Q9QZ11
SS
Gene name |
Exo1 |
Protein name |
Exonuclease 1 |
Names |
mExo1 , EC 3.1.-.- , Exonuclease I |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:26909 |
EC number |
3.1.-.-: Acting on ester bonds |
Protein Class |
|
Descriptions
Human exonuclease 1 (Exo1) plays important roles in DNA repair and recombination processes that maintain genomic integrity. It is a member of the 50 structure-specific nuclease family of exonucleases and endonucleases that includes FEN-1, XPG, and GEN1.<br>Upon mismatch recognition, first MutSα searches for Exo1 via bidirectional, one-dimensional diffusion along the DNA. Next, MutSα encounters Exo1 prebound at a nick and interacts with the C-terminal domain of Exo1, thereby alleviating the autoinhibition of the Exo1.
Autoinhibitory domains (AIDs)
Target domain |
1-201 (Exonuclease 1-like domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9QZ11
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9QZ11-F1 | Predicted | AlphaFoldDB |
65 variants for Q9QZ11
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs211985209 | 18 | N>T | No | EVA | |
| rs3388521734 | 50 | E>K | No | EVA | |
| rs3388518850 | 146 | V>M | No | EVA | |
| rs3388517290 | 179 | C>G | No | EVA | |
| rs3388519541 | 208 | D>N | No | EVA | |
| rs3388521676 | 214 | K>M | No | EVA | |
| rs3388519715 | 215 | F>I | No | EVA | |
| rs3539968023 | 243 | R>K | No | EVA | |
| rs3388518768 | 263 | M>I | No | EVA | |
| rs3388519676 | 268 | P>L | No | EVA | |
| rs3388519225 | 276 | I>N | No | EVA | |
| rs3388520191 | 303 | D>N | No | EVA | |
| rs3388519980 | 308 | E>G | No | EVA | |
| rs229861950 | 317 | V>I | No | EVA | |
| rs250442440 | 318 | G>D | No | EVA | |
| rs3388518843 | 327 | L>H | No | EVA | |
| rs244233232 | 332 | V>I | No | EVA | |
| rs3388514921 | 343 | P>L | No | EVA | |
| rs3388519629 | 345 | T>I | No | EVA | |
| rs3143423 | 366 | T>A | No | EVA | |
| rs237356043 | 392 | K>N | No | EVA | |
| rs3539980047 | 433 | Y>F | No | EVA | |
| rs3388518838 | 467 | H>Y | No | EVA | |
| rs3388520541 | 480 | K>I | No | EVA | |
| rs32545751 | 483 | T>S | No | EVA | |
| rs3388520174 | 493 | G>D | No | EVA | |
| rs3388518844 | 501 | R>G | No | EVA | |
| rs3391036449 | 511 | F>I | No | EVA | |
| rs32546567 | 521 | G>S | No | EVA | |
| rs3388519599 | 522 | Q>* | No | EVA | |
| rs237027442 | 536 | S>R | No | EVA | |
| rs245333345 | 541 | L>P | No | EVA | |
| rs3388520586 | 547 | E>K | No | EVA | |
| rs234516104 | 549 | H>Q | No | EVA | |
| rs3143431 | 557 | T>M | No | EVA | |
| rs237481650 | 560 | L>P | No | EVA | |
| rs223610105 | 596 | L>V | No | EVA | |
| rs3388518849 | 598 | S>R | No | EVA | |
| rs3412902104 | 599 | C>Y | No | EVA | |
| rs3388519704 | 618 | S>I | No | EVA | |
| rs3388519624 | 636 | E>V | No | EVA | |
| rs3148638 | 648 | K>Q | No | EVA | |
| rs3143432 | 652 | L>P | No | EVA | |
| rs3143432 | 652 | L>Q | No | EVA | |
| rs227470538 | 655 | T>K | No | EVA | |
| rs254025801 | 665 | S>P | No | EVA | |
| rs3143433 | 666 | S>L | No | EVA | |
| rs226047492 | 667 | R>G | No | EVA | |
| rs3388517025 | 671 | S>N | No | EVA | |
| rs245274003 | 675 | S>T | No | EVA | |
| rs215978864 | 677 | G>S | No | EVA | |
| rs254834997 | 692 | G>D | No | EVA | |
| rs266247176 | 738 | M>L | No | EVA | |
| rs3391074998 | 748 | P>T | No | EVA | |
| rs226254284 | 759 | K>M | No | EVA | |
| rs226254284 | 759 | K>R | No | EVA | |
| rs32548607 | 764 | M>L | No | EVA | |
| rs3388520575 | 785 | L>V | No | EVA | |
| rs3388519562 | 796 | E>K | No | EVA | |
| rs3388514519 | 797 | K>R | No | EVA | |
| rs3388519206 | 799 | P>L | No | EVA | |
| rs225128234 | 801 | C>W | No | EVA | |
| rs3388519689 | 808 | V>I | No | EVA | |
| rs3388518188 | 809 | K>* | No | EVA | |
| rs3388521762 | 834 | A>S | No | EVA |
No associated diseases with Q9QZ11
7 regional properties for Q9QZ11
