Q9QZC2

SS
Gene name
Plxnc1 (Vespr)
Protein name
Plexin-C1
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:54712
EC number
Protein Class

Descriptions

Plexins are a large family of cell surface receptors for the axon guidance molecules semaphorins. Semaphorin-plexin signaling is essential for the regulation of neuronal development and other processes. Dysfunction in plexin pathways has been implicated in various diseases including neurological disorders and cancer.
Plexins are transmembrane proteins with a multidomain extracellular region that contains an N-terminal Sema domain. Before semaphorin binding, Plexin is an inactive monomer or dimer in which the RapGAP activity is autoinhibited. Binding of semaphorin to the Sema domain of plexin leads to activation of its cytoplasmic region, which relays the signal to downstream pathways. Mouse Plexin-A3 (P70208) possesses a segment preceding C1 domain and RDB domain as autoinhibitory elements.

Autoinhibitory domains (AIDs)

1-452 (Sema domain) SS

Target domain

1019-1541 (Plexin, cytoplasmic RasGAP domain)

Relief mechanism

Partner binding

Assay

Mutagenesis experiment

955-1018 (Segment preceding C1 domain) SS

Target domain

1019-1541 (Plexin, cytoplasmic RasGAP domain)

Relief mechanism

Assay

1190-1308 (RBD domain) SS

Target domain

1019-1541 (Plexin, cytoplasmic RasGAP domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9QZC2

Entry ID Method Resolution Chain Position Source
AF-Q9QZC2-F1 Predicted AlphaFoldDB

8 variants for Q9QZC2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs236212660 339 H>R No Ensembl
rs49244455 357 G>E No Ensembl
rs217156724 603 S>T No Ensembl
rs51300746 797 A>T No Ensembl
rs253293244 932 R>S No Ensembl
rs50887778 974 Y>H No Ensembl
rs1133237294 1057 E>K No Ensembl
rs45918195 1203 N>S No Ensembl

No associated diseases with Q9QZC2

8 regional properties for Q9QZC2

Type Name Position InterPro Accession
domain Arf GTPase activating protein 454 - 577 IPR001164
domain SH3 domain 1085 - 1147 IPR001452
domain Pleckstrin homology domain 339 - 433 IPR001849
repeat Ankyrin repeat 615 - 702 IPR002110
domain BAR domain 54 - 286 IPR004148
domain ASAP, PH domain 331 - 437 IPR037844
domain ASAP1, BAR domain 54 - 268 IPR037928
domain ASAP1, SH3 domain 1089 - 1145 IPR038016

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
semaphorin receptor complex A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.

1 GO annotations of molecular function

Name Definition
semaphorin receptor activity Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

6 GO annotations of biological process

Name Definition
negative regulation of cell adhesion Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
positive regulation of axonogenesis Any process that activates or increases the frequency, rate or extent of axonogenesis.
regulation of cell migration Any process that modulates the frequency, rate or extent of cell migration.
regulation of cell shape Any process that modulates the surface configuration of a cell.
regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase.
semaphorin-plexin signaling pathway involved in axon guidance Any semaphorin-plexin signaling pathway that is involved in axon guidance.

