Q9QYF3
SS
Gene name |
Myo5a |
Protein name |
Unconventional myosin-Va |
Names |
Dilute myosin heavy chain, non-muscle |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:25017 |
EC number |
|
Protein Class |
|
Descriptions
Myosin Va (MyoVa) is a protein that functions as a dimer for processive walking on actin filaments. Autoinhibition of MyoVa involves the motor domain (MD) and the globular tail domain (GTD), with the motor adopting a closed, autoinhibited state that is inactive for ATPase activity. This state prevents the unnecessary consumption of ATP and uncontrolled movement when not transporting cargo. MyoVa exists in several states, including closed, half-closed, transition, and open states. The closed state of MyoVa can be changed to a half-closed state when the d-strand temporarily dissociates from the GTD, resulting in the dynamic confirmation of the short side in the triangular-shaped structure, which is called the closed state. In the presence of both a GTBM-containing protein and Rab11a, the half-closed conformation undergoes a significant motion of both the MD and the lever arm (LA), resulting in the disassembly of the hinge structure, which is referred to as a transition state. Finally, the unstable transition conformation quickly shifts to the open conformation, allowing the GTPs to tightly associate with cargo and the MDs to hydrolyze ATP for the walking process. Notably, a single cargo binding of either a GTBM-binding protein or Rab11a is insufficient to effectively activate MyoVa.
Autoinhibitory domains (AIDs)
Target domain |
1419-1803 (Globular tail domain, GTD) |
Relief mechanism |
Ligand binding, Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9QYF3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9QYF3-F1 | Predicted | AlphaFoldDB |
No variants for Q9QYF3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9QYF3 | |||||
1 associated diseases with Q9QYF3
Without disease ID
11 regional properties for Q9QYF3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| binding_site | IQ motif, EF-hand binding site | 765 - 787 | IPR000048-1 |
| binding_site | IQ motif, EF-hand binding site | 788 - 810 | IPR000048-2 |
| binding_site | IQ motif, EF-hand binding site | 813 - 835 | IPR000048-3 |
| binding_site | IQ motif, EF-hand binding site | 836 - 858 | IPR000048-4 |
| binding_site | IQ motif, EF-hand binding site | 861 - 883 | IPR000048-5 |
| binding_site | IQ motif, EF-hand binding site | 884 - 906 | IPR000048-6 |
| domain | Myosin head, motor domain | 63 - 764 | IPR001609 |
| domain | Dilute domain | 1507 - 1783 | IPR002710 |
| domain | Myosin, N-terminal, SH3-like | 8 - 60 | IPR004009 |
| domain | Class V myosin, motor domain | 83 - 751 | IPR036103 |
| domain | Myosin 5a, cargo-binding domain | 1454 - 1828 | IPR037988 |
28 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| actomyosin | Any complex of actin, myosin, and accessory proteins. |
| actomyosin, myosin complex part | The myosin part of any complex of actin, myosin, and accessory proteins. |
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| filopodium tip | The end of a filopodium distal to the body of the cell. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| insulin-responsive compartment | A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2. |
| intermediate filament | A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes |
| melanosome | A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. |
| myosin complex | A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| photoreceptor outer segment | The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins. |
| postsynapse | The part of a synapse that is part of the post-synaptic cell. |
| postsynaptic actin cytoskeleton | The actin cytoskeleton that is part of a postsynapse. |
| recycling endosome | An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. |
| ribonucleoprotein complex | A macromolecular complex that contains both RNA and protein molecules. |
| ruffle | Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. |
| Schaffer collateral - CA1 synapse | A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell. |
| secretory granule | A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. |
| smooth endoplasmic reticulum | The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER. |
| synaptic vesicle | A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. |
| unconventional myosin complex | A portmanteau term for myosins other than myosin II. |
| vesicle | Any small, fluid-filled, spherical organelle enclosed by membrane. |
16 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP-dependent protein binding | Binding to a protein or protein complex using energy from ATP hydrolysis. |
