Q9QY40

SS
Gene name
Plxnb3 (Kiaa1206, Plxn6)
Protein name
Plexin-B3
Names
Plexin-6
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:140571
EC number
Protein Class

Descriptions

Plexins are a large family of cell surface receptors for the axon guidance molecules semaphorins. Semaphorin-plexin signaling is essential for the regulation of neuronal development and other processes. Dysfunction in plexin pathways has been implicated in various diseases including neurological disorders and cancer. <br> Plexins are transmembrane proteins with a multidomain extracellular region that contains an N-terminal Sema domain. Before semaphorin binding, Plexin is an inactive monomer or dimer in which the RapGAP activity is autoinhibited. Binding of semaphorin to the Sema domain of plexin leads to activation of its cytoplasmic region, which relays the signal to downstream pathways. Mouse Plexin-A3 (P70208) possesses a segment preceding C1 domain and RDB domain as autoinhibitory elements.

Autoinhibitory domains (AIDs)

10-461 (Sema domain) SS

Target domain

1317-1869 (Plexin, cytoplasmic RasGAP domain)

Relief mechanism

Partner binding

Assay

1491-1610 (RBD domain) SS

Target domain

1317-1869 (Plexin, cytoplasmic RasGAP domain)

Relief mechanism

Partner binding

Assay

1267-1347 (Segment preceding C1 domain) SS

Target domain

1317-1869 (Plexin, RasGAP domain)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9QY40

Entry ID Method Resolution Chain Position Source
AF-Q9QY40-F1 Predicted AlphaFoldDB

