Q9S9N1
SS
Gene name |
HSP70-5 (HSP70B, At1g16030, T24D18.14) |
Protein name |
Heat shock 70 kDa protein 5 |
Names |
Heat shock protein 70-5 , AtHsp70-5 , Heat shock protein 70b |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G16030 |
EC number |
|
Protein Class |
|
Descriptions
HSPA8 (or hsc70) is a heat shock cognate protein involved in many cellular processes. During recovery from stress, HSPA8, initially accumulating in the nucleoplasm for folding/refolding of proteins, transiently concentrates in nucleoli for nucleolar morphology and function restoration. The inhibitory region is positioned at one of the three domains of HSPA8 protein, which is the N-terminal ATPase domain, specifically in residues 263-287 of domain IIB. Under normal growth conditions, the constitutive nucleolar targeting function that is provided by residues 225-262 is diminished by the autoinhibitory element located in residues 263-287. When cells recover from stress, the autoinhibitory element is inactivated, and the constitutive nucleolar targeting function restores.
Autoinhibitory domains (AIDs)
Target domain |
230-267 (Nucleolar targeting region) |
Relief mechanism |
Others |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9S9N1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9S9N1-F1 | Predicted | AlphaFoldDB |
22 variants for Q9S9N1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH04584043 | 5 | S>P | No | 1000Genomes | |
| ENSVATH01057322 | 6 | E>D | No | 1000Genomes | |
| ENSVATH01057321 | 17 | Y>C | No | 1000Genomes | |
| tmp_1_5504278_A_T | 17 | Y>N | No | 1000Genomes | |
| tmp_1_5504035_A_G | 98 | S>P | No | 1000Genomes | |
| ENSVATH04584036 | 110 | Y>H | No | 1000Genomes | |
| ENSVATH13904555 | 130 | M>V | No | 1000Genomes | |
| ENSVATH00026163 | 141 | T>I | No | 1000Genomes | |
| tmp_1_5503895_G_T | 144 | N>K | No | 1000Genomes | |
| tmp_1_5503563_T_G | 255 | K>T | No | 1000Genomes | |
| ENSVATH04584034 | 379 | A>T | No | 1000Genomes | |
| tmp_1_5503112_G_T | 405 | S>R | No | 1000Genomes | |
| ENSVATH04584032 | 441 | P>S | No | 1000Genomes | |
| ENSVATH11306601 | 475 | G>R | No | 1000Genomes | |
| ENSVATH13904513 | 494 | S>A | No | 1000Genomes | |
| ENSVATH11306600 | 521 | E>K | No | 1000Genomes | |
| tmp_1_5502718_C_A | 537 | V>L | No | 1000Genomes | |
| ENSVATH11306599 | 564 | A>V | No | 1000Genomes | |
| tmp_1_5502618_T_G | 570 | E>A | No | 1000Genomes | |
| ENSVATH04584030 | 580 | D>A | No | 1000Genomes | |
| tmp_1_5502541_C_T | 596 | E>K | No | 1000Genomes | |
| tmp_1_5502423_C_T | 635 | G>D | No | 1000Genomes |
No associated diseases with Q9S9N1
3 regional properties for Q9S9N1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Heat shock protein 70, conserved site | 11 - 18 | IPR018181-1 |
| conserved_site | Heat shock protein 70, conserved site | 202 - 215 | IPR018181-2 |
| conserved_site | Heat shock protein 70, conserved site | 339 - 353 | IPR018181-3 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| plant-type cell wall | A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP-dependent protein folding chaperone | Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| response to heat | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. |
| response to virus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. |
