Q9R0K7
SS
Gene name |
Atp2b2 (Pmca2) |
Protein name |
Plasma membrane calcium-transporting ATPase 2 |
Names |
PMCA2 , EC 7.2.2.10 , Plasma membrane calcium ATPase isoform 2 , Plasma membrane calcium pump isoform 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:11941 |
EC number |
7.2.2.10: Linked to the hydrolysis of a nucleoside triphosphate |
Protein Class |
|
Descriptions
The plasmid membrane Ca2+ pump (PMCA) extrudes Ca2+ from the cytosol to the extracellular space playing an important role in the maintenance of the resting level of intracellular Ca2+ and in the control of the Ca2+ transients. The PMCAs are of major physiological importance, with different isoforms being essential for presynaptic and postsynaptic Ca2+ regulation in neurons and for feedback signaling in the heart and sperm motility. The PMCAs belong to the subtype 2B of P-type ATPases. The C-terminal segment of the PMCA functions as an autoinhibitory domain by interacting with the catalytic core. Ca2+-calmodulin binds to the C-terminal segment and stops inhibition by switching the PMCA to an activated state of higher maximum activity and affinity for Ca2+. In the PMCA3, the G1107D replacement impairs the autoinhibition mechanism by introducing a negative charge perturbing the contacts between the calmodulin binding domain and the pump core.
Autoinhibitory domains (AIDs)
Target domain |
335-1041 (P-type ATPase domain) |
Relief mechanism |
Partner binding, Ligand binding |
Assay |
|
Target domain |
434-1036 (P-type ATPase domain) |
Relief mechanism |
Partner binding |
Assay |
|
Target domain |
434-1036 (P-type ATPase domain) |
Relief mechanism |
Partner binding, Ligand binding |
Assay |
|
Accessory elements
No accessory elements
References
- Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100
- Calì T et al. (2017) "The ataxia related G1107D mutation of the plasma membrane Ca(2+) ATPase isoform 3 affects its interplay with calmodulin and the autoinhibition process", Biochimica et biophysica acta. Molecular basis of disease, 1863, 165-173
- Carafoli E (1994) "Biogenesis: plasma membrane calcium ATPase: 15 years of work on the purified enzyme", FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 8, 993-1002
- Tidow H et al. (2010) "Expression, purification, crystallization and preliminary X-ray analysis of calmodulin in complex with the regulatory domain of the plasma-membrane Ca2+-ATPase ACA8", Acta crystallographica. Section F, Structural biology and crystallization communications, 66, 361-3
- Saffioti NA et al. (2021) "Conformational changes during the reaction cycle of plasma membrane Ca2+-ATPase in the autoinhibited and activated states", The Biochemical journal, 478, 2019-2034
- Calì T et al. (2018) "The PMCA pumps in genetically determined neuronal pathologies", Neuroscience letters, 663, 2-11
- Corradi GR et al. (2007) "Intramolecular fluorescence resonance energy transfer between fused autofluorescent proteins reveals rearrangements of the N- and C-terminal segments of the plasma membrane Ca2+ pump involved in the activation", The Journal of biological chemistry, 282, 35440-8
- Osborn KD et al. (2005) "Single-molecule characterization of the dynamics of calmodulin bound to oxidatively modified plasma-membrane Ca2+-ATPase", Biochemistry, 44, 11074-81
- Lopreiato R et al. (2014) "The plasma membrane calcium pump: new ways to look at an old enzyme", The Journal of biological chemistry, 289, 10261-10268
- Bredeston LM et al. (2004) "Loss of autoinhibition of the plasma membrane Ca(2+) pump by substitution of aspartic 170 by asparagin. A ctivation of plasma membrane calcium ATPase 4 without disruption of the interaction between the catalytic core and the C-terminal regulatory domain", The Journal of biological chemistry, 279, 41619-25
- Pinto Fde T et al. (2002) "Deletions in the acidic lipid-binding region of the plasma membrane Ca2+ pump. A mutant with high affinity for Ca2+ resembling the acidic lipid-activated enzyme", The Journal of biological chemistry, 277, 12784-9
Autoinhibited structure
Activated structure
1 structures for Q9R0K7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9R0K7-F1 | Predicted | AlphaFoldDB |
62 variants for Q9R0K7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388854541 | 5 | T>I | No | EVA | |
| rs3388854482 | 13 | N>K | No | EVA | |
| rs3388852322 | 21 | G>E | No | EVA | |
| rs3388854515 | 25 | G>R | No | EVA | |
| rs3388852298 | 27 | T>I | No | EVA | |
| rs3388814864 | 51 | G>V | No | EVA | |
| rs3388850903 | 52 | D>E | No | EVA | |
| rs3388845195 | 120 | G>* | No | EVA | |