140 variants for Q9QY40

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3410563163 68 S>R No EVA
rs3408348956 69 P>A No EVA
rs3410821506 73 M>R No EVA
rs3389579802 103 T>S No EVA
rs3389567504 107 N>Y No EVA
rs3389543249 143 Y>F No EVA
rs3389575718 159 L>P No EVA
rs3389556436 179 A>T No EVA
rs3389567537 202 Q>E No EVA
rs3389543292 209 L>P No EVA
rs3410821567 228 F>I No EVA
rs3389556495 254 A>V No EVA
rs3389567572 262 N>S No EVA
rs3389519618 306 A>T No EVA
rs3389543265 328 G>S No EVA
rs3410298369 332 S>N No EVA
rs3389543300 343 V>A No EVA
rs3389559046 346 R>S No EVA
rs3389559021 374 P>L No EVA
rs3410929468 412 K>Q No EVA
rs3410821549 440 L>P No EVA
rs3389564646 452 T>I No EVA
rs3389543314 453 A>V No EVA
rs227919974 460 L>P No EVA
rs3411299312 487 Q>H No EVA
rs3410298381 487 Q>P No EVA
rs3409319750 488 G>* No EVA
rs3389543267 496 C>Y No EVA
rs3389512157 538 P>T No EVA
rs228027325 542 T>A No EVA
rs228027325 542 T>P No EVA
rs3409408797 551 C>Y No EVA
rs31669926 555 G>D No EVA
rs3389543262 611 S>R No EVA
rs214742252 624 A>T No EVA
rs3389572603 627 S>G No EVA
rs3389579732 644 G>R No EVA
rs3389557072 649 E>* No EVA
rs3389557072 649 E>K No EVA
rs3389563303 670 C>R No EVA
rs3554569580 672 Q>P No EVA
rs225882244 708 H>Y No EVA
rs3389558870 723 S>F No EVA
rs3389512099 752 V>M No EVA
rs3410929407 753 P>A No EVA
rs3410718076 763 R>G No EVA
rs3389543245 769 D>V No EVA
rs3410821545 790 A>P No EVA
rs3410718093 791 N>I No EVA
rs3409866772 793 S>R No EVA
rs3409319762 818 E>A No EVA
rs3409866793 818 E>Q No EVA
rs3389563270 835 P>S No EVA
rs3389557081 841 A>T No EVA
rs3389557122 845 L>M No EVA
rs240548034 845 L>Q No EVA
rs3389567536 859 A>V No EVA
rs3410821986 863 A>V No EVA
rs3389520901 870 D>G No EVA
rs3408348979 870 D>N No EVA
rs3389572566 872 S>P No EVA
rs3389575634 873 L>H No EVA
rs3389512094 875 R>L No EVA
rs3389564131 877 S>T No EVA
rs3389575708 880 I>T No EVA
rs3389579814 926 G>C No EVA
rs3389579811 928 Q>L No EVA
rs3389471560 929 A>P No EVA
rs3389556464 942 Q>H No EVA
rs3389471590 952 G>S No EVA
rs3389564048 968 I>K No EVA
rs3389471625 971 T>I No EVA
rs3389560593 980 A>T No EVA
rs3389575669 981 V>E No EVA
rs3389575689 1016 R>L No EVA
rs3411040531 1024 V>G No EVA
rs3389560601 1031 V>I No EVA
rs3389543276 1033 W>* No EVA
rs3389563322 1039 V>M No EVA
rs237395328 1057 A>V No EVA
rs3408349005 1093 S>C No EVA
rs3389564690 1093 S>I No EVA
rs3389531263 1101 A>T No EVA
rs3389471554 1104 D>E No EVA
rs3389567573 1181 D>E No EVA
rs3389567569 1206 T>I No EVA
rs3389575699 1220 G>D No EVA
rs3389564125 1237 M>I No EVA
rs3410876123 1269 K>* No EVA
rs3410930764 1269 K>R No EVA
rs3389512134 1300 T>I No EVA
rs3410718114 1311 S>T No EVA
rs3411299258 1312 D>G No EVA
rs3409408880 1314 E>GHW* No EVA
rs3408349001 1331 F>L No EVA
rs3413018459 1334 G>A No EVA
rs227746725 1347 L>P No EVA
rs3389556476 1352 R>S No EVA
rs3389564667 1357 R>C No EVA
rs1131910601 1380 L>I No EVA
rs3410876084 1381 E>D No EVA
rs3410718117 1397 L>* No EVA
rs3408348999 1415 T>P No EVA
rs3410930751 1416 L>* No EVA
rs3389556480 1424 Y>H No EVA
rs3389567501 1428 N>K No EVA
rs29039894 1429 P>T No EVA
rs3409408831 1456 L>* No EVA
rs3410821953 1456 L>M No EVA
rs3410822003 1461 G>R No EVA
rs3408349014 1462 E>Q No EVA
rs3411299307 1482 A>T No EVA
rs3389575700 1497 L>I No EVA
rs3411040535 1514 P>S No EVA
rs3409866735 1515 E>G No EVA
rs260670695 1522 N>S No EVA
rs3389520906 1535 T>I No EVA
rs3389575668 1574 G>C No EVA
rs3389575674 1585 S>Y No EVA
rs3389520864 1609 V>A No EVA
rs3389564148 1612 P>L No EVA
rs3409408871 1623 S>T No EVA
rs3389557070 1666 S>I No EVA
rs3389579724 1678 A>S No EVA
rs3389563323 1729 A>V No EVA
rs3408349023 1745 T>S No EVA
rs3389575638 1768 V>M No EVA
rs3389564088 1769 S>L No EVA
rs3410877058 1772 E>K No EVA
rs3410674582 1773 D>G No EVA
rs3389556429 1787 C>Y No EVA
rs3411299241 1808 E>V No EVA
rs3409866745 1816 V>L No EVA
rs237072766 1818 K>M No EVA
rs3389520904 1821 A>E No EVA
rs3389563275 1829 A>V No EVA
rs3410563208 1830 S>C No EVA
rs3389520948 1844 N>S No EVA
rs3389575652 1851 C>S No EVA
rs3389579794 1901 D>E No EVA

No associated diseases with Q9QY40

17 regional properties for Q9QY40

Type Name Position InterPro Accession
domain Death domain 1393 - 1487 IPR000488
domain ZU5 domain 911 - 1068 IPR000906-1
domain ZU5 domain 1070 - 1216 IPR000906-2
repeat Ankyrin repeat 11 - 109 IPR002110-1
repeat Ankyrin repeat 110 - 171 IPR002110-2
repeat Ankyrin repeat 172 - 237 IPR002110-3
repeat Ankyrin repeat 238 - 270 IPR002110-4
repeat Ankyrin repeat 271 - 303 IPR002110-5
repeat Ankyrin repeat 301 - 369 IPR002110-6
repeat Ankyrin repeat 369 - 435 IPR002110-7
repeat Ankyrin repeat 436 - 501 IPR002110-8
repeat Ankyrin repeat 502 - 534 IPR002110-9
repeat Ankyrin repeat 532 - 597 IPR002110-10
repeat Ankyrin repeat 601 - 633 IPR002110-11
repeat Ankyrin repeat 634 - 732 IPR002110-12
repeat Ankyrin repeat 733 - 765 IPR002110-13
domain Ankyrin, UPA domain 1236 - 1364 IPR040745

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • Colocalizes with RIT2/RIN at the plasma membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cell surface The external part of the cell wall and/or plasma membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
semaphorin receptor complex A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.

