Q9R117

SS
Gene name
Tyk2
Protein name
Non-receptor tyrosine-protein kinase TYK2
Names
EC 2.7.10.2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:54721
EC number
2.7.10.2: Protein-tyrosine kinases
Protein Class

Descriptions

Jak2 is a member of the Janus (Jak) family of non-receptor protein tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) and is crucial in signaling through multiple cytokine receptors. Jak2 has a kinase domain (JH1) and pseudokinase domain (JH2). JH2 has three regions for autoinhibition of JH1: IR3 (758-807) directly inhibits JH1, and IR2 (725-757) and IR1 (619-670) enhances IR3-mediated inhibition of JH1.

Autoinhibitory domains (AIDs)

677-728 (IR1 region) SS

Target domain

894-1173 (Protein kinase domain)

Relief mechanism

Partner binding

Assay

782-815 (IR2 region) SS

Target domain

894-1173 (Protein kinase domain)

Relief mechanism

Partner binding

Assay

816-865 (IR3 region) SS

Target domain

894-1173 (Protein kinase domain)

Relief mechanism

Partner binding

Assay

Accessory elements

1037-1063 (Activation loop from InterPro)

Target domain

894-1166 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

3 structures for Q9R117

Entry ID Method Resolution Chain Position Source
4E1Z X-ray 250 A A 884-1174 PDB
4E20 X-ray 260 A A 885-1174 PDB
AF-Q9R117-F1 Predicted AlphaFoldDB

91 variants for Q9R117

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389028751 80 A>T No EVA
rs3389027681 86 A>G No EVA
rs221236036 101 D>G No EVA
rs221236036 101 D>V No EVA
rs3389026348 110 F>Y No EVA
rs3389019672 120 P>S No EVA
rs3389002729 144 V>A No EVA
rs3389015413 159 G>* No EVA
rs3400115745 163 F>L No EVA
rs3389028773 167 V>M No EVA
rs3389026363 176 E>* No EVA
rs3389020899 191 F>I No EVA
rs3399872754 203 V>L No EVA
rs3399872795 204 P>L No EVA
rs3400115675 206 E>G No EVA
rs3399666412 207 E>D No EVA
rs3389029948 208 M>L No EVA
rs3399989305 210 R>* No EVA
rs36251163 238 H>R No EVA
rs3547083474 242 R>C No EVA
rs1131981162 242 R>H No EVA
rs3389029889 243 R>S No EVA
rs3398914238 244 F>I No EVA
rs3389019670 257 V>D No EVA
rs3389024960 281 C>S No EVA
rs3389029921 282 H>D No EVA
rs3389020950 283 L>G No EVA
rs3389025002 284 E>G No EVA
rs3389002782 287 A>T No EVA
rs3389032824 298 N>K No EVA
rs3389029915 329 W>R No EVA
rs261201765 332 L>M No EVA
rs37889479 335 Q>L No EVA
rs29836503 359 K>E No EVA
rs227502348 364 L>P No EVA
rs3388996508 381 D>G No EVA
rs36633997 389 E>D No EVA
rs37048474 449 G>S No EVA
rs3399338164 451 H>L No EVA
rs3389032814 458 F>L No EVA
rs3389035169 485 T>N No EVA
rs51785678 493 F>L No EVA
rs239019637 524 A>D No EVA
rs3389027687 565 R>L No EVA
rs3389002722 585 H>N No EVA
rs3389019632 591 Q>L No EVA
rs3389025034 597 Q>R No EVA
rs3388975859 601 T>S No EVA
rs3388995084 610 V>M No EVA
rs3389020911 623 P>S No EVA
rs3388995087 633 Q>H No EVA
rs3389025022 643 P>L No EVA
rs3399886076 656 A>P No EVA
rs3399783388 662 V>HV* No EVA
rs3388975889 676 R>S No EVA
rs3389027671 695 W>* No EVA
rs3389029940 695 W>R No EVA
rs3389002720 698 R>G No EVA
rs3389002749 699 Q>* No EVA
rs3412115867 711 V>L No EVA
rs3389008238 763 A>V No EVA
rs3389015433 780 C>* No EVA
rs3389032810 781 L>V No EVA
rs3389015360 782 S>C No EVA
rs3389015360 782 S>F No EVA
rs3389026390 790 T>I No EVA
rs3389008292 803 E>A No EVA
rs3389035162 804 I>N No EVA
rs3389015403 822 R>W No EVA
rs3389015365 832 E>V No EVA
rs217207879 835 S>C No EVA
rs3389028808 836 P>Q No EVA
rs3547270739 842 T>P No EVA
rs3389025038 852 Q>K No EVA
rs1134187294 892 R>H No EVA
rs3389025030 893 Y>F No EVA
rs3389027691 896 K>R No EVA
rs3389032819 954 E>D No EVA
rs3389032809 963 C>Y No EVA
rs3389019633 1002 Q>* No EVA
rs3389008231 1072 E>K No EVA
rs3389019656 1077 Y>C No EVA
rs3389029910 1080 D>E No EVA
rs3389025001 1093 T>I No EVA
rs242748833 1103 M>T No EVA
rs3389026380 1109 I>F No EVA
rs3399920862 1135 D>H No EVA
rs3399886091 1146 K>R No EVA
rs3399886091 1146 K>R* No EVA
rs3389028790 1155 F>L No EVA
rs3389019709 1180 V>M No EVA

