Q9SB89
PR
Gene name |
RH27 (At5g65900, F6H11.20, K14B20.7) |
Protein name |
DEAD-box ATP-dependent RNA helicase 27 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G65900 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SB89
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SB89-F1 | Predicted | AlphaFoldDB |
49 variants for Q9SB89
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH07486941 | 7 | E>D | No | 1000Genomes | |
| ENSVATH00753997 | 13 | N>S | No | 1000Genomes | |
| tmp_5_26358376_A_G | 17 | K>E | No | 1000Genomes | |
| ENSVATH00753998 | 28 | E>K | No | 1000Genomes | |
| ENSVATH03481249 | 35 | P>L | No | 1000Genomes | |
| ENSVATH12946958 | 36 | A>S | No | 1000Genomes | |
| ENSVATH12946958 | 36 | A>T | No | 1000Genomes | |
| ENSVATH03481250 | 38 | E>K | No | 1000Genomes | |
| tmp_5_26358451_G_T | 42 | D>Y | No | 1000Genomes | |
| tmp_5_26358469_G_A | 48 | A>T | No | 1000Genomes | |
| ENSVATH00753999 | 49 | K>E | No | 1000Genomes | |
| tmp_5_26358503_CGAA_GGAA,C,CGAAGAA | 59 | P>R | No | 1000Genomes | |
| ENSVATH08587350 | 67 | N>K | No | 1000Genomes | |
| ENSVATH07486942 | 79 | E>K | No | 1000Genomes | |
| tmp_5_26358593_A_C | 89 | K>T | No | 1000Genomes | |
| ENSVATH12946963 | 99 | R>H | No | 1000Genomes | |
| tmp_5_26358653_T_C | 109 | V>A | No | 1000Genomes | |
| tmp_5_26358655_A_G | 110 | I>V | No | 1000Genomes | |
| tmp_5_26358695_A_C | 123 | Q>P | No | 1000Genomes | |
| ENSVATH12946964 | 124 | R>G | No | 1000Genomes | |
| ENSVATH14650577 | 126 | D>N | No | 1000Genomes | |
| ENSVATH00754001 | 127 | T>A | No | 1000Genomes | |
| ENSVATH03481251 | 141 | E>A | No | 1000Genomes | |
| tmp_5_26358761_T_A | 145 | L>* | No | 1000Genomes | |
| ENSVATH03481252 | 145 | L>M | No | 1000Genomes | |
| tmp_5_26358804_G_T | 159 | L>F | No | 1000Genomes | |
| tmp_5_26358819_C_A | 164 | N>K | No | 1000Genomes | |
| tmp_5_26358838_G_A | 171 | E>K | No | 1000Genomes | |
| tmp_5_26358851_C_G | 175 | A>G | No | 1000Genomes | |
| tmp_5_26358997_A_C | 192 | E>D | No | 1000Genomes | |
| tmp_5_26359101_C_T | 227 | T>I | No | 1000Genomes | |
| tmp_5_26359115_A_G | 232 | I>V | No | 1000Genomes | |
| ENSVATH12946989 | 268 | T>I | No | 1000Genomes | |
| tmp_5_26359373_C_T | 291 | L>F | No | 1000Genomes | |
| tmp_5_26359389_G_A | 296 | G>D | No | 1000Genomes | |
| tmp_5_26359531_A_G | 317 | N>S | No | 1000Genomes | |
| tmp_5_26359541_A_T | 320 | E>D | No | 1000Genomes | |
| ENSVATH00754009 | 327 | N>K | No | 1000Genomes | |
| ENSVATH07486953 | 332 | T>S | No | 1000Genomes | |
| ENSVATH14650583 | 384 | A>T | No | 1000Genomes | |
| ENSVATH12946994 | 388 | L>F | No | 1000Genomes | |
| ENSVATH00754020 | 437 | N>S | No | 1000Genomes | |
| ENSVATH14650584 | 449 | A>T | No | 1000Genomes | |
| tmp_5_26360951_A_C | 575 | N>T | No | 1000Genomes | |
| tmp_5_26360971_A_T | 582 | T>S | No | 1000Genomes | |
| tmp_5_26361165_A_G | 608 | K>R | No | 1000Genomes | |
| tmp_5_26361168_G_A | 609 | R>K | No | 1000Genomes | |
| ENSVATH07486963 | 617 | R>S | No | 1000Genomes | |
| tmp_5_26361240_A_T | 633 | Y>F | No | 1000Genomes |
No associated diseases with Q9SB89
7 regional properties for Q9SB89
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | ATP-dependent RNA helicase DEAD-box, conserved site | 306 - 314 | IPR000629 |
| domain | Helicase, C-terminal | 386 - 534 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 178 - 349 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 173 - 377 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 154 - 182 | IPR014014 |