61 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P11484 | SSB1 | Ribosome-associated molecular chaperone SSB1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| P40150 | SSB2 | Ribosome-associated molecular chaperone SSB2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| P22202 | SSA4 | Heat shock protein SSA4 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| P09435 | SSA3 | Heat shock protein SSA3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| P10592 | SSA2 | Heat shock protein SSA2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| P10591 | SSA1 | Heat shock protein SSA1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| Q2YDD0 | HSPA14 | Heat shock 70 kDa protein 14 | Bos taurus (Bovine) | SS |
| P0CB32 | HSPA1L | Heat shock 70 kDa protein 1-like | Bos taurus (Bovine) | SS |
| P19120 | HSPA8 | Heat shock cognate 71 kDa protein | Bos taurus (Bovine) | SS |
| Q27975 | HSPA1A | Heat shock 70 kDa protein 1A | Bos taurus (Bovine) | SS |
| E1C2P3 | HSPA14 | Heat shock 70 kDa protein 14 | Gallus gallus (Chicken) | SS |
| O73885 | HSPA8 | Heat shock cognate 71 kDa protein | Gallus gallus (Chicken) | SS |
| P08106 | Heat shock 70 kDa protein | Gallus gallus (Chicken) | SS | |
| P77319 | hscC | Chaperone protein HscC | Escherichia coli (strain K12) | PR |
| P0A6Y8 | dnaK | Chaperone protein DnaK | Escherichia coli (strain K12) | SS |
| P02825 | Hsp70Ab | Major heat shock 70 kDa protein Ab | Drosophila melanogaster (Fruit fly) | SS |
| P82910 | Hsp70Aa | Major heat shock 70 kDa protein Aa | Drosophila melanogaster (Fruit fly) | SS |
| Q9VG58 | Hsp70Bbb | Major heat shock 70 kDa protein Bbb | Drosophila melanogaster (Fruit fly) | SS |
| Q9BIR7 | Hsp70Bc | Major heat shock 70 kDa protein Bc | Drosophila melanogaster (Fruit fly) | SS |
| Q8INI8 | Hsp70Ba | Major heat shock 70 kDa protein Ba | Drosophila melanogaster (Fruit fly) | SS |
| Q9BIS2 | Hsp70Bb | Major heat shock 70 kDa protein Bb | Drosophila melanogaster (Fruit fly) | SS |
| P11146 | Hsc70-2 | Heat shock 70 kDa protein cognate 2 | Drosophila melanogaster (Fruit fly) | SS |
| O97125 | Hsp68 | Heat shock protein 68 | Drosophila melanogaster (Fruit fly) | SS |
| P11147 | Hsc70-4 | Heat shock 70 kDa protein cognate 4 | Drosophila melanogaster (Fruit fly) | SS |
| P29843 | Hsc70-1 | Heat shock 70 kDa protein cognate 1 | Drosophila melanogaster (Fruit fly) | SS |
| A2Q0Z1 | HSPA8 | Heat shock cognate 71 kDa protein | Equus caballus (Horse) | SS |
| Q96MM6 | HSPA12B | Heat shock 70 kDa protein 12B | Homo sapiens (Human) | PR |
| O43301 | HSPA12A | Heat shock 70 kDa protein 12A | Homo sapiens (Human) | PR |
| Q0VDF9 | HSPA14 | Heat shock 70 kDa protein 14 | Homo sapiens (Human) | SS |
| P0DMV9 | HSPA1B | Heat shock 70 kDa protein 1B | Homo sapiens (Human) | SS |
| P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | Homo sapiens (Human) | SS |
| P17066 | HSPA6 | Heat shock 70 kDa protein 6 | Homo sapiens (Human) | SS |
| P34931 | HSPA1L | Heat shock 70 kDa protein 1-like | Homo sapiens (Human) | SS |
| P54652 | HSPA2 | Heat shock-related 70 kDa protein 2 | Homo sapiens (Human) | SS |
| P11142 | HSPA8 | Heat shock cognate 71 kDa protein | Homo sapiens (Human) | EV |
| P11143 | HSP70 | Heat shock 70 kDa protein | Zea mays (Maize) | SS |
| Q99M31 | Hspa14 | Heat shock 70 kDa protein 14 | Mus musculus (Mouse) | SS |
| Q8K0U4 | Hspa12a | Heat shock 70 kDa protein 12A | Mus musculus (Mouse) | PR |