No associated diseases with Q9R117

17 regional properties for Q9R117

Type Name Position InterPro Accession
domain FERM domain 33 - 430 IPR000299
domain Protein kinase domain 589 - 866 IPR000719-1
domain Protein kinase domain 894 - 1166 IPR000719-2
domain SH2 domain 448 - 553 IPR000980
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 590 - 863 IPR001245-1
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 895 - 1164 IPR001245-2
active_site Tyrosine-protein kinase, active site 1016 - 1028 IPR008266
domain Tyrosine-protein kinase, non-receptor, TYK2, N-terminal 172 - 185 IPR016045-1
domain Tyrosine-protein kinase, non-receptor, TYK2, N-terminal 269 - 279 IPR016045-2
domain Tyrosine-protein kinase, non-receptor, TYK2, N-terminal 516 - 526 IPR016045-3
binding_site Protein kinase, ATP binding site 900 - 927 IPR017441
domain Band 4.1 domain 29 - 278 IPR019749
domain Tyrosine-protein kinase, catalytic domain 589 - 863 IPR020635-1
domain Tyrosine-protein kinase, catalytic domain 894 - 1166 IPR020635-2
domain JAK, FERM F2 lobe domain 145 - 269 IPR041046
domain FERM F1 lobe ubiquitin-like domain 33 - 127 IPR041155
domain JAK1-3/TYK2, pleckstrin homology-like domain 290 - 431 IPR041381

Functions

Description
EC Number 2.7.10.2 Protein-tyrosine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
interleukin-12 receptor complex A protein complex that binds interleukin-12 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits.
interleukin-23 receptor complex A protein complex that binds interleukin-23 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
growth hormone receptor binding Binding to a growth hormone receptor.
non-membrane spanning protein tyrosine kinase activity Catalysis of the reaction
type 1 angiotensin receptor binding Binding to a type 1 angiotensin receptor.

14 GO annotations of biological process

Name Definition
cell differentiation The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
cell population proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population.
cytokine-mediated signaling pathway The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
growth hormone receptor signaling pathway via JAK-STAT The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive regulation of interleukin-17 production Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.
positive regulation of natural killer cell proliferation Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation.
positive regulation of NK T cell proliferation Any process that activates or increases the frequency, rate or extent of natural killer T cell proliferation.
positive regulation of receptor signaling pathway via JAK-STAT Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
positive regulation of T cell proliferation Any process that activates or increases the rate or extent of T cell proliferation.
positive regulation of T-helper 17 type immune response Any process that activates or increases the frequency, rate or extent of T-helper 17 type immune response.
positive regulation of type II interferon production Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.

