Q9QWN8

PR
Gene name
Sptbn2 (Spnb3)
Protein name
Spectrin beta chain, non-erythrocytic 2
Names
Beta SpIII sigma 1, Beta-III spectrin, Glutamate transporter EAAT4-associated protein 41, SPNB-3, Spectrin-like protein GTRAP41
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

2155-2236 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9QWN8

Entry ID Method Resolution Chain Position Source
AF-Q9QWN8-F1 Predicted AlphaFoldDB

No variants for Q9QWN8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9QWN8

No associated diseases with Q9QWN8

3 regional properties for Q9QWN8

Type Name Position InterPro Accession
domain Protein kinase domain 388 - 666 IPR000719
active_site Serine/threonine-protein kinase, active site 514 - 526 IPR008271
binding_site Protein kinase, ATP binding site 394 - 417 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
  • Cytoplasm, cell cortex
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

19 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
cell junction A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
cell projection A prolongation or process extending from a cell, e.g. a flagellum or axon.
cortical actin cytoskeleton The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endosome A vacuole to which materials ingested by endocytosis are delivered.
glutamatergic synapse A synapse that uses glutamate as a neurotransmitter.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nuclear matrix The dense fibrillar network lying on the inner side of the nuclear membrane.
parallel fiber to Purkinje cell synapse An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells.
paranodal junction A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynaptic spectrin-associated cytoskeleton The portion of the spectrin-associated cytoskeleton contained within the postsynapse.
presynapse The part of a synapse that is part of the presynaptic cell.
spectrin Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins.
synaptic vesicle A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.

4 GO annotations of molecular function

Name Definition
actin filament binding Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
phospholipid binding Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester.
structural constituent of cytoskeleton The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
structural constituent of synapse The action of a molecule that contributes to the structural integrity of a synapse.

