Q9R0G8

PR
Gene name
Nrk (Nesk)
Protein name
Nik-related protein kinase
Names
Nck-interacting kinase-like embryo specific kinase, NESK, NIK-like embryo-specific kinase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:27206
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

759-882 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9R0G8

Entry ID Method Resolution Chain Position Source
AF-Q9R0G8-F1 Predicted AlphaFoldDB

108 variants for Q9R0G8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389572359 17 Q>K No EVA
rs3411274690 32 G>S No EVA
rs3410664205 90 L>P No EVA
rs3389586696 141 V>M No EVA
rs3389569360 161 I>F No EVA
rs3411706041 168 L>F No EVA
rs3412555091 170 A>V No EVA
rs3412174885 244 G>V No EVA
rs3389576279 266 L>I No EVA
rs3389569947 279 S>T No EVA
rs3412273222 293 C>* No EVA
rs3389569392 302 P>S No EVA
rs3389543150 316 I>L No EVA
rs3389483405 318 N>H No EVA
rs262171511 350 E>D No EVA
rs3389554891 352 A>V No EVA
rs3411940651 354 E>G No EVA
rs3389533981 366 C>Y No EVA
rs3410781111 370 L>H No EVA
rs3411940684 370 L>I No EVA
rs3389569313 386 H>Y No EVA
rs3389576323 398 Q>K No EVA
rs3389576346 402 Q>H No EVA
rs29258667 404 Q>K No EVA
rs3389576959 418 P>H No EVA
rs250016246 439 L>R No EVA
rs3389554876 444 Q>H No EVA
rs3389526280 446 V>D No EVA
rs234232048 465 M>T No EVA
rs3412041401 469 L>P No EVA
rs3389576997 496 L>I No EVA
rs215034373 499 E>G No EVA
rs3411275973 516 R>M No EVA
rs3411276035 522 R>W No EVA
rs3412360181 525 Q>H No EVA
rs238591317 526 A>P No EVA
rs3389585307 536 V>I No EVA
rs3389569896 537 P>S No EVA
rs3389574208 556 A>P No EVA
rs3410781085 565 E>D No EVA
rs3412555149 567 K>Q No EVA
rs3412041829 568 E>V No EVA
rs3389569859 574 V>M No EVA
rs3412082789 580 L>R No EVA
rs3411706083 596 D>E No EVA
rs3411706024 597 R>* No EVA
rs3412082734 601 I>F No EVA
rs3412149509 601 I>N No EVA
rs243089962 615 A>V No EVA
rs3412041351 616 W>* No EVA
rs243518137 661 S>C No EVA
rs265334196 667 T>S No EVA
rs3412360159 701 W>L No EVA
rs1133938814 707 E>Q No EVA
rs229311880 708 F>S No EVA
rs3413149975 719 H>Q No EVA
rs3389577013 724 D>N No EVA
rs3389526291 727 N>I No EVA
rs3410781070 790 K>Q No EVA
rs3412082741 790 K>R No EVA
rs29258624 847 S>A No EVA
rs3389569877 858 Q>* No EVA
rs3389570228 882 T>A No EVA
rs254548294 902 P>S No EVA
rs3412174906 945 G>D No EVA
rs219959118 954 D>V No EVA
rs229666336 997 H>R No EVA
rs3389554874 999 D>V No EVA
rs3389576268 1000 G>R No EVA
rs250056518 1010 V>A No EVA
rs3412360176 1028 A>T No EVA
rs3412277812 1034 G>* No EVA
rs3410665382 1035 A>P No EVA
rs3410665378 1036 N>Y No EVA
rs3389574225 1037 R>M No EVA
rs3413136768 1037 R>W No EVA
rs3412556001 1038 G>R No EVA
rs3412360175 1038 G>V No EVA
rs3412082777 1039 N>H No EVA
rs3412994641 1042 G>D No EVA
rs263120522 1058 F>I No EVA
rs3412273259 1064 V>I No EVA
rs29261237 1083 I>V No EVA
rs3410665401 1121 S>G No EVA
rs3389586705 1125 Y>F No EVA
rs3389585331 1133 Y>F No EVA
rs3412041473 1142 Y>C No EVA
rs3389570301 1148 G>E No EVA
rs3389577012 1175 K>R No EVA
rs3389572377 1183 Q>L No EVA
rs3389570251 1186 E>D No EVA
rs3389585285 1190 L>* No EVA
rs29259382 1203 V>M No EVA
rs3389580501 1223 R>G No EVA
rs3412277880 1224 Q>L No EVA
rs3412174865 1257 I>N No EVA
rs3412273326 1273 K>I No EVA
rs227813657 1288 D>E No EVA
rs3410665424 1309 S>R No EVA
rs3412273335 1310 S>* No EVA
rs3412360155 1310 S>T No EVA
rs3389589161 1320 E>* No EVA
rs3389533987 1322 E>Q No EVA
rs3389569389 1324 M>I No EVA
rs3412360134 1343 L>H No EVA
rs226367514 1353 A>T No EVA
rs3412277887 1396 R>H No EVA
rs3411706298 1397 S>RE* No EVA

No associated diseases with Q9R0G8

1 regional properties for Q9R0G8

Type Name Position InterPro Accession
conserved_site TATA-box binding protein, conserved site 246 - 295 IPR030491