| rs3388849310 | 172 | D>E | No | EVA | |
| rs3388851779 | 180 | R>Q | No | EVA | |
| rs3388856923 | 217 | K>E | No | EVA | |
| rs3388851842 | 219 | G>D | No | EVA | |
| rs3388845207 | 236 | I>F | No | EVA | |
| rs3388814825 | 275 | A>V | No | EVA | |
| rs3388850940 | 277 | G>D | No | EVA | |
| 283 | G>S | dfw; results in impaired long-term Ca2+ export at stereocilia [UniProt] | No | ||
| rs3388853475 | 293 | G>S | No | EVA | |
| rs3388845241 | 324 | D>E | No | EVA | |
| rs3413095739 | 340 | V>A | No | EVA | |
| rs3388837090 | 377 | V>M | No | EVA | |
| rs3388833082 | 379 | N>D | No | EVA | |
| rs3388846463 | 380 | K>Q | No | EVA | |
| rs3388852330 | 393 | Q>H | No | EVA | |
| 412 | E>K | No | |||
| rs3388854553 | 437 | R>H | No | EVA | |
| rs3388849630 | 452 | C>S | No | EVA | |
| rs3388849337 | 456 | T>R | No | EVA | |
| rs3388846468 | 486 | N>I | No | EVA | |
| rs3397252652 | 486 | N>Y | No | EVA | |
| rs3396830095 | 487 | A>G | No | EVA | |
| rs3397300379 | 488 | K>M | No | EVA | |
| rs3388837115 | 491 | E>D | No | EVA | |
| rs3388845253 | 499 | I>F | No | EVA | |
| rs3388849329 | 511 | E>K | No | EVA | |
| rs3388845203 | 520 | V>E | No | EVA | |
| rs3388850906 | 524 | T>A | No | EVA | |
| rs3388829784 | 531 | F>Y | No | EVA | |
| rs3388814803 | 532 | V>M | No | EVA | |
| rs3388850902 | 580 | K>* | No | EVA | |
| rs3413041026 | 596 | G>E | No | EVA | |
| rs3388850915 | 599 | E>G | No | EVA | |
| rs3388852288 | 604 | R>W | No | EVA | |
| rs3388829756 | 633 | D>E | No | EVA | |
| rs3388814855 | 633 | D>N | No | EVA | |
| rs3388846492 | 634 | F>Y | No | EVA | |
| rs3388846454 | 646 | N>I | No | EVA | |
| rs3388852333 | 667 | E>* | No | EVA | |
| rs3388849258 | 686 | T>I | No | EVA | |
| rs3388850914 | 691 | N>T | No | EVA | |
| rs3388833027 | 728 | I>V | No | EVA | |
| rs3397296107 | 730 | Q>L | No | EVA | |
| rs30756873 | 731 | E>D | No | EVA | |
| rs3388829695 | 757 | G>C | No | EVA | |
| rs3388854498 | 964 | N>K | No | EVA | |
| rs3388841766 | 968 | A>D | No | EVA | |
| rs3397289804 | 982 | F>L | No | EVA | |
| rs3413127790 | 1058 | E>D | No | EVA | |
| rs3388841743 | 1087 | R>W | No | EVA | |
| rs3388856973 | 1116 | R>* | No | EVA | |
| rs3396994355 | 1170 | S>G | No | EVA | |
| rs3388848876 | 1198 | L>F | No | EVA | |
| rs3396994348 | 1199 | L>S | No | EVA |
1 associated diseases with Q9R0K7
Without disease ID
5 regional properties for Q9R0K7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cation-transporting P-type ATPase, N-terminal | 47 - 123 | IPR004014 |
| domain | Cation-transporting P-type ATPase, C-terminal | 858 - 1036 | IPR006068 |
| ptm | P-type ATPase, phosphorylation site | 454 - 460 | IPR018303 |
| domain | Plasma membrane calcium transporting P-type ATPase, C-terminal | 1081 - 1127 | IPR022141 |
| domain | P-type ATPase, haloacid dehalogenase domain | 434 - 825 | IPR044492 |
Functions
| Description | ||
|---|---|---|
| EC Number | 7.2.2.10 | Linked to the hydrolysis of a nucleoside triphosphate |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
20 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| cilium | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| dendritic spine membrane | The portion of the plasma membrane surrounding a dendritic spine. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| GABA-ergic synapse | A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| neuronal cell body membrane | The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites. |
| parallel fiber to Purkinje cell synapse | An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells. |
| photoreceptor ribbon synapse | A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic density membrane | The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. |
| postsynaptic membrane | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. |
| presynaptic active zone membrane | The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters. |
| presynaptic membrane | A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction |
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| calcium-dependent ATPase activity | Catalysis of the reaction |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| glutamate receptor binding | Binding to a glutamate receptor. |
| P-type calcium transporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction |
| PDZ domain binding | Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins. |
30 GO annotations of biological process
| Name | Definition |
|---|---|
| auditory receptor cell stereocilium organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells. |