4 GO annotations of molecular function

Name Definition
cell-cell adhesion mediator activity The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell.
protein domain specific binding Binding to a specific domain of a protein.
Rho GDP-dissociation inhibitor binding Binding to a Rho GDP-dissociation inhibitor protein.
semaphorin receptor activity Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

13 GO annotations of biological process

Name Definition
cell chemotaxis The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
homophilic cell adhesion via plasma membrane adhesion molecules The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
negative regulation of cell adhesion Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
negative regulation of cell migration Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
negative regulation of GTPase activity Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
negative regulation of lamellipodium assembly Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
positive chemotaxis The directed movement of a motile cell or organism towards a higher concentration of a chemical.
positive regulation of axonogenesis Any process that activates or increases the frequency, rate or extent of axonogenesis.
positive regulation of endothelial cell proliferation Any process that activates or increases the rate or extent of endothelial cell proliferation.
positive regulation of neuron projection development Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
regulation of cell shape Any process that modulates the surface configuration of a cell.
semaphorin-plexin signaling pathway The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.
semaphorin-plexin signaling pathway involved in axon guidance Any semaphorin-plexin signaling pathway that is involved in axon guidance.

27 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q769I5 MET Hepatocyte growth factor receptor Bos taurus (Bovine) PR
A0M8S8 MET Hepatocyte growth factor receptor Felis catus (Cat) (Felis silvestris catus) PR
Q04912 MST1R Macrophage-stimulating protein receptor Homo sapiens (Human) EV
P08581 MET Hepatocyte growth factor receptor Homo sapiens (Human) EV
O43157 PLXNB1 Plexin-B1 Homo sapiens (Human) EV SS
Q9HCM2 PLXNA4 Plexin-A4 Homo sapiens (Human) SS
O75051 PLXNA2 Plexin-A2 Homo sapiens (Human) SS
P51805 PLXNA3 Plexin-A3 Homo sapiens (Human) SS
Q9UIW2 PLXNA1 Plexin-A1 Homo sapiens (Human) EV SS
O15031 PLXNB2 Plexin-B2 Homo sapiens (Human) SS
Q9ULL4 PLXNB3 Plexin-B3 Homo sapiens (Human) SS
Q62190 Mst1r Macrophage-stimulating protein receptor Mus musculus (Mouse) SS
P16056 Met Hepatocyte growth factor receptor Mus musculus (Mouse) PR
B2RXS4 Plxnb2 Plexin-B2 Mus musculus (Mouse) SS
P70206 Plxna1 Plexin-A1 Mus musculus (Mouse) EV SS
P70207 Plxna2 Plexin-A2 Mus musculus (Mouse) SS
Q3UH93 Plxnd1 Plexin-D1 Mus musculus (Mouse) SS
Q80UG2 Plxna4 Plexin-A4 Mus musculus (Mouse) SS
Q8CJH3 Plxnb1 Plexin-B1 Mus musculus (Mouse) SS
Q9QZC2 Plxnc1 Plexin-C1 Mus musculus (Mouse) SS
P70208 Plxna3 Plexin-A3 Mus musculus (Mouse) EV SS
Q2QLE0 MET Hepatocyte growth factor receptor Sus scrofa (Pig) PR
P97523 Met Hepatocyte growth factor receptor Rattus norvegicus (Rat) PR