27 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q769I5 MET Hepatocyte growth factor receptor Bos taurus (Bovine) PR
A0M8S8 MET Hepatocyte growth factor receptor Felis catus (Cat) (Felis silvestris catus) PR
Q04912 MST1R Macrophage-stimulating protein receptor Homo sapiens (Human) EV
P08581 MET Hepatocyte growth factor receptor Homo sapiens (Human) EV
O43157 PLXNB1 Plexin-B1 Homo sapiens (Human) EV SS
Q9HCM2 PLXNA4 Plexin-A4 Homo sapiens (Human) SS
O75051 PLXNA2 Plexin-A2 Homo sapiens (Human) SS
P51805 PLXNA3 Plexin-A3 Homo sapiens (Human) SS
Q9UIW2 PLXNA1 Plexin-A1 Homo sapiens (Human) EV SS
O15031 PLXNB2 Plexin-B2 Homo sapiens (Human) SS
Q9ULL4 PLXNB3 Plexin-B3 Homo sapiens (Human) SS
Q62190 Mst1r Macrophage-stimulating protein receptor Mus musculus (Mouse) SS
P16056 Met Hepatocyte growth factor receptor Mus musculus (Mouse) PR
B2RXS4 Plxnb2 Plexin-B2 Mus musculus (Mouse) SS
P70206 Plxna1 Plexin-A1 Mus musculus (Mouse) EV SS
P70207 Plxna2 Plexin-A2 Mus musculus (Mouse) SS
Q3UH93 Plxnd1 Plexin-D1 Mus musculus (Mouse) SS
Q80UG2 Plxna4 Plexin-A4 Mus musculus (Mouse) SS
Q8CJH3 Plxnb1 Plexin-B1 Mus musculus (Mouse) SS
Q9QY40 Plxnb3 Plexin-B3 Mus musculus (Mouse) SS
P70208 Plxna3 Plexin-A3 Mus musculus (Mouse) EV SS
Q2QLE0 MET Hepatocyte growth factor receptor Sus scrofa (Pig) PR
P97523 Met Hepatocyte growth factor receptor Rattus norvegicus (Rat) PR
D3ZPX4 Plxna3 Plexin-A3 Rattus norvegicus (Rat) SS
D3ZLH5 Plxnb3 Plexin-B3 Rattus norvegicus (Rat) SS
Q6BEA0 plxna4 Plexin-A4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
B0S5N4 plxna3 Plexin A3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MEVSRRKTPP RPPYPAAPLP LIAYLLALAA PARGADEPVW RSEQAIGAIA ASRADGVFVA
70 80 90 100 110 120
SGSCLDQLDY SLKNRLSRLY RDQAGNCTEP VSLAPPARPR PGSSFSKLLL PYREGATGLE
130 140 150 160 170 180
GLLLTGWTFD RGACEVRPLG NLNRSSLRNG TEVVSCHPQG STAGVVYRAS GTDLWYLAVA
190 200 210 220 230 240
ATYVLPEPET ANRCNPAASD RDTAIALKNT EGRSLATQEL GRLKLRGSAG SLHFVDAFLW
250 260 270 280 290 300
NGSVYFPYYP YNYTSGAATG WPSMARIAQS TEVLFQGQAA LDCDHGHPEG RRLLLSSSLV
310 320 330 340 350 360
EAVDIWAGVF SAATGEGQER RSPATTALCL FRMSEIQAHA RSCSWDFQAT EHNCKEGDRP
370 380 390 400 410 420
ERVQPIASST LIHSDLTSVY GTVVMNRTVL FLGTGDGQLL KVVLGENLTS NCPEVIYEIK
430 440 450 460 470 480
EETPVFYKLV PHPMKNIYIY LTAGKEVRRI PVANCSKRKS CSECLAAADP HCGWCLPLQR
490 500 510 520 530 540
CTFQGDCTHA GSFENWLDIS SGPKKCPKIQ ILRSLRERTT VTIVGSISAR HSECVVKNAD
550 560 570 580 590 600
TGKLLCQGRS QLNWTCACNI PSRPSYNVLV VNATFSFPSW NLSERFNFTN CASLKECPAC
610 620 630 640 650 660
IRSGCAWCKR DKKCIHPFTP CEPSDYERNQ ELCQVAVEKS PKDSGGGRVK ESKRNRTDGA
670 680 690 700 710 720
VQVFYIKAIE PQKISTLGKS NVIVTGANFT QASNITMILR GTSTCERDVI RVSHVLNDTH
730 740 750 760 770 780
MKFSLPSSRK EMKDVCIQFD GGTCSSAGAL SYIALPHCSL IVPATTWISG GQNITIMGRN
790 800 810 820 830 840
FDVIDNLIIS HELKGNANVN INVSEYCAAT FCRFLAPNLK SSKVRTNVAV KLRVQDTYLD
850 860 870 880 890 900
CGTLQYLEDP RFTGYRVESE IDTELEVKIQ KENDNFNISK DDIDITLFHG ENKQFNCSFE
910 920 930 940 950 960
NITRNQDLTT ILCKIKSIKN ANTIASSSKK VRVKLGNLEL YVEQESVPST WYFLIALPIL
970 980 990 1000 1010 1020
LAIVIVVAVV VTRYKSKELS RKQSQQLELL ESELRKEIRD GFAELQMDKL DVVDSFGTVP
1030 1040 1050 1060 1070 1080
FLDYKHFALR TFFPESGGFT HIFTEDMHNR DANDKNESLT ALDALICNKS FLVTVIHTLE
1090 1100 1110 1120 1130 1140
KQKNFSVKDR CLFASFLTIA LQTKLVYLTS ILEVLTRDLM EQCSNMQPKL MLRRTESVVE
1150 1160 1170 1180 1190 1200
KLLTNWMSVC LSGFLRETVG EPFYLLVTTL NQKINKGPVD VITCKALYTL NEDWLLWQVP
1210 1220 1230 1240 1250 1260
EFNTVALNVV FEKIPENESA DVCRNISVNV LDCDTIGQAK EKVFQAFLSK NGSPYGLQLN
1270 1280 1290 1300 1310 1320
EIGLELQVGT RQKELLDIDS SSVILEDGIT KLNTIGHYEI SNGSTIKVFK KIANFTSDVE
1330 1340 1350 1360 1370 1380
YSDDHCHLIL PDSEAFQVVQ GKRHRGKHKF KVKEMYLTKL LSTKVAIHSV LEKLFRSIWS
1390 1400 1410 1420 1430 1440
LPNSRAPFAI KYFFDFLDAQ AENKKITDPD VVHIWKTNSL PLRFWVNILK NPQFVFDIKK
1450 1460 1470 1480 1490 1500
TPHIDSCLSV IAQAFMDAFS LTEQQLGKEA PTNKLLYAKD IPTYKEEVKS YYKAIRDLPP
1510 1520 1530 1540 1550 1560
LSSLEMEEFL TQESKKHENE FNEEVALTEI YKYIVKYFDE ILNKLERERG LEEAQKQLLH
1570
VKVLFDEKKK CKWM