| calcium ion transport | The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| cell morphogenesis | The developmental process in which the size or shape of a cell is generated and organized. |
| cerebellar granule cell differentiation | The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex. |
| cerebellar Purkinje cell differentiation | The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem. |
| cerebellar Purkinje cell layer morphogenesis | The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. |
| cerebellum development | The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. |
| cGMP metabolic process | The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate. |
| cochlea development | The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound. |
| detection of mechanical stimulus involved in sensory perception of sound | The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal. |
| establishment of localization in cell | Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. |
| inner ear development | The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure. |
| inner ear morphogenesis | The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively. |
| inner ear receptor cell differentiation | The process in which relatively unspecialized cells, acquire specialized structural and/or functional features of inner ear receptor cells. Inner ear receptor cells are mechanorecptors found in the inner ear responsible for transducing signals involved in balance and sensory perception of sound. |
| intracellular calcium ion homeostasis | A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell. |
| lactation | The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young. |
| locomotion | Self-propelled movement of a cell or organism from one location to another. |
| locomotory behavior | The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. |
| neuromuscular process controlling balance | Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors. |
| neuron cellular homeostasis | The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state. |
| neuron differentiation | The process in which a relatively unspecialized cell acquires specialized features of a neuron. |
| organelle organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. |
| otolith mineralization | The precipitation of specific crystal forms of calcium carbonate with extracellular matrix proteins in the otolith organs of the vertebrate inner ear. |
| positive regulation of calcium ion transport | Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of cell size | Any process that modulates the size of a cell. |
| regulation of cytosolic calcium ion concentration | Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. |
| regulation of synaptic plasticity | A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. |
| sensory perception of sound | The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. |
| serotonin metabolic process | The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. |
| synapse organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). |
31 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P38929 | PMC1 | Calcium-transporting ATPase 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| D3K0R6 | ATP2B4 | Plasma membrane calcium-transporting ATPase 4 | Bos taurus (Bovine) | SS |
| P20020 | ATP2B1 | Plasma membrane calcium-transporting ATPase 1 | Homo sapiens (Human) | SS |
| P23634 | ATP2B4 | Plasma membrane calcium-transporting ATPase 4 | Homo sapiens (Human) | EV |
| Q16720 | ATP2B3 | Plasma membrane calcium-transporting ATPase 3 | Homo sapiens (Human) | EV |
| Q01814 | ATP2B2 | Plasma membrane calcium-transporting ATPase 2 | Homo sapiens (Human) | SS |
| G5E829 | Atp2b1 | Plasma membrane calcium-transporting ATPase 1 | Mus musculus (Mouse) | SS |
| Q6Q477 | Atp2b4 | Plasma membrane calcium-transporting ATPase 4 | Mus musculus (Mouse) | SS |
| P23220 | ATP2B1 | Plasma membrane calcium-transporting ATPase 1 | Sus scrofa (Pig) | SS |
| Q64542 | Atp2b4 | Plasma membrane calcium-transporting ATPase 4 | Rattus norvegicus (Rat) | SS |
| P11505 | Atp2b1 | Plasma membrane calcium-transporting ATPase 1 | Rattus norvegicus (Rat) | SS |
| Q64568 | Atp2b3 | Plasma membrane calcium-transporting ATPase 3 | Rattus norvegicus (Rat) | SS |
| P11506 | Atp2b2 | Plasma membrane calcium-transporting ATPase 2 | Rattus norvegicus (Rat) | SS |
| Q2QMX9 | ACA10 | Calcium-transporting ATPase 10, plasma membrane-type | Oryza sativa subsp japonica (Rice) | SS |
