Q9QYJ6
PR
Gene name |
Pde10a |
Protein name |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
Names |
|
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:63885 |
EC number |
3.1.4.17: Phosphoric diester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
13 structures for Q9QYJ6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2O8H | X-ray | 180 A | A | 452-794 | PDB |
| 2OVV | X-ray | 200 A | A | 452-794 | PDB |
| 2OVY | X-ray | 180 A | A | 452-794 | PDB |
| 3HQW | X-ray | 170 A | A | 452-794 | PDB |
| 3HQY | X-ray | 200 A | A | 452-794 | PDB |
| 3HQZ | X-ray | 170 A | A | 452-794 | PDB |
| 3HR1 | X-ray | 153 A | A | 452-794 | PDB |
| 3LXG | X-ray | 230 A | A | 463-770 | PDB |
| 3QPN | X-ray | 200 A | A | 452-794 | PDB |
| 3QPO | X-ray | 180 A | A | 452-794 | PDB |
| 3QPP | X-ray | 180 A | A | 452-794 | PDB |
| 6K9U | X-ray | 235 A | A | 463-770 | PDB |
| AF-Q9QYJ6-F1 | Predicted | AlphaFoldDB |
No variants for Q9QYJ6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9QYJ6 | |||||
No associated diseases with Q9QYJ6
5 regional properties for Q9QYJ6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 452 - 769 | IPR002073 |
| domain | GAF domain | 101 - 254 | IPR003018-1 |
| domain | GAF domain | 276 - 432 | IPR003018-2 |
| domain | HD/PDEase domain | 522 - 697 | IPR003607 |
| conserved_site | 3'5'-cyclic nucleotide phosphodiesterase, conserved site | 563 - 574 | IPR023174 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.4.17 | Phosphoric diester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| perikaryon | The portion of the cell soma (neuronal cell body) that excludes the nucleus. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3',5'-cyclic-AMP phosphodiesterase activity | Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+. |
| 3',5'-cyclic-GMP phosphodiesterase activity | Catalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+. |
| 3',5'-cyclic-nucleotide phosphodiesterase activity | Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate. |
| cAMP binding | Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). |
| cGMP binding | Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). |
| cGMP-stimulated cyclic-nucleotide phosphodiesterase activity | Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP. |
| cyclic-nucleotide phosphodiesterase activity | Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. |
| metal ion binding | Binding to a metal ion. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cAMP catabolic process | The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). |
| cGMP catabolic process | The chemical reactions and pathways resulting in the breakdown of cyclic GMP, guanosine 3',5'-phosphate. |
| negative regulation of cAMP-mediated signaling | Any process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling. |
| negative regulation of cGMP-mediated signaling | Any process that decreases the rate, frequency or extent of cGMP-mediated signaling. |
| regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway | Any process that modulates the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway. |
| regulation of protein kinase A signaling | Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
32 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q28156 | PDE5A | cGMP-specific 3',5'-cyclic phosphodiesterase | Bos taurus (Bovine) | SS |
| P23439 | PDE6B | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta | Bos taurus (Bovine) | PR |
| P52731 | PDE6C | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' | Gallus gallus (Chicken) | PR |
| H2QL32 | PDE9A | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | Pan troglodytes (Chimpanzee) | PR |
| Q9VJ79 | Pde11 | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 | Drosophila melanogaster (Fruit fly) | SS |
| Q9W4T4 | dnc | 3',5'-cyclic-AMP phosphodiesterase, isoform I | Drosophila melanogaster (Fruit fly) | SS |
| Q9HCR9 | PDE11A | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | Homo sapiens (Human) | SS |
| O76083 | PDE9A | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | Homo sapiens (Human) | PR |
