Q9QXL2

EV SS
Gene name
Kif21a (Kiaa1708)
Protein name
Kinesin-like protein KIF21A
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:16564
EC number
Protein Class
CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED (PTHR47969)

Descriptions

Kinesin-like protein KIF21A is microtubule-binding motor protein involved in neuronal axonal transport. Kif21a adopts an autoinhibited state through the direct interaction of its motor and 3rd coiled-coil stalk domain. Kif21a mutations activate the motor protein, increasing transport activity, which contradicts typical autoinhibition observed in other proteins where mutations usually result in loss of function.

Autoinhibitory domains (AIDs)

1055-1085 (3rd coiled-coil stalk domain) EV

Target domain

9-371 (Motor domain)

Relief mechanism

Others

Assay

Structural analysis, Deletion assay, Mutagenesis experiment

940-1025 (Coiled coil region) SS

Target domain

7-379 (Kinesin motor domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q9QXL2

Entry ID Method Resolution Chain Position Source
5YAY X-ray 155 A B 1142-1169 PDB
5YBE X-ray 211 A B 1151-1169 PDB
AF-Q9QXL2-F1 Predicted AlphaFoldDB

63 variants for Q9QXL2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389362977 34 V>G No EVA
rs3406787573 56 D>Y No EVA
rs3405604893 57 I>* No EVA
rs3405539505 57 I>N No EVA
rs3406143170 59 S>Y No EVA
rs3405605011 60 Q>H No EVA
rs3389362940 119 R>K No EVA
rs3389383240 172 K>N No EVA
rs3389300601 174 N>K No EVA
rs3389381625 193 R>G No EVA
rs3389376780 230 F>V No EVA
rs3389362898 239 V>M No EVA
rs219840404 247 N>K No EVA
rs31998945 261 N>K No EVA
rs3389382246 275 L>P No EVA
rs3389381638 278 S>P No EVA
rs3389398412 289 E>D No EVA
rs3389334264 340 S>R No EVA
rs50037350 376 M>V No EVA
rs3405895985 476 S>C No EVA
rs3406615174 511 T>M No EVA
rs3389300640 523 F>L No EVA
rs3389383228 534 T>N No EVA
rs3389352802 608 S>N No EVA
rs3389389305 652 I>V No EVA
rs3389376725 806 K>M No EVA
rs3389346454 823 V>E No EVA
rs3406615197 828 K>R No EVA
rs3389398434 832 V>F No EVA
rs1134651280 850 V>I No EVA
rs31998442 875 T>A No EVA
rs245478117 908 R>K No EVA
rs235088058 910 G>R No EVA
rs31998435 911 F>L No EVA
rs1133011829 914 R>G No EVA
rs3389376718 924 K>R No EVA
rs3413074261 935 I>L No EVA
rs3389398380 958 E>G No EVA
rs31997551 988 I>S No EVA
rs3389387245 990 E>D No EVA
rs3389300592 1007 D>N No EVA
rs3389378797 1081 Q>E No EVA
rs238333745 1113 A>T No EVA
rs259883128 1149 V>M No EVA
rs3389373121 1170 S>R No EVA
rs263837344 1182 A>T No EVA
rs31991348 1185 S>P No EVA
rs31991348 1185 S>T No EVA
rs3389381564 1210 D>N No EVA
rs1133422810 1236 K>E No EVA
rs3389300628 1288 V>L No EVA
rs3389382237 1311 S>F No EVA
rs221060503 1339 H>Y No EVA
rs3389352768 1448 G>R No EVA
rs3389387278 1473 R>I No EVA
rs31990350 1509 I>V No EVA
rs3389398443 1525 G>W No EVA
rs3389387284 1526 A>G No EVA
rs3389300599 1546 A>T No EVA
rs3389373118 1602 R>G No EVA
rs3389383218 1612 D>N No EVA
rs1134632896 1640 A>G No EVA
rs3389387241 1647 R>I No EVA

No associated diseases with Q9QXL2

2 regional properties for Q9QXL2

Type Name Position InterPro Accession
domain Ubiquitin-like domain 16 - 93 IPR000626
domain Rad60/SUMO-like domain 18 - 86 IPR022617

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
  • Cell projection, dendrite
  • Cell projection, axon
  • In neurons, localized to axons and dendrites
PANTHER Family PTHR47969 CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED
PANTHER Subfamily PTHR47969:SF30 KINESIN MOTOR DOMAIN-CONTAINING PROTEIN
PANTHER Protein Class cytoskeletal protein
microtubule binding motor protein
microtubule or microtubule-binding cytoskeletal protein
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
kinesin complex Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

5 GO annotations of molecular function

Name Definition
ankyrin repeat binding Binding to an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.
microtubule motor activity A motor activity that generates movement along a microtubule, driven by ATP hydrolysis.