D3ZPX4 Plxna3 Plexin-A3 Rattus norvegicus (Rat) SS
D3ZLH5 Plxnb3 Plexin-B3 Rattus norvegicus (Rat) SS
Q6BEA0 plxna4 Plexin-A4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
B0S5N4 plxna3 Plexin A3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MLTDFLQAPV MAPWSPFSLH LLLLFLPLLP LTRVHRFSVP NTSFNHLVLA PDQGKLYVGA
70 80 90 100 110 120
VNHLFQLSPE LKMESVAVTG PVIDSPDCVP FRDLAECPQA QLTDNANQLL LVSSRTQELV
130 140 150 160 170 180
ACGQVKQGVC EKRRLGDVTQ VLYQAEDPGD GQFVAANTLG VTTVGLVVPL PGRDLLLVAR
190 200 210 220 230 240
GLAGKLSAGV PPLTVRQLAG PQPFSSEGLG RLVVGDFSDY NNSYVGAFSD AHSAYFVFRR
250 260 270 280 290 300
RGARAQTEYR SYVARVCLRD VNLYSYVEMP LTCHGQGLIQ AAFLTPDTLL GAFSAGTSQA
310 320 330 340 350 360
QAALCAFPLA DLDRSMEQAR RLCYTTGGQG PSGMEEATVE YGVTSRCVTL PPDSPESYPC
370 380 390 400 410 420
GDEHTPSPIA GRQPLEAQPL LQLGQSISAV AALQTDGHTI AFLGDTQGQL HKVFLNSSHG
430 440 450 460 470 480
QVYHSQQVGP PGSAISPDLL VDSNGDHLYV LTAQQVDRIL VAACPQFPNC TTCLQARDPL
490 500 510 520 530 540
CGWCILQGRC TRRGECGRAA QPNHWLWSYE DNHCPYIQSL LPAQHPRQEQ GQIILSVPRL
550 560 570 580 590 600
PTLAMDEYFH CAFGGYNSLA QVEEPHVVCT TPPQDQMPPN PPGSDHVTLP LALMFEDVVL
610 620 630 640 650 660
TATTFSFYDC SAVQALEVAA PCRACVSSLW RCHWCPQSSH CIYGEHCPEG EKAVYSAQEV
670 680 690 700 710 720
DILVRGPEAC PQVEGLASPQ LVPVGWESHV TLHIQNLHYF QGLPALYHCW LELPGKLQKL
730 740 750 760 770 780
PASLEETSRD SGLIHCQAQQ FYPSMSQWEL PVPIYVTRGE IQRLDNAGDL HVTLYDCAMG
790 800 810 820 830 840
HPDCSHCQAA NGSLSCLWCG DGQPACRYGP LCPPGAVEQL CPIPSIDVIE PLTGPPEGGL
850 860 870 880 890 900
AITILGSNLG QAFNDVRNAV TVAGQPCNPD PSLYRISARI VCVTSPAPNG TAGPVQVAIK
910 920 930 940 950 960
SRPPGISTQN FTYQDPVLLS LNPQWGPQAG GTQLTIHGQY LQTGGNISVF VGDQPCPIQE
970 980 990 1000 1010 1020
PVCPEAIICH TMPQTEPGEA VVLIVFGHVE RKLLTTPFRY TANPQLVEAE PSVSFRGGGR
1030 1040 1050 1060 1070 1080
VIRVRGTGLD VVWQPLLSVW LEDEPKVKAL GVQAQDANPR RSCGAPAADP QACIHLESGL
1090 1100 1110 1120 1130 1140
LQCSTLCSVN SSSLLLCHSP AVPDGALPKR VFFALDNMQV DFASASGGQG FLYQPNPRLA
1150 1160 1170 1180 1190 1200
PLSHEGITHP YHLKPGHVLD VEGEGLNLGI SKEEVQVHIG DGECLVKTLT LTHLYCEPPP
1210 1220 1230 1240 1250 1260
QAPQPTNGSG TLPQFVVQMG NLRLALGPVQ YEAESMMSTF PVEAQLGLGM GAAVLIAAVL
1270 1280 1290 1300 1310 1320
LLTLMYRHKS KKALRDYQKV LVQLENLETG VGDQCRKEFT DLMTEMTDLT SDLEASGIPF
1330 1340 1350 1360 1370 1380
LDYRTYAERA FFPGHVGCPL QPGLEGLGEE GRSVTVRQGL TQLSNLLNSK LFLLTLIHTL
1390 1400 1410 1420 1430 1440
EEQPSFSQRD RCHVASLLSL ALHSKLEYLT DIMRTLLGDL AAHYVHKNPK LMLRRTETMV
1450 1460 1470 1480 1490 1500
EKLLTNWLSI CLYTFLKEVA GEPLYMLFRA IKYQVDKGPV DAVTGKAKRT LNDSHLLRED
1510 1520 1530 1540 1550 1560
VEFQPLTLMA LVGPEADRAA GNSGVHRVPA RVLDTDTITQ VKEKVLDQIY KGTPFSQRPS
1570 1580 1590 1600 1610 1620
VHSLDLEWRS GLAGHLTLSD EDLTSVTQNH WKRLNTLQHY KVPDGATVVL IPQVHNGGTV
1630 1640 1650 1660 1670 1680
SQSLGQTGCP SGENTPMLED GEEGGVRLWH LVKATEEAEG AKVRRSSLRD RERERSRAKA
1690 1700 1710 1720 1730 1740
IPEIYLTRLL SMKGTLQKFV DDTFQAILSM NRPVPIAVKY LFDFLDELAE KHGIEDPETL
1750 1760 1770 1780 1790 1800
HIWKTNSLLL RFWVNVLKNP QLIFDVQVSD NEDAILAVIA QTFIDSCMVS EHKVGRDSPV
1810 1820 1830 1840 1850 1860
NKLLYAREIP RYKQMVEKYY ADIRQSSPAS YQEMNSALAE LSGNYSSAPH CLEALRELYN
1870 1880 1890 1900
HIHRYYDQII SALEEDPVAQ KMQLACRLQQ VAALVEYKVT DL