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| calcium-dependent protein binding | Binding to a protein or protein complex in the presence of calcium. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| cytoskeletal motor activity | Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force). |
| disordered domain specific binding | Binding to a disordered domain of a protein. |
| identical protein binding | Binding to an identical protein or proteins. |
| microfilament motor activity | A motor activity that generates movement along a microfilament, driven by ATP hydrolysis. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| protein-containing complex binding | Binding to a macromolecular complex. |
| small GTPase binding | Binding to a small monomeric GTPase. |
| SNARE binding | Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. |
| syntaxin-1 binding | Binding to a syntaxin-1 SNAP receptor. |
40 GO annotations of biological process
| Name | Definition |
|---|---|
| actin filament organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. |
| actin filament-based movement | Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. |
| axo-dendritic protein transport | The directed movement of proteins along microtubules in neuron projections. |
| cellular response to insulin stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. |
| chemical synaptic transmission | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
| developmental pigmentation | The developmental process that results in the deposition of coloring matter in an organism, tissue or cell. |
| dopamine metabolic process | The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. |
| endoplasmic reticulum localization | Any process in which endoplasmic reticulum is transported to, and/or maintained in, a specific location within the cell. |
| establishment of endoplasmic reticulum localization to postsynapse | The directed movement of endoplasmic reticulum into a postsynaptic compartment such as a dendritic spine. |
| exocytosis | A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. |
| hair follicle maturation | A developmental process, independent of morphogenetic (shape) change, that is required for a hair follicle to attain its fully functional state. |
| insulin secretion | The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects. |
| locomotion involved in locomotory behavior | Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. |
| long-chain fatty acid biosynthetic process | The chemical reactions and pathways resulting in the formation of a long-chain fatty acid, a fatty acid with an aliphatic tail of 13 to 21 carbons. |
| macroautophagy | The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded. |
| melanin biosynthetic process | The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups |
| melanin metabolic process | The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups |
| melanocyte differentiation | The process in which a relatively unspecialized cell acquires specialized features of a melanocyte. |
| melanosome localization | Any process in which a melanosome is transported to, and/or maintained in, a specific location within the cell. |
| melanosome transport | The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| myelination | The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. |
| negative regulation of dopamine secretion | Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of dopamine. |
| negative regulation of synaptic transmission, glutamatergic | Any process that stops, prevents, or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. |
| neuromuscular process controlling balance | Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors. |
| odontogenesis | The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food. |
| pigmentation | The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells. |
| positive regulation of cellular response to insulin stimulus | Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus. |
| positive regulation of protein localization to plasma membrane | Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. |
| positive regulation of vascular associated smooth muscle cell migration | Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration. |
| post-Golgi vesicle-mediated transport | The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles. |
| protein localization to plasma membrane | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. |
| protein-containing complex assembly | The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. |
| reactive gliosis | A neuroinflammatory response, occurring over several days, during which glial cells undergo nonspecific reactive changes in response to damage to the central nervous system (CNS); typically involves the proliferation or hypertrophy of different types of glial cells. |
| regulation of exocytosis | Any process that modulates the frequency, rate or extent of exocytosis. |
