442 | D>V | No | 1000Genomes | |
| ENSVATH02486756 | 443 | D>G | No | 1000Genomes |
No associated diseases with Q9SCQ7
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of apoptotic process | Any process that modulates the occurrence or rate of cell death by apoptotic process. |
20 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P51122 | ANP32A | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Bos taurus (Bovine) | SS |
| Q3SZC6 | ANP32B | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Bos taurus (Bovine) | SS |
| Q5F4A3 | ANP32E | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Gallus gallus (Chicken) | SS |
| Q5ZMN0 | ANP32B | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Gallus gallus (Chicken) | SS |
| Q8HY67 | ANP32A | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Canis lupus familiaris (Dog) (Canis familiaris) | SS |
| Q9V895 | Anp32a | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Drosophila melanogaster (Fruit fly) | SS |
| P39687 | ANP32A | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Homo sapiens (Human) | EV |
| Q92688 | ANP32B | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Homo sapiens (Human) | SS |
| Q9BTT0 | ANP32E | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Homo sapiens (Human) | SS |
| O43423 | ANP32CP | Putative uncharacterized protein ANP32CP | Homo sapiens (Human) | SS |
| O35381 | Anp32a | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Mus musculus (Mouse) | SS |
| Q9EST5 | Anp32b | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Mus musculus (Mouse) | SS |
| P97822 | Anp32e | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Mus musculus (Mouse) | SS |
| Q5XIE0 | Anp32e | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Rattus norvegicus (Rat) | SS |
| Q9EST6 | Anp32b | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Rattus norvegicus (Rat) | SS |
| P49911 | Anp32a | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Rattus norvegicus (Rat) | SS |
| Q7Y180 | Os03g0668900 | Acidic leucine-rich nuclear phosphoprotein 32-related protein 2 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6P1U7 | anp32b | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q6NUW5 | anp32e | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q7ZUP0 | anp32a | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDEIWERAVE | AALDGQTDRL | ATRTLTLDGA | VKCVQGRLPP | PSVLEKFQNL | QHLSVANIGV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SSLEQFPRLG | NLQKLILSDN | RITVGLEFLV | EAGLDSFCDL | DLSNNRIQFV | EDLAPLAELK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LVSLDLYECP | VTRLKDYRSR | VFGLIKTLKY | LDKTDAEGNE | RPESDDEDDE | EDEEDEEEEE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EGDEEDPGSG | EIDGDERAEA | PRMSNGHSER | VDGVVDVDED | EESDAEDDES | EQATGVNGTS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YRANGFRLEA | VNGEEVREDD | GDDSESGEEE | VGEDNDVVEV | HEIEDSENEE | DGVDDEEDDE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EDEEEEEVDN | ADRGLGGSGS | TSRLMNAGEI | DGHEQGDDDE | DGDGETGEDD | QGVEDDGEFA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DEDDDVEEED | EESGEGYLVQ | PVSQVEDHDA | VGNDIEPINE | DNDPDEEEEV | EDDLPIPDQS |
| 430 | 440 | ||||
| LASSSRPKRK | RDDDDDGEDD | DDDDEER |