Q9R1M3

PR
Gene name
Tspy1 (Tspy)
Protein name
Testis-specific Y-encoded protein 1
Names
rTSPY
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:25223
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-186 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9R1M3

Entry ID Method Resolution Chain Position Source
AF-Q9R1M3-F1 Predicted AlphaFoldDB

No variants for Q9R1M3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9R1M3

No associated diseases with Q9R1M3

3 regional properties for Q9R1M3

Type Name Position InterPro Accession
domain Protein kinase domain 4 - 259 IPR000719
active_site Serine/threonine-protein kinase, active site 124 - 136 IPR008271
binding_site Protein kinase, ATP binding site 10 - 33 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Predominantly cytoplasmic
  • Also found in nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.

4 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
gonadal mesoderm development The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism.
nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O19110 TSPY1 Testis-specific Y-encoded protein 1 Bos taurus (Bovine) PR
A6NKD2 TSPY2 Testis-specific Y-encoded protein 2 Homo sapiens (Human) PR
P0CW00 TSPY8 Testis-specific Y-encoded protein 8 Homo sapiens (Human) PR
P0CV98 TSPY3 Testis-specific Y-encoded protein 3 Homo sapiens (Human) PR
P0CV99 TSPY4 Testis-specific Y-encoded protein 4 Homo sapiens (Human) PR
Q01534 TSPY1 Testis-specific Y-encoded protein 1 Homo sapiens (Human) PR
P0CW01 TSPY10 Testis-specific Y-encoded protein 10 Homo sapiens (Human) PR
Q63945 Set Protein SET Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MENSEEESVG VAPQEFRELV LLESSLLEGE PSVQAPEQSP GAPAGDNQMV KPLVICGPVE
70 80 90 100 110 120
DWVPLAEVLH HPDTCEEGDE ATMAELKVTE VVDVKNEGEE VKDQKQEGEQ DQQPELEKNP
130 140 150 160 170 180
EQACDSKDQQ GIQRLPLSGG GPAERRSKME ELELLQLELS FVNARCSGAF ARIKAKVAKM
190 200 210 220 230 240
RRPHFDRRKT IIQGIPGFWA KAMMNHPQMS SIISNQDEDL LSYMLSLEVE EYNPGLRMCR
250 260 270 280 290 300
MMFFFSENPY FRNDIVTKDY QLSIIGYKES DSSTIEWIGQ AEHGYANCMQ DTTRLTFFNW
310 320 330
LCAHKFPGSN RIAEIIMDDL WPNPLYYYPK EDHS