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

10 GO annotations of biological process

Name Definition
actin cytoskeleton reorganization A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
MAPK cascade An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
negative regulation of cell population proliferation Any process that stops, prevents or reduces the rate or extent of cell proliferation.
neuron projection morphogenesis The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
parturition The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs.
positive regulation of JNK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of MAPK cascade Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.
regulation of spongiotrophoblast cell proliferation Any process that modulates the rate, frequency or extent of spongiotrophoblast cell proliferation.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O95819 MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens (Human) PR
Q7Z2Y5 NRK Nik-related protein kinase Homo sapiens (Human) PR
Q9JM52 Mink1 Misshapen-like kinase 1 Mus musculus (Mouse) PR
P83510 Tnik Traf2 and NCK-interacting protein kinase Mus musculus (Mouse) PR
P97820 Map4k4 Mitogen-activated protein kinase kinase kinase kinase 4 Mus musculus (Mouse) PR
10 20 30 40 50 60
MAGPGSWRDK EVTDLGQLPD PTGIFSLDKA IGLGTYGRIF LGIHEKTGSL VAVKVMSARK
70 80 90 100 110 120
TPLPEIGRRV RVNKYQKSVG WRYSDEEEDL RTELNLLRKY SFHKNIVTFY GAFFKLNPPG
130 140 150 160 170 180
HQHQLWMVME LCAAGSVTDV VRMTRNQSLK EDWIAYICRE ILQGLAHLHA HQVIHRDIKG
190 200 210 220 230 240
QNVLLTHDAE VKIVDFGVSA QVSRTNGRRN SFIGTPYWMA PEVIHCDEDP RCSYDYRSDV
250 260 270 280 290 300
WSVGITAIEM AEGAPPLCKL QPLEALCVIL REAAPKVKSS GWSRKFQNFM ENCMIKNFLF
310 320 330 340 350 360
RPTSGNMLLH PFVHDIKNER RVVESLTKHL TGIIQKREKK GIPVAFEGEE AAKEQYITRR
370 380 390 400 410 420
FRGPSCTPEL LRVPTSSRCR PLRVLHGEPP QPRWLPDQED PQDQELQQLQ KAAGVFMPLH
430 440 450 460 470 480
SQDNTSKLFP KQVEVAPYLR GAAQVVMPVL VQVEAPPQVS KAAQMLKSLP TQDNKATSPE
490 500 510 520 530 540
VQAPVAEGQQ AQHEALETEQ PKDLDQVPEE FQGQDRAPEQ PRQGQAAEQQ QIHNPVPEQP
550 560 570 580 590 600
PEEDREPEQA EVQEEAVEPP QAEIEDKEPE VVQVHAQVLL PLLSQNRHVL LPLHLDRQLL
610 620 630 640 650 660
IPVGEQNEEV PRAQAWDLEA SRAVGAVQAL IEGLSRDLLR APNAFVTKPL GPLQIFLENL
670 680 690 700 710 720
STDGFYTEPE PTQKKKSKVA SLRKAIAKRL RPKRFRAKAL WRLEDFEFSD VETSRRRRHR
730 740 750 760 770 780
RWEDIFNQHE EQLRRVENDR EDDSSDNDEV FHSIQAEVQI EPHAANPAGN EVHERSAPMP
790 800 810 820 830 840
CNRNRTHRVK FSPSVGEEEP SLEEAQPQQQ QQQPMNIRPR NCLNPQNFQA QSDSSSEEDS
850 860 870 880 890 900
PVTRRKSQSS PPYSTIDQKL LIDIHVPDGF KVGKISPPVY LTNEWVGYNA LSEIFWDDWI
910 920 930 940 950 960
MPTRPARPPE EDGDYVELYD ADANANGDEE VANGAYEDPR DGANGHDDMN NQLDQANGYE
970 980 990 1000 1010 1020
GHGAAGYNGG DVGGNHGAAF NGPRANYPRA GILKNGHNDG RALNRGAFGV FGDNAARAFH
1030 1040 1050 1060 1070 1080
GAAGEAGAAF GNHGANRGNG RGNRNREANG RNEENGAFGR DQHVFPEFEH EESDRGTETS
1090 1100 1110 1120 1130 1140
DSIALEITSF DGEQNSGRPV SSTTMGFPIG RSSPRGSDFG SDISYNSPIL HVYEKDFSSE
1150 1160 1170 1180 1190 1200
VYCGSLWGVN LLLGTQSHLY LMDRSGKAEI VKLIKRRPFR QIQVVEQLNL LITISGKKNR
1210 1220 1230 1240 1250 1260
LRVYHLSWLR NKILNNDPKS KKRQKAMRKK EEACKAIDKL IGCEHFSVLQ HEETTYIAVA
1270 1280 1290 1300 1310 1320
VKSSIHLFAW APKSFDENTA IKVFPTRDLK PLTVDLAVGS EKTLKIFFSS ANGYHIIDAE
1330 1340 1350 1360 1370 1380
SEVMSEVTLP NNNVVILPDC LGLGVMLSLN AEAASEEANE QLLKKILDVW KDIPSSVAFE
1390 1400 1410 1420 1430 1440
CTKRITGWDQ KAIEVRSLQS TILENELKRR SIKKLRFLCA RGDKMFFAST LSNDHSRVYL
1450
MSLGKLEELH RSYAV