76 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A0JNB0 FYN Tyrosine-protein kinase Fyn Bos taurus (Bovine) SS
Q0VBZ0 CSK Tyrosine-protein kinase CSK Bos taurus (Bovine) SS
Q3ZC95 BTK Tyrosine-protein kinase Bos taurus (Bovine) EV SS
P42683 LCK Proto-oncogene tyrosine-protein kinase LCK Gallus gallus (Chicken) SS
P41239 CSK Tyrosine-protein kinase CSK Gallus gallus (Chicken) SS
P00523 SRC Proto-oncogene tyrosine-protein kinase Src Gallus gallus (Chicken) EV
Q02977 YRK Proto-oncogene tyrosine-protein kinase Yrk Gallus gallus (Chicken) SS
Q8JH64 BTK Tyrosine-protein kinase BTK Gallus gallus (Chicken) SS
P09324 YES1 Tyrosine-protein kinase Yes Gallus gallus (Chicken) SS
Q05876 FYN Tyrosine-protein kinase Fyn Gallus gallus (Chicken) SS
Q75R65 JAK2 Tyrosine-protein kinase JAK2 Gallus gallus (Chicken) SS
P08630 Btk Tyrosine-protein kinase Btk Drosophila melanogaster (Fruit fly) SS
Q9V9J3 Src42A Tyrosine-protein kinase Src42A Drosophila melanogaster (Fruit fly) SS
P00528 Src64B Tyrosine-protein kinase Src64B Drosophila melanogaster (Fruit fly) SS
Q24592 hop Tyrosine-protein kinase hopscotch Drosophila melanogaster (Fruit fly) PR
P41240 CSK Tyrosine-protein kinase CSK Homo sapiens (Human) SS
P51451 BLK Tyrosine-protein kinase Blk Homo sapiens (Human) SS
P06239 LCK Tyrosine-protein kinase Lck Homo sapiens (Human) EV
P23458 JAK1 Tyrosine-protein kinase JAK1 Homo sapiens (Human) SS
P06241 FYN Tyrosine-protein kinase Fyn Homo sapiens (Human) SS
P51813 BMX Cytoplasmic tyrosine-protein kinase BMX Homo sapiens (Human) SS
P12931 SRC Proto-oncogene tyrosine-protein kinase Src Homo sapiens (Human) EV
P09769 FGR Tyrosine-protein kinase Fgr Homo sapiens (Human) SS
P42680 TEC Tyrosine-protein kinase Tec Homo sapiens (Human) SS
O60674 JAK2 Tyrosine-protein kinase JAK2 Homo sapiens (Human) EV
P42679 MATK Megakaryocyte-associated tyrosine-protein kinase Homo sapiens (Human) SS
P52333 JAK3 Tyrosine-protein kinase JAK3 Homo sapiens (Human) SS
Q08881 ITK Tyrosine-protein kinase ITK/TSK Homo sapiens (Human) EV
P07948 LYN Tyrosine-protein kinase Lyn Homo sapiens (Human) SS
Q13882 PTK6 Protein-tyrosine kinase 6 Homo sapiens (Human) EV
P08631 HCK Tyrosine-protein kinase HCK Homo sapiens (Human) EV
P07947 YES1 Tyrosine-protein kinase Yes Homo sapiens (Human) SS
P42685 FRK Tyrosine-protein kinase FRK Homo sapiens (Human) EV
Q06187 BTK Tyrosine-protein kinase BTK Homo sapiens (Human) EV
P29597 TYK2 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens (Human) EV
P08103 Hck Tyrosine-protein kinase HCK Mus musculus (Mouse) SS
P16277 Blk Tyrosine-protein kinase Blk Mus musculus (Mouse) SS
Q62270 Srms Tyrosine-protein kinase Srms Mus musculus (Mouse) SS
Q64434 Ptk6 Protein-tyrosine kinase 6 Mus musculus (Mouse) SS
P05480 Src Proto-oncogene tyrosine-protein kinase Src Mus musculus (Mouse) EV
P14234 Fgr Tyrosine-protein kinase Fgr Mus musculus (Mouse) SS
P35991 Btk Tyrosine-protein kinase BTK Mus musculus (Mouse) EV
P41241 Csk Tyrosine-protein kinase CSK Mus musculus (Mouse) EV
P25911 Lyn Tyrosine-protein kinase Lyn Mus musculus (Mouse) EV
P06240 Lck Proto-oncogene tyrosine-protein kinase LCK Mus musculus (Mouse) SS
P24604 Tec Tyrosine-protein kinase Tec Mus musculus (Mouse) SS
Q04736 Yes1 Tyrosine-protein kinase Yes Mus musculus (Mouse) SS
P39688 Fyn Tyrosine-protein kinase Fyn Mus musculus (Mouse) SS
Q03526 Itk Tyrosine-protein kinase ITK/TSK Mus musculus (Mouse) SS
P41242 Matk Megakaryocyte-associated tyrosine-protein kinase Mus musculus (Mouse) SS
Q922K9 Frk Tyrosine-protein kinase FRK Mus musculus (Mouse) SS
