Q9QZC4
Gene name |
Pcyt1b (Cctb) |
Protein name |
Choline-phosphate cytidylyltransferase B |
Names |
Virus-encoded semaphorin protein receptor, CCT-beta, CTP:phosphocholine cytidylyltransferase B, CCT B, CT B, Phosphorylcholine transferase B |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:286936 |
EC number |
2.7.7.15: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9QZC4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9QZC4-F1 | Predicted | AlphaFoldDB |
No variants for Q9QZC4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9QZC4 | |||||
No associated diseases with Q9QZC4
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.15 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| choline-phosphate cytidylyltransferase activity | Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline. |
| phosphatidylcholine binding | Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| CDP-choline pathway | The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine. |
| ovarian follicle development | The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure. |
| phosphatidylcholine biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. |
| response to vasopressin | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vasopressin stimulus. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P49585 | PCYT1A | Choline-phosphate cytidylyltransferase A | Homo sapiens (Human) | SS |
| Q9Y5K3 | PCYT1B | Choline-phosphate cytidylyltransferase B | Homo sapiens (Human) | PR |
| P49586 | Pcyt1a | Choline-phosphate cytidylyltransferase A | Mus musculus (Mouse) | SS |
| Q811Q9 | Pcyt1b | Choline-phosphate cytidylyltransferase B | Mus musculus (Mouse) | SS |
| P19836 | Pcyt1a | Choline-phosphate cytidylyltransferase A | Rattus norvegicus (Rat) | EV |
| F4JJE0 | CCT2 | Choline-phosphate cytidylyltransferase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPVVTTDAES | ETGIPKSLSN | EPPSETMEEI | EHTCPQPRLT | LTAPAPFADE | SSCQCQAPHE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KLTIAQARLG | TPVDRPVRVY | ADGIFDLFHS | GHARALMQAK | TLFPNSYLLV | GVCSDDLTHK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FKGFTVMNEA | ERYEALRHCR | YVDEVIRDAP | WTLTPEFLEK | HKIDFVAHDD | IPYSSAGSDD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VYKHIKEAGM | FVPTQRTEGI | STSDIITRIV | RDYDVYARRN | LQRGYTAKEL | NVSFINEKKY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RFQNQVDKMK | EKVKNVEERS | KEFVNRVEEK | SHDLIQKWEE | KSREFIGNFL | ELFGPDGAWK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QMFQERSSRM | LQALSPKQSP | VSSPTRSRSP | SRSPSPTFSW | LPNKTSPPSS | PKAASASISS |
| MSEGDEDEK |