| Q07343 | PDE4B | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (Human) | EV SS |
| Q08499 | PDE4D | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (Human) | EV |
| O76074 | PDE5A | cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (Human) | EV |
| Q08493 | PDE4C | cAMP-specific 3',5'-cyclic phosphodiesterase 4C | Homo sapiens (Human) | EV SS |
| P51160 | PDE6C | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' | Homo sapiens (Human) | PR |
| P27815 | PDE4A | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Homo sapiens (Human) | EV SS |
| P35913 | PDE6B | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta | Homo sapiens (Human) | PR |
| Q9Y233 | PDE10A | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | Homo sapiens (Human) | PR |
| P23440 | Pde6b | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta | Mus musculus (Mouse) | PR |
| O89084 | Pde4a | 3',5'-cyclic-AMP phosphodiesterase 4A | Mus musculus (Mouse) | SS |
| O70628 | Pde9a | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | Mus musculus (Mouse) | PR |
| Q8CG03 | Pde5a | cGMP-specific 3',5'-cyclic phosphodiesterase | Mus musculus (Mouse) | SS |
| P0C1Q2 | Pde11a | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | Mus musculus (Mouse) | SS |
| Q3UEI1 | Pde4c | cAMP-specific 3',5'-cyclic phosphodiesterase 4C | Mus musculus (Mouse) | PR |
| Q01063 | Pde4d | 3',5'-cyclic-AMP phosphodiesterase 4D | Mus musculus (Mouse) | SS |
| Q8CA95 | Pde10a | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | Mus musculus (Mouse) | PR |
| P54748 | Pde4a | 3',5'-cyclic-AMP phosphodiesterase 4A | Rattus norvegicus (Rat) | SS |
| P14646 | Pde4b | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Rattus norvegicus (Rat) | SS |
| P14270 | Pde4d | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Rattus norvegicus (Rat) | PR |
| Q8QZV1 | Pde9a | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | Rattus norvegicus (Rat) | PR |
| Q8VID6 | Pde11a | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | Rattus norvegicus (Rat) | SS |
| O54735 | Pde5a | cGMP-specific 3',5'-cyclic phosphodiesterase | Rattus norvegicus (Rat) | SS |
| P14644 | Pde4c | cAMP-specific 3',5'-cyclic phosphodiesterase 4C | Rattus norvegicus (Rat) | PR |
| Q22000 | pde-4 | Probable 3',5'-cyclic phosphodiesterase pde-4 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEDGPSNNAS | CFRRLTECFL | SPSLTDEKVK | AYLSLHPQVL | DEFVSESVSA | ETVEKWLKRK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NNKAEDEPSP | KEVSRYQDTN | MQGVVYELNS | YIEQRLDTGG | DNHLLLYELS | SIIRIATKAD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GFALYFLGEC | NNSLCVFTPP | GMKEGQPRLI | PAGPITQGTT | ISAYVAKSRK | TLLVEDILGD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ERFPRGTGLE | SGTRIQSVLC | LPIVTAIGDL | IGILELYRHW | GKEAFCLSHQ | EVATANLAWA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SVAIHQVQVC | RGLAKQTELN | DFLLDVSKTY | FDNIVAIDSL | LEHIMIYAKN | LVNADRCALF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QVDHKNKELY | SDLFDIGEEK | EGKPVFKKTK | EIRFSIEKGI | AGQVARTGEV | LNIPDAYADP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RFNREVDLYT | GYTTRNILCM | PIVSRGSVIG | VVQMVNKISG | SAFSKTDENN | FKMFAVFCAL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ALHCANMYHR | IRHSECIYRV | TMEKLSYHSI | CTSEEWQGLM | HFNLPARICR | DIELFHFDIG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PFENMWPGIF | VYMIHRSCGT | SCFELEKLCR | FIMSVKKNYR | RVPYHNWKHA | VTVAHCMYAI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LQNNNGLFTD | LERKGLLIAC | LCHDLDHRGF | SNSYLQKFDH | PLAALYSTST | MEQHHFSQTV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SILQLEGHNI | FSTLSSSEYE | QVLEIIRKAI | IATDLALYFG | NRKQLEEMYQ | TGSLNLHNQS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| HRDRVIGLMM | TACDLCSVTK | LWPVTKLTAN | DIYAEFWAEG | DEMKKLGIQP | IPMMDRDKRD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EVPQGQLGFY | NAVAIPCYTT | LTQILPPTEP | LLKACRDNLN | QWEKVIRGEE | TAMWISGPAT |
| 790 | |||||
| SKSTSEKPTR | KVDD |