Q62120 Jak2 Tyrosine-protein kinase JAK2 Mus musculus (Mouse) EV
Q62137 Jak3 Tyrosine-protein kinase JAK3 Mus musculus (Mouse) SS
P52332 Jak1 Tyrosine-protein kinase JAK1 Mus musculus (Mouse) SS
A1Y2K1 FYN Tyrosine-protein kinase Fyn Sus scrofa (Pig) SS
O19064 JAK2 Tyrosine-protein kinase JAK2 Sus scrofa (Pig) SS
Q62662 Frk Tyrosine-protein kinase FRK Rattus norvegicus (Rat) SS
Q62844 Fyn Tyrosine-protein kinase Fyn Rattus norvegicus (Rat) SS
Q07014 Lyn Tyrosine-protein kinase Lyn Rattus norvegicus (Rat) SS
P50545 Hck Tyrosine-protein kinase HCK Rattus norvegicus (Rat) SS
Q9WUD9 Src Proto-oncogene tyrosine-protein kinase Src Rattus norvegicus (Rat) SS
Q01621 Lck Proto-oncogene tyrosine-protein kinase LCK Rattus norvegicus (Rat) SS
Q6P6U0 Fgr Tyrosine-protein kinase Fgr Rattus norvegicus (Rat) SS
Q62689 Jak2 Tyrosine-protein kinase JAK2 Rattus norvegicus (Rat) SS
Q63272 Jak3 Tyrosine-protein kinase JAK3 Rattus norvegicus (Rat) SS
P32577 Csk Tyrosine-protein kinase CSK Rattus norvegicus (Rat) SS
P41243 Matk Megakaryocyte-associated tyrosine-protein kinase Rattus norvegicus (Rat) SS
F1LM93 Yes1 Tyrosine-protein kinase Yes Rattus norvegicus (Rat) SS
O45539 src-2 Tyrosine protein-kinase src-2 Caenorhabditis elegans SS
G5ECJ6 csk-1 Tyrosine-protein kinase csk-1 Caenorhabditis elegans SS
G5EE56 src-1 Tyrosine protein-kinase src-1 Caenorhabditis elegans SS
A1A5H8 yes1 Tyrosine-protein kinase yes Danio rerio (Zebrafish) (Brachydanio rerio) SS
F1RDG9 fynb Tyrosine-protein kinase fynb Danio rerio (Zebrafish) (Brachydanio rerio) SS
O12990 jak1 Tyrosine-protein kinase JAK1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q1JPZ3 src Proto-oncogene tyrosine-protein kinase Src Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q6EWH2 fyna Tyrosine-protein kinase fyna Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MVGTMPLCGR RAILEDSKAD GTEAQPLVPT GCLMVLLHWP GPEGGEPWVT FSQTSLTAEE
70 80 90 100 110 120
VCIHIAHKVG ITPPCLNLFA LYNAQAKVWL PPNHILDTSQ DMNLYFRMRF YFRNWHGMNP
130 140 150 160 170 180
QEPAVYRCGF PGAETSSDRA EQGVQLLDSA SFEYLFEQGK HEFMNDVVSL RDLSSEEEIH
190 200 210 220 230 240
HFKNESLGMA FLHLCHLALS RGVPLEEMAR EISFKNCIPH SFRQHIRQHN VLTRLRLHRV
250 260 270 280 290 300
FRRFLRAFRP GHLSQQVVMV KYLATLERLA PRFGSERIPV CHLEVLAQPE RDPCYIQNSG
310 320 330 340 350 360
QTAGDPGPEL PSGPPTHEVL VTGTGGIQWH PLQTQESERG NSRGNPHGSR SGKKPKAPKA
370 380 390 400 410 420
GEHLTESPQE PPWTYFCDFQ DISHVVLKER RVHIHLQDNK CLLLCLCSQA EALSFVALVD
430 440 450 460 470 480
GYFRLTADSS HYLCHEVAPP RLVTSIQNGI HGPLMDPFVQ AKLWPEDGLY LIQWSTSHLH
490 500 510 520 530 540
RLILTVAHRN PAFSNGPRGL RLRKFPITQQ PGAFVLDGWG RSFASLGDLR LALQGCSLRA
550 560 570 580 590 600
GDDCFPLHHC CLPRPREISN LVIMRGSRAH TRPLNLSQLS FHRVHQDEIT QLSHLGQGTR
610 620 630 640 650 660
TNVYEGLLRV GGPDEGKVDN GCPPEPGGTS GQQLRVVLKV LDPSHHDIAL AFYETASLMS
670 680 690 700 710 720
QVSHMHLAFL HGVCVRGSEN IIVTEFVEHG PLDVWLRRQR GQVPMTWKMV VAQQLASALS
730 740 750 760 770 780
YLEDKNLVHG NVCGRNILLA RLGLEEGTNP FIKLSDPGVG QGALSREERV ERIPWTAPEC
790 800 810 820 830 840
LSGGTSSLGT ATDMWGFGAT LLEICFDGEA PLQGRGPSEK ERFYTKKHQL PEPSSPELAT
850 860 870 880 890 900
LTRQCLTYEP AQRPSFRTIL RDLTRLQPQN LVGTSAVNSD SPASDPTVFH KRYLKKIRDL
910 920 930 940 950 960
GEGHFGKVSL YCYDPTNDGT GEMVAVKALK EGCGPQLRSG WQREIEILRT LYHEHIVKYK
970 980 990 1000 1010 1020
GCCEDQGEKS VQLVMEYVPL GSLRDYLPRH CVGLAQLLLF AQQICEGMAY LHAQHYIHRD
1030 1040 1050 1060 1070 1080
LAARNVLLDN DRLVKIGDFG LAKAVPEGHE YYRVREDGDS PVFWYAPECL KECKFYYASD
1090 1100 1110 1120 1130 1140
VWSFGVTLYE LLTYCDSNQS PHMKFTELIG HTQGQMTVLR LTELLERGER LPRPDRCPCE
1150 1160 1170 1180
IYHLMKNCWE TEASFRPTFQ NLVPILQTAQ EKYQGQVPSV FSVC