| regulation of postsynaptic cytosolic calcium ion concentration | Any process that regulates the concentration of calcium in the postsynaptic cytosol. |
| secretory granule localization | Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell. |
| synapse organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). |
| vesicle transport along actin filament | Movement of a vesicle along an actin filament, mediated by motor proteins. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
| visual perception | The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q02440 | MYO5A | Unconventional myosin-Va | Gallus gallus (Chicken) | SS |
| Q9Y4I1 | MYO5A | Unconventional myosin-Va | Homo sapiens (Human) | SS |
| Q99104 | Myo5a | Unconventional myosin-Va | Mus musculus (Mouse) | EV |
| P70569 | Myo5b | Unconventional myosin-Vb | Rattus norvegicus (Rat) | SS |
| Q9M2K0 | XI-J | Myosin-16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAASELYTKF | ARVWIPDPEE | VWKSAELLKD | YKPGDKVLLL | HLEEGKDLEY | RLDPKTSELP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HLRNPDILVG | ENDLTALSYL | HEPAVLHNLR | VRFIDSKLIY | TYCGIVLVAI | NPYEQLPIYG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EDIINAYSGQ | NMGDMDPHIF | AVAEEAYKQM | ARDERNQSII | VSGESGAGKT | VSAKYAMRYF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ATVSGSASEA | NVEEKVLASN | PIMESIGNAK | TTRNDNSSRF | GKYIEIGFDK | RYRIIGANMR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TYLLEKSRVV | FQAEEERNYH | IFYQLCASAK | LPEFKMLRLG | NADSFHYTKQ | GGSPMIEGVD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DAKEMAHTRQ | ACTLLGISES | YQMGIFRILA | GILHLGNVGF | ASRDSDSCTI | PPKHEPLIIF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| CDLMGVDYEE | MCHWLCHRKL | ATATETYIKP | ISKLQATNAR | DALAKHIYAK | LFNWIVGHVN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QALHSAVKQH | SFIGVLDIYG | FETFEINSFE | QFCINYANEK | LQQQFNMHVF | KLEQEEYMKE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QIPWTLIDFY | DNQPCINLIE | SKLGILDLLD | EECKMPKGTD | DTWAQKLYNT | HLNKCALFEK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PRMSNKAFII | KHFADKVEYQ | CEGFLEKNKD | TVFEEQIKVL | KSSKFKMLPE | LFQDDEKAIS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PTSATSSGRT | PLTRVPVKPT | KGRPGQTAKE | HKKTVGLQFR | NSLHLLMETL | NATTPHYVRC |
| 670 | 680 | 690 | 700 | 710 | 720 |
| IKPNDFKFPF | TFDEKRAVQQ | LRACGVLETI | RISAAGFPSR | WTYQEFFSRY | RVLMKQKDVL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GDRKQTCQNV | LEKLILDKDK | YQFGKTKIFF | RAGQVAYLEK | LRADKLRAAC | IRIQKTIRGW |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LLRKRYLCMQ | RAAITVQRYV | RGYQARCYAK | FLRRTKAATT | IQKYWRMYVV | RRKYKIRRAA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TIVLQSYLRG | YLARNRYRKI | LREHKAVIIQ | KRVRGWLART | HYKRTMKAII | YLQCCFRRMM |
| 910 | 920 | 930 | 940 | 950 | 960 |
| AKRELKKLKI | EARSVERYKK | LHIGMENKIM | QLQRKVDEQN | KDYKCLMEKL | TNLEGVYNSE |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| TEKLRNDVER | LQLSEEEAKV | ATGRVLSLQE | EIAKLRKDLE | QTRSEKKSIE | ERADKYKQET |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| EQLVSNLKEE | NTLLKQEKET | LNHLMVEQAK | EMTETMERKL | VEETKQLELD | LNDERLRYQN |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| LLNEFSRLEE | RYDDLKEEMT | LMLNVPKPGH | KRTDSTHSSN | ESEYTFSSEF | AETEDIAPRT |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| EEPTEKKVPL | DMSLFLKLQK | RVTELGQEKQ | LMQDELDRKE | EQVLRSKAKG | GERPQIRGAE |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| LGYESLKRQE | LESENKKLKN | ELNELRKALS | EKSAPEVNAP | GAPAYRVLME | QLTAVSEELD |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| VRKEEVLILR | SQLVSQKEAI | QPKDDKNTMT | DSTILLEDVQ | KMKDKGEIAQ | AYIGLKETNR |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| LLESQLQSQK | RSHENEAEAL | RGEIQSLKEE | NNRQQQLLAQ | NLQLPPEARI | EASLQHEITR |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| LTNENLDLME | QLEKQDKTVR | KLKKQLKVFA | KKIGELEVGQ | MENISPGQII | DEPIRPVNIP |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| RKGKDFQGML | EYKREDEQKL | VKNLILELKP | RGVAVNLISG | LPAYILFMCV | RHADYLDDDQ |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| KVRSLLTSTI | NSIKKVLKKR | GDDFETVSFW | LSNTCRFLHC | LKQYSGEEGF | MKHNTSRQNE |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| HCLTNFDLAE | YRQVLSDLAI | QIYQQLVRVL | ENILQPMIVS | GMLEHETIQG | VSGVKPTGLR |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| KRTSSIADEG | TYTLDSILRQ | LNSFHSVMCQ | HGMDPELIKQ | VVKQMFYIVG | AITLNNLLLR |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| KDMCSWSKGM | QIRYNVSQLE | EWLRDKNLMN | SGAKETLEPL | IQAAQLLQVK | KKTDDDAEAI |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| CSMCNALTTA | QIVKVLNLYT | PVNEFEERVS | VSFIRTIQVR | LRDRKDSPQL | LMDAKHIFPV |
| 1810 | 1820 | ||||
| TFPFNPSSLA | LETIQIPASL | GLGFIARV |