| Q9CZJ2 | Hspa12b | Heat shock 70 kDa protein 12B | Mus musculus (Mouse) | PR |
| P16627 | Hspa1l | Heat shock 70 kDa protein 1-like | Mus musculus (Mouse) | SS |
| P17156 | Hspa2 | Heat shock-related 70 kDa protein 2 | Mus musculus (Mouse) | SS |
| P17879 | Hspa1b | Heat shock 70 kDa protein 1B | Mus musculus (Mouse) | SS |
| P63017 | Hspa8 | Heat shock cognate 71 kDa protein | Mus musculus (Mouse) | SS |
| Q61696 | Hspa1a | Heat shock 70 kDa protein 1A | Mus musculus (Mouse) | SS |
| Q6S4N2 | HSPA1B | Heat shock 70 kDa protein 1B | Sus scrofa (Pig) | SS |
| P0DMW0 | Hspa1a | Heat shock 70 kDa protein 1A | Rattus norvegicus (Rat) | SS |
| P0DMW1 | Hspa1b | Heat shock 70 kDa protein 1B | Rattus norvegicus (Rat) | SS |
| P14659 | Hspa2 | Heat shock-related 70 kDa protein 2 | Rattus norvegicus (Rat) | SS |
| P55063 | Hspa1l | Heat shock 70 kDa protein 1-like | Rattus norvegicus (Rat) | SS |
| P63018 | Hspa8 | Heat shock cognate 71 kDa protein | Rattus norvegicus (Rat) | SS |
| P09446 | hsp-1 | Heat shock protein hsp-1 | Caenorhabditis elegans | SS |
| P26413 | HSP70 | Heat shock 70 kDa protein | Glycine max (Soybean) (Glycine hispida) | SS |
| O65719 | HSP70-3 | Heat shock 70 kDa protein 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| P22954 | HSP70-2 | Heat shock 70 kDa protein 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9C7X7 | HSP70-18 | Heat shock 70 kDa protein 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LHA8 | HSP70-4 | Heat shock 70 kDa protein 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| P22953 | HSP70-1 | Heat shock 70 kDa protein 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| P24629 | HSC-I | Heat shock cognate 70 kDa protein 1 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | SS |
| P27322 | HSC-2 | Heat shock cognate 70 kDa protein 2 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | SS |
| Q5RGE6 | hspa14 | Heat shock 70 kDa protein 14 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90473 | hspa8 | Heat shock cognate 71 kDa protein | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATKSEKAIG | IDLGTTYSCV | GVWMNDRVEI | IPNDQGNRTT | PSYVAFTDTE | RLIGDAAKNQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VALNPQNTVF | DAKRLIGRKF | SDPSVQSDIL | HWPFKVVSGP | GEKPMIVVSY | KNEEKQFSPE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EISSMVLVKM | KEVAEAFLGR | TVKNAVVTVP | AYFNDSQRQA | TKDAGAISGL | NVLRIINEPT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AAAIAYGLDK | KGTKAGEKNV | LIFDLGGGTF | DVSLLTIEEG | VFEVKATAGD | THLGGEDFDN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RLVNHFVAEF | RRKHKKDIAG | NARALRRLRT | ACERAKRTLS | STAQTTIEID | SLHEGIDFYA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TISRARFEEM | NMDLFRKCMD | PVEKVLKDAK | LDKSSVHDVV | LVGGSTRIPK | IQQLLQDFFN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GKELCKSINP | DEAVAYGAAV | QAAILTGEGS | EKVQDLLLLD | VAPLSLGLET | AGGVMTVLIP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RNTTVPCKKE | QVFSTYADNQ | PGVLIQVYEG | ERARTRDNNL | LGTFELKGIP | PAPRGVPQIN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VCFDIDANGI | LNVSAEDKTA | GVKNQITITN | DKGRLSKEEI | EKMVQDAEKY | KAEDEQVKKK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VEAKNSLENY | AYNMRNTIKD | EKLAQKLTQE | DKQKIEKAID | ETIEWIEGNQ | LAEVDEFEYK |
| 610 | 620 | 630 | 640 | ||
| LKELEGICNP | IISKMYQGGA | AAGGMPTDGD | FSSSGAAGGP | KIEEVD |