| Q2QY12 | ACA9 | Probable calcium-transporting ATPase 9, plasma membrane-type | Oryza sativa subsp japonica (Rice) | SS |
| Q6ATV4 | ACA3 | Calcium-transporting ATPase 3, plasma membrane-type | Oryza sativa subsp japonica (Rice) | SS |
| Q7X8B5 | ACA5 | Calcium-transporting ATPase 5, plasma membrane-type | Oryza sativa subsp japonica (Rice) | SS |
| Q7XEK4 | ACA7 | Calcium-transporting ATPase 7, plasma membrane-type | Oryza sativa subsp japonica (Rice) | EV |
| Q8RUN1 | ACA1 | Calcium-transporting ATPase 1, plasma membrane-type | Oryza sativa subsp japonica (Rice) | SS |
| Q65X71 | ACA6 | Probable calcium-transporting ATPase 6, plasma membrane-type | Oryza sativa subsp japonica (Rice) | SS |
| Q2RAS0 | ACA8 | Probable calcium-transporting ATPase 8, plasma membrane-type | Oryza sativa subsp japonica (Rice) | SS |
| O22218 | ACA4 | Calcium-transporting ATPase 4, plasma membrane-type | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64806 | ACA7 | Putative calcium-transporting ATPase 7, plasma membrane-type | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81108 | ACA2 | Calcium-transporting ATPase 2, plasma membrane-type | Arabidopsis thaliana (Mouse-ear cress) | EV |
| Q9LF79 | ACA8 | Calcium-transporting ATPase 8, plasma membrane-type | Arabidopsis thaliana (Mouse-ear cress) | EV |
| Q9LIK7 | ACA13 | Putative calcium-transporting ATPase 13, plasma membrane-type | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LU41 | ACA9 | Calcium-transporting ATPase 9, plasma membrane-type | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LY77 | ACA12 | Calcium-transporting ATPase 12, plasma membrane-type | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M2L4 | ACA11 | Putative calcium-transporting ATPase 11, plasma membrane-type | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SZR1 | ACA10 | Calcium-transporting ATPase 10, plasma membrane-type | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q37145 | ACA1 | Calcium-transporting ATPase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGDMTNSDFY | SKNQRNESSH | GGEFGCTMEE | LRSLMELRGT | EAVVKIKETY | GDTEAICRRL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KTSPVEGLPG | TAPDLEKRKQ | IFGQNFIPPK | KPKTFLQLVW | EALQDVTLII | LEIAAIISLG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LSFYHPPGES | NEGCATAQGG | AEDEGEAEAG | WIEGAAILLS | VICVVLVTAF | NDWSKEKQFR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GLQSRIEQEQ | KFTVVRAGQV | VQIPVAEIVV | GDIAQIKYGD | LLPADGLFIQ | GNDLKIDESS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LTGESDQVRK | SVDKDPMLLS | GTHVMEGSGR | MVVTAVGVNS | QTGIIFTLLG | AGGEEEEKKD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KKAKQQDGAA | AMEMQPLKSA | EGGDADDKKK | ANMHKKEKSV | LQGKLTKLAV | QIGKAGLVMS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AITVIILVLY | FTVDTFVVNK | KPWLTECTPV | YVQYFVKFFI | IGVTVLVVAV | PEGLPLAVTI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SLAYSVKKMM | KDNNLVRHLD | ACETMGNATA | ICSDKTGTLT | TNRMTVVQAY | VGDVHYKEIP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DPSSINAKTL | ELLVNAIAIN | SAYTTKILPP | EKEGALPRQV | GNKTECGLLG | FVLDLRQDYE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PVRSQMPEEK | LYKVYTFNSV | RKSMSTVIKM | PDESFRMYSK | GASEIVLKKC | CKILSGAGEA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RVFRPRDRDE | MVKKVIEPMA | CDGLRTICVA | YRDFPSSPEP | DWDNENDILN | ELTCICVVGI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EDPVRPEVPE | AIRKCQRAGI | TVRMVTGDNI | NTARAIAIKC | GIIHPGEDFL | CLEGKEFNRR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| IRNEKGEIEQ | ERIDKIWPKL | RVLARSSPTD | KHTLVKGIID | STHTEQRQVV | AVTGDGTNDG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| PALKKADVGF | AMGIAGTDVA | KEASDIILTD | DNFSSIVKAV | MWGRNVYDSI | SKFLQFQLTV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| NVVAVIVAFT | GACITQDSPL | KAVQMLWVNL | IMDTFASLAL | ATEPPTETLL | LRKPYGRNKP |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LISRTMMKNI | LGHAVYQLTL | IFTLLFVGEK | MFQIDSGRNA | PLHSPPSEHY | TIIFNTFVMM |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| QLFNEINARK | IHGERNVFDG | IFRNPIFCTI | VLGTFAIQIV | IVQFGGKPFS | CSPLQLDQWM |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| WCIFIGLGEL | VWGQVIATIP | TSRLKFLKEA | GRLTQKEEIP | EEELNEDVEE | IDHAERELRR |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| GQILWFRGLN | RIQTQIRVVK | AFRSSLYEGL | EKPESRTSIH | NFMAHPEFRI | EDSQPHIPLI |
| 1150 | 1160 | 1170 | 1180 | 1190 | |
| DDTDLEEDAA | LKQNSSPPSS | LNKNNSAIDS | GINLTTDTSK | SATSSSPGSP | IHSLETSL |