Q9RV79

PR
Gene name
miaB
Protein name
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase
Names
(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase
Species
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
KEGG Pathway
dra:DR_1150
EC number
2.8.4.3: Transferring alkylthio groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-70 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9RV79

Entry ID Method Resolution Chain Position Source
AF-Q9RV79-F1 Predicted AlphaFoldDB

No variants for Q9RV79

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9RV79

No associated diseases with Q9RV79

4 regional properties for Q9RV79

Type Name Position InterPro Accession
domain Elp3/MiaA/NifB-like, radical SAM core domain 184 - 406 IPR006638
domain Radical SAM 180 - 413 IPR007197
domain Methylthiotransferase, N-terminal 47 - 162 IPR013848
conserved_site Methylthiotransferase, conserved site 188 - 208 IPR020612

Functions

Description
EC Number 2.8.4.3 Transferring alkylthio groups
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
metal ion binding Binding to a metal ion.
methylthiotransferase activity Catalysis of the addition of a methylthioether group (-SCH3) to a nucleic acid or protein acceptor.
N6-isopentenyladenosine methylthiotransferase activity Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-isopentenyladenosine (i6A) in tRNA, to form 2-methylthio-N6-isopentenyladenosine (ms2i6A).

1 GO annotations of biological process

Name Definition
tRNA methylthiolation The addition of a methylthioether group (-SCH3) to a nucleotide in a tRNA molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGQKAKAQAP TTHPRPHTLS SQVAPALPRR PRHAAPESLR QARGEVMKAH LITYGCQMNE
70 80 90 100 110 120
YDTHLVQSQL VSFGADIVES PDEADFVLVN TCAVRGKPVD KVRSLLGDLR KQKAQRSLVV
130 140 150 160 170 180
GMMGCLAQLE EGQQIARKFE VDVLLGPGSL LDIGAALESN ERFWGLQFKD ELHDHIPPPP
190 200 210 220 230 240
SGKLQAHLTI MRGCDHHCTY CIVPTTRGPQ VSRHPDDILR ELDMQLAAGV REVTLLGQNV
250 260 270 280 290 300
NAYGVDQGAK LKGYPSFADL LRMVGASGIE RVKFTTSHPM NFTEDVAAAI GETPAICEFV
310 320 330 340 350 360
HLPVQSGSDR VLRRMAREYN REKYLTHIAQ IKKHIPDVVL ATDIIVGFPG ETEEDFQDTL
370 380 390 400 410 420
SLYDEVGYDS AYMFIYSPRP GTPSYKHFQD LPRELKTERL QRLIARQKDW SARKNAQKVG
430 440 450 460 470 480
TVQQVLLRGD AHDAGFLEGH TRGNHPTVVP KAIGADGAGV YQVRIDHATP HMMYGHILGP
490 500
DGQPLPEQPR FNPEAAAVGG ALPML