1 GO annotations of biological process

Name Definition
microtubule-based movement A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q86VH2 KIF27 Kinesin-like protein KIF27 Homo sapiens (Human) SS
Q2M1P5 KIF7 Kinesin-like protein KIF7 Homo sapiens (Human) EV
O75037 KIF21B Kinesin-like protein KIF21B Homo sapiens (Human) EV
O95239 KIF4A Chromosome-associated kinesin KIF4A Homo sapiens (Human) SS
Q2VIQ3 KIF4B Chromosome-associated kinesin KIF4B Homo sapiens (Human) SS
Q7Z4S6 KIF21A Kinesin-like protein KIF21A Homo sapiens (Human) EV
Q61768 Kif5b Kinesin-1 heavy chain Mus musculus (Mouse) EV
P28738 Kif5c Kinesin heavy chain isoform 5C Mus musculus (Mouse) SS
P33175 Kif5a Kinesin heavy chain isoform 5A Mus musculus (Mouse) SS
Q7M6Z4 Kif27 Kinesin-like protein KIF27 Mus musculus (Mouse) SS
Q9QXL1 Kif21b Kinesin-like protein KIF21B Mus musculus (Mouse) SS
Q99PW8 Kif17 Kinesin-like protein KIF17 Mus musculus (Mouse) SS
B7ZNG0 Kif7 Kinesin-like protein KIF7 Mus musculus (Mouse) SS
Q9EQW7 Kif13a Kinesin-like protein KIF13A Mus musculus (Mouse) SS
Q7M6Z5 Kif27 Kinesin-like protein KIF27 Rattus norvegicus (Rat) SS
F1M5N7 Kif21b Kinesin-like protein KIF21B Rattus norvegicus (Rat) SS
Q58G59 kif7 Kinesin-like protein kif7 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MLGAADESSV RVAVRIRPQL AKEKIEGCHI CTSVTPGEPQ VFLGKDKAFT FDYVFDIDSQ
70 80 90 100 110 120
QEQIYTQCIE KLIEGCFEGY NATVFAYGQT GAGKTYTMGT GFDVNIMEEE QGIISRAVRH
130 140 150 160 170 180
LFKSIDEKKT SAIKNGLPPP EFKVNAQFLE LYNEEVLDLF DTTRDIDAKN KKSNIRIHED
190 200 210 220 230 240
STGGIYTVGV TTRTVNTEPE MMQCLKLGAL SRTTASTQMN VQSSRSHAIF TIHVCQTRVC
250 260 270 280 290 300
PQTDAENATD NKLISESSPM NEFETLTAKF HFVDLAGSER LKRTGATGER AKEGISINCG
310 320 330 340 350 360
LLALGNVISA LGDKSKRATH VPYRDSKLTR LLQDSLGGNS QTIMIACVSP SDRDFMETLN
370 380 390 400 410 420
TLKYANRARN IKNKVMVNQD RASQQINALR SEITRLQMEL MEYKTGKRII DEEGVESIND
430 440 450 460 470 480
MFHENAMLQT ENNNLRVRIK AMQETVDALR ARITQLVSEQ ANQVLARAGE GNEEISNMIH
490 500 510 520 530 540
SYIKEIEDLR AKLLESEAVN ENLRKNLTRA TARSPYFSAS SAFSPTILSS DKETIEIIDL
550 560 570 580 590 600
AKKDLEKLKR KEKKKKKRLQ KLEESGREER SVAGKDDNAD TDQEKKEEKG VSEKENNELD
610 620 630 640 650 660
VEENQEVSDH EDEEEEEEDE EEEDDIEGEE SSDESDSESD EKANYQADLA NITCEIAIKQ
670 680 690 700 710 720
KLIDELENSQ KRLQTLKKQY EEKLMMLQHK IRDTQLERDQ VLQNLGSVES YSEEKAKKVK
730 740 750 760 770 780
CEYEKKLHAM NKELQRLQTA QKEHARLLKN QSQYEKQLKK LQQDVMEMKK TKVRLMKQMK
790 800 810 820 830 840
EEQEKARLTE SRRNREIAQL KKDQRKRDHQ LRLLEAQKRN QEVVLRRKTE EVTALRRQVR
850 860 870 880 890 900
PMSDKVAGKV TRKLSSSESP APDTGSSAAS GEADTSRPGT QQKMRIPVAR VQALPTPTTN
910 920 930 940 950 960
GTRKKYQRKG FTGRVFTSKT ARMKWQLLER RVTDIIMQKM TISNMEADMN RLLRQREELT
970 980 990 1000 1010 1020
KRREKLSKRR EKIVKESGEG DKSVANIIEE MESLTANIDY INDSIADCQA NIMQMEEAKE
1030 1040 1050 1060 1070 1080
EGETLDVTAV INACTLTEAR YLLDHFLSMG INKGLQAAQK EAQIKVLEGR LKQTEITSAT
1090 1100 1110 1120 1130 1140
QNQLLFHMLK EKAELNPELD ALLGHALQDL DGAPPENEED SSEEDGPLHS PGSEGSTLSS
1150 1160 1170 1180 1190 1200
DLMKLCGEVK PKNKARRRTT TQMELLYADS SEVASDTSAG DASLSGPLAP VAEGQEIGMN
1210 1220 1230 1240 1250 1260
TETSGTSARD KELLAPSGLP SKIGSISRQS SLSEKKVPEP SPVTRRKAYE KADKPKAKEH
1270 1280 1290 1300 1310 1320
KHSDSGASET SLSPPSSPPS RPRNELNVFN RLTVPQGTPS VQQDKSDESD SSLSEVHRGI
1330 1340 1350 1360 1370 1380
INPFPACKGV RASPLQCVHI AEGHTKAVLC VDSTDDLLFT GSKDRTCKVW NLVTGQEIMS
1390 1400 1410 1420 1430 1440
LGVHPNNVVS VKYCNYTSLV FTVSTSYIKV WDIRESAKCI RTLTSSGQVT LGEACSASTS
1450 1460 1470 1480 1490 1500
RTVAIPSGES QINQIALNPT GTFLYAASGN AVRMWDLKRF QSTGKLTGHL GPVMCLTVDQ
1510 1520 1530 1540 1550 1560
ISNGQDLIIT GSKDHYIKMF DVTEGALGTV SPTHNFEPPH YDGIEALAIQ GDNLFSGSRD
1570 1580 1590 1600 1610 1620
NGIKKWDLAQ KGLLQQVPNA HKDWVCALGL VPGHPVLLSG CRGGILKLWN VDTFVPVGEM
1630 1640 1650 1660 1670
RGHDSPINAI CVNSTHVFTA ADDRTVRIWK AHNLQDGQLS DTGDLGEDIA SN