AiPD: Autoinhibited Protein Database

Gene name	Rnf103 (Zfp103)
Protein name	E3 ubiquitin-protein ligase RNF103
Names	KF-1, mKF-1, RING finger protein 103, RING-type E3 ubiquitin transferase RNF103, Zinc finger protein 103, Zfp-103
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:22644
EC number	2.3.2.27: Aminoacyltransferases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

55-130 (Predicted disordered autoinhibitory region) PR

55-130 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9R1W3-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388834590	79	M>V	No	EVA
rs3388839765	81	G>V	No	EVA
rs3388828465	173	L>F	No	EVA
rs3388830986	188	M>I	No	EVA
rs1134727388	221	E>D	No	EVA
rs1132040745	223	L>F	No	EVA
rs1134059314	224	K>Q	No	EVA
rs3388835689	268	V>L	No	EVA
rs3388839800	269	E>D	No	EVA
rs3388831069	287	S>T	No	EVA
rs3388831068	302	H>P	No	EVA
rs3388802020	305	E>D	No	EVA
rs3388834576	352	R>Q	No	EVA
rs3388822775	355	V>F	No	EVA
rs30674898	388	D>E	No	EVA
rs3388839798	409	D>E	No	EVA
rs30667118	414	T>S	No	EVA
rs3388801981	424	Y>H	No	EVA
rs3388842322	441	S>R	No	EVA
rs3388839845	442	N>K	No	EVA
rs3388813763	443	N>I	No	EVA
rs3388801962	447	N>K	No	EVA
rs3388834564	450	N>K	No	EVA
rs3388837278	455	S>T	No	EVA
rs3388822747	462	T>N	No	EVA
rs3388818634	521	V>I	No	EVA
rs241142267	567	T>I	No	EVA
rs47446556	592	S>L	No	EVA
rs3388835707	660	C>Y	No	EVA

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	13 - 304	IPR000719
conserved_site	Mitogen-activated protein (MAP) kinase, conserved site	48 - 149	IPR003527
binding_site	Protein kinase, ATP binding site	19 - 43	IPR017441

		Description
EC Number	2.3.2.27	Aminoacyltransferases
Subcellular Localization	Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Name	Definition
metal ion binding	Binding to a metal ion.
ubiquitin-protein transferase activity	Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.

Name	Definition
protein ubiquitination	The process in which one or more ubiquitin groups are added to a protein.
ubiquitin-dependent ERAD pathway	The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9VE61	CG7694	E3 ubiquitin-protein ligase RNF181 homolog	Drosophila melanogaster (Fruit fly)	PR
Q86Y13	DZIP3	E3 ubiquitin-protein ligase DZIP3	Homo sapiens (Human)	PR
Q9Y3E7	CHMP3	Charged multivesicular body protein 3	Homo sapiens (Human)	EV
O00237	RNF103	E3 ubiquitin-protein ligase RNF103	Homo sapiens (Human)	PR
Q9EPZ8	Rnf103	E3 ubiquitin-protein ligase RNF103	Rattus norvegicus (Rat)	PR
Q9SI09	XERICO	Probable E3 ubiquitin-protein ligase XERICO	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9ZV51	ATL56	RING-H2 finger protein ATL56	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SKK8	ATL22	RING-H2 finger protein ATL22	Arabidopsis thaliana (Mouse-ear cress)	PR
P0CH02	ATL21B	Putative RING-H2 finger protein ATL21B	Arabidopsis thaliana (Mouse-ear cress)	PR
P0CH01	ATL21A	Putative RING-H2 finger protein ATL21A	Arabidopsis thaliana (Mouse-ear cress)	PR
O22255	ATL64	RING-H2 finger protein ATL64	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8RXX9	ATL6	E3 ubiquitin-protein ligase ATL6	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8GYT9	SIS3	E3 ubiquitin-protein ligase SIS3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LZJ6	ATL5	RING-H2 finger protein ATL5	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8GXF8	SGR9	E3 ubiquitin-protein ligase SGR9, amyloplastic	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8LGA5	ATL31	E3 ubiquitin-protein ligase ATL31	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LUZ9	ATL63	RING-H2 finger protein ATL63	Arabidopsis thaliana (Mouse-ear cress)	PR