12 GO annotations of biological process

Name Definition
actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
actin filament capping The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.
adult behavior Behavior in a fully developed and mature organism.
cellular response to ethanol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
cerebellar Purkinje cell layer morphogenesis The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.
multicellular organism growth The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
postsynapse organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse.
regulation of calcium ion-dependent exocytosis Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis.
synapse assembly The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).
synaptic vesicle docking The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process.
synaptic vesicle exocytosis Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 Homo sapiens (Human) PR
P11277 SPTB Spectrin beta chain, erythrocytic Homo sapiens (Human) PR
O15020 SPTBN2 Spectrin beta chain, non-erythrocytic 2 Homo sapiens (Human) PR
P15508 Sptb Spectrin beta chain, erythrocytic Mus musculus (Mouse) PR
Q62261 Sptbn1 Spectrin beta chain, non-erythrocytic 1 Mus musculus (Mouse) PR
Q9QXQ0 Actn4 Alpha-actinin-4 Rattus norvegicus (Rat) SS
Q9Z1P2 Actn1 Alpha-actinin-1 Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MSSTLSPTDF DSLEIQGQYS DINNRWDLPD SDWDNDSSSA RLFERSRIKA LADEREAVQK
70 80 90 100 110 120
KTFTKWVNSH LARVTCRVGD LYSDLRDGRN LLRLLEVLSG ETLPKPTKGR MRIHCLENVD
130 140 150 160 170 180
KALQFLKEQK VHLENMGSHD IVDGNHRLTL GLVWTIILRF QIQDISVETE DNKEKKSAKD
190 200 210 220 230 240
ALLLWCQMKT AGYPNVNVHN FTTSWRDGLA FNAIVHKHRP DLLDFESLKK CNAHYNLQNA
250 260 270 280 290 300
FNLAEKELGL TKLLDPEDVN VDQPDEKSII TYVATYYHYF SKMKALAVEG KRIGKVLDHA
310 320 330 340 350 360
MEAEHLVEKY ESLASELLQW IEQTIVTLND RQLANSLSGV QNQLQSFNSY RTVEKPPKFT
370 380 390 400 410 420
EKGNLEVLLF TIQSKLRANN QKVYTPREGR LISDINKAWE RLEKAEHERE LALRTELIRQ
430 440 450 460 470 480
EKLEQLAARF DRKAAMRETW LSENQRLVSQ DNFGLELAAV EAAVRKHEAI ETDIVAYSGR
490 500 510 520 530 540
VQAVDAVAAE LAAEHYHDIK RIAARQNNVA RLWDFLREMV AARRERLLLN LELQKVFQDL
550 560 570 580 590 600
LYLMDWMAEM KGRLQSQDLG KHLAGVEDLL QLHELVEADI AVQAERVRAV SASALRFCDP
610 620 630 640 650 660
GKEYRPCDPQ LVSERVATLE QSYEALCELA ATRRARLEES RRLWRFLWEV GEAEAWVREQ
670 680 690 700 710 720
QHLLASAETG RDLTGVLRLL NKHTALRGEM SGRLGPLKLT LEQGQQLVAE GHPGANQAST
730 740 750 760 770 780
RAAELQAQWE RLEALAEERA QRLAQAASLY QFQADANDME AWLVDALRLV SSPEVGHDEF
790 800 810 820 830 840
STQALARQHR ALEEEIRAHR PTLDALREQA AALPPALSHT PEVQGRVPTL EQHYEELQAR
850 860 870 880 890 900
AGERARALEA ALAFYTMLSE AGACGLWVEE KEQWLNGLAL PERLEDLEVV QQRFETLEPE
910 920 930 940 950 960
MNALAARVTA VSDIAEQLLK ASPPGKDRII GTQEQLNQRW QQFRSLADGK KAALTSALSI
970 980 990 1000 1010 1020
QNYHLECTET QAWMREKTKV IESTQDLGND LAGVLALQRK LAGTERDLEA ISARVGELTQ
1030 1040 1050 1060 1070 1080
EANALAAGHP AQAPAINTRL GEVQTGWEDL RATMRRREES LGEARRLQDF LRSLDDFQAW
1090 1100 1110 1120 1130 1140
LGRTQTAVAS EEGPATLPEA EALLAQHAAL RGEVERAQSE YSRLRTLGEE VTRDQADPQC
1150 1160 1170 1180 1190 1200
LFLRQRLEAL GTGWEELGRM WESRQGRLAQ AHGFQGFLRD ARQAEGVLSS QEYFLSHTEM
1210 1220 1230 1240 1250 1260
PGTLQAADAA IKKLEDFMST MDANGERIRG LLEAGRQLVS KGNIHAEKIQ EKADSIEKRH
1270 1280 1290 1300 1310 1320
RKNQEAVQQL LGRLRDNREQ QHFLQDCQEL KLWIDEKMLT AQDVSYDEAR NLHTKWQKHQ
1330 1340 1350 1360 1370 1380
AFMAELAANK DWLDKVDKEG RELTLEKPEL KVLVSEKLED LHRRWDELET TTQAKARSLF
1390 1400 1410 1420 1430 1440
DANRAELFAQ SCSALESWLE SLQAQLHSDD YGKDLTSVNI LLKKQQMLER EMAVREKEVE
1450 1460 1470 1480 1490 1500
AIQAQAKALA QEDQSAGEVE RTSRAVEEKF RALCQPMKDR CRRLQASREQ HQFHRDVEDE
1510 1520 1530 1540 1550 1560
ILWVTERLPM ASSLEHGKDL PSVQLLMKKN QTLQKEIQGH EPRIADLKER QRTLGTAAAG
1570 1580 1590 1600 1610 1620
PELAELQEMW KRLSHELELR GKRLEEALRA QQFYRDAAEA EAWMGEQELH MMGQEKAKDE
1630 1640 1650 1660 1670 1680
LSAQAEVKKH QVLEQALADY AQTIKQLAAS SQDMIDHEHP ESTRLTIRQA QVDKLYAGLK
1690 1700 1710 1720 1730 1740
ELAGERRERL QEHLRLCQLR RELDDLEQWI QEREVVAASH ELGQDYEHVT MLRDKFREFS
1750 1760 1770 1780 1790 1800
RDTSTIGQER VDSANALANG LIAGGHAARA TVAEWKDSLN EAWADLLELL DTRGQVLAAA
1810 1820 1830 1840 1850 1860
YELQRFLHGA RQALARVQHK QQQLPDGTGR DLNAAEALQR RHCAYEHDIQ ALSTQVQQVQ
1870 1880 1890 1900 1910 1920
DDGLRLQKAY AGDKAEEIGR HMQAVAEAWA QLQGSSAARR QLLLDTTDKF RFFKAVRELM
1930 1940 1950 1960 1970 1980
LWMDGINLQM DAQERPRDVS SADLVIKNQQ GIKAEIEARA DRFSACIDMG QELLARNHYA
1990 2000 2010 2020 2030 2040
AEEISEKLSQ LQSRRQETAE KWQEKMDWLQ LVLEVLVFGR DAGMAEAWLC SQEPLVRSAE
2050 2060 2070 2080 2090 2100
LGCTVDEVES LIKRHEAFQK SAVAWEERFS ALEKLTALEE RENEQKRKRE EEERRKQPPT
2110 2120 2130 2140 2150 2160
SEPMASQPEG SLVDGQRVLD TAWDGTQSKL PPSTQAPSIN GVCTDTESSQ PLLEQQRLEQ
2170 2180 2190 2200 2210 2220
SNVPEGPGSG TGDESSGPRG ERQTLPRGPA PSPMPQSRSS ESAHVATLPA RGAELSAQEQ
2230 2240 2250 2260 2270 2280
MEGTLCRKQE MEAFNKKAAN RSWQNVYCVL RRGSLGFYKD ARAASAGVPY HGEVPVSLAR
2290 2300 2310 2320 2330 2340
AQGSVAFDYR KRKHVFKLGL QDGKEYLFQA KDEAEMSSWL RVVNAAIATA SSASGEPEEP
2350 2360 2370 2380
VVPSASRGLT RAMTMPPVSQ PEGSIVLRSK DGREREREKR FSFFKKNK