| domain | Domain of unknown function DUF4217 | 535 - 598 | IPR025313 |
| domain | DDX18/Has1, DEAD-box helicase domain | 165 - 361 | IPR044773 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
| stem cell fate specification | The process in which a cell becomes capable of differentiating autonomously into a stem cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q03532 | HAS1 | ATP-dependent RNA helicase HAS1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q8K363 | Ddx18 | ATP-dependent RNA helicase DDX18 | Mus musculus (Mouse) | PR |
| Q0DBS1 | Os06g0535100 | Putative DEAD-box ATP-dependent RNA helicase 51 | Oryza sativa subsp japonica (Rice) | PR |
| O80792 | RH33 | Putative DEAD-box ATP-dependent RNA helicase 33 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FFQ1 | RH31 | DEAD-box ATP-dependent RNA helicase 31 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LIH9 | RH51 | DEAD-box ATP-dependent RNA helicase 51 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SA27 | RH36 | DEAD-box ATP-dependent RNA helicase 36 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FVV4 | RH55 | DEAD-box ATP-dependent RNA helicase 55 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9CAI7 | TIF4A-3 | Eukaryotic initiation factor 4A-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O22907 | RH24 | DEAD-box ATP-dependent RNA helicase 24 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q56X76 | RH39 | DEAD-box ATP-dependent RNA helicase 39 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8GY84 | RH10 | DEAD-box ATP-dependent RNA helicase 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84TG1 | RH57 | DEAD-box ATP-dependent RNA helicase 57 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P41377 | TIF4A-2 | Eukaryotic initiation factor 4A-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P41376 | EIF4A1 | Eukaryotic initiation factor 4A-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8H0U8 | RH42 | DEAD-box ATP-dependent RNA helicase 42 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MANLDMEQHS | SENEEIKKKK | HKKRARDEAK | KLKQPAMEEE | PDHEDGDAKE | NNALIDEEPK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KKKKKKNKKR | GDTDDGEDEA | VAEEEPKKKK | KKNKKLQQRG | DTNDEEDEVI | AEEEEPKKKK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KKQRKDTEAK | SEEEEVEDKE | EEKKLEETSI | MTNKTFESLS | LSDNTYKSIK | EMGFARMTQI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QAKAIPPLMM | GEDVLGAART | GSGKTLAFLI | PAVELLYRVK | FTPRNGTGVL | VICPTRELAI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QSYGVAKELL | KYHSQTVGKV | IGGEKRKTEA | EILAKGVNLL | VATPGRLLDH | LENTNGFIFK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NLKFLVMDEA | DRILEQNFEE | DLKKILNLLP | KTRQTSLFSA | TQSAKVEDLA | RVSLTSPVYI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DVDEGRKEVT | NEGLEQGYCV | VPSAMRLLFL | LTFLKRFQGK | KKIMVFFSTC | KSTKFHAELF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RYIKFDCLEI | RGGIDQNKRT | PTFLQFIKAE | TGILLCTNVA | ARGLDFPHVD | WIVQYDPPDN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PTDYIHRVGR | TARGEGAKGK | ALLVLTPQEL | KFIQYLKAAK | IPVEEHEFEE | KKLLDVKPFV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ENLISENYAL | KESAKEAYKT | YISGYDSHSM | KDVFNVHQLN | LTEVATSFGF | SDPPKVALKI |
| 610 | 620 | 630 | |||
| DRGGYRSKRE | PVNKFKRGRG | GGRPGGKSKF | ERY |