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | XPG, N-terminal | 1 - 99 | IPR006085 |
| domain | XPG-I domain | 138 - 225 | IPR006086 |
| conserved_site | Helix-hairpin-helix motif, class 2 | 212 - 245 | IPR008918 |
| conserved_site | XPG conserved site | 71 - 85 | IPR019974-1 |
| conserved_site | XPG conserved site | 141 - 155 | IPR019974-2 |
| domain | Exonuclease-1, H3TH domain | 213 - 289 | IPR037315 |
| domain | Exonuclease 1-like, PIN-like domain | 1 - 201 | IPR044752 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.-.- | Acting on ester bonds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nuclear body | Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
9 GO annotations of molecular function
| Name | Definition |
|---|---|
| 5'-3' DNA exonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule. |
| 5'-3' exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. |
| 5'-flap endonuclease activity | Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. |
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| double-stranded DNA 5'-3' DNA exonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule. |
| flap endonuclease activity | Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis. |
| metal ion binding | Binding to a metal ion. |
| single-stranded DNA 5'-3' DNA exonuclease activity | Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA double-strand break processing | The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang. |
| DNA recombination | Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. |
| humoral immune response mediated by circulating immunoglobulin | An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus. |
| isotype switching | The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. |
| meiotic cell cycle | Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. |
| mismatch repair | A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. |
| nucleobase-containing compound metabolic process | Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. |
| somatic hypermutation of immunoglobulin genes | Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGIQGLLQFI | QEASEPVNVK | KYKGQAVAVD | TYCWLHKGAI | ACAEKLAKGE | PTDRYVGFCM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KFVNMLLSYG | VKPILIFDGC | TLPSKKEVER | SRRERRQSNL | LKGKQLLREG | KVSEARDCFA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RSINITHAMA | HKVIKAARAL | GVDCLVAPYE | ADAQLAYLNK | AGIVQAVITE | DSDLLAFGCK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KVILKMDQFG | NGLEVDQARL | GMCKQLGDVF | TEEKFRYMCI | LSGCDYLASL | RGIGLAKACK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VLRLANNPDI | VKVIKKIGHY | LRMNITVPED | YITGFIRANN | TFLYQLVFDP | IQRKLVPLNA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YGDDVNPETL | TYAGQYVGDS | VALQIALGNR | DVNTFEQIDD | YSPDTMPAHS | RSHSWNEKAG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QKPPGTNSIW | HKNYCPRLEV | NSVSHAPQLK | EKPSTLGLKQ | VISTKGLNLP | RKSCVLKRPR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NEALAEDDLL | SQYSSVSKKI | KENGCGDGTS | PNSSKMSKSC | PDSGTAHKTD | AHTPSKMRNK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FATFLQRRNE | ESGAVVVPGT | RSRFFCSSQD | FDNFIPKKES | GQPLNETVAT | GKATTSLLGA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LDCPDTEGHK | PVDANGTHNL | SSQIPGNAAV | SPEDEAQSSE | TSKLLGAMSP | PSLGTLRSCF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SWSGTLREFS | RTPSPSASTT | LQQFRRKSDP | PACLPEASAV | VTDRCDSKSE | MLGETSQPLH |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ELGCSSRSQE | SMDSSCGLNT | SSLSQPSSRD | SGSEESDCNN | KSLDNQGEQN | SKQHLPHFSK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KDGLRRNKVP | GLCRSSSMDS | FSTTKIKPLV | PARVSGLSKK | SGSMQTRKHH | DVENKPGLQT |
| 790 | 800 | 810 | 820 | 830 | |
| KISELWKNFG | FKKDSEKLPS | CKKPLSPVKD | NIQLTPETED | EIFNKPECVR | AQRAIFH |