AiPD: Autoinhibited Protein Database

Gene name	Ddx25 (Grth)
Protein name	ATP-dependent RNA helicase DDX25
Names	DEAD box protein 25, Gonadotropin-regulated testicular RNA helicase
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:30959
EC number	3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

4-122 (Predicted disordered autoinhibitory region) PR

4-122 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9QY15-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389012698	34	G>D	No	EVA
rs3389032369	41	P>A	No	EVA
rs3400082837	104	R>YSQP*	No	EVA
rs3389035903	106	K>*	No	EVA
rs3389035930	108	E>Q	No	EVA
rs3389034688	176	P>R	No	EVA
rs3389032505	186	R>H	No	EVA
rs3388982499	215	V>F	No	EVA
rs3389032553	218	Q>K	No	EVA
rs3389040869	219	I>T	No	EVA
rs3389034672	252	V>L	No	EVA
rs3389038365	353	K>*	No	EVA
rs3389033445	354	W>*	No	EVA
rs3389032336	356	T>S	No	EVA
rs3413085439	357	V>*	No	EVA
rs3389032541	375	V>E	No	EVA
rs3389008579	398	V>D	No	EVA
rs3400082825	406	K>*	No	EVA
rs3389026087	442	K>R	No	EVA
rs3388982533	451	V>M	No	EVA

Type	Name	Position	InterPro Accession
domain	Helicase, C-terminal	312 - 479	IPR001650
domain	DEAD/DEAH box helicase domain	123 - 287	IPR011545
domain	Helicase superfamily 1/2, ATP-binding domain	117 - 316	IPR014001
domain	RNA helicase, DEAD-box type, Q motif	98 - 126	IPR014014

		Description
EC Number	3.6.4.13	Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization	Cytoplasm Nucleus	Detected in both cytoplasm and nucleus of testicular cells Also detected in chromatoid bodies of round spermatids
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
chromatoid body	A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182).
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic stress granule	A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding	Binding to an RNA molecule or a portion thereof.
RNA helicase activity	Unwinding of an RNA helix, driven by ATP hydrolysis.

Name	Definition
mRNA export from nucleus	The directed movement of mRNA from the nucleus to the cytoplasm.
poly(A)+ mRNA export from nucleus	The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm.
regulation of translation	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
spermatid development	The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2TBP1	DDX25	ATP-dependent RNA helicase DDX25	Bos taurus (Bovine)	PR
Q3ZBV2	DDX19A	ATP-dependent RNA helicase DDX19A	Bos taurus (Bovine)	SS
Q9NUU7	DDX19A	ATP-dependent RNA helicase DDX19A	Homo sapiens (Human)	PR
Q9UMR2	DDX19B	ATP-dependent RNA helicase DDX19B	Homo sapiens (Human)	PR
Q9UHL0	DDX25	ATP-dependent RNA helicase DDX25	Homo sapiens (Human)	PR
Q91VC3	Eif4a3	Eukaryotic initiation factor 4A-III	Mus musculus (Mouse)	PR
Q61496	Ddx4	ATP-dependent RNA helicase DDX4	Mus musculus (Mouse)	SS
Q62095	Ddx3y	ATP-dependent RNA helicase DDX3Y	Mus musculus (Mouse)	SS
P16381	D1Pas1	Putative ATP-dependent RNA helicase Pl10	Mus musculus (Mouse)	SS
Q62167	Ddx3x	ATP-dependent RNA helicase DDX3X	Mus musculus (Mouse)	SS
Q61655	Ddx19a	ATP-dependent RNA helicase DDX19A	Mus musculus (Mouse)	SS
Q501J6	Ddx17	Probable ATP-dependent RNA helicase DDX17	Mus musculus (Mouse)	PR
Q8VDW0	Ddx39a	ATP-dependent RNA helicase DDX39A	Mus musculus (Mouse)	PR
Q9Z1N5	Ddx39b	Spliceosome RNA helicase Ddx39b	Mus musculus (Mouse)	PR
Q91VN6	Ddx41	Probable ATP-dependent RNA helicase DDX41	Mus musculus (Mouse)	PR
Q99MJ9	Ddx50	ATP-dependent RNA helicase DDX50	Mus musculus (Mouse)	PR
Q61656	Ddx5	Probable ATP-dependent RNA helicase DDX5	Mus musculus (Mouse)	PR
Q10RI7	Os03g0158200	DEAD-box ATP-dependent RNA helicase 38	Oryza sativa subsp japonica (Rice)	PR
Q93ZG7	RH38	DEAD-box ATP-dependent RNA helicase 38	Arabidopsis thaliana (